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Search results 101 to 162 out of 162 for Lyzl4

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:1485377
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826047
Age: embryonic day 14.5
Image: euxassay_005328_17
Specimen Label: euxassay_005328_17
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:1485377
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826047
Age: embryonic day 14.5
Image: euxassay_005328_19
Specimen Label: euxassay_005328_19
Detected: true
Specimen Num: 16
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Publication
39555667 | J:360707
First Author: Pan J
Year: 2025
Journal: Adv Sci (Weinh)
Title: Microglial Lyzl4 Facilitates β-Amyloid Clearance in Alzheimer's Disease.
Volume: 12
Issue: 2
Pages: e2412184
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Publication
27357688 | J:234235
First Author: Miyata H
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice.
Volume: 113
Issue: 28
Pages: 7704-10
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR030057 | LYZL1/LYZL2
Type: Family
Description: The vertebrate lysozyme family is composed of lysozyme c, lactalbumin and calcium-binding lysozyme. The classical lysozyme c has been extensively studied []. From human testis cDNA libraries, a group of lysozyme c-like sequences is identified [, ]. The function of this group of lysozyme c-like proteins is not clear. Some of them (LYZL2, SLLP1/SPACA3/LYXL3, LYZL4 and LYZL6) are expressed in the male reproductive tract [, ]and may be involved in fertilisation.This entry represents LYZL1 and LYZL2.
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Publication
15982649 | J:100617
First Author: Herrero MB
Year: 2005
Journal: Dev Biol
Title: Mouse SLLP1, a sperm lysozyme-like protein involved in sperm-egg binding and fertilization.
Volume: 284
Issue: 1
Pages: 126-42
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Publication
22634100 | -
First Author: Alesi V
Year: 2012
Journal: Gene
Title: 335.4 kb microduplication in chromosome band Xp11.2p11.3 associated with developmental delay, growth retardation, autistic disorder and dysmorphic features.
Volume: 505
Issue: 2
Pages: 384-7
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Protein Domain
IPR030058 | LYZL3
Type: Family
Description: The vertebrate lysozyme family is composed of lysozyme c, lactalbumin and calcium-binding lysozyme. The classical lysozyme c has been extensively studied []. From human testis cDNA libraries, a group of lysozyme c-like sequences is identified [, ]. The function of this group of lysozyme c-like proteins is not clear. Some of them (LYZL2, SLLP1/SPACA3/LYXL3, LYZL4 and LYZL6) are expressed in the male reproductive tract [, ]and may be involved in fertilisation.Lysozyme-like protein 3 (LYZL3), also known as sperm acrosome membrane-associated protein 3 (SPACA3/SLLP1/LYXL3), is one of them. Mouse LYZL3 (SLLP1) has been shown to be involved in sperm-egg binding and fertilisation [].
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Protein Domain
IPR030064 | LYZL5
Type: Family
Description: The vertebrate lysozyme family is composed of lysozyme c, lactalbumin and calcium-binding lysozyme. The classical lysozyme c has been extensively studied []. From human testis cDNA libraries, a group of lysozyme c-like sequences is identified [, ]. The function of this group of lysozyme c-like proteins is not clear. Some of them (LYZL2, SLLP1/SPACA3/LYXL3, LYZL4 and LYZL6) are expressed in the male reproductive tract [, ]and may be involved in fertilisation.Lysozyme-like protein 5 (LYZL5), also known as sperm acrosome-associated protein 5 (SPACA5/SLLP-X), is highly expressed in testis and maps to the X chromosome [].
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Protein Domain
IPR030063 | LYZL6
Type: Family
Description: The vertebrate lysozyme family is composed of lysozyme c, lactalbumin and calcium-binding lysozyme. The classical lysozyme c has been extensively studied []. From human testis cDNA libraries, a group of lysozyme c-like sequences is identified [, ]. The function of this group of lysozyme c-like proteins is not clear. Some of them (LYZL2, SLLP1/SPACA3/LYXL3, LYZL4 and LYZL6) are expressed in the male reproductive tract [, ]and may be involved in fertilisation.LYZL6 exhibits antibacterial activity and may contribute to the innate immunity of the male genital tract [].
