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Search results 101 to 200 out of 224 for Mcm9

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:2110343
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4826133
Age: embryonic day 14.5
Image: euxassay_006813_17
Specimen Label: euxassay_006813_17
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
 
Probe: MGI:2110343
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4826133
Age: embryonic day 14.5
Image: euxassay_006813_18
Specimen Label: euxassay_006813_18
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
 
Probe: MGI:2110343
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4826133
Age: embryonic day 14.5
Image: euxassay_006813_19
Specimen Label: euxassay_006813_19
Detected: true
Specimen Num: 19
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GXD Expression
GXD Expression
 
Probe: MGI:2110343
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4826133
Age: embryonic day 14.5
Image: euxassay_006813_20
Specimen Label: euxassay_006813_20
Detected: true
Specimen Num: 20
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GXD Expression
GXD Expression
 
Probe: MGI:2110343
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4826133
Age: embryonic day 14.5
Image: euxassay_006813_21
Specimen Label: euxassay_006813_21
Detected: true
Specimen Num: 21
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GXD Expression
GXD Expression
Probe: MGI:3584914
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:3585413
Age: embryonic day 16.0
Image: E16
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E16
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2110343
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1778223
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4826133
Age: embryonic day 14.5
Image: euxassay_006813_09
Specimen Label: euxassay_006813_09
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:2110343
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1778223
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4826133
Age: embryonic day 14.5
Image: euxassay_006813_10
Specimen Label: euxassay_006813_10
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:2110343
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1778223
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4826133
Age: embryonic day 14.5
Image: euxassay_006813_15
Specimen Label: euxassay_006813_15
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:2110343
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1778223
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4826133
Age: embryonic day 14.5
Image: euxassay_006813_16
Specimen Label: euxassay_006813_16
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:3584914
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3585413
Age: embryonic day 14.0
Note: Expression was detected in the outer and inner neuroblastic layers. The expression level was higher in the inner layer
Specimen Label: E14
Detected: true
Specimen Num: 1
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Publication
27757957 | J:241732
First Author: O'Driscoll M
Year: 2017
Journal: J Pathol
Title: The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery.
Volume: 241
Issue: 2
Pages: 192-207
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Publication
21689717 | J:175560
First Author: Lamberti A
Year: 2011
Journal: Biochimie
Title: Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.
Volume: 93
Issue: 10
Pages: 1738-46
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: DNA helicase MCM9
Type: chain
End: 1134
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Protein
A0A1W2P801
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
Q2KHI9
Organism: Mus musculus/domesticus
Length: 1134  
Fragment?: false
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Protein
Q2KHI9-2
Organism: Mus musculus/domesticus
Length: 1290  
Fragment?: false
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Protein
Q2KHI9-3
Organism: Mus musculus/domesticus
Length: 386  
Fragment?: false
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Protein
Q3V0E3
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: false
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DO Term
DOID:0080496 | ovarian dysgenesis 4
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Publication
16226853 | -
 
First Author: Lutzmann M
Year: 2005
Journal: Gene
Title: Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family.
Volume: 362
Pages: 51-6
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Publication
22771115 | -
First Author: Nishimura K
Year: 2012
Journal: Mol Cell
Title: Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.
Volume: 47
Issue: 4
Pages: 511-22
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GO Term
GO:0097362 | MCM8-MCM9 complex
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Allele
Del(10Mcm9-Asf1a)1Byg | MGI:4126239
Name: gene trap XE518 induced deletion 1, BayGenomics
Allele Type: Gene trapped
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Del(10Mcm9-Asf1a)1Byg/Del(10Mcm9-Asf1a)1Byg
Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(10Mcm9-Asf1a)1Byg/+
Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity: ht
Has Mutant Allele: true
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Publication
39195969 | J:341798
First Author: Lin M
Year: 2023
Journal: Nat Cardiovasc Res
Title: MCM8-mediated mitophagy protects vascular health in response to nitric oxide signaling in a mouse model of Kawasaki disease.
Volume: 2
Issue: 8
Pages: 778-792
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Protein Coding Gene
MGI:1913884 | Mcm8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30743181 | -
 
