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Search results 101 to 200 out of 201 for Ltc4s

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Hits by Pathway

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Hits by Strain

Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1775122
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274122
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287422
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3266022
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1624622
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Note: Expression was not detected in the digestive system.
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721422
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1646922
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1683322
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1700022
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1832122
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Note: Expression was not detected in the immune system.
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1741222
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754022
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1833322
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287022
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1821522
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702122
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756322
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757722
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4416626
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5421890
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: EB2296; Specimen B902
Detected: false
Specimen Num: 1
•
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Publication
8706658 | J:34202
First Author: Lam BK
Year: 1996
Journal: Eur J Biochem
Title: Molecular cloning, expression and characterization of mouse leukotriene C4 synthase.
Volume: 238
Issue: 3
Pages: 606-12
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Publication
14970333 | J:88647
First Author: Beller TC
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis.
Volume: 101
Issue: 9
Pages: 3047-52
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Publication
21357742 | J:176841
First Author: Barrett NA
Year: 2011
Journal: J Exp Med
Title: Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes.
Volume: 208
Issue: 3
Pages: 593-604
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Publication
23002438 | J:190624
First Author: Barrett NA
Year: 2012
Journal: J Immunol
Title: Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation.
Volume: 189
Issue: 9
Pages: 4556-65
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Publication
16407308 | J:110309
First Author: Balestrieri B
Year: 2006
Journal: J Biol Chem
Title: Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis.
Volume: 281
Issue: 10
Pages: 6691-8
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Publication
26663781 | J:256646
First Author: Poczobutt JM
Year: 2016
Journal: J Immunol
Title: Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.
Volume: 196
Issue: 2
Pages: 891-901
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Publication
19416808 | J:148535
First Author: Zarini S
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation.
Volume: 106
Issue: 20
Pages: 8296-301
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Publication
16567388 | J:123751
First Author: Chen M
Year: 2006
Journal: J Exp Med
Title: Neutrophil-derived leukotriene B4 is required for inflammatory arthritis.
Volume: 203
Issue: 4
Pages: 837-42
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Publication
30649890 | J:280621
First Author: Montford JR
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Inhibition of 5-lipoxygenase decreases renal fibrosis and progression of chronic kidney disease.
Volume: 316
Issue: 4
Pages: F732-F742
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Publication
30291131 | J:265942
 
First Author: Bankova LG
Year: 2018
Journal: Sci Immunol
Title: The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation.
Volume: 3
Issue: 28
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Publication
22416124 | J:182213
First Author: Oyoshi MK
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis.
Volume: 109
Issue: 13
Pages: 4992-7
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Publication
19124755 | J:143482
First Author: Barrett NA
Year: 2009
Journal: J Immunol
Title: Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells.
Volume: 182
Issue: 2
Pages: 1119-28
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Publication
27185938 | J:338988
First Author: Bankova LG
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99.
Volume: 113
Issue: 22
Pages: 6242-7
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Publication
29282304 | J:258129
First Author: Liu T
Year: 2018
Journal: J Immunol
Title: Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity.
Volume: 200
Issue: 3
Pages: 915-927
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Publication
21307302 | J:171000
First Author: Sapieha P
Year: 2011
Journal: Sci Transl Med
Title: 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids.
Volume: 3
Issue: 69
Pages: 69ra12
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Publication
31135881 | J:279267
First Author: Sasaki F
Year: 2019
Journal: Int Immunol
Title: The leukotriene receptors as therapeutic targets of inflammatory diseases.
Volume: 31
Issue: 9
Pages: 607-615
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Publication
20219953 | J:160350
First Author: Queto T
Year: 2010
Journal: J Leukoc Biol
Title: Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow.
Volume: 87
Issue: 5
Pages: 885-93
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Publication
28011865 | J:238774
First Author: von Moltke J
Year: 2017
Journal: J Exp Med
Title: Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s.
Volume: 214
Issue: 1
Pages: 27-37
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Publication
37437602 | J:341091
First Author: Florsheim EB
Year: 2023
Journal: Nature
Title: Immune sensing of food allergens promotes avoidance behaviour.
Volume: 620
Issue: 7974
Pages: 643-650
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Publication
15905575 | J:98963
First Author: Abonia JP
Year: 2005
Journal: J Immunol
Title: Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle.
Volume: 174
Issue: 11
Pages: 7285-91
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Publication
34932383 | J:338728
First Author: Ualiyeva S
Year: 2021
Journal: Sci Immunol
Title: Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation.
Volume: 6
Issue: 66
Pages: eabj0474
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Publication
23624557 | J:197334
First Author: Taketomi Y
Year: 2013
Journal: Nat Immunol
Title: Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Volume: 14
Issue: 6
Pages: 554-63
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Publication
39002541 | J:353367
First Author: Taketomi Y
Year: 2024
Journal: Immunity
Title: Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts.
Volume: 57
Issue: 8
Pages: 1828-1847.e11
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Ltc4s<em1Smoc> | MGI:7290898
Name: leukotriene C4 synthase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475724 | C57BL/6JSmoc-Ltc4s<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
17632548 | -
First Author: Ago H
Year: 2007
Journal: Nature
Title: Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis.
Volume: 448
Issue: 7153
Pages: 609-12
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Publication
31681188 | -
 
First Author: Kammerscheit X
Year: 2019
Journal: Front Microbiol
Title: From Cyanobacteria to Human, MAPEG-Type Glutathione-S-Transferases Operate in Cell Tolerance to Heat, Cold, and Lipid Peroxidation.
Volume: 10
Pages: 2248
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Publication
32745470 | -
First Author: Thulasingam M
Year: 2020
Journal: J Mol Biol
Title: Integral Membrane Enzymes in Eicosanoid Metabolism: Structures, Mechanisms and Inhibitor Design.
Volume: 432
Issue: 18
Pages: 4999-5022
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Publication
31456794 | -
 
First Author: Kammerscheit X
Year: 2019
Journal: Front Microbiol
Title: First in vivo Evidence That Glutathione-S-Transferase Operates in Photo-Oxidative Stress in Cyanobacteria.
Volume: 10
Pages: 1899
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Protein Domain
IPR001129 | Membr-assoc_MAPEG
Type: Family
Description: This entry represents a widespread protein family known as MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) []. This group of membrane associated proteins with highly divergent functions, such as the metabolism of eicosanoids [, ]. Included are:5-lipoxygenase activating protein (gene FLAP), which seems to be required for the activation of 5-lipoxygenase.Leukotriene C4 synthase (), which catalyses the production of LTC4 from LTA4. The structure of human LTC4S was solved by X-ray crystallography []. Microsomal glutathione S-transferase II () (GST-II), which also produces LTC4 from LTA4. These enzymes play an important role in the resistance to temperature stresses and lipid peroxidation [, ]. Prostaglandin E synthase, which catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.
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Protein
Q9CPU4
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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Publication
10091672 | -
First Author: Jakobsson PJ
Year: 1999
Journal: Protein Sci
Title: Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism.
Volume: 8
Issue: 3
Pages: 689-92
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Protein
A2RST1
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: false
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Protein
Q91VS7
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: false
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Protein
Q9JM51
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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Protein
A0A0A6YWX7
Organism: Mus musculus/domesticus
Length: 82  
Fragment?: false
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Protein
Q53ZD4
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: false
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Protein
Q3UDM3
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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Protein
A0A0N4SVZ0
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: false
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Protein
E9QJW0
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
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Protein
Q8BNP8
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: false
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Protein
P30355
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Protein
Q60860
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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