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Search results 101 to 200 out of 1089 for Jak2

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Type Details Score
Publication
9624169 | J:48179
First Author: Yamauchi T
Year: 1998
Journal: J Biol Chem
Title: Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase.
Volume: 273
Issue: 25
Pages: 15719-26
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Publication
31545956 | J:282154
 
First Author: Tian RH
Year: 2019
Journal: Brain Res
Title: Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression.
Volume: 1725
Pages: 146472
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Publication
30635286 | J:276224
First Author: Uras IZ
Year: 2019
Journal: Blood
Title: CDK6 coordinates JAK2 V617F mutant MPN via NF-κB and apoptotic networks.
Volume: 133
Issue: 15
Pages: 1677-1690
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Publication
16824542 | J:200437
First Author: Hu J
Year: 2006
Journal: J Mol Biol
Title: Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS.
Volume: 361
Issue: 1
Pages: 69-79
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Publication
23558526 | J:202797
First Author: Marty C
Year: 2013
Journal: Leukemia
Title: A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression.
Volume: 27
Issue: 11
Pages: 2187-95
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Allele
Tg(H2-K<b>-Jak2*V617F)2Shmd | MGI:5444028
Name: transgene insertion 2, Kazuya Shimoda
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Dcc<Tg(H2-Kb-Jak2*V617F)1Shmd> | MGI:5444031
Name: DCC netrin 1 receptor; transgene insertion 1, Kazuya Shimoda
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
21726629 | -
First Author: Sayyah J
Year: 2011
Journal: Cell Signal
Title: Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation.
Volume: 23
Issue: 11
Pages: 1806-15
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Publication
2482828 | J:22689
First Author: Wilks AF
Year: 1989
Journal: Gene
Title: The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family.
Volume: 85
Issue: 1
Pages: 67-74
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Publication
33667305 | J:327654
First Author: Rao TN
Year: 2021
Journal: Blood
Title: JAK2-V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality.
Volume: 137
Issue: 16
Pages: 2139-2151
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Publication
20068132 | J:164339
First Author: Robertson S
Year: 2010
Journal: Diabetes
Title: Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions.
Volume: 59
Issue: 4
Pages: 782-90
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Publication
23502962 | J:197987
First Author: Chow A
Year: 2013
Journal: Nat Med
Title: CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress.
Volume: 19
Issue: 4
Pages: 429-36
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Publication
23533276 | J:196179
First Author: Tang JZ
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.
Volume: 110
Issue: 15
Pages: 6091-6
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Protein Domain
IPR020693 | Tyr_kinase_non-rcpt_Jak2
Type: Family
Description: Janus kinases (JAKs) are tyrosine kinases that function in membrane-proximal signalling events initiated by a variety of extracellular factors binding to cell surface receptors []. Many type I and II cytokine receptors lack a protein tyrosine kinase domain and rely on JAKs to initiate the cytoplasmic signal transduction cascade. Ligand binding induces oligomerisation of the receptors, which then activates the cytoplasmic receptor-associated JAKs. These subsequently phosphorylate tyrosine residues along the receptor chains with which they are associated. The phosphotyrosine residues are a target for a variety of SH2 domain-containing transducer proteins. Amongst these are the signal transducers and activators of transcription (STAT) proteins, which, after binding to the receptor chains, are phosphorylated by the JAK proteins. Phosphorylation enables the STAT proteins to dimerise and translocate into the nucleus, where they alter the expression of cytokine-regulated genes. This system is known as the JAK-STAT pathway.Four mammalian JAK family members have been identified: JAK1, JAK2, JAK3, and TYK2. They are relatively large kinases of approximately 1150 amino acids, with molecular weights of ~120-130kDa. Their amino acid sequences are characterised by the presence of 7 highly conserved domains, termed JAK homology (JH) domains. The C-terminal domain (JH1) is responsible for the tyrosine kinase function. The next domain in the sequence (JH2) is known as the tyrosine kinase-like domain, as its sequence shows high similarity to functional kinases but does not possess any catalytic activity. Although the function of this domain is not well established, there is some evidence for a regulatory role on the JH1 domain, thus modulating catalytic activity. The N-terminal portion of the JAKs (spanning JH7 to JH3) is important for receptor association and non-catalytic activity, and consists of JH3-JH4, which is homologous to the SH2 domain, and lastly JH5-JH7, which is a FERM domain.This entry represents the non-receptor tyrosine kinase JAK2 []. JAK2 was initially cloned using a PCR-based strategy utilising primers corresponding to conserved motifs within the catalytic domain of protein-tyrosine kinases []. In common with JAK1 and TYK2, and by contrast with JAK3, JAK2 appears to be ubiquitously expressed.
