Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
620
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang W |
Year: |
1998 |
Journal: |
Mol Cell |
Title: |
PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. |
Volume: |
2 |
Issue: |
6 |
Pages: |
877-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mollinari C |
Year: |
2002 |
Journal: |
J Cell Biol |
Title: |
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. |
Volume: |
157 |
Issue: |
7 |
Pages: |
1175-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurasawa Y |
Year: |
2004 |
Journal: |
EMBO J |
Title: |
Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. |
Volume: |
23 |
Issue: |
16 |
Pages: |
3237-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu C |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. |
Volume: |
102 |
Issue: |
2 |
Pages: |
343-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Subramanian R |
Year: |
2010 |
Journal: |
Cell |
Title: |
Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein. |
Volume: |
142 |
Issue: |
3 |
Pages: |
433-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wolfe BA |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000110 |
|
•
•
•
•
•
|
Publication |
First Author: |
Di Cunto F |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. |
Volume: |
273 |
Issue: |
45 |
Pages: |
29706-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schuyler SC |
Year: |
2003 |
Journal: |
J Cell Biol |
Title: |
The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins. |
Volume: |
160 |
Issue: |
4 |
Pages: |
517-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang HY |
Year: |
2005 |
Journal: |
J Cell Sci |
Title: |
Dynamic interaction of NtMAP65-1a with microtubules in vivo. |
Volume: |
118 |
Issue: |
Pt 14 |
Pages: |
3195-201 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mao T |
Year: |
2005 |
Journal: |
Plant Physiol |
Title: |
Two microtubule-associated proteins of the Arabidopsis MAP65 family function differently on microtubules. |
Volume: |
138 |
Issue: |
2 |
Pages: |
654-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mao G |
Year: |
2005 |
Journal: |
Plant J |
Title: |
Modulated targeting of GFP-AtMAP65-1 to central spindle microtubules during division. |
Volume: |
43 |
Issue: |
4 |
Pages: |
469-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sasabe M |
Year: |
2006 |
Journal: |
Curr Opin Plant Biol |
Title: |
MAP65: a bridge linking a MAP kinase to microtubule turnover. |
Volume: |
9 |
Issue: |
6 |
Pages: |
563-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Smertenko AP |
Year: |
2006 |
Journal: |
J Cell Sci |
Title: |
Control of the AtMAP65-1 interaction with microtubules through the cell cycle. |
Volume: |
119 |
Issue: |
Pt 15 |
Pages: |
3227-37 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This is a family of microtubule associated proteins, including MAP65 (MAP65-1/2/3/4/5/6/7/8/9) from Arabidopsis, Ase1 from yeast, and PRC1 from mammals.Ase1 is required for spindle elongation and stabilisation. It is cell cycle-regulated by anaphase promoting complex []. It is a potential Cdc28p substrate []. MAP65-1 plays a role in stabilising anti-parallel microtubules in the central spindle at anaphase to early cytokinesis. MAP65-1 is cell cycle regulated by phosphorylation [, , , , ].PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone []. It is a key regulator of cytokinesis that cross-links antiparallel microtubules at an average distance of 35 nM [, ]. PRC1 is also required for KIF14 (a kinesin-3 family motor protein) localisation to the central spindle and midbody [, , ]and is required to recruit PLK1 to the spindle. It stimulates PLK1 phosphorylation of RACGAP1/HsCyk-4 to allow recruitment of ECT2 to the central spindle []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Citron Rho-interacting kinase (CRIK) is a dual specificity protein kinase, which catalyses the autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues []. It plays an important role in the regulation of cytokinesis and the development of the central nervous system. It is required for KIF14 localization to the central spindle and mid-body. It is also a putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. This protein occurs in at least two different isoforms: CRIK (about 240kDa), in which the kinase domain is followed by the sequence of Citron (a Rho/Rac binding protein); and CRIK-short kinase (CRIK-SK, about 54kDa), which consists mostly of the kinase domain. CRIK may fulfil more specialised functions in specific cell types []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
175
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ubersax JA |
Year: |
2003 |
Journal: |
Nature |
Title: |
Targets of the cyclin-dependent kinase Cdk1. |
Volume: |
425 |
Issue: |
6960 |
Pages: |
859-64 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2055
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2028
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2070
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2055
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2013
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|