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Search results 101 to 200 out of 206 for Mark2

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:5616334
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-23
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5616439
Age: postnatal adult
Note: Expressed in the region of the spindles.
Specimen Label: 2J/L
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5616334
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:5616439
Age: embryonic day 1.0
Note: Expressed in a network pattern, and densely around the nuclear envelopes.
Specimen Label: 2H
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5616334
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:5616439
Age: embryonic day 1.0
Note: Expressed in the region of the spindles.
Specimen Label: 2I
Detected: true
Specimen Num: 4
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Publication
20733003 | J:163905
First Author: Lennerz JK
Year: 2010
Journal: Mol Cell Biol
Title: Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.
Volume: 30
Issue: 21
Pages: 5043-56
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Publication
25078447 | J:218998
First Author: Figueiredo CA
Year: 2014
Journal: PLoS One
Title: Optimal attenuation of experimental autoimmune encephalomyelitis by intravenous immunoglobulin requires an intact interleukin-11 receptor.
Volume: 9
Issue: 7
Pages: e101947
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Publication
30654821 | J:295057
First Author: DiBona VL
Year: 2019
Journal: J Neuroinflammation
Title: Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury.
Volume: 16
Issue: 1
Pages: 11
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Publication
16123238 | J:100660
First Author: Moore CA
Year: 2005
Journal: Reproduction
Title: PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles.
Volume: 130
Issue: 3
Pages: 311-20
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Publication
18003716 | J:133294
First Author: Lee S
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice.
Volume: 294
Issue: 2
Pages: E261-70
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Publication
19808021 | J:153661
First Author: Fu A
Year: 2009
Journal: Cell Metab
Title: Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.
Volume: 10
Issue: 4
Pages: 285-95
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Publication
22186730 | J:311919
First Author: Daley WP
Year: 2012
Journal: Development
Title: ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity.
Volume: 139
Issue: 2
Pages: 411-22
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Publication
18292230 | J:132677
First Author: Dickey CA
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Akt and CHIP coregulate tau degradation through coordinated interactions.
Volume: 105
Issue: 9
Pages: 3622-7
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Publication
19808022 | J:153660
First Author: Granot Z
Year: 2009
Journal: Cell Metab
Title: LKB1 regulates pancreatic beta cell size, polarity, and function.
Volume: 10
Issue: 4
Pages: 296-308
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Publication
27841695 | J:317799
First Author: Gervais EM
Year: 2016
Journal: Organogenesis
Title: Par-1b is required for morphogenesis and differentiation of myoepithelial cells during salivary gland development.
Volume: 12
Issue: 4
Pages: 194-216
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Publication
9027487 | J:37839
First Author: Wada Y
Year: 1997
Journal: Genomics
Title: Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human.
Volume: 39
Issue: 1
Pages: 66-73
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Publication
15950600 | J:99397
First Author: Vinot S
Year: 2005
Journal: Dev Biol
Title: Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction.
Volume: 282
Issue: 2
Pages: 307-19
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Publication
33705388 | J:304551
First Author: Lu YN
Year: 2021
Journal: PLoS Biol
Title: MARK2 phosphorylates eIF2α in response to proteotoxic stress.
Volume: 19
Issue: 3
Pages: e3001096
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Publication
9501310 | J:46258
First Author: Guida LC
Year: 1998
Journal: Mamm Genome
Title: Genetic mapping of the galanin-GMAP (Galn) gene to mouse chromosome 19.
Volume: 9
Issue: 3
Pages: 240-2
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Publication
18562307 | J:140256
First Author: Hartleben B
Year: 2008
Journal: J Biol Chem
Title: Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity.
Volume: 283
Issue: 34
Pages: 23033-8
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Publication
9730611 | J:49762
First Author: Fernandes M
Year: 1998
Journal: Cytogenet Cell Genet
Title: Comparative mapping of two adjacent regions of MMU19 with their human counterpart on HSA11q13.
Volume: 81
Issue: 3-4
Pages: 237-46
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Publication
22333836 | J:183948
First Author: Tao H
Year: 2012
Journal: Dev Biol
Title: Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis.
Volume: 364
Issue: 2
Pages: 138-48
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Publication
18227155 | J:134078
First Author: Hezel AF
Year: 2008
Journal: Mol Cell Biol
Title: Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.
Volume: 28
Issue: 7
Pages: 2414-25
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Publication
20551175 | J:161201
First Author: Gao N
Year: 2010
Journal: Genes Dev
Title: Cdx2 regulates endo-lysosomal function and epithelial cell polarity.
Volume: 24
Issue: 12
Pages: 1295-305
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Publication
31636950 | J:330942
 