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Publication
3120013 | -
First Author: Stewart CB
Year: 1987
Journal: Nature
Title: Adaptive evolution in the stomach lysozymes of foregut fermenters.
Volume: 330
Issue: 6146
Pages: 401-4
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Publication
3413092 | -
First Author: Chung LP
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: Cloning the human lysozyme cDNA: inverted Alu repeat in the mRNA and in situ hybridization for macrophages and Paneth cells.
Volume: 85
Issue: 17
Pages: 6227-31
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Publication
28182716 | -
First Author: Huang P
Year: 2017
Journal: PLoS One
Title: LYZL6, an acidic, bacteriolytic, human sperm-related protein, plays a role in fertilization.
Volume: 12
Issue: 2
Pages: e0171452
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Protein Domain
IPR000974 | Glyco_hydro_22_lys
Type: Family
Description: O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.Glycoside hydrolase family 22 comprises enzymes with two known activities; lysozyme type C () and alpha-lactalbumins. Asp and/or the carbonyl oxygen of the C-2 acetamido group of the substrate acts as the catalytic nucleophile/base. Lysozyme is a muramidase that hydrolyses beta-1,4-links between N-acetyl-muramic acid and N-acetyl-D-glucosamine in the peptidoglycan of bacterial cell walls [], thus helping to fight invading bacteria. In this capacity, the enzyme is found in tears and saliva, but it has also been recruited for a digestive role in the true stomach (abomasum) of ruminants and colobine monkeys: here it probably degrades the cell walls of bacteria passing from the foregut, allowing the breakdown products to be digested by other stomach enzymes [, ]. The stomach form of lysozyme is endowed with special physiochemical properties that allow it to function in an acidic and protease-rich environment.Lysozyme C is similar to alpha-lactalbumin in terms of primary sequence and structure [], and both have probably evolved from a common ancestral protein. There is, however, no similarity in function, lactalbumin being involved in the formation of lactose and is essential for milk production. Another significant difference between the two enzymes is that while all lactalbumins have the ability to bind calcium, this property is restricted to only a few lysozymes [].From human testis cDNA libraries, a group of lysozyme c-like sequences is identified [, ]. The function of this group of lysozyme c-like proteins is not clear. Some of them (LYZL2, SLLP1/SPACA3/LYXL3, LYZL4 and LYZL6) are expressed in the male reproductive tract [, , ]and may be involved in fertilisation.
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Protein
A2AE20
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
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Protein
A0A077S1H9
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
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Protein
Q9CPX3
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
Q9DA11
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
Q9D9X8
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
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Protein
A0A077S9M6
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: false
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Protein
D3Z796
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
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Protein
A0A077S9Z4
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
A0A077S2U3
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
P17897
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
P08905
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
Q9D249
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: false
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Protein
A0A077S2U6
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
Q8BM27
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Protein
A0A077S9N1
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
Q8BM26
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: false
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Publication
6715332 | -
First Author: Shewale JG
Year: 1984
Journal: J Biol Chem
Title: Evolution of alpha-lactalbumins. The complete amino acid sequence of the alpha-lactalbumin from a marsupial (Macropus rufogriseus) and corrections to regions of sequence in bovine and goat alpha-lactalbumins.
Volume: 259
Issue: 8
Pages: 4947-56
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Publication
3666156 | -
First Author: Nitta K
Year: 1987
Journal: FEBS Lett
Title: The calcium-binding property of equine lysozyme.
Volume: 223
Issue: 2
Pages: 405-8
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Publication
2738070 | -
First Author: Irwin DM
Year: 1989
Journal: J Biol Chem
Title: Multiple cDNA sequences and the evolution of bovine stomach lysozyme.
Volume: 264
Issue: 19
Pages: 11387-93
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Publication
7624375 | -
First Author: Henrissat B
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.
Volume: 92
Issue: 15
Pages: 7090-4
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Publication
8535779 | -
First Author: Davies G
Year: 1995
Journal: Structure
Title: Structures and mechanisms of glycosyl hydrolases.
Volume: 3
Issue: 9
Pages: 853-9
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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