Type |
Details |
Score |
Publication |
First Author: |
Tahara N |
Year: |
2018 |
Journal: |
Dev Biol |
Title: |
Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules. |
Volume: |
434 |
Issue: |
1 |
Pages: |
74-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cai CL |
Year: |
2003 |
Journal: |
Dev Cell |
Title: |
Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. |
Volume: |
5 |
Issue: |
6 |
Pages: |
877-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Akiyama R |
Year: |
2014 |
Journal: |
Dev Biol |
Title: |
Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the β-catenin pathway. |
Volume: |
387 |
Issue: |
1 |
Pages: |
37-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pacheco-Leyva I |
Year: |
2016 |
Journal: |
Stem Cell Reports |
Title: |
CITED2 Cooperates with ISL1 and Promotes Cardiac Differentiation of Mouse Embryonic Stem Cells. |
Volume: |
7 |
Issue: |
6 |
Pages: |
1037-1049 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamashita T |
Year: |
2018 |
Journal: |
PLoS Genet |
Title: |
High-resolution transcriptional dissection of in vivo Atoh1-mediated hair cell conversion in mature cochleae identifies Isl1 as a co-reprogramming factor. |
Volume: |
14 |
Issue: |
7 |
Pages: |
e1007552 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kappen C |
Year: |
2013 |
Journal: |
Transgenic Res |
Title: |
Transgenic studies on homeobox genes in nervous system development: spina bifida in Isl1 transgenic mice. |
Volume: |
22 |
Issue: |
2 |
Pages: |
343-58 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6175619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190630 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Isl1 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6175619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190630 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Isl1 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6175619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190630 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Isl1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6175619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190630 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Isl1 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6175619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190630 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Isl1 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6175619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190630 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Isl1 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6175619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190630 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Isl1 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sirbu IO |
Year: |
2008 |
Journal: |
Dev Dyn |
Title: |
Retinoic acid controls heart anteroposterior patterning by down-regulating Isl1 through the Fgf8 pathway. |
Volume: |
237 |
Issue: |
6 |
Pages: |
1627-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Snarr BS |
Year: |
2007 |
Journal: |
Circ Res |
Title: |
Isl1 expression at the venous pole identifies a novel role for the second heart field in cardiac development. |
Volume: |
101 |
Issue: |
10 |
Pages: |
971-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim E |
Year: |
2019 |
Journal: |
Dev Cell |
Title: |
Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation. |
Volume: |
51 |
Issue: |
6 |
Pages: |
675-683.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu M |
Year: |
2024 |
Journal: |
J Neurosci |
Title: |
ISL1 and POU4F1 Directly Interact to Regulate the Differentiation and Survival of Inner Ear Sensory Neurons. |
Volume: |
44 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Narkis G |
Year: |
2012 |
Journal: |
Dev Dyn |
Title: |
Isl1 and Ldb co-regulators of transcription are essential early determinants of mouse limb development. |
Volume: |
241 |
Issue: |
4 |
Pages: |
787-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Waclaw RR |
Year: |
2017 |
Journal: |
Mol Cell Neurosci |
Title: |
Foxo1 is a downstream effector of Isl1 in direct pathway striatal projection neuron development within the embryonic mouse telencephalon. |
Volume: |
80 |
|
Pages: |
44-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weinberger F |
Year: |
2015 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Assessment of DNA synthesis in Islet-1⁺ cells in the adult murine heart. |
Volume: |
456 |
Issue: |
1 |
Pages: |
294-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ehrman LA |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. |
Volume: |
110 |
Issue: |
42 |
Pages: |
E4026-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mu X |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2. |
Volume: |
105 |
Issue: |
19 |
Pages: |
6942-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roy A |
Year: |
2012 |
Journal: |
Development |
Title: |
Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. |
Volume: |
139 |
Issue: |
17 |
Pages: |
3109-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deng M |
Year: |
2014 |
Journal: |
Gene Expr Patterns |
Title: |
Comparative expression analysis of POU4F1, POU4F2 and ISL1 in developing mouse cochleovestibular ganglion neurons. |
Volume: |
15 |
Issue: |
1 |
Pages: |
31-7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6449762 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750321 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:6449800 |
