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Search results 101 to 132 out of 132 for Mc5r

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Type Details Score
Publication
25163632 | -
First Author: Delhanty PJ
Year: 2014
Journal: Mol Biol Rep
Title: Functional characterization of a new human melanocortin-4 receptor homozygous mutation (N72K) that is associated with early-onset obesity.
Volume: 41
Issue: 12
Pages: 7967-72
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Publication
32248247 | -
First Author: Xu Y
Year: 2020
Journal: Cell Mol Life Sci
Title: Melanocortin 5 receptor signaling pathway in health and disease.
Volume: 77
Issue: 19
Pages: 3831-3840
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Publication
12646665 | -
First Author: Farooqi IS
Year: 2003
Journal: N Engl J Med
Title: Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.
Volume: 348
Issue: 12
Pages: 1085-95
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Publication
23869017 | -
First Author: Sebag JA
Year: 2013
Journal: Science
Title: Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish.
Volume: 341
Issue: 6143
Pages: 278-81
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Protein Domain
IPR001908 | MC3-5R
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].Adrenocorticotrophin (ACTH), melanocyte-stimulating hormones (MSH) andbeta-endorphin are peptide products of pituitary pro-opiomelanocortin.ACTH regulates synthesis and release of glucocorticoids and aldosteronein the adrenal cortex; it also has a trophic action on these cells.ACTH and beta-endorphin are synthesised and released in response tocorticotrophin-releasing factor at times of stress (heat, cold, infections,etc.) - their release leads to increased metabolism and analgesia.MSH has a trophic action on melanocytes, and regulates pigment productionin fish and amphibia. The ACTH receptor is found in high levels inthe adrenal cortex - binding sites are present in lower levels in theCNS. The MSH receptor is expressed in high levels in melanocytes,melanomas and their derived cell lines. Receptors are found in lowlevels in the CNS. MSH regulates temperature control in the septal regionof the brain and releases prolactin from the pituitary.This entry represents Melanocortin receptor 3-5 (MC3-5R) from chordates. These protein are receptors for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. MC3R is required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain []. MC4R plays a central role in energy homeostasis and somatic growth [, , ]. MC5R is a possible mediator of the immunomodulation properties of melanocortins, playing a role in immune reaction and inflammatory response as well as in the regulation of sexual behaviour, thermoregulation, and exocrine secretion [].
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Protein
D5MR23
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
D5MR29
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
D5MR31
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
D5MR33
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
D5MR32
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
D5MR27
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
D5MR28
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
D5MR24
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
D5MR30
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
P33033
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
P56450
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: false
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Protein
P41149
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
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Protein
G3UWB6
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: false
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Protein
Q544G7
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
Q496T0
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: false
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Protein
Q3ZAT4
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
Q49NR1
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: false
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Publication
2111655 | -
 
First Author: Birnbaumer L
Year: 1990
Journal: Annu Rev Pharmacol Toxicol
Title: G proteins in signal transduction.
Volume: 30
Pages: 675-705
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Publication
2830256 | -
First Author: Casey PJ
Year: 1988
Journal: J Biol Chem
Title: G protein involvement in receptor-effector coupling.
Volume: 263
Issue: 6
Pages: 2577-80
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Publication
8386361 | -
First Author: Attwood TK
Year: 1993
Journal: Protein Eng
Title: Design of a discriminating fingerprint for G-protein-coupled receptors.
Volume: 6
Issue: 2
Pages: 167-76
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Publication
12679517 | J:83410
First Author: Vassilatis DK
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: The G protein-coupled receptor repertoires of human and mouse.
Volume: 100
Issue: 8
Pages: 4903-8
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Publication
8170923 | -
First Author: Attwood TK
Year: 1994
Journal: Protein Eng
Title: Fingerprinting G-protein-coupled receptors.
Volume: 7
Issue: 2
Pages: 195-203
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Publication
8081729 | -
First Author: Kolakowski LF Jr
Year: 1994
Journal: Receptors Channels
Title: GCRDb: a G-protein-coupled receptor database.
Volume: 2
Issue: 1
Pages: 1-7
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Publication
15914470 | -
First Author: Foord SM
Year: 2005
Journal: Pharmacol Rev
Title: International Union of Pharmacology. XLVI. G protein-coupled receptor list.
Volume: 57
Issue: 2
Pages: 279-88
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Publication
18948278 | -
First Author: Harmar AJ
Year: 2009
Journal: Nucleic Acids Res
Title: IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.
Volume: 37
Issue: Database issue
Pages: D680-5
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Publication
16753280 | J:115055
First Author: Bjarnadóttir TK
Year: 2006
Journal: Genomics
Title: Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse.
Volume: 88
Issue: 3
Pages: 263-73
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Publication
23020293 | -
 
First Author: Civelli O
Year: 2013
Journal: Annu Rev Pharmacol Toxicol
Title: G protein-coupled receptor deorphanizations.
Volume: 53
Pages: 127-46
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