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Search results 101 to 111 out of 111 for Map3k13

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Type

Details

Score

Allele

Map3k13<em1Yjin> | MGI:6840986

Name:	mitogen-activated protein kinase kinase kinase 13; endonuclease-mediated mutation 1, Yishin Jin
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

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Publication

11163770 | -

First Author:	Ikeda A
Year:	2001
Journal:	FEBS Lett
Title:	Identification and characterization of functional domains in a mixed lineage kinase LZK.
Volume:	488
Issue:	3
Pages:	190-5

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Publication

11726277 | -

First Author:	Ikeda A
Year:	2001
Journal:	J Biochem
Title:	Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway.
Volume:	130
Issue:	6
Pages:	773-81

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Protein Domain

IPR027258 | MAPKKK13

Type:

Family

Description:

MAP3K13 (also known as leucine zipper-bearing kinase LZK) activates the c-Jun-NH2 terminal kinase (JNK) pathway through activation of the MAP kinase kinase MAP2K7 [, ]. MAP3K13 acts synergistically with peroxiredoxin-3 (PRDX3) to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B []. MAP3K13 forms dimers/oligomers through its dual leucine zipper-like motif, and that this is necessary for activation of the JNK/SAPK pathway [].

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Allele

Map3k13<tm1Djz> | MGI:5888730

Name:	mitogen-activated protein kinase kinase kinase 13; targeted mutation 1, Donald J Zack
Allele Type:	Targeted
Attribute String:	Conditional ready, Null/knockout, Reporter

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Publication

12492477 | -

First Author:	Masaki M
Year:	2003
Journal:	Eur J Biochem
Title:	Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically.
Volume:	270
Issue:	1
Pages:	76-83

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Protein Domain

IPR017419 | MAP3K12_MAP3K13

Type:

Family

Description:

This entry represents mitogen-activated protein kinase kinase kinase, types 12/13 (MAP3K12 and MAP3K13), which form part of the mixed lineage kinase (MLK) family. MAP3K12 (also known as leucine-zipper protein kinase (ZPK), dual leucine zipper-bearing kinase (DLK) or MAPK-upstream kinase (MUK)) is a MAPKKK class protein kinase that induces JNK/SAPK activation. MAP3K12 is known to interact with MUK-binding inhibitory protein (MBIP). MBIP contains two tandem leucine-zipper-like motifs; MBIP interacts with one of the two leucine-zipper-like motifs of MAP3K12 and inhibits the activity of MAP3K12 to induce JNK/SAPK activation [, ]. MAP3K12 is autophosphorylated on Ser/Thr in cytosol under basal conditions, and dephosphorylated when membrane-associated.MAP3K13 (also known as leucine zipper-bearing kinase LZK) activates the c-Jun-NH2 terminal kinase (JNK) pathway through activation of the MAP kinase kinase MAP2K7 []. MAP3K13 acts synergistically with peroxiredoxin-3 (PRDX3) to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B [].

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Publication

14697235 | -

First Author:	Itoh A
Year:	2004
Journal:	Biochem Biophys Res Commun
Title:	SP3 acts as a positive regulator on the core promoter of human ZPK gene.
Volume:	313
Issue:	3
Pages:	612-8

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Protein

Q1HKZ5

Organism:	Mus musculus/domesticus
Length:	959
Fragment?:	false

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Publication

10801814 | -

First Author:	Fukuyama K
Year:	2000
Journal:	J Biol Chem
Title:	MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase.
Volume:	275
Issue:	28
Pages:	21247-54

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Protein

Q60700

Organism:	Mus musculus/domesticus
Length:	888
Fragment?:	false

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