Age: |
embryonic day 13.5 |
Image: |
S1 E13.5 Isl1 |
Note: |
Expression overlaps with expression of Isl1. |
Specimen Label: |
S1 E13.5 Isl1 |
Detected: |
true |
Specimen Num: |
20 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6449762 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3292723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:6449800 |
Age: |
embryonic day 15.5 |
Image: |
S1 E15.5 Isl1 |
|
Specimen Label: |
S1 E15.5 Isl1 |
Detected: |
true |
Specimen Num: |
24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ehrman JM |
Year: |
2022 |
Journal: |
J Neurosci |
Title: |
Formation of the Mouse Internal Capsule and Cerebral Peduncle: A Pioneering Role for Striatonigral Axons as Revealed in Isl1 Conditional Mutants. |
Volume: |
42 |
Issue: |
16 |
Pages: |
3344-3364 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5695106 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-11-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1698219 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:5695113 |
Age: |
embryonic day 11.5 |
Image: |
4F |
Note: |
A subset of cranial neurons were stained only by Isl1 antibody, but not anti-lacZ. |
Specimen Label: |
4F |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
1998-12-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672519 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:1316702 |
Age: |
embryonic day 11.5 |
Image: |
e11.5 |
Note: |
The expression of Isl1 persists in cells in the ventral domain of Rathke's pouch. |
Specimen Label: |
e11.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3699193 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2004-05-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666819 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:3039467 |
Age: |
embryonic day 11.5 |
Image: |
5F |
Note: |
Cells that express Isl1 do not express lacZ and vice versa. |
Specimen Label: |
5F |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
1998-12-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1751420 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1316702 |
Age: |
embryonic day 12.5 |
Image: |
e12.5 |
Note: |
Isl1 expression is in the ventral region of the anterior pituitary. |
Specimen Label: |
e12.5 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5695106 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-11-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679719 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:5695113 |
Age: |
embryonic day 11.5 |
Image: |
4E |
Note: |
A subset of cranial neurons were stained only by Isl1 antibody, but not anti-lacZ. |
Specimen Label: |
4E |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3529591 |
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2015-11-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690619 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:5695112 |
Age: |
embryonic day 11.5 |
Image: |
4B |
Note: |
Expression largely overlapped with Isl1 staining in the outer mantle layer where differentiated neurons reside. |
Specimen Label: |
4B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5695106 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-11-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679819 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:5695113 |
Age: |
embryonic day 11.5 |
Image: |
4G |
Note: |
A subset of cranial neurons were stained only by Isl1 antibody, but not anti-lacZ. |
Specimen Label: |
4G |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2149733 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2016-12-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702321 |
Pattern: |
Scattered |
Stage: |
TS21 |
Assay Id: |
MGI:5812712 |
Age: |
embryonic day 13.5 |
Image: |
6A |
Note: |
There were a few scattered Isl1 immunopositive cells in the gastric epithelium. |
Specimen Label: |
6A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
1998-12-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672517 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:1316702 |
Age: |
embryonic day 10.5-11.0 |
Image: |
e10.5 |
Note: |
Isl1 expression is gradually extinguished from Rathke's pouch cells located closest to the infundibulum. |
Specimen Label: |
e10.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3699193 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2004-05-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666819 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:3039467 |
Age: |
embryonic day 11.5 |
Image: |
5E |
Note: |
Cells that express Isl1 do not express lacZ and vice versa. |
Specimen Label: |
5E |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2001-04-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1758220 |
Pattern: |
Single cells |
Stage: |
TS20 |
Assay Id: |
MGI:1933408 |
Age: |
embryonic day 12.5 |
Image: |
3G |
Note: |
Isl1 expression was used as a marker for differentiation motor neurons. |
Specimen Label: |
3G |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7524696 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-09-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754020 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:7524725 |
Age: |
embryonic day 12.5 |
Image: |
7H |
Note: |
Domain continues caudally to putative reticular nucleus. Domain expressing Lhx1, Isl1 and Pax6 but not Lhx5. |
Specimen Label: |
