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Search results 101 to 200 out of 398 for Keap1

0.038s
Type Details Score
Publication
First Author: Fu J
Year: 2019
Journal: J Biol Chem
Title: Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus.
Volume: 294
Issue: 1
Pages: 327-340
Publication  
First Author: Murakami S
Year: 2017
Journal: Mol Cell Biol
Title: NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells.
Volume: 37
Issue: 19
Publication
First Author: Fukutomi T
Year: 2014
Journal: Mol Cell Biol
Title: Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1.
Volume: 34
Issue: 5
Pages: 832-46
Publication
First Author: He X
Year: 2007
Journal: Toxicol Sci
Title: Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association.
Volume: 98
Issue: 1
Pages: 298-309
Publication
First Author: Reisman SA
Year: 2009
Journal: Toxicol Sci
Title: Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species.
Volume: 108
Issue: 1
Pages: 35-47
Publication
First Author: Osburn WO
Year: 2008
Journal: Toxicol Sci
Title: Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice.
Volume: 104
Issue: 1
Pages: 218-27
Publication
First Author: Reisman SA
Year: 2009
Journal: Toxicol Sci
Title: Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.
Volume: 109
Issue: 1
Pages: 31-40
Publication
First Author: Ichimura Y
Year: 2013
Journal: Mol Cell
Title: Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Volume: 51
Issue: 5
Pages: 618-31
Publication
First Author: Furusawa Y
Year: 2014
Journal: Genes Cells
Title: Nrf2 induces fibroblast growth factor 21 in diabetic mice.
Volume: 19
Issue: 12
Pages: 864-78
Publication
First Author: Soares MA
Year: 2016
Journal: Diabetes
Title: Restoration of Nrf2 Signaling Normalizes the Regenerative Niche.
Volume: 65
Issue: 3
Pages: 633-46
Publication
First Author: Uruno A
Year: 2016
Journal: Mol Cell Biol
Title: Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism.
Volume: 36
Issue: 11
Pages: 1655-72
Publication
First Author: Jeong Y
Year: 2017
Journal: Cancer Discov
Title: Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance.
Volume: 7
Issue: 1
Pages: 86-101
Publication
First Author: Xu J
Year: 2012
Journal: Diabetes
Title: Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.
Volume: 61
Issue: 12
Pages: 3208-18
Publication
First Author: Knatko EV
Year: 2021
Journal: Commun Biol
Title: Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer.
Volume: 4
Issue: 1
Pages: 1081
Publication  
First Author: Suzuki T
Year: 2017
Journal: Mol Cell Biol
Title: Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice.
Volume: 37
Issue: 15
Publication
First Author: Okada K
Year: 2008
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.
Volume: 295
Issue: 4
Pages: G735-47
Publication
First Author: Taguchi K
Year: 2014
Journal: Mol Cell Biol
Title: Nrf2 enhances cholangiocyte expansion in Pten-deficient livers.
Volume: 34
Issue: 5
Pages: 900-13
Publication
First Author: Ugun-Klusek A
Year: 2017
Journal: Cell Death Dis
Title: Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.
Volume: 8
Issue: 1
Pages: e2531
Publication
First Author: Liu Y
Year: 2021
Journal: J Biol Chem
Title: Loss of PKA regulatory subunit 1α aggravates cardiomyocyte necrosis and myocardial ischemia/reperfusion injury.
Volume: 297
Issue: 1
Pages: 100850
Publication
First Author: Li B
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2.
Volume: 444
Issue: 4
Pages: 555-61
Publication
First Author: Sakai E
Year: 2017
Journal: FASEB J
Title: Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis.
Volume: 31
Issue: 9
Pages: 4011-4022
Publication
First Author: Motohashi H
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway.
Volume: 101
Issue: 17
Pages: 6379-84
Publication
First Author: Zhang Y
Year: 2006
Journal: Biochem J
Title: Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum.
Volume: 399
Issue: 3
Pages: 373-85
Publication
First Author: Zhao W
Year: 2022
Journal: J Neuroinflammation
Title: Astrocytic Nrf2 expression protects spinal cord from oxidative stress following spinal cord injury in a male mouse model.
Volume: 19
Issue: 1
Pages: 134
Publication  
First Author: Ma A
Year: 2019
Journal: Free Radic Biol Med
Title: Upregulating Nrf2 in the RVLM ameliorates sympatho-excitation in mice with chronic heart failure.
Volume: 141
Pages: 84-92
Publication
First Author: Pyaram K
Year: 2019
Journal: Cell Rep
Title: Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.
Volume: 27
Issue: 3
Pages: 699-707.e4
Publication
First Author: DeBlasi JM
Year: 2023
Journal: Cancer Res
Title: Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression.
Volume: 83
Issue: 12
Pages: 1953-1967
Publication  
First Author: Dionne G
Year: 2022
Journal: Gene Expr Patterns
Title: Expression and localization of NRF2/Keap1 signalling pathway genes in mouse preimplantation embryos exposed to free fatty acids.
