Type |
Details |
Score |
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
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|
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•
•
•
•
•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
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•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
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•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
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•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
MAP1A heavy chain |
Type: |
chain |
End: |
2542 |
|
•
•
•
•
•
|
Component |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
MAP1A light chain-2 interacts with GTP-RhoB to control epidermal growth factor (EGF)-dependent EGF receptor signaling. |
|
•
•
•
•
•
|
Publication |
First Author: |
Mann SS |
Year: |
1994 |
Journal: |
J Biol Chem |
Title: |
Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. |
Volume: |
269 |
Issue: |
15 |
Pages: |
11492-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lajoie-Mazenc I |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
MAP1A light chain-2 interacts with GTP-RhoB to control epidermal growth factor (EGF)-dependent EGF receptor signaling. |
Volume: |
283 |
Issue: |
7 |
Pages: |
4155-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Orbán-Németh Z |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family. |
Volume: |
280 |
Issue: |
3 |
Pages: |
2257-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Utreras E |
Year: |
2008 |
Journal: |
Dev Neurosci |
Title: |
Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination. |
Volume: |
30 |
Issue: |
1-3 |
Pages: |
200-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tortosa E |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation. |
Volume: |
286 |
Issue: |
47 |
Pages: |
40638-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Villarroel-Campos D |
Year: |
2014 |
Journal: |
Dev Neurobiol |
Title: |
The MAP1B case: an old MAP that is new again. |
Volume: |
74 |
Issue: |
10 |
Pages: |
953-71 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
MAP1-family proteins are microtubule-associated proteins (MAPs) that bind along the microtubule lattice. Mammalian genomes usually contain three family members, MAP1A, MAP1B and MAP1S. Only one family member, Futsch, is found in Drosophila.Human MAP1A and MAP1B, are predominantly expressed in neurons, where they are thought to be important in the formation and development of axons and dendrites [, ]. Human MAP1A and MAP1B stabilise microtubules and interact with other cellular components, including filamentous actin and signalling proteins. The activity of MAP1A and MAP1B is controlled by upstream signalling mechanisms, including the MAP kinase and glycogen synthase kinase-3 beta pathways []. This entry represent MAP1B. It may bind to at least two tubulin subunits in the polymer. This bridging of subunits might be involved in nucleating microtubule polymerisation and in stabilising microtubules []. Besides its microtubule regulation functions, MAP1B also acts as a signalling protein involved in normal physiology and pathological conditions in the nervous system []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
528
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
236
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
396
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
324
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
61
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
377
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
691
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
724
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Halpain S |
Year: |
2006 |
Journal: |
Genome Biol |
Title: |
The MAP1 family of microtubule-associated proteins. |
Volume: |
7 |
Issue: |
6 |
Pages: |
224 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2464
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2464
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
79
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
133
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
239
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Dallol A |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Depletion of the Ras association domain family 1, isoform A-associated novel microtubule-associated protein, C19ORF5/MAP1S, causes mitotic abnormalities. |
Volume: |
67 |
Issue: |
2 |
Pages: |
492-500 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu L |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
Distinct structural domains within C19ORF5 support association with stabilized microtubules and mitochondrial aggregation and genome destruction. |
Volume: |
65 |
Issue: |
10 |
Pages: |
4191-201 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wong EY |
Year: |
2004 |
Journal: |
Biol Reprod |
Title: |
Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein. |
Volume: |
70 |
Issue: |
3 |
Pages: |
775-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie R |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation. |
Volume: |
286 |
Issue: |
12 |
Pages: |
10367-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu L |
Year: |
2009 |
Journal: |
Cell Oncol |
Title: |
Dual function microtubule- and mitochondria-associated proteins mediate mitotic cell death. |
Volume: |
31 |
Issue: |
5 |
Pages: |
393-405 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
MAP1-family proteins are microtubule-associated proteins (MAPs) that bind along the microtubule lattice. Mammalian genomes usually contain three family members, MAP1A, MAP1B and MAP1S. Only one family member, Futsch, is found in Drosophila.Human MAP1A and MAP1B, are predominantly expressed in neurons, where they are thought to be important in the formation and development of axons and dendrites []. Human MAP1A and MAP1B stabilise microtubules and interact with other cellular components, including filamentous actin and signaling proteins. The activity of MAP1A and MAP1B is controlled by upstream signaling mechanisms, including the MAP kinase and glycogen synthase kinase-3 beta pathways []. Human MAP1S is a heterodimer with a heavy and a light chain. Both MAP1S heavy and light chains interact with microtubules, while MAP1S light chain interacts with actin []. MAP1S is involved in the formation of microtubule bundles []. It mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD) []. It bridges autophagic components with microtubules and mitochondria plays a role in apoptosis [, , ]. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
973
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
864
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
973
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato Y |
Year: |
1998 |
Journal: |
J Biochem |
Title: |
Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment. |
Volume: |
124 |
Issue: |
1 |
Pages: |
209-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukuyama R |
Year: |
1995 |
Journal: |
J Neurosci Res |
Title: |
Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15. |
Volume: |
40 |
Issue: |
6 |
Pages: |
820-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu L |
Year: |
2012 |
Journal: |
Autophagy |
Title: |
MAP1S enhances autophagy to suppress tumorigenesis. |
Volume: |
8 |
Issue: |
2 |
Pages: |
278-80 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
MAP1-family proteins are microtubule-associated proteins (MAPs) that bind along the microtubule lattice. Mammalian genomes usually contain three family members, MAP1A, MAP1B and MAP1S. Only one family member, Futsch, is found in Drosophila.Human MAP1S is a heterodimer with a heavy and a light chain. Both MAP1S heavy and light chains interact with microtubules, while MAP1S light chain interacts with actin []. Unlike MAP1A and MAP1B, MAP1S is expressed in a wide range of tissues in addition to neurons []. MAP1S serves as a linker to connect mitochondria with microtubules for trafficking, and to bridge the autophagy machinery with microtubules and mitochondria to affect autophagosomal biogenesis and degradation [, , , ]. In mice, MAP1S may enhance autophagy to suppress genomic instability and tumorigenesis []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Maurer MH |
Year: |
2004 |
Journal: |
J Neurochem |
Title: |
Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor. |
Volume: |
91 |
Issue: |
4 |
Pages: |
1007-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiao L |
Year: |
2020 |
Journal: |
FASEB J |
Title: |
Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related α-synuclein A53T mice. |
Volume: |
34 |
Issue: |
9 |
Pages: |
12239-12254 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andrés-Benito P |
Year: |
2023 |
Journal: |
Int J Mol Sci |
Title: |
Deregulated Transcription and Proteostasis in Adult mapt Knockout Mouse. |
Volume: |
24 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Barón-Mendoza I |
Year: |
2021 |
Journal: |
Front Cell Neurosci |
Title: |
Changes in the Number and Morphology of Dendritic Spines in the Hippocampus and Prefrontal Cortex of the C58/J Mouse Model of Autism. |
Volume: |
15 |
|
Pages: |
726501 |
|
•
•
•
•
•
|