| Type |
Details |
Score |
| Publication |
| First Author: |
Bartolini F |
| Year: |
2008 |
| Journal: |
J Cell Biol |
| Title: |
The formin mDia2 stabilizes microtubules independently of its actin nucleation activity. |
| Volume: |
181 |
| Issue: |
3 |
| Pages: |
523-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schrøder JM |
| Year: |
2007 |
| Journal: |
Curr Biol |
| Title: |
EB1 is required for primary cilia assembly in fibroblasts. |
| Volume: |
17 |
| Issue: |
13 |
| Pages: |
1134-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Komarova Y |
| Year: |
2005 |
| Journal: |
Mol Biol Cell |
| Title: |
EB1 and EB3 control CLIP dissociation from the ends of growing microtubules. |
| Volume: |
16 |
| Issue: |
11 |
| Pages: |
5334-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu XS |
| Year: |
2005 |
| Journal: |
J Cell Biol |
| Title: |
Melanophilin and myosin Va track the microtubule plus end on EB1. |
| Volume: |
171 |
| Issue: |
2 |
| Pages: |
201-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hume AN |
| Year: |
2007 |
| Journal: |
J Cell Sci |
| Title: |
Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes. |
| Volume: |
120 |
| Issue: |
Pt 17 |
| Pages: |
3111-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu X |
| Year: |
2008 |
| Journal: |
Cell |
| Title: |
ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. |
| Volume: |
135 |
| Issue: |
1 |
| Pages: |
137-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharma M |
| Year: |
2006 |
| Journal: |
J Biol Chem |
| Title: |
Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. |
| Volume: |
281 |
| Issue: |
25 |
| Pages: |
17140-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hein MY |
| Year: |
2015 |
| Journal: |
Cell |
| Title: |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. |
| Volume: |
163 |
| Issue: |
3 |
| Pages: |
712-23 |
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•
•
•
•
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| Publication |
| First Author: |
Xie W |
| Year: |
2022 |
| Journal: |
Cell Rep |
| Title: |
CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart. |
| Volume: |
41 |
| Issue: |
13 |
| Pages: |
111864 |
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•
•
•
•
•
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| Publication |
| First Author: |
Shan Y |
| Year: |
2021 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Drebrin regulates cytoskeleton dynamics in migrating neurons through interaction with CXCR4. |
| Volume: |
118 |
| Issue: |
3 |
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•
•
•
•
•
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| Publication |
| First Author: |
Camargo Ortega G |
| Year: |
2019 |
| Journal: |
Nature |
| Title: |
The centrosome protein AKNA regulates neurogenesis via microtubule organization. |
| Volume: |
567 |
| Issue: |
7746 |
| Pages: |
113-117 |
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•
•
•
•
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| Publication |
| First Author: |
Chilov D |
| Year: |
2011 |
| Journal: |
Dev Biol |
| Title: |
Phosphorylated β-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain. |
| Volume: |
357 |
| Issue: |
1 |
| Pages: |
259-68 |
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•
•
•
•
•
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| Publication |
| First Author: |
Landin Malt A |
| Year: |
2019 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Par3 is essential for the establishment of planar cell polarity of inner ear hair cells. |
| Volume: |
116 |
| Issue: |
11 |
| Pages: |
4999-5008 |
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•
•
•
•
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| Publication |
| First Author: |
Lo JC |
| Year: |
2012 |
| Journal: |
PLoS Genet |
| Title: |
RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. |
| Volume: |
8 |
| Issue: |
10 |
| Pages: |
e1002969 |
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•
•
•
•
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| Publication |
| First Author: |
Tamplin OJ |
| Year: |
2008 |
| Journal: |
BMC Genomics |
| Title: |
Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. |
| Volume: |
9 |
|
| Pages: |
511 |
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•
•
•
•
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| First Author: |
Freeman TC |
| Year: |
1998 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Expression Mapping of Mouse Genes |
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•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Backcross DNA Panel Mapping Resource |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
JAX BSS Panel Mapping Data |
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•
•
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| Publication |
| First Author: |
Ko MS |
| Year: |
2000 |
| Journal: |
Development |
| Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
| Volume: |
127 |
| Issue: |
8 |
| Pages: |
1737-49 |
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•
•
•
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| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2018 |
| Journal: |
Database Release |
| Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
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•
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•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
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| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
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•
•
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| Publication |
| First Author: |
Stryke D |
| Year: |
2003 |
| Journal: |
Nucleic Acids Res |
| Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
| Volume: |
31 |
| Issue: |
1 |
| Pages: |
278-81 |
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•
•
•
•