First Author: Griffin WC
Year: 2019
Journal: DNA Repair (Amst)
Title: The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance.
Volume: 76
Pages: 1-10
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Protein
A0A0A0MQF4
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
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Protein Domain
IPR031327 | MCM
Type: Family
Description: MCM proteins are DNA-dependent ATPases required for the initiation of eukaryotic DNA replication [, , ]. In eukaryotes there is a family of eight proteins, MCM2 to MCM9. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins []. These proteins are evolutionarily related and belong to the AAA+ superfamily. They contain the Mcm family domain, which includes motifs that are required for ATP hydrolysis (such as the Walker A and B, and R-finger motifs). Mcm2-7 forms a hexameric complex []in which individual subunits associate with different affinities, and there is a tightly associated core of Mcm4 (Cdc21), Mcm6 (Mis5) and Mcm7 []. Mcm2-7 complex is the replicative helicase involved in replication initiation and elongation [], whereas Mcm8 and Mcm9 from and separate one, conserved among many eukaryotes except yeast and C. elegans. Mcm8/9 complex play a role during replication elongation or recombination, being involved in the repair of double-stranded DNA breaks and DNA interstrand cross-links by homologous recombination. Drosophila is the only organism that has MCM8 without MCM9, involved in meiotic recombination [, ].This family is also present in the archebacteria in 1 to 4 copies. Methanocaldococcus jannaschii (Methanococcus jannaschii) has four members, MJ0363, MJ0961, MJ1489 and MJECL13.Schizosaccharomyces pombe (Fission yeast) MCMs, like those in metazoans, are found in the nucleus throughout the cell cycle. This is in contrast to the Saccharomyces cerevisiae (Baker's yeast) in which MCM proteins move in and out of the nucleus during each cell cycle. The assembly of the MCM complex in S. pombe is required for MCM localisation, ensuring that only intact MCM complexes remain in the nucleus [].
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Protein Domain
IPR001208 | MCM_dom
Type: Domain
Description: Proteins shown to be required for the initiation of eukaryotic DNA replication share a highly conserved domain of about 210 amino-acid residues [, , ]. The latter shows some similarities []with that of various other families of DNA-dependent ATPases. Eukaryotes seem to possess a family of eight proteins that contain this domain. They were first identified in yeast where most of them have a direct role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called 'minichromosome maintenance proteins' with gene symbols prefixedby MCM. These six proteins are:MCM2, also known as cdc19 (in S.pombe).MCM3, also known as DNA polymerase alphaholoenzyme-associated protein P1,RLF beta subunit or ROA.MCM4, also known as CDC54, cdc21 (in S.pombe) or dpa (in Drosophila).MCM5, also known as CDC46 or nda4 (in S.pombe).MCM6, also known as mis5 (in S.pombe).MCM7, also known as CDC47 or Prolifera (in A.thaliana).MCM8, also known as as REC (in Drosophila).MCMThese proteins are evolutionarily related and belong to the AAA+ superfamily. They contain the Mcm family domain, which includes motifs that are required for ATP hydrolysis (such as the Walker A and B, and R-finger motifs). Mcm2-7 forms a hexameric complex which is the replicative helicase involved in replication initiation and elongation, whereas Mcm8 and Mcm9 from and separate one, conserved among many eukaryotes except yeast and C. elegans. Mcm8/9 complex play a role during replication elongation or recombination, being involved in the repair of double-stranded DNA breaks and DNA interstrand cross-links by homologous recombination. Drosophila is the only organism that has MCM8 without MCM9, involved in meiotic recombination [, ].
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Protein
A0A1W2P804
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
E9Q956
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
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Protein
H9KV11
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
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Protein
H7BXC1
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
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Publication
9305914 | -
First Author: Ishimi Y
Year: 1997
Journal: J Biol Chem
Title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
Volume: 272
Issue: 39
Pages: 24508-13
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Publication
9366552 | -
First Author: Adachi Y
Year: 1997
Journal: Genes Cells
Title: A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast.
Volume: 2
Issue: 7
Pages: 467-79
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Publication
9658174 | -
First Author: Sherman DA
Year: 1998
Journal: Mol Biol Cell
Title: Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex.
Volume: 9
Issue: 7
Pages: 1833-45
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Publication
10588642 | -
First Author: Pasion SG
Year: 1999
Journal: Mol Biol Cell
Title: Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.
Volume: 10
Issue: 12
Pages: 4043-57
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Protein
Q9CWV1
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
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Protein
Q8C1Z0
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q8C2I9
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: true
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Protein
Q8C5L1
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: true
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Publication
1454522 | -
First Author: Coxon A
Year: 1992
Journal: Nucleic Acids Res
Title: Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication.
Volume: 20
Issue: 21
Pages: 5571-7
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Publication
8332451 | -
First Author: Koonin EV
Year: 1993
Journal: Nucleic Acids Res
Title: A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication.
Volume: 21
Issue: 11
Pages: 2541-7
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Publication
8265339 | -
First Author: Hu B
Year: 1993
Journal: Nucleic Acids Res
Title: The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.
Volume: 21
Issue: 23
Pages: 5289-93
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Publication
14731643 | -
First Author: Tye BK
Year: 1994
Journal: Trends Cell Biol
Title: The MCM2-3-5 proteins: are they replication licensing factors?
Volume: 4
Issue: 5
Pages: 160-6
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Protein
P97311
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q61881
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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Protein
P97310
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
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Protein
P49718
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
P49717
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
P25206
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
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Protein
Q542I2
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q3U4T8
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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Protein
Q3V122
Organism: Mus musculus/domesticus
Length: 720  
Fragment?: false
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Protein
Q921D5
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q3UJN1
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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