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Publication
20541703 | J:160883
First Author: Mullally A
Year: 2010
Journal: Cancer Cell
Title: Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells.
Volume: 17
Issue: 6
Pages: 584-96
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Publication
28538171 | J:254311
First Author: Kirschner K
Year: 2017
Journal: Cell Rep
Title: Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.
Volume: 19
Issue: 8
Pages: 1503-1511
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Publication
32479500 | J:289626
First Author: Spivak JL
Year: 2020
Journal: PLoS One
Title: Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera.
Volume: 15
Issue: 6
Pages: e0232801
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Publication
36100613 | J:344212
First Author: Rai S
Year: 2022
Journal: Nat Commun
Title: Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm.
Volume: 13
Issue: 1
Pages: 5346
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Publication
30651633 | J:274256
First Author: Guo Y
Year: 2019
Journal: Leukemia
Title: ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis.
Volume: 33
Issue: 5
Pages: 1287-1291
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Publication
24469804 | J:206659
First Author: Etheridge SL
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: JAK2V617F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasms.
Volume: 111
Issue: 6
Pages: 2295-300
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Publication
22286129 | J:267924
First Author: Hantschel O
Year: 2012
Journal: Nat Chem Biol
Title: BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia.
Volume: 8
Issue: 3
Pages: 285-93
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Publication
20472827 | J:163497
First Author: Marty C
Year: 2010
Journal: Blood
Title: Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice.
Volume: 116
Issue: 5
Pages: 783-7
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Publication
7538110 | J:266147
First Author: He TC
Year: 1995
Journal: J Biol Chem
Title: Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway.
Volume: 270
Issue: 19
Pages: 11055-61
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Publication
1620548 | J:19806
First Author: Harpur AG
Year: 1992
Journal: Oncogene
Title: JAK2, a third member of the JAK family of protein tyrosine kinases.
Volume: 7
Issue: 7
Pages: 1347-53
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Publication
8063772 | J:19924
First Author: Zhuang H
Year: 1994
Journal: J Biol Chem
Title: Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2.
Volume: 269
Issue: 34
Pages: 21411-4
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Publication
7607555 | J:36028
First Author: Duhé RJ
Year: 1995
Journal: Gene
Title: Cloning of the gene encoding rat JAK2, a protein tyrosine kinase.
Volume: 158
Issue: 2
Pages: 281-5
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Publication
9446644 | J:45713
First Author: Dalal I
Year: 1998
Journal: Blood
Title: Cloning and characterization of the human homolog of mouse Jak2.
Volume: 91
Issue: 3
Pages: 844-51
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Publication
19835845 | J:155611
First Author: Sur R
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Role of Janus kinase-2 in IgE receptor-mediated leukotriene C4 production by mast cells.
Volume: 390
Issue: 3
Pages: 786-90
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Publication
36329047 | J:357317
First Author: Al-Rifai R
Year: 2022
Journal: Nat Commun
Title: JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm.
Volume: 13
Issue: 1
Pages: 6592
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Publication
28744010 | J:257879
First Author: Zhan H
Year: 2018
Journal: Leukemia
Title: The JAK2V617F-bearing vascular niche promotes clonal expansion in myeloproliferative neoplasms.
Volume: 32
Issue: 2
Pages: 462-469
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Publication
16025117 | J:100458
First Author: de Jonge WJ
Year: 2005
Journal: Nat Immunol
Title: Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway.
Volume: 6
Issue: 8
Pages: 844-51
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Publication
9202126 | J:43733
First Author: Endo TA
Year: 1997
Journal: Nature
Title: A new protein containing an SH2 domain that inhibits JAK kinases.
Volume: 387
Issue: 6636
Pages: 921-4
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Publication
29202466 | J:257910
First Author: Zhao B
Year: 2018
Journal: J Clin Invest
Title: Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.
