| Type |
Details |
Score |
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; wild type |
|
|
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; gene trap CSE072, BayGenomics |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; gene trap CSH192, BayGenomics |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; gene trap OST38226, Lexicon Genetics |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; gene trap OST56181, Lexicon Genetics |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; gene trap OST215699, Lexicon Genetics |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; gene trap OST380359, Lexicon Genetics |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; gene trap D074A09, German Gene Trap Consortium |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; gene trap W038A01, German Gene Trap Consortium |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; gene trap EUCJ00126e06, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; gene trap IST15078D7, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; gene trap IST15086A6, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
LSM1 homolog, mRNA degradation associated; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, targeted mutation, coisogenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Lsm1/Lsm1 |
| Background: |
C57BL/6N-Lsm1/Ieg |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Lsm1/Lsm1<+> |
| Background: |
C57BL/6N-Lsm1/Ieg |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lian S |
| Year: |
2007 |
| Journal: |
Mol Biol Cell |
| Title: |
Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies. |
| Volume: |
18 |
| Issue: |
9 |
| Pages: |
3375-87 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE61729 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
Baseline |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
71
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
70
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents Sm-like protein Lsm1 and Lsm8. Lsm8 is found in the nuclear Lsm2-8 complex, which associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6.U5 snRNP, and free U6 snRNP). The Lsm2-8 complex binds and stabilizes the 3'-terminal poly(U) tract of U6 snRNA and facilitates the assembly of U4-U6 di-snRNP and U4-U6-U5 tri-snRNP [, , ].Lsm1 can be found in the cytoplasmic Lsm1-7 complex, which associates with deadenylated mRNA and promotes decapping in the 5'-3' mRNA decay pathway [, ]. The Sm and the Lsm proteins, characterised by the Sm-domain, have RNA-related functions. The Sm heptamer ring associates with four (U1, U2, U4, U5) snRNPs, while Lsm2-8 heptamer is part of the U6 snRNP. Another Lsm heptameric complex, Lsm1-7, which differs from Lsm2-8 by one Lsm protein, functions in mRNA decapping, a crucial step in the mRNA degradation pathway []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
96
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
100
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Beggs JD |
| Year: |
2005 |
| Journal: |
Biochem Soc Trans |
| Title: |
Lsm proteins and RNA processing. |
| Volume: |
33 |
| Issue: |
Pt 3 |
| Pages: |
433-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou L |
| Year: |
2014 |
| Journal: |
Nature |
| Title: |
Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. |
| Volume: |
506 |
| Issue: |
7486 |
| Pages: |
116-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2000 |
| Journal: |
Genome Res |
| Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
| Volume: |
10 |
| Issue: |
10 |
| Pages: |
1617-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
1999 |
| Journal: |
Methods Enzymol |
| Title: |
High-efficiency full-length cDNA cloning. |
| Volume: |
303 |
|
| Pages: |
19-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shibata K |
| Year: |
2000 |
| Journal: |
Genome Res |
| Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
| Volume: |
10 |
| Issue: |
11 |
| Pages: |
1757-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Katayama S |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
Antisense transcription in the mammalian transcriptome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1564-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gerhard DS |
| Year: |
2004 |
| Journal: |
Genome Res |
| Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| Volume: |
14 |
| Issue: |
10B |
| Pages: |
2121-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huttlin EL |
| Year: |
2010 |
| Journal: |
Cell |
| Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
| Volume: |
143 |
| Issue: |
7 |
| Pages: |
1174-89 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Church DM |
| Year: |
2009 |
| Journal: |
PLoS Biol |
| Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
e1000112 |
|
•
•
•
•
•
|