7H |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5695106 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-11-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1756919 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:5695113 |
Age: |
embryonic day 11.5 |
Image: |
4F |
Note: |
A subset of cranial neurons were stained only by Isl1 antibody, but not anti-lacZ. |
Specimen Label: |
4F |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5695106 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-11-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679519 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:5695113 |
Age: |
embryonic day 11.5 |
Image: |
4G |
Note: |
A subset of cranial neurons were stained only by Isl1 antibody, but not anti-lacZ. |
Specimen Label: |
4G |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Terry NA |
Year: |
2014 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Impaired enteroendocrine development in intestinal-specific Islet1 mouse mutants causes impaired glucose homeostasis. |
Volume: |
307 |
Issue: |
10 |
Pages: |
G979-91 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2149733 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2018-08-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716821 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6195299 |
Age: |
embryonic day 13.5 |
Image: |
4C |
Note: |
Isl1 was transiently expressed with Atoh7 during retinal ganglion cells migration and maintained in the ganglion cell layer. |
Specimen Label: |
4C |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elshatory Y |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells. |
Volume: |
27 |
Issue: |
46 |
Pages: |
12707-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Whitney IE |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Genetic modulation of horizontal cell number in the mouse retina. |
Volume: |
108 |
Issue: |
23 |
Pages: |
9697-702 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6473333 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-11-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689521 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:7382852 |
Age: |
embryonic day 13.5 |
Image: |
6E |
Note: |
Thalamocortical axons (asterisk, unlabeled) crossed the diencephalon-telencephalon boundary above a patch of Nkx2-1 positive cells and Isl1 positive cells from the diencephalon. |
Specimen Label: |
6E |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2149733 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2004-03-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1720124 |
Pattern: |
Single cells |
Stage: |
TS24 |
Assay Id: |
MGI:3029195 |
Age: |
embryonic day 16.0 |
|
Note: |
Expression of this marker indicates ectopic differentiation of pancreatic beta cells in the common bile duct. The cells coexpress Isl1 and insulin. |
Specimen Label: |
q E12.5 Insulin/Isl1 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5695106 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-11-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1634619 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:5695113 |
Age: |
embryonic day 11.5 |
Image: |
4K |
Note: |
Expressed in myocardial cells of the distal outflow tract, albeit at lower levels. Few if any endocardial cells or outflow cushion mesenchymal cells exhibited Isl1 expression. |
Specimen Label: |
4K |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2149733 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2013-10-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716820 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:5509329 |
Age: |
embryonic day 12.5 |
Image: |
4C,C',C''' |
Note: |
Expression in the ganglion cell layer overlapped completely with expression of Oc2, but only a proportion of Oc2-positive cells expressed Isl1 in the neuroblast layer. |
Specimen Label: |
4C,C',C''' |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
1998-12-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1626213 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:1316702 |
Age: |
embryonic day 8.5 |
Image: |
e8.5 |
Note: |
Expression of Isl1 is detected in oral roof ectoderm cells that underlie the ventral diencephalon and give rise to Rathke's pouch. |
Specimen Label: |
e8.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nathan E |
Year: |
2008 |
Journal: |
Development |
Title: |
The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development. |
Volume: |
135 |
Issue: |
4 |
Pages: |
647-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ediger BN |
Year: |
2014 |
Journal: |
Diabetes |
Title: |
Islet-1 Is essential for pancreatic β-cell function. |
Volume: |
63 |
Issue: |
12 |
Pages: |
4206-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Laugwitz KL |
Year: |
2005 |
Journal: |
Nature |
Title: |
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. |
Volume: |
433 |
Issue: |
7026 |
Pages: |
647-53 |
|
•
•
•
•
•
|
Allele |
Name: |
ISL1 transcription factor, LIM/homeodomain; targeted mutation 4, Sylvia M Evans |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Hypomorph |
|
•
•
•
•
•
|
Publication |
First Author: |
Westerlund J |
Year: |
2008 |
Journal: |
Dev Dyn |
Title: |
Expression of Islet1 in thyroid development related to budding, migration, and fusion of primordia. |
Volume: |
237 |
Issue: |
12 |
Pages: |
3820-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2014 |
Journal: |
Mol Endocrinol |
Title: |
LIM-homeodomain transcription factor Isl-1 mediates kisspeptin's effect on insulin secretion in mice. |