Volume: 128
Issue: 1
Pages: 125-140
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Publication
25595737 | J:221914
First Author: Grisouard J
Year: 2015
Journal: Blood
Title: Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN.
Volume: 125
Issue: 13
Pages: 2131-40
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Publication
25339357 | J:220785
First Author: Sangkhae V
Year: 2014
Journal: Blood
Title: The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm.
Volume: 124
Issue: 26
Pages: 3956-63
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Protein
Q62120
Organism: Mus musculus/domesticus
Length: 1132  
Fragment?: false
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Publication
28965767 | J:253956
First Author: Kleppe M
Year: 2017
Journal: Cell Stem Cell
Title: Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.
Volume: 21
Issue: 4
Pages: 489-501.e7
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Publication
35016033 | J:326371
First Author: Mao Y
Year: 2022
Journal: Mol Cell
Title: Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses.
Volume: 82
Issue: 3
Pages: 527-541.e7
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Publication
12426001 | J:172891
First Author: Rojas M
Year: 2002
Journal: Cell Immunol
Title: Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis.
Volume: 217
Issue: 1-2
Pages: 58-66
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Publication
19234114 | J:245237
First Author: De Domenico I
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2.
Volume: 106
Issue: 10
Pages: 3800-5
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Publication
19508864 | J:150654
First Author: Cho HJ
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons.
Volume: 386
Issue: 1
Pages: 175-80
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Publication
23831231 | J:205316
 
First Author: Choi HI
Year: 2013
Journal: Free Radic Biol Med
Title: Peroxiredoxin V selectively regulates IL-6 production by modulating the Jak2-Stat5 pathway.
Volume: 65
Pages: 270-9
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Publication
19638583 | J:151772
First Author: Sakamoto K
Year: 2009
Journal: Cancer Res
Title: Targeting janus kinase 2 in Her2/neu-expressing mammary cancer: Implications for cancer prevention and therapy.
Volume: 69
Issue: 16
Pages: 6642-50
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Publication
20197548 | J:184283
First Author: Akada H
Year: 2010
Journal: Blood
Title: Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease.
Volume: 115
Issue: 17
Pages: 3589-97
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Publication
22275361 | J:183287
First Author: Shi SY
Year: 2012
Journal: J Biol Chem
Title: Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance.
Volume: 287
Issue: 13
Pages: 10277-88
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Publication
28100771 | J:274004
First Author: Shi SY
Year: 2017
Journal: J Biol Chem
Title: Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice.
Volume: 292
Issue: 9
Pages: 3789-3799
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Publication
24531222 | J:210481
First Author: Shi SY
Year: 2014
Journal: Diabetologia
Title: Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing.
Volume: 57
Issue: 5
Pages: 1016-26
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Publication
29643232 | J:261882
 
First Author: Wolach O
Year: 2018
Journal: Sci Transl Med
Title: Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms.
Volume: 10
Issue: 436
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Publication
26475415 | J:227864
First Author: Gan XT
Year: 2015
Journal: Am J Pathol
Title: Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2.
Volume: 185
Issue: 12
Pages: 3202-10
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Publication
23223021 | J:208594
First Author: Zhang Y
Year: 2013
Journal: Diabetes
Title: Amyloid-β induces hepatic insulin resistance in vivo via JAK2.
Volume: 62
Issue: 4
Pages: 1159-66
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Publication
31697834 | J:285063
First Author: Mansier O
Year: 2019
Journal: Blood
Title: Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells.
Volume: 134
Issue: 26
Pages: 2383-2387
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Publication
29467301 | J:260048
 
First Author: Prestipino A
Year: 2018
Journal: Sci Transl Med
Title: Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.
Volume: 10
Issue: 429
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Publication
22065597 | J:181654
First Author: Gautier EF
Year: 2012
Journal: Blood
Title: The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.
Volume: 119
Issue: 5
Pages: 1190-9
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Publication
7527668 | J:266151
First Author: Miura O
Year: 1994
Journal: Blood
Title: Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor.
Volume: 84
Issue: 12
Pages: 4135-41
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Publication
11536325 | J:173749
First Author: Dell'Albani P
Year: 2001
Journal: J Neurosci Res
Title: JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures.
