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Search results 101 to 126 out of 126 for Med12

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Type

Details

Score

Publication

17088561 | -

First Author:	Wang X
Year:	2006
Journal:	Proc Natl Acad Sci U S A
Title:	A subunit of the mediator complex regulates vertebrate neuronal development.
Volume:	103
Issue:	46
Pages:	17284-9

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Protein Domain

IPR019035 | Mediator_Med12

Type:

Domain

Description:

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. On recruitment the Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. The Mediator complex is composed of at least 31 subunits: MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The subunits form at least three structurally distinct submodules. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation.The head module contains: MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22. The middle module contains: MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31. CSE2/MED9 interacts directly with MED4. The tail module contains: MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The CDK8 module contains: MED12, MED13, CCNC and CDK8. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.Med12 is a component of the evolutionarily conserved Mediator complex []. The Med12 subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signaling pathway via its interaction with Gli3 within the Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription [].

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Protein

Q8BQM9

Organism:	Mus musculus/domesticus
Length:	2157
Fragment?:	false

•

Protein

A2AGH6

Organism:	Mus musculus/domesticus
Length:	2190
Fragment?:	false

•

Protein

A2AGH9

Organism:	Mus musculus/domesticus
Length:	2182
Fragment?:	false

•

Protein

A2AGH8

Organism:	Mus musculus/domesticus
Length:	2157
Fragment?:	false

•

Protein

A0A0G2JET8

Organism:	Mus musculus/domesticus
Length:	2185
Fragment?:	false

•

Publication

18451032 | -

First Author:	Carrera I
Year:	2008
Journal:	Proc Natl Acad Sci U S A
Title:	Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13.
Volume:	105
Issue:	18
Pages:	6644-9

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HT Experiment

GSE100088 | MED12cKO heart ventricles from male mice [RNA-seq]


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

•

Allele

Tg(Med12-EGFP)KC98Gsat | MGI:4847228

Name:	transgene insertion KC98, GENSAT Project at Rockefeller University
Allele Type:	Transgenic
Attribute String:	Reporter

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DO Term

DOID:0080985 | syndromic X-linked intellectual disorder Lujan-Fryns-type

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Strain

MGI:5004128 | STOCK Tg(Med12-EGFP)KC98Gsat/Mmucd

Attribute String:

mutant stock, transgenic

•

Protein

Q6ZPK9

Organism:	Mus musculus/domesticus
Length:	399
Fragment?:	true

•

Protein Domain

IPR021989 | Mediator_Med12_catenin-bd

Type:

Domain

Description:

This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. It is found in the C-terminal region of the mediator of RNA polymerase II transcription subunit 12. Both development and carcinogenesis are driven by signal transduction within the canonical Wnt/beta-catenin pathway through both programmed and unprogrammed changes in gene transcription. Beta-catenin physically and functionally targets this PQL (proline-, glutamine-, leucine-rich) region of the Med12 subunit of Mediator to activate transcription. The beta-catenin transactivation domain binds directly to isolated Med12 and intact Mediator both in vitro and in vivo, and Mediator is recruited to Wnt-responsive genes in a beta-catenin-dependent manner.

•

Protein Domain

IPR021990 | Mediator_Med12_LCEWAV

Type:	Domain
Description:	This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. The function of this particular region of the Mediator subunit Med12 is not known, but there is a conserved sequence motif: LCEWAV, from which the name derives.

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Publication

17290221 | -

First Author:	Loncle N
Year:	2007
Journal:	EMBO J
Title:	Distinct roles for Mediator Cdk8 module subunits in Drosophila development.
Volume:	26
Issue:	4
Pages:	1045-54

•

Protein Domain

IPR021643 