Type |
Details |
Score |
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Allele |
Name: |
leucine zipper, putative tumor suppressor 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Protein Domain |
Type: |
Family |
Description: |
The leucine zipper tumor suppressor (LZTS) family members are thought to play roles in cell growth modulation, mitosis and cancer cell growth suppression [, ]. This entry includes the protein families LZTS 1-3 from animals. LZTS1 (also known as FEZ1) plays a role in mitosis []. It is associated with assembled microtubules and is involved in the stabilization of active p34CDC2 (Cdk1) []. LZTS2 (LAPSER1) interacts with p80 katanin and regulates katanin-mediated microtubule severing. It alters cell proliferation by regulating cytokinesis. It is localised to the centrosome and the midbody in mitotic cells and modulates beta-catenin signalling and localisation []. LZTS3 (ProSAP-interacting protein 1, ProSAPiP1) interacts with the PDZ domain of ProSAP2/Shank3, a scaffolding protein for components of the postsynaptic density (PSD) of excitatory brain synapses []. It also interacts with the postsynaptic protein Sipa1l3/SPAR3 []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
599
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
700
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
598
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
599
 |
Fragment?: |
false |
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•
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Publication |
First Author: |
Ishii H |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis. |
Volume: |
98 |
Issue: |
18 |
Pages: |
10374-9 |
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•
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•
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Publication |
First Author: |
Vecchione A |
Year: |
2007 |
Journal: |
Cell Div |
Title: |
Fez1/Lzts1 a new mitotic regulator implicated in cancer development. |
Volume: |
2 |
|
Pages: |
24 |
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•
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Publication |
First Author: |
Teufel A |
Year: |
2005 |
Journal: |
Oncol Rep |
Title: |
In silico characterization of LZTS3, a potential tumor suppressor. |
Volume: |
14 |
Issue: |
2 |
Pages: |
547-51 |
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•
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Publication |
First Author: |
Dolnik A |
Year: |
2016 |
Journal: |
J Neurochem |
Title: |
Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3. |
Volume: |
136 |
Issue: |
1 |
Pages: |
28-35 |
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Publication |
First Author: |
Wendholt D |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3. |
Volume: |
281 |
Issue: |
19 |
Pages: |
13805-16 |
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