Volume: |
28 |
Issue: |
8 |
Pages: |
1276-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Engleka KA |
Year: |
2012 |
Journal: |
Circ Res |
Title: |
Islet1 derivatives in the heart are of both neural crest and second heart field origin. |
Volume: |
110 |
Issue: |
7 |
Pages: |
922-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
LIM-homeodomain transcription factor Isl-1 mediates the effect of leptin on insulin secretion in mice. |
Volume: |
288 |
Issue: |
17 |
Pages: |
12395-405 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
1999-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691617 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:1342769 |
Age: |
embryonic day 10.5 |
Image: |
2.G |
Note: |
Protein is detected in the locus coeruleus, in the ventral column of motor neuron precursers, which extends caudally from rostral r2. Isl1 expression coincides with that of Gata2 in r4, but extends more ventrally in other parts of the neural tube. |
Specimen Label: |
2.G |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2148090 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
1999-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1609217 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:1342769 |
Age: |
embryonic day 10.5 |
Image: |
2.G |
Note: |
Protein is detected in the locus coeruleus, in the ventral column of motor neuron precursers, which extends caudally from rostral r2. Isl1 expression coincides with that of Gata2 in r4, but extends more ventrally in other parts of the neural tube. |
Specimen Label: |
2.G |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vedantham V |
Year: |
2015 |
Journal: |
Circ Res |
Title: |
RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells. |
Volume: |
116 |
Issue: |
5 |
Pages: |
797-803 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boillée S |
Year: |
2006 |
Journal: |
Science |
Title: |
Onset and progression in inherited ALS determined by motor neurons and microglia. |
Volume: |
312 |
Issue: |
5778 |
Pages: |
1389-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Siddiqi F |
Year: |
2021 |
Journal: |
Cereb Cortex |
Title: |
Islet1 Precursors Contribute to Mature Interneuron Subtypes in Mouse Neocortex. |
Volume: |
31 |
Issue: |
11 |
Pages: |
5206-5224 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brinkmeier ML |
Year: |
2024 |
Journal: |
Endocrinology |
Title: |
Long Noncoding RNAs Expressed in Mouse Pituitary Development and Mature Hormone-Producing Cells. |
Volume: |
165 |
Issue: |
12 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Abed S |
Year: |
2022 |
Journal: |
Front Cell Neurosci |
Title: |
Adult Expression of Tbr2 Is Required for the Maintenance but Not Survival of Intrinsically Photosensitive Retinal Ganglion Cells. |
Volume: |
16 |
|
Pages: |
826590 |
|
•
•
•
•
•
|
Publication |
First Author: |
Macova I |
Year: |
2019 |
Journal: |
J Neurosci |
Title: |
Neurod1 Is Essential for the Primary Tonotopic Organization and Related Auditory Information Processing in the Midbrain. |
Volume: |
39 |
Issue: |
6 |
Pages: |
984-1004 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dupays L |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
Tbx2 misexpression impairs deployment of second heart field derived progenitor cells to the arterial pole of the embryonic heart. |
Volume: |
333 |
Issue: |
1 |
Pages: |
121-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shen N |
Year: |
2016 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Frizzled3 Shapes the Development of Retinal Rod Bipolar Cells. |
Volume: |
57 |
Issue: |
6 |
Pages: |
2788-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buffinton CM |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Myocardial wall stiffening in a mouse model of persistent truncus arteriosus. |
Volume: |
12 |
Issue: |
9 |
Pages: |
e0184678 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ando K |
Year: |
2003 |
Journal: |
J Mol Endocrinol |
Title: |
Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1. |
Volume: |
31 |
Issue: |
3 |
Pages: |
419-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jung Y |
Year: |
2018 |
Journal: |
Endocrinology |
Title: |
Isl1β Overexpression With Key β Cell Transcription Factors Enhances Glucose-Responsive Hepatic Insulin Production and Secretion. |
Volume: |
159 |
Issue: |
2 |
Pages: |
869-882 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barzelay A |
Year: |
2012 |
Journal: |
Atherosclerosis |
Title: |
Islet-1 gene delivery improves myocardial performance after experimental infarction. |
Volume: |
223 |
Issue: |
2 |
Pages: |
284-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bejerano G |
Year: |
2006 |
Journal: |
Nature |
Title: |
A distal enhancer and an ultraconserved exon are derived from a novel retroposon. |
Volume: |
441 |
Issue: |
7089 |
Pages: |
87-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bohuslavova R |
Year: |
2017 |
Journal: |
Mol Neurobiol |
Title: |
Pax2-Islet1 Transgenic Mice Are Hyperactive and Have Altered Cerebellar Foliation. |
Volume: |
54 |
Issue: |
2 |
Pages: |
1352-1368 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang M |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
Hair cell overexpression of Islet1 reduces age-related and noise-induced hearing loss. |
Volume: |
33 |
Issue: |
38 |
Pages: |
15086-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun Y |
Year: |
2008 |
Journal: |
Nat Neurosci |
Title: |