Volume: 65
Issue: 5
Pages: 417-24
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Publication
14998905 | J:91003
First Author: Ito M
Year: 2004
Journal: Biol Reprod
Title: Localization of janus kinase 2 to the nuclei of mature oocytes and early cleavage stage mouse embryos.
Volume: 71
Issue: 1
Pages: 89-96
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Publication
20696946 | J:166649
First Author: Gorantla SP
Year: 2010
Journal: Blood
Title: Oncogenic JAK2V617F requires an intact SH2-like domain for constitutive activation and induction of a myeloproliferative disease in mice.
Volume: 116
Issue: 22
Pages: 4600-11
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Publication
27401344 | J:236469
First Author: Shimizu T
Year: 2016
Journal: J Exp Med
Title: Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis.
Volume: 213
Issue: 8
Pages: 1479-96
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Publication
8934548 | J:36866
First Author: Kumar A
Year: 1996
Journal: Oncogene
Title: Structural organization and chromosomal mapping of JAK3 locus.
Volume: 13
Issue: 9
Pages: 2009-14
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Publication
21149549 | J:176862
First Author: Choi D
Year: 2010
Journal: J Exp Med
Title: Erythropoietin protects against diabetes through direct effects on pancreatic beta cells.
Volume: 207
Issue: 13
Pages: 2831-42
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Publication
27154187 | J:236060
First Author: Casu C
Year: 2016
Journal: Blood
Title: Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera.
Volume: 128
Issue: 2
Pages: 265-76
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Publication
33770504 | J:306939
First Author: Yasuda M
Year: 2021
Journal: Neuron
Title: An activity-dependent determinant of synapse elimination in the mammalian brain.
Volume: 109
Issue: 8
Pages: 1333-1349.e6
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Publication
12147240 | J:78881
First Author: Olsen H
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells.
Volume: 296
Issue: 1
Pages: 139-44
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Publication
23454976 | J:304576
First Author: Kershaw NJ
Year: 2013
Journal: Nat Struct Mol Biol
Title: SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
Volume: 20
Issue: 4
Pages: 469-76
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Publication
9548458 | J:44275
First Author: Yu CL
Year: 1997
Journal: J Immunol
Title: Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase.
Volume: 159
Issue: 11
Pages: 5206-10
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Publication
16084495 | J:100329
First Author: Kakihana K
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Calmodulin physically interacts with the erythropoietin receptor and enhances Jak2-mediated signaling.
Volume: 335
Issue: 2
Pages: 424-31
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Publication
21364286 | J:172022
First Author: Sos BC
Year: 2011
Journal: J Clin Invest
Title: Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.
Volume: 121
Issue: 4
Pages: 1412-23
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Publication
23630962 | J:199725
First Author: Lee JJ
Year: 2013
Journal: Infect Immun
Title: Toll-like receptor 4-linked Janus kinase 2 signaling contributes to internalization of Brucella abortus by macrophages.
Volume: 81
Issue: 7
Pages: 2448-58
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Publication
28424277 | J:321056
First Author: Alghamdi TA
Year: 2017
Journal: J Am Soc Nephrol
Title: Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes.
Volume: 28
Issue: 9
Pages: 2641-2653
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Publication
23487027 | J:197933
First Author: Mullally A
Year: 2013
Journal: Blood
Title: Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera.
Volume: 121
Issue: 18
Pages: 3692-702
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Publication
15354294 | J:92299
First Author: Krempler A
Year: 2004
Journal: Genesis
Title: Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice.
Volume: 40
Issue: 1
Pages: 52-7
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Publication
19884384 | J:155335
First Author: Barclay JL
Year: 2010
Journal: Mol Endocrinol
Title: In vivo targeting of the growth hormone receptor (GHR) Box1 sequence demonstrates that the GHR does not signal exclusively through JAK2.
Volume: 24
Issue: 1
Pages: 204-17
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Publication
37100881 | J:353876
First Author: Willekens C
Year: 2023
Journal: Leukemia
Title: SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice.
Volume: 37
Issue: 6
Pages: 1287-1297
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Publication
29355841 | J:258362
First Author: McKenney AS
Year: 2018
Journal: J Clin Invest
Title: JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.