First Author: Chu Q
Year: 2019
Journal: Cell Discov
Title: STK11 is required for the normal program of ciliated cell differentiation in airways.
Volume: 5
Pages: 36
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Publication
23604909 | J:198500
First Author: Nakahara M
Year: 2013
Journal: Mamm Genome
Title: Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice.
Volume: 24
Issue: 5-6
Pages: 228-39
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: Serine/threonine-protein kinase MARK2
Type: chain
End: 776
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UniProt Feature
UniProt Feature
Begin: 227
Description: Phosphoserine; by MARK2
Type: modified residue
End: 227
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Publication
31461655 | J:294285
First Author: Ichinose S
Year: 2019
Journal: Cell Rep
Title: The Spatiotemporal Construction of the Axon Initial Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling.
Volume: 28
Issue: 9
Pages: 2413-2426.e7
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Protein
Q05512
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: false
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Protein
Q05512-2
Organism: Mus musculus/domesticus
Length: 774  
Fragment?: false
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Protein
Q05512-4
Organism: Mus musculus/domesticus
Length: 731  
Fragment?: false
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Protein
Q05512-3
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
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Protein
E9Q8H5
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Protein
F6ZEX4
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
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Protein
F7A3Q3
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: true
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Protein
F6Z4Q6
Organism: Mus musculus/domesticus
Length: 54  
Fragment?: true
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Protein
F6UY70
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: true
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Protein
E9Q2J6
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
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Protein
E9Q2G8
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
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Protein
F7CRG8
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
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Protein
E9PZ55
Organism: Mus musculus/domesticus
Length: 24  
Fragment?: true
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Interaction Experiment
Lu YN (2021)
Description: MARK2 phosphorylates eIF2? in response to proteotoxic stress.
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Allele
Mark2<em2Smoc> | MGI:7290982
Name: MAP/microtubule affinity regulating kinase 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6770928 | C57BL/6JSmoc-Mark2<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Mark2<em1Smoc> | MGI:7290981
Name: MAP/microtubule affinity regulating kinase 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6770927 | C57BL/6JSmoc-Mark2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
11756552 | -
First Author: Dan C
Year: 2002
Journal: Mol Cell Biol
Title: PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells.
Volume: 22
Issue: 2
Pages: 567-77
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Publication
16014608 | -
First Author: Matenia D
Year: 2005
Journal: Mol Biol Cell
Title: PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin.
Volume: 16
Issue: 9
Pages: 4410-22
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Publication
19415746 | -
First Author: Gong W
Year: 2009
Journal: Int J Cancer
Title: P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration.
Volume: 125
Issue: 3
Pages: 548-55
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Publication
18465753 | -
First Author: Wu X
Year: 2008
Journal: J Cell Biochem
Title: p21 activated kinase 5 activates Raf-1 and targets it to mitochondria.
Volume: 105
Issue: 1
Pages: 167-75
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Publication
12897128 | J:84802
First Author: Cotteret S
Year: 2003
Journal: Mol Cell Biol
Title: p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.
Volume: 23
Issue: 16
Pages: 5526-39
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Protein Domain
IPR028754 | PAK5
Type: Family
Description: Serine/threonine-protein kinase PAK 5 (PAK5, also known as PAK7) belongs to the mammalian p21-activated kinase (PAK) family of serine/threonine kinases that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival []. PAK5 (PAK7) induces filopodia formation and neurite outgrowth in neuroblastoma cells, perhaps through the Cdc42/Rac pathway []. It is an inhibitor of the MARK2 kinase, which leads to stable microtubules and dynamic actin []. It also has functions in apoptosis [], MAP Kinase pathway []and cancer malignant progression [].
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Publication
10542369 | J:261285
First Author: Ebneth A
Year: 1999
Journal: Cell Motil Cytoskeleton
Title: Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.
Volume: 44
Issue: 3
Pages: 209-24
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Publication
32839317 | J:296029
First Author: Zhou Z
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity.
Volume: 117
Issue: 36
Pages: 22193-22203
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Publication
23902687 | J:206886
First Author: Sato Y
Year: 2013
Journal: J Cell Sci
Title: The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells.
Volume: 126
Issue: Pt 20
Pages: 4671-83
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Publication
33596087 | J:308617
First Author: Mashukova A
Year: 2021
Journal: Mol Biol Cell
Title: The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80.
Volume: 32
Issue: 8
Pages: 690-702
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Publication
21311567 | J:203104
First Author: Wu PR
Year: 2011
Journal: Cell Death Differ
Title: DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity.
Volume: 18
Issue: 9
Pages: 1507-20
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Publication
28550165 | J:340658
First Author: Kruse R
Year: 2017
Journal: Mol Cell Proteomics
Title: Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein.
Volume: 16
Issue: 10
Pages: 1718-1735
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Publication
16257959 | J:105696
First Author: Kosuga S
Year: 2005
Journal: J Biol Chem
Title: GSK-3beta directly phosphorylates and activates MARK2/PAR-1.
Volume: 280
Issue: 52
Pages: 42715-22
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Publication
25613821 | J:218160
 
First Author: Shionoya T
Year: 2015
Journal: BMC Dev Biol
Title: Distinct expression and localization of the type II diacylglycerol kinase isozymes δ, η and κ in the mouse reproductive organs.
Volume: 15
Pages: 6
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Protein
Q4KL59
Organism: Mus musculus/domesticus
Length: 338  
Fragment?: false
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Protein
Q8C015
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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