Type |
Details |
Score |
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Allele |
Name: |
potassium voltage-gated channel, subfamily H (eag-related), member 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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Publication |
First Author: |
Morais Cabral JH |
Year: |
1998 |
Journal: |
Cell |
Title: |
Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. |
Volume: |
95 |
Issue: |
5 |
Pages: |
649-55 |
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Publication |
First Author: |
Lecain E |
Year: |
1999 |
Journal: |
Hear Res |
Title: |
Potassium channel ether à go-go mRNA expression in the spiral ligament of the rat. |
Volume: |
133 |
Issue: |
1-2 |
Pages: |
133-8 |
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Publication |
First Author: |
Occhiodoro T |
Year: |
1998 |
Journal: |
FEBS Lett |
Title: |
Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. |
Volume: |
434 |
Issue: |
1-2 |
Pages: |
177-82 |
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•
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Publication |
First Author: |
Bijlenga P |
Year: |
1998 |
Journal: |
J Physiol |
Title: |
An ether -Ã -go-go K+ current, Ih-eag, contributes to the hyperpolarization of human fusion-competent myoblasts. |
Volume: |
512 ( Pt 2) |
|
Pages: |
317-23 |
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Publication |
First Author: |
Saganich MJ |
Year: |
2001 |
Journal: |
J Neurosci |
Title: |
Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain. |
Volume: |
21 |
Issue: |
13 |
Pages: |
4609-24 |
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Publication |
First Author: |
Ferreira NR |
Year: |
2012 |
Journal: |
Neurotox Res |
Title: |
Ether-Ã -go-go 1 (Eag1) potassium channel expression in dopaminergic neurons of basal ganglia is modulated by 6-hydroxydopamine lesion. |
Volume: |
21 |
Issue: |
3 |
Pages: |
317-33 |
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Publication |
First Author: |
Ziechner U |
Year: |
2006 |
Journal: |
FEBS J |
Title: |
Inhibition of human ether à go-go potassium channels by Ca2+/calmodulin binding to the cytosolic N- and C-termini. |
Volume: |
273 |
Issue: |
5 |
Pages: |
1074-86 |
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Protein Domain |
Type: |
Family |
Description: |
This entry represents the EAG (Ether-a-go-go) voltage-dependent potassium channel family member KCNH1 (EAG1) from animals. Human and rat KCNH1 harbours an N-terminal PAS dimerisation domain, a C-terminal cyclic nucleotide binding homology domain (cNBHD), and calmodulin-binding motifs both at the N- and C-termini [, ]. KCNH1 is widely expressed in the central nervous system, probably participating in neuronal signalling [, ]. KCNH1 channels may also be involved in sensory functions of auditory transduction and phototransduction [, ]. KCNH1 channels are also essential for induction of human myoblast differentiation and fusion [, ].The voltage-gated potassium channel ether-a-go-go (eag) was first identified in Drosophila melanogaster based on the leg-shaking mutant phenotype [, ]. Later, the EAG (Ether-a-go-go) voltage-dependent potassium channel family was classified into 3 subfamilies: EAG, EAG-related gene (ERG), and EAG-like K+ channel (ELK). The mammalian EAG subfamily comprises of two members, termed EAG1 (KCNH1, KV10.1) and EAG2 (KCNH5, KV10.2) []. |
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Publication |
First Author: |
Ludwig J |
Year: |
2000 |
Journal: |
Mol Cell Neurosci |
Title: |
Cloning and functional expression of rat eag2, a new member of the ether-Ã -go-go family of potassium channels and comparison of its distribution with that of eag1. |
Volume: |
16 |
Issue: |
1 |
Pages: |
59-70 |
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Publication |
First Author: |
Warmke J |
Year: |
1991 |
Journal: |
Science |
Title: |
A distinct potassium channel polypeptide encoded by the Drosophila eag locus. |
Volume: |
252 |
Issue: |
5012 |
Pages: |
1560-2 |
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•
•
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•
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Publication |
First Author: |
Kaplan WD |
Year: |
1969 |
Journal: |
Genetics |
Title: |
The behavior of four neurological mutants of Drosophila. |
Volume: |
61 |
Issue: |
2 |
Pages: |
399-409 |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
98
 |
Fragment?: |
true |
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•
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HT Experiment |
Series Id: |
GSE44110 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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•
•
•
•
•
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Publication |
First Author: |
Frings S |
Year: |
1998 |
Journal: |
J Gen Physiol |
Title: |
Characterization of ether-Ã -go-go channels present in photoreceptors reveals similarity to IKx, a K+ current in rod inner segments. |
Volume: |
111 |
Issue: |
4 |
Pages: |
583-99 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
989
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
962
 |
Fragment?: |
false |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
962
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
989
 |
Fragment?: |
false |
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•
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