Volume: 128
Issue: 2
Pages: 789-804
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Publication
24692758 | J:212407
First Author: Li J
Year: 2014
Journal: Blood
Title: JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease.
Volume: 123
Issue: 20
Pages: 3139-51
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Publication
25644777 | J:352396
First Author: Hosseinzadeh Z
Year: 2015
Journal: J Membr Biol
Title: Up-regulation of Kv1.3 channels by janus kinase 2.
Volume: 248
Issue: 2
Pages: 309-17
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Publication
18158285 | J:132400
First Author: Lu X
Year: 2008
Journal: J Biol Chem
Title: Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F.
Volume: 283
Issue: 9
Pages: 5258-66
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Publication
28339658 | J:243960
First Author: Xu B
Year: 2017
Journal: Biol Reprod
Title: Acute cell volume regulation by Janus kinase 2-mediated sodium/hydrogen exchange activation develops at the late one-cell stage in mouse preimplantation embryos.
Volume: 96
Issue: 3
Pages: 542-550
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Publication
23750118 | J:201427
First Author: Kent DG
Year: 2013
Journal: PLoS Biol
Title: Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion.
Volume: 11
Issue: 6
Pages: e1001576
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Publication
17761766 | J:145813
First Author: Loesch K
Year: 2007
Journal: Endocrinology
Title: Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells.
Volume: 148
Issue: 12
Pages: 5955-65
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7782332 | J:143703
First Author: Argetsinger LS
Year: 1995
Journal: J Biol Chem
Title: Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1.
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24619965 | J:319044
First Author: Granzow M
Year: 2014
Journal: Hepatology
Title: Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis.
Volume: 60
Issue: 1
Pages: 334-48
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15156153 | J:175195
First Author: Kamakura S
Year: 2004
Journal: Nat Cell Biol
Title: Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.
Volume: 6
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Pages: 547-54
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18480424 | J:138595
First Author: Libani IV
Year: 2008
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Title: Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia.
Volume: 112
Issue: 3
Pages: 875-85
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31865052 | J:297273
 
First Author: Jing W
Year: 2020
Journal: Int Immunopharmacol
Title: Breast cancer cells promote CD169+ macrophage-associated immunosuppression through JAK2-mediated PD-L1 upregulation on macrophages.
Volume: 78
Pages: 106012
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22999860 | J:192755
First Author: Das A
Year: 2012
Journal: J Mol Cell Cardiol
Title: Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway.
Volume: 53
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Pages: 858-69
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First Author: Tao W
Year: 2014
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Title: c-Abl activates janus kinase 2 in normal hematopoietic cells.
Volume: 289
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27998978 | J:240716
First Author: Ueda F
Year: 2017
Journal: J Biol Chem
Title: Three Tyrosine Residues in the Erythropoietin Receptor Are Essential for Janus Kinase 2 V617F Mutant-induced Tumorigenesis.
Volume: 292
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Pages: 1826-1846
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First Author: Aringer M
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Journal: Life Sci
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Volume: 64
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First Author: Siyanova EY
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Journal: Oncogene
Title: Tyrosine kinase gene expression in the mouse small intestine.
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First Author: Kimura K
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Journal: Diabetes
Title: Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation.
Volume: 61
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Pages: 61-73
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23389690 | J:324429
First Author: Park SJ
Year: 2013
Journal: Neuropsychopharmacology
Title: Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.
Volume: 38
Issue: 8
Pages: 1426-37
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First Author: Dodington DW
Year: 2021
Journal: JCI Insight
Title: JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice.
Volume: 6
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Journal: Blood
Title: Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.
Volume: 119
Issue: 23
Pages: 5522-31
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First Author: Themanns M
Year: 2016
Journal: Sci Rep
Title: Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.
Volume: 6
Pages: 34719
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First Author: Lee H
Year: 2010
Journal: Nat Med
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Volume: 16
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Pages: 1421-8
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First Author: Sakamoto K
Year: 2010
Journal: Oncogene
Title: Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer.
Volume: 29
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Title: The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl.
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Journal: Mol Endocrinol
Title: The role of interleukin-11 in pregnancy involves up-regulation of alpha2-macroglobulin gene through janus kinase 2-signal transducer and activator of transcription 3 pathway in the decidua.
Volume: 20
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Pages: 3240-50
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