Volume: 46
Pages: 119281
Publication
First Author: Taguchi K
Year: 2010
Journal: Mol Cell Biol
Title: Genetic analysis of cytoprotective functions supported by graded expression of Keap1.
Volume: 30
Issue: 12
Pages: 3016-26
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kotilinek LA
Year: 2002
Journal: J Neurosci
Title: Reversible memory loss in a mouse transgenic model of Alzheimer's disease.
Volume: 22
Issue: 15
Pages: 6331-5
Publication
First Author: Noel S
Year: 2015
Journal: J Am Soc Nephrol
Title: T Lymphocyte-Specific Activation of Nrf2 Protects from AKI.
Volume: 26
Issue: 12
Pages: 2989-3000
Publication
First Author: Oishi T
Year: 2020
Journal: NPJ Aging Mech Dis
Title: Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss.
Volume: 6
Issue: 1
Pages: 14
Publication
First Author: Xu J
Year: 2013
Journal: PLoS One
Title: Keap1-knockdown decreases fasting-induced fatty liver via altered lipid metabolism and decreased fatty acid mobilization from adipose tissue.
Volume: 8
Issue: 11
Pages: e79841
Publication
First Author: Kobayashi M
Year: 2009
Journal: Mol Cell Biol
Title: The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds.
Volume: 29
Issue: 2
Pages: 493-502
Publication
First Author: Kaspar JW
Year: 2012
Journal: J Cell Sci
Title: Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression.
Volume: 125
Issue: Pt 4
Pages: 1027-38
GXD Expression    
Probe: MGI:4429828
Assay Type: RNA in situ
Annotation Date: 2010-02-24
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4429917
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4429828
Assay Type: RNA in situ
Annotation Date: 2010-02-24
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3270519
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4429917
Age: embryonic day 11.5
Note: Expression is present in the muscle-forming region.
Specimen Label: Table 1
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4429828
Assay Type: RNA in situ
Annotation Date: 2010-02-24
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3270519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4429917
Age: embryonic day 11.5
Note: Staining is present in the muscle.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
Publication
First Author: Wu KC
Year: 2012
Journal: PLoS One
Title: Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver.
Volume: 7
Issue: 7
Pages: e39006
Publication
First Author: Wu KC
Year: 2012
Journal: Toxicol Appl Pharmacol
Title: Nrf2 activation prevents cadmium-induced acute liver injury.
Volume: 263
Issue: 1
Pages: 14-20
Publication
First Author: Wu KC
Year: 2012
Journal: Toxicol Appl Pharmacol
Title: Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation.
Volume: 262
Issue: 3
Pages: 321-9
Publication
First Author: Lu YF
Year: 2014
Journal: PLoS One
Title: Overexpression of Nrf2 protects against microcystin-induced hepatotoxicity in mice.
Volume: 9
Issue: 3
Pages: e93013
Publication
First Author: Wakabayashi N
Year: 2014
Journal: Mol Cell Biol
Title: Notch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signaling.
Volume: 34
Issue: 4
Pages: 653-63
Publication
First Author: Zhang YK
Year: 2013
Journal: PLoS One
Title: Genetic activation of Nrf2 protects against fasting-induced oxidative stress in livers of mice.
Volume: 8
Issue: 3
Pages: e59122
Publication
First Author: Wu KC
Year: 2011
Journal: Toxicol Sci
Title: Beneficial role of Nrf2 in regulating NADPH generation and consumption.
Volume: 123
Issue: 2
Pages: 590-600
Publication
First Author: Sussan TE
Year: 2015
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function.
Volume: 309
Issue: 1
Pages: L27-36
Publication
First Author: Satoh H
Year: 2022
Journal: Carcinogenesis
Title: Genomic landscape of chemical-induced lung tumors under Nrf2 different expression levels.
Volume: 43
Issue: 7
Pages: 613-623
Publication
First Author: Eba S
Year: 2013
Journal: Am J Respir Cell Mol Biol
Title: The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.
Volume: 49
Issue: 2
Pages: 324-33
Publication
First Author: Quinti L
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
Volume: 114
Issue: 23
Pages: E4676-E4685
Publication
First Author: Wei Y
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching.
Volume: 110
Issue: 41
Pages: E3910-8
Publication  
First Author: Jobbagy S
Year: 2020
Journal: JCI Insight
Title: Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus.
Volume: 5
Issue: 1
Publication  
First Author: Nezu M
Year: 2017
Journal: Sci Signal
Title: Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.
Volume: 10
Issue: 479
Publication
First Author: Satoh H
Year: 2010
Journal: Carcinogenesis
Title: Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung.
Volume: 31
Issue: 10
Pages: 1833-43
Publication
First Author: Sakai E
Year: 2021
Journal: Sci Rep
Title: Liquid-phase ASEM imaging of cellular and structural details in cartilage and bone formed during endochondral ossification: Keap1-deficient osteomalacia.