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| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Helmholtz Zentrum Muenchen GmbH |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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•
•
•
•
•
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| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2014 |
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| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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•
•
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| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
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| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
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•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
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| Title: |
MGI Sequence Curation Reference |
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| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
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| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
685-90 |
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| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
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| Title: |
Nomenclature Committee Use |
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| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
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14109-14 |
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| First Author: |
GemPharmatech |
| Year: |
2020 |
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GemPharmatech Website. |
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| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
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| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
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| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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UniProt-GOA |
| Year: |
2012 |
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| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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GOA curators |
| Year: |
2016 |
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Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
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Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
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| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
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The Gene Ontology Consortium |
| Year: |
2010 |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Diez-Roux G |
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2011 |
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PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
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e1000582 |
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Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
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Mouse Genome Informatics Computational Sequence to Gene Associations |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
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Annotation inferences using phylogenetic trees |
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Mouse Genome Database and National Center for Biotechnology Information |
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Allen Institute for Brain Science |
| Year: |
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Allen Institute |
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Allen Brain Atlas: mouse riboprobes |
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Mouse Genome Informatics Scientific Curators |
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2009 |
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Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
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Database Download |
| Title: |
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Mouse Genome Informatics Group |
| Year: |
2003 |
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Database Procedure |
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Automatic Encodes (AutoE) Reference |
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Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Mouse Genome Informatics |
| Year: |
2010 |
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Database Release |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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Obtaining and loading genome assembly coordinates from NCBI annotations |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
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Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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•
•
•
|
| UniProt Feature |
| Begin: |
918 |
| Description: |
(S/T)X(I/L)P motif 3; required for interaction with MAPRE1 |
| Type: |
short sequence motif |
| End: |
921 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
500 |
| Description: |
SXIP motif 1; mediates interaction with MAPRE1 and targeting to microtubule plus ends |
| Type: |
short sequence motif |
| End: |
503 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
523 |
| Description: |
SXIP motif 2; mediates interaction with MAPRE1 and targeting to microtubule plus ends |
| Type: |
short sequence motif |
| End: |
