Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
459
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
lipin 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Irie K |
Year: |
1993 |
Journal: |
Mol Gen Genet |
Title: |
A gene, SMP2, involved in plasmid maintenance and respiration in Saccharomyces cerevisiae encodes a highly charged protein. |
Volume: |
236 |
Issue: |
2-3 |
Pages: |
283-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Hara L |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase. |
Volume: |
281 |
Issue: |
45 |
Pages: |
34537-48 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Lipin family consists of lipin proteins, which are magnesium-dependent phosphatidate phosphatase enzymes that provide diacylglycerol for synthesis of triacylglycerol and phospholipids. Mammalian lipin proteins also exhibit transcriptional coactivator activity []. Common polymorphisms in human LPIN1 and LPIN2 genes are associated with traits underlying common metabolic diseases, including increased adiposity, hypertension, insulin sensitivity, and response to commonly used antidiabetic drugs []. Saccharomyces cerevisiae lipin, PAH1, controls transcription of phospholipid biosynthetic genes and nuclear structure by regulating the amount of membrane present at the nuclear envelope. PAH is also involved in plasmid maintenance, in respiration and in cell proliferation [, , ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Sanderson LM |
Year: |
2009 |
Journal: |
Mol Cell Biol |
Title: |
Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver. |
Volume: |
29 |
Issue: |
23 |
Pages: |
6257-67 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
420
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Santos-Rosa H |
Year: |
2005 |
Journal: |
EMBO J |
Title: |
The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth. |
Volume: |
24 |
Issue: |
11 |
Pages: |
1931-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Csaki LS |
Year: |
2010 |
Journal: |
Annu Rev Nutr |
Title: |
Lipins: multifunctional lipid metabolism proteins. |
Volume: |
30 |
|
Pages: |
257-72 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
115
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
158
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
924
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
924
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
924
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
950
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
891
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
973
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
931
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
684
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
891
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
891
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
848
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
888
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
858
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
817
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
858
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
848
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Villén J |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Large-scale phosphorylation analysis of mouse liver. |
Volume: |
104 |
Issue: |
5 |
Pages: |
1488-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|