Volume: 11
Issue: 1
Pages: 5722
Publication
First Author: Singh A
Year: 2013
Journal: J Clin Invest
Title: Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis.
Volume: 123
Issue: 7
Pages: 2921-34
Publication
First Author: Reisman SA
Year: 2009
Journal: Toxicol Sci
Title: Nrf2 activation enhances biliary excretion of sulfobromophthalein by inducing glutathione-S-transferase activity.
Volume: 109
Issue: 1
Pages: 24-30
Publication
First Author: Zhang YK
Year: 2012
Journal: Toxicol Appl Pharmacol
Title: Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet.
Volume: 264
Issue: 3
Pages: 305-14
Publication  
First Author: Schaer DJ
Year: 2023
Journal: J Clin Invest
Title: Hemorrhage-activated NRF2 in tumor-associated macrophages drives cancer growth, invasion, and immunotherapy resistance.
Volume: 134
Issue: 3
Publication
First Author: Paul MK
Year: 2014
Journal: Cell Stem Cell
Title: Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling.
Volume: 15
Issue: 2
Pages: 199-214
Publication  
First Author: Zhang Y
Year: 2020
Journal: Toxicol Appl Pharmacol
Title: Effects of ablation and activation of Nrf2 on bile acid homeostasis in male mice.
Volume: 403
Pages: 115170
Publication  
First Author: Panda H
Year: 2022
Journal: Free Radic Biol Med
Title: Halofuginone micelle nanoparticles eradicate Nrf2-activated lung adenocarcinoma without systemic toxicity.
Volume: 187
Pages: 92-104
Publication
First Author: Granado N
Year: 2011
Journal: Glia
Title: Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum.
Volume: 59
Issue: 12
Pages: 1850-63
Publication
First Author: Satoh H
Year: 2016
Journal: Cancer Res
Title: NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth.
Volume: 76
Issue: 10
Pages: 3088-96
Publication
First Author: Baumel-Alterzon S
Year: 2022
Journal: Diabetes
Title: Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation.
Volume: 71
Issue: 5
Pages: 989-1011
Publication  
First Author: Koriyama Y
Year: 2013
Journal: Brain Res
Title: Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cellline.
Volume: 1499
Pages: 145-57
Publication  
First Author: Shanmugam G
Year: 2019
Journal: Redox Biol
Title: Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice.
Volume: 27
Pages: 101212
Publication  
First Author: Li L
Year: 2020
Journal: Molecules
Title: Protective Effect of Astaxanthin on Ochratoxin A-Induced Kidney Injury to Mice by Regulating Oxidative Stress-Related NRF2/KEAP1 Pathway.
Volume: 25
Issue: 6
Publication
First Author: Motohashi H
Year: 2010
Journal: Blood
Title: NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation.
Volume: 115
Issue: 3
Pages: 677-86
Publication
First Author: Keleku-Lukwete N
Year: 2019
Journal: Blood Adv
Title: Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice.
Volume: 3
Issue: 8
Pages: 1285-1297
Publication
First Author: Ye X
Year: 2023
Journal: Commun Biol
Title: Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2.
Volume: 6
Issue: 1
Pages: 1060
Publication
First Author: Vasavda C
Year: 2022
Journal: Sci Adv
Title: Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain.
Volume: 8
Issue: 31
Pages: eabo5633
Publication
First Author: Wei Y
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A.
Volume: 112
Issue: 50
Pages: E6927-36
Publication  
First Author: Wakabayashi N
Year: 2023
Journal: Int J Mol Sci
Title: Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model.
Volume: 24
Issue: 17
Publication
First Author: Miller WP
Year: 2020
Journal: J Biol Chem
Title: The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation.
Volume: 295
Issue: 21
Pages: 7350-7361
Publication
First Author: Ohtsuji M
Year: 2008
Journal: J Biol Chem
Title: Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes.
Volume: 283
Issue: 48
Pages: 33554-62
Publication
First Author: Yagishita Y
Year: 2017
Journal: Cell Rep
Title: Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress.
Volume: 18
Issue: 8
Pages: 2030-2044
Publication
First Author: Baardman J
Year: 2018
Journal: Cell Rep
Title: A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.
Volume: 25
Issue: 8
Pages: 2044-2052.e5
Publication    
First Author: Kang YP
Year: 2019
Journal: Elife
Title: Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer.
Volume: 8
Publication  
First Author: Fragoulis A
Year: 2022
Journal: Redox Biol
Title: Nrf2 induces malignant transformation of hepatic progenitor cells by inducing β-catenin expression.
Volume: 57
Pages: 102453
Publication
First Author: Harvey CJ
Year: 2011
Journal: Sci Transl Med
Title: Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model.
Volume: 3
Issue: 78
Pages: 78ra32
Publication  
First Author: Kim EY
Year: 2022
Journal: Antioxidants (Basel)
Title: NRF2 Activation in Autophagy Defects Suppresses a Pharmacological Transactivation of the Nuclear Receptor FXR.
Volume: 11
Issue: 2