526 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Microtubule-associated protein RP/EB family member 2 (also known as RP1 or EB2) belongs to the RP/EB family, which consists of MAPRE1 (EB1), MAPRE2 (RP1, also known as EB2) and MAPRE3 (EBF3, also known as EB3). Unlike EB1 and EB3, EB2 does not promote persistent microtubule growth by suppressing catastrophes []. It has been shown that MAPRE2 is highly expressed in pancreatic cancer cells, and seems to be involved in perineural invasion []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Microtubule-assocaiated protein RP/EB family member 3 (EB3) belongs to the RP/EB family, which consists of MAPRE1 (EB1), MAPRE2 (RP1, also known as EB2) and MAPRE3 (EBF3, also known as EB3). EB3 promotes persistent microtubule growth by suppressing catastrophes []. Unlike EB1 or EB2, EB3 also binds to the F-actin-binding protein drebrin and the E3 ubiquitin ligase SIAH-1 []. EB3 is specifically upregulated upon myogenic differentiation. Knockdown of EB3, but not that of EB1, prevents myoblast elongation and fusion into myotubes []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Komarova Y |
| Year: |
2009 |
| Journal: |
J Cell Biol |
| Title: |
Mammalian end binding proteins control persistent microtubule growth. |
| Volume: |
184 |
| Issue: |
5 |
| Pages: |
691-706 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Honnappa S |
| Year: |
2009 |
| Journal: |
Cell |
| Title: |
An EB1-binding motif acts as a microtubule tip localization signal. |
| Volume: |
138 |
| Issue: |
2 |
| Pages: |
366-76 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Microtubule-associated protein RP/EB family member 1 (EB1) belongs to the RP/EB family, which consists of MAPRE1 (EB1), MAPRE2 (RP1, also known as EB2) and MAPRE3 (EBF3, also known as EB3). EB1 binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. EB1 contains an N-terminal calponin homology (CH) domain that is responsible for the interaction with microtubules (MTs), and a C-terminal coiled coil domain that extends into a four-helix bundle, required for dimer formation []. Through their C-terminal sequences, EBs interact with most other known +TIPs (plus end tracking proteins) and recruit many of them to the growing MT ends [, ]. EB1 is involved in MT anchoring at the centrosome and cell migration []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wen Y |
| Year: |
2004 |
| Journal: |
Nat Cell Biol |
| Title: |
EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration. |
| Volume: |
6 |
| Issue: |
9 |
| Pages: |
820-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Askham JM |
| Year: |
2002 |
| Journal: |
Mol Biol Cell |
| Title: |
Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. |
| Volume: |
13 |
| Issue: |
10 |
| Pages: |
3627-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Abiatari I |
| Year: |
2009 |
| Journal: |
Int J Oncol |
| Title: |
The microtubule-associated protein MAPRE2 is involved in perineural invasion of pancreatic cancer cells. |
| Volume: |
35 |
| Issue: |
5 |
| Pages: |
1111-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Straube A |
| Year: |
2007 |
| Journal: |
Curr Biol |
| Title: |
EB3 regulates microtubule dynamics at the cell cortex and is required for myoblast elongation and fusion. |
| Volume: |
17 |
| Issue: |
15 |
| Pages: |
1318-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Akhmanova A |
| Year: |
2008 |
| Journal: |
Nat Rev Mol Cell Biol |
| Title: |
Tracking the ends: a dynamic protein network controls the fate of microtubule tips. |
| Volume: |
9 |
| Issue: |
4 |
| Pages: |
309-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Trembley MA |
| Year: |
2018 |
| Journal: |
Circulation |
| Title: |
Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy. |
| Volume: |
138 |
| Issue: |
17 |
| Pages: |
1864-1878 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
De Groot CO |
| Year: |
2010 |
| Journal: |
J Biol Chem |
| Title: |
Molecular insights into mammalian end-binding protein heterodimerization. |
| Volume: |
285 |
| Issue: |
8 |
| Pages: |
5802-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu H |
| Year: |
2010 |
| Journal: |
Mol Microbiol |
| Title: |
Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesis. |
| Volume: |
78 |
| Issue: |
4 |
| Pages: |
1038-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Geraldo S |
| Year: |
2008 |
| Journal: |
Nat Cell Biol |
| Title: |
Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis. |
| Volume: |
10 |
| Issue: |
10 |
| Pages: |
1181-9 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents the microtubule-associated protein RP/EB (MAPRE) family, including MAPRE1 (EB1), MAPRE2 (RP1, also known as EB2), MAPRE3 (EBF3, also known as EB3) and their homologues from eukaryotes. Despite their high protein sequence conservation, the individual EBs exhibit different regulatory and functional properties []. For instance, EB1 and EB3, but not EB2, promote persistent microtubule growth by suppressing catastrophes [].EB1 contains an N-terminal calponin homology (CH) domain that is responsible for the interaction with microtubules (MTs), and a C-terminal coiled coil domain that extends into a four-helix bundle, required for dimer formation []. Through their C-terminal sequences, EBs interact with most other known +TIPs (plus end tracking proteins) and recruit many of them to the growing MT ends [, ]. EB1 is involved in MT anchoring at the centrosome and cell migration []. EB2 is highly expressed in pancreatic cancer cells, and seems to be involved in perineural invasion []. EB3 is specifically upregulated upon myogenic differentiation. Knockdown of EB3, but not that of EB1, prevents myoblast elongation and fusion into myotubes []. This entry also includes bZIP transcription factor hapX from the yeast Neosartorya fumigata, which is a transcription factor required for repression of genes during iron starvation []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
140
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
171
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
268
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
326
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
281
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
284
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
268
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
260
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
281
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
266
 |
| Fragment?: |
false |
|
•
•
•
•
•
|