| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1775122 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3274122 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287422 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3266022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1624622 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was not detected in the digestive system. |
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1721422 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1646922 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1736222 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1683322 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1700022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1832122 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1876522 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was not detected in the immune system. |
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1741222 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3599822 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3280922 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1833322 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752522 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1821522 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3557722 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1702122 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756322 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1668822 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757722 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757522 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1738322 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1802422 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was not detected in the skull (base and vault). |
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417605 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2672022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421999 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was not detected in whisker follicle. |
| Specimen Label: |
EN2007; Specimen N877 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fukatsu K |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 is regulated by actin filaments and 4.1N in neuronal dendrites. |
| Volume: |
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| Issue: |
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Sex-specific perturbation of complex lipids in response to medium-chain fatty acids in very long-chain acyl-CoA dehydrogenase deficiency. |
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Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice. |
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Zambrowicz BP |
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2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
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| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
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•
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| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
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| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
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| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
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| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
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•
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| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
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| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
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| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
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| Title: |
Annotation inferences using phylogenetic trees |
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| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
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| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
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| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
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| First Author: |
Bairoch A |
| Year: |
1999 |
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Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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| First Author: |
Boyden LM |
| Year: |
2017 |
| Journal: |
Am J Hum Genet |
| Title: |
Mutations in KDSR Cause Recessive Progressive Symmetric Erythrokeratoderma. |
| Volume: |
100 |
| Issue: |
6 |
| Pages: |
978-984 |
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| DO Term |
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| Publication |
| First Author: |
Beeler T |
| Year: |
1998 |
| Journal: |
J Biol Chem |
| Title: |
The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant. |
| Volume: |
273 |
| Issue: |
46 |
| Pages: |
30688-94 |
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•
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| Publication |
| First Author: |
Chao DY |
| Year: |
2011 |
| Journal: |
Plant Cell |
| Title: |
Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana. |
| Volume: |
23 |
| Issue: |
3 |
| Pages: |
1061-81 |
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| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents a group of 3-ketodihydrosphingosine reductases, including KDSR from animals and Tsc10 from yeasts and plants. They catalyse the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS) and are required for sphingolipid biosynthesis [, , ].Proteins in this entry show strong conservation of the active site tetrad and glycine rich NAD-binding motif of the classical SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central β-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing [, , ].Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction [, , ]. |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
332
 |
| Fragment?: |
false |
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•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
332
 |
| Fragment?: |
false |
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•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
315
 |
| Fragment?: |
false |
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•
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| Publication |
| First Author: |
Kleiger G |
| Year: |
2002 |
| Journal: |
J Mol Biol |
| Title: |
GXXXG and GXXXA motifs stabilize FAD and NAD(P)-binding Rossmann folds through C(alpha)-H... O hydrogen bonds and van der waals interactions. |
| Volume: |
323 |
| Issue: |
1 |
| Pages: |
69-76 |
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| Publication |
| First Author: |
Persson B |
| Year: |
2003 |
| Journal: |
Chem Biol Interact |
| Title: |
Coenzyme-based functional assignments of short-chain dehydrogenases/reductases (SDRs). |
| Volume: |
143-144 |
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| Pages: |
271-8 |
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•
•
•
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| Publication |
| First Author: |
Kavanagh KL |
| Year: |
2008 |
| Journal: |
Cell Mol Life Sci |
| Title: |
Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes. |
| Volume: |
65 |
| Issue: |
24 |
| Pages: |
3895-906 |
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•
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| Publication |
| First Author: |
Jörnvall H |
| Year: |
1995 |
| Journal: |
Biochemistry |
| Title: |
Short-chain dehydrogenases/reductases (SDR). |
| Volume: |
34 |
| Issue: |
18 |
| Pages: |
6003-13 |
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