A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. |
Volume: |
11 |
Issue: |
11 |
Pages: |
1283-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keenan ID |
Year: |
2012 |
Journal: |
FEBS Lett |
Title: |
Origin of non-cardiac endothelial cells from an Isl1+ lineage. |
Volume: |
586 |
Issue: |
13 |
Pages: |
1790-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hael CE |
Year: |
2020 |
Journal: |
Mol Metab |
Title: |
The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight. |
Volume: |
34 |
|
Pages: |
43-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mayoral SR |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Initiation of CNS Myelination in the Optic Nerve Is Dependent on Axon Caliber. |
Volume: |
25 |
Issue: |
3 |
Pages: |
544-550.e3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun Y |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. |
Volume: |
304 |
Issue: |
1 |
Pages: |
286-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Villa Del Campo C |
Year: |
2014 |
Journal: |
Cell Rep |
Title: |
Cell competition promotes phenotypically silent cardiomyocyte replacement in the mammalian heart. |
Volume: |
8 |
Issue: |
6 |
Pages: |
1741-1751 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou B |
Year: |
2008 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium. |
Volume: |
375 |
Issue: |
3 |
Pages: |
450-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu J |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development. |
Volume: |
286 |
Issue: |
17 |
Pages: |
15352-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bohuslavova R |
Year: |
2021 |
Journal: |
Int J Mol Sci |
Title: |
NEUROD1 Is Required for the Early α and β Endocrine Differentiation in the Pancreas. |
Volume: |
22 |
Issue: |
13 |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
349
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Milgrom-Hoffman M |
Year: |
2011 |
Journal: |
Development |
Title: |
The heart endocardium is derived from vascular endothelial progenitors. |
Volume: |
138 |
Issue: |
21 |
Pages: |
4777-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jia G |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement. |
Volume: |
9 |
Issue: |
1 |
Pages: |
4877 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lana-Elola E |
Year: |
2016 |
Journal: |
Elife |
Title: |
Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. |
Volume: |
5 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Conway SJ |
Year: |
2019 |
Journal: |
Gene Expr Patterns |
Title: |
Armadillo-like helical domain containing-4 is dynamically expressed in both the first and second heart fields. |
Volume: |
34 |
|
Pages: |
119077 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin L |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. |
Volume: |
104 |
Issue: |
22 |
Pages: |
9313-8 |
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•
•
•
•
•
|
Publication |
First Author: |
Zhang F |
Year: |
2015 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Divergent cell cycle kinetics of midgestation ventricular cells entail a higher engraftment efficiency after cell transplantation. |
Volume: |
308 |
Issue: |
3 |
Pages: |
C220-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Whitman MC |
Year: |
2018 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis. |
Volume: |
59 |
Issue: |
12 |
Pages: |
5201-5209 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chi L |
Year: |
2023 |
Journal: |
Biol Open |
Title: |
G9a inactivation in progenitor cells with Isl1-Cre with reduced recombinase activity models aspects of Dandy-Walker complex. |
Volume: |
12 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hatzistergos KE |
Year: |
2020 |
Journal: |
Sci Adv |
Title: |
A novel cardiomyogenic role for Isl1(+) neural crest cells in the inflow tract. |
Volume: |
6 |
Issue: |
49 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kwon C |
Year: |
2009 |
Journal: |
Nat Cell Biol |
Title: |
A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. |
Volume: |
11 |
Issue: |
8 |
Pages: |
951-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anderson RH |
Year: |
2023 |
Journal: |
J Anat |
Title: |
Development of the arterial roots and ventricular outflow tracts. |
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|
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•
•
•
•
•
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Publication |
First Author: |
Falgairolle M |
Year: |
2017 |
Journal: |
Elife |
Title: |
Motoneurons regulate the central pattern generator during drug-induced locomotor-like activity in the neonatal mouse. |
Volume: |
6 |
|
|
|
•
•
•
•
•
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Publication |
First Author: |
Bui TV |
Year: |
2013 |
Journal: |
Neuron |
Title: |
Circuits for grasping: spinal dI3 interneurons mediate cutaneous control of motor behavior. |
Volume: |
78 |
Issue: |
1 |
Pages: |
191-204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bui TV |
Year: |
2016 |
Journal: |
Elife |
Title: |
Spinal microcircuits comprising dI3 interneurons are necessary for motor functional recovery following spinal cord transection. |
Volume: |
5 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wizeman JW |
Year: |
2019 |
Journal: |
Elife |
Title: |
Specification of diverse cell types during early neurogenesis of the mouse cerebellum. |
Volume: |
8 |
|
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•
•
•
•
•
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