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Search results 101 to 115 out of 115 for Magoh

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Type Details Score
HT Experiment
E-GEOD-19168 | Expression profiling analysis of mouse E10.5 Magoh mutant brain cortices
Series Id: GSE19168
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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GXD Expression
GXD Expression
   
Probe: MGI:7425117
Assay Type: RT-PCR
Annotation Date: 2023-01-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Stage: TS19
Assay Id: MGI:7425169
Age: embryonic day 11.5
Image: 4
Specimen Label: Emx1-Cre; Magoh lox/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7425119
Assay Type: RT-PCR
Annotation Date: 2023-01-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Stage: TS19
Assay Id: MGI:7425170
Age: embryonic day 11.5
Image: 4
Specimen Label: Emx1-Cre; Magoh lox/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7425121
Assay Type: RT-PCR
Annotation Date: 2023-01-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Stage: TS19
Assay Id: MGI:7425171
Age: embryonic day 11.5
Image: S2
Specimen Label: Emx1-Cre; Magoh lox/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7425122
Assay Type: RT-PCR
Annotation Date: 2023-01-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Stage: TS19
Assay Id: MGI:7425172
Age: embryonic day 11.5
Image: S2
Specimen Label: Emx1-Cre; Magoh lox/+
Detected: true
Specimen Num: 2
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Publication
23917022 | -
First Author: Singh KK
Year: 2013
Journal: RNA Biol
Title: Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.
Volume: 10
Issue: 8
Pages: 1291-8
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Publication
19033377 | -
First Author: Nielsen KH
Year: 2009
Journal: RNA
Title: Mechanism of ATP turnover inhibition in the EJC.
Volume: 15
Issue: 1
Pages: 67-75
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Protein Domain
IPR033744 | RRM_RBM8
Type: Domain
Description: This entry corresponds to the RNA recognition motif of RBM8. RNA-binding protein RBM8, also termed binder of OVCA1-1 (BOV-1) or RNA-binding protein Y14, is one of the components of the exon-exon junction complex (EJC) []. It has two isoforms, RBM8A and RBM8B, both of which are identical except that RBM8B is 16 amino acids shorter at its N terminus []. RBM8, together with other EJC components (such as Magoh, Aly/REF, RNPS1, Srm160, and Upf3), plays critical roles in postsplicing processing, including nuclear export and cytoplasmic localization of the mRNA, and the nonsense-mediated mRNA decay (NMD) surveillance process. RBM8 binds to mRNA 20-24 nucleotides upstream of a spliced exon-exon junction. It is also involved in spliced mRNA nuclear export, and the process of nonsense-mediated decay of mRNAs with premature stop codons. RBM8 forms a specific heterodimer complex with the EJC protein Magoh which then associates with Aly/REF, RNPS1, DEK, and SRm160 on the spliced mRNA, and inhibits ATP turnover by eIF4AIII, thereby trapping the EJC core onto RNA [, ].RBM8 contains an N-terminal putative bipartite nuclear localization signal, one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), in the central region, and a C-terminal serine-arginine rich region (SR domain) and glycine-arginine rich region (RG domain) [].
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Publication
11013075 | -
First Author: Salicioni AM
Year: 2000
Journal: Genomics
Title: Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor.
Volume: 69
Issue: 1
Pages: 54-62
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Publication
29301961 | -
First Author: Zhan X
Year: 2018
Journal: Science
Title: Structure of a human catalytic step I spliceosome.
Volume: 359
Issue: 6375
Pages: 537-545
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Protein
Q9CWZ3
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: false
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Protein
A0A0G2JFX7
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: false
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Protein
A0A0N4SUH6
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: false
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Protein
A0A0G2JEA9
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: false
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Publication
12781131 | -
First Author: Lau CK
Year: 2003
Journal: Curr Biol
Title: Structure of the Y14-Magoh core of the exon junction complex.
Volume: 13
Issue: 11
Pages: 933-41
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