|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 173 out of 173 for Ksr1

<< First    < Previous  |  Next >    Last >>
0.022s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:5285974
Assay Type: Immunohistochemistry
Annotation Date: 2011-09-21
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5285977
Age: postnatal week 6
Note: Expression is in the cell bodies of the pyramidal neurons.
Specimen Label: 3A
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5285974
Assay Type: Immunohistochemistry
Annotation Date: 2011-09-21
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5285977
Age: postnatal week 6
Specimen Label: 3B
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5285974
Assay Type: Immunohistochemistry
Annotation Date: 2011-09-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5285977
Age: embryonic day 10.5
Specimen Label: 4B
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5285974
Assay Type: Immunohistochemistry
Annotation Date: 2011-09-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5285977
Age: embryonic day 10.5
Specimen Label: 4C
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5285974
Assay Type: Immunohistochemistry
Annotation Date: 2011-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160719
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:5285977
Age: embryonic day 6.5
Specimen Label: 4A
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5285974
Assay Type: Immunohistochemistry
Annotation Date: 2011-09-21
Strength: Strong
Sex: Male
Emaps: EMAPS:3575728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5285977
Age: postnatal week 6
Note: Localization is primarily at the plasma membrane region.
Specimen Label: 3E
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5285974
Assay Type: Immunohistochemistry
Annotation Date: 2011-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160429
Pattern: Regionally restricted
Stage: TS09
Assay Id: MGI:5285977
Age: embryonic day 6.5
Note: Expression is in the cell layers of the amnion and the extraembryonic membranes.
Specimen Label: 4A
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5285974
Assay Type: Immunohistochemistry
Annotation Date: 2011-09-21
Strength: Present
Sex: Female
Emaps: EMAPS:2989928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5285977
Age: postnatal week 6
Specimen Label: Not shown
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5285974
Assay Type: Immunohistochemistry
Annotation Date: 2011-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3512128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5285977
Age: postnatal week 6
Note: Localization is primarily at the plasma membrane region.
Specimen Label: 3D
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5285974
Assay Type: Immunohistochemistry
Annotation Date: 2011-09-21
Strength: Present
Sex: Female
Emaps: EMAPS:3563328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5285977
Age: postnatal week 6
Specimen Label: 3C
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5285974
Assay Type: Immunohistochemistry
Annotation Date: 2011-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160629
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:5285977
Age: embryonic day 6.5
Specimen Label: 4A
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5285974
Assay Type: Immunohistochemistry
Annotation Date: 2011-09-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5285977
Age: embryonic day 10.5
Specimen Label: 4B
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5285974
Assay Type: Immunohistochemistry
Annotation Date: 2011-09-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5285977
Age: embryonic day 10.5
Specimen Label: 4C
Detected: true
Specimen Num: 9
•
•
•
•
•
Publication
28180061 | J:262342
First Author: Guo L
Year: 2017
Journal: Mol Metab
Title: Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis.
Volume: 6
Issue: 2
Pages: 194-205
•
•
•
•
•
Publication
19883615 | J:155434
First Author: Costanzo-Garvey DL
Year: 2009
Journal: Cell Metab
Title: KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.
Volume: 10
Issue: 5
Pages: 366-78
•
•
•
•
•
Publication
22529300 | J:188744
First Author: Filbert EL
Year: 2012
Journal: J Immunol
Title: Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells.
Volume: 188
Issue: 11
Pages: 5421-7
•
•
•
•
•
Publication
9427625 | J:45012
First Author: Denouel-Galy A
Year: 1998
Journal: Curr Biol
Title: Murine Ksr interacts with MEK and inhibits Ras-induced transformation.
Volume: 8
Issue: 1
Pages: 46-55
•
•
•
•
•
Publication
24672054 | J:314791
First Author: Giurisato E
Year: 2014
Journal: Mol Biol Cell
Title: The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and store-operated calcium entry (SOCE).
Volume: 25
Issue: 11
Pages: 1769-81
•
•
•
•
•
Publication
24525234 | J:209645
First Author: Cullis J
Year: 2014
Journal: Cancer Cell
Title: The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1.
Volume: 25
Issue: 2
Pages: 181-95
•
•
•
•
•
Publication
12133899 | J:78002
First Author: Giblett SM
Year: 2002
Journal: Cell Growth Differ
Title: Expression of kinase suppressor of Ras in the normal adult and embryonic mouse.
Volume: 13
Issue: 7
Pages: 307-13
•
•
•
•
•
Publication
22510884 | J:184683
First Author: Röring M
Year: 2012
Journal: EMBO J
Title: Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling.
Volume: 31
Issue: 11
Pages: 2629-47
•
•
•
•
•
Publication
15240686 | J:91922
First Author: Laurent MN
Year: 2004
Journal: J Immunol
Title: Kinase suppressor of Ras couples Ras to the ERK cascade during T cell development.
Volume: 173
Issue: 2
Pages: 986-92
•
•
•
•
•
Publication
22572157 | J:187529
First Author: Quiel A
Year: 2012
Journal: Biosens Bioelectron
Title: Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip.
Volume: 36
Issue: 1
Pages: 207-11
•
•
•
•
•
Publication
19114553 | J:145761
First Author: Casar B
Year: 2009
Journal: Mol Cell Biol
Title: Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins.
Volume: 29
Issue: 5
Pages: 1338-53
•
•
•
•
•
Publication
7626882 | J:25181
First Author: Nehls M
Year: 1995
Journal: Mamm Genome
Title: YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11.
Volume: 6
Issue: 5
Pages: 321-31
•
•
•
•
•
Publication
23673330 | J:197131
First Author: Lanctot AA
Year: 2013
Journal: Dev Cell
Title: Spatially dependent dynamic MAPK modulation by the Nde1-Lis1-Brap complex patterns mammalian CNS.
Volume: 25
Issue: 3
Pages: 241-55
•
•
•
•
•
Publication
28973166 | J:253459
First Author: Inoue SI
Year: 2017
Journal: Hum Mol Genet
Title: Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice.
Volume: 26
Issue: 23
Pages: 4715-4727
•
•
•
•
•
Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
•
•
•
•
•
Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
•
•
•
•
•
Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
•
•
•
•
•
Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Interaction Experiment
Goettel JA (2011)
Description: KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1.
•
•
•
•
•
Publication
18426801 | -
First Author: Jagemann LR
Year: 2008
Journal: J Biol Chem
Title: The functional interaction of 14-3-3 proteins with the ERK1/2 scaffold KSR1 occurs in an isoform-specific manner.
Volume: 283
Issue: 25
Pages: 17450-62
•
•
•
•
•
Publication
12932319 | -
First Author: Ory S
Year: 2003
Journal: Curr Biol
Title: Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites.
Volume: 13
Issue: 16
Pages: 1356-64
•
•
•
•
•
Protein Domain
IPR046933 | SAM_KSR1_N_sf
Type: Homologous_superfamily
Description: Pseudokinases kinase suppressor of Ras 1 and 2 (KSR1/2) are scaffolds that bridge RAF isoforms and their substrate, mitogen-activated protein kinase kinase (MEK). They dimerize with kinase-competent RAFs (ARAF, BRAF and CRAF) to stimulate catalysis allosterically []. This entry represents the N-terminal helical hairpin which, together with the SAM-like domain () constitutes the N-terminal regulatory region that mediates heterodimerization of BRAF with KSR1. Additionally, MEK binding to the kinase domain of KSR1 asymmetrically drives BRAF-KSR1 heterodimerization, resulting in the concomitant stimulation of BRAF catalytic activity towards free MEK molecules [].
•
•
•
•
•
Protein Domain
IPR046861 | SAM_KSR1_N
Type: Domain
Description: Pseudokinases kinase suppressor of Ras 1 and 2 (KSR1/2) are scaffolds that bridge RAF isoforms and their substrate, mitogen-activated protein kinase kinase (MEK). They dimerize with kinase-competent RAFs (ARAF, BRAF and CRAF) to stimulate catalysis allosterically []. This entry represents the N-terminal helical hairpin which, together with the SAM-like domain () constitutes the N-terminal regulatory region that mediates heterodimerization of BRAF with KSR1. Additionally, MEK binding to the kinase domain of KSR1 asymmetrically drives BRAF-KSR1 heterodimerization, resulting in the concomitant stimulation of BRAF catalytic activity towards free MEK molecules [].
•
•
•
•
•
Publication
29433126 | -
First Author: Lavoie H
Year: 2018
Journal: Nature
Title: MEK drives BRAF activation through allosteric control of KSR proteins.
Volume: 554
Issue: 7693
Pages: 549-553
•
•
•
•
•
Protein
C4IXV3
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
•
•
•
•
•
Publication
8946910 | J:36717
First Author: Therrien M
Year: 1996
Journal: Genes Dev
Title: KSR modulates signal propagation within the MAPK cascade.
Volume: 10
Issue: 21
Pages: 2684-95
•
•
•
•
•
Protein
Q61097
Organism: Mus musculus/domesticus
Length: 873  
Fragment?: false
•
•
•
•
•
Protein
Q3UVC0
Organism: Mus musculus/domesticus
Length: 959  
Fragment?: false
•
•
•
•
•
Protein
Q5SXE4
Organism: Mus musculus/domesticus
Length: 637  
Fragment?: false
•
•
•
•
•
Protein
A5X3G4
Organism: Mus musculus/domesticus
Length: 947  
Fragment?: false
•
•
•
•
•
Protein
M0QW59
Organism: Mus musculus/domesticus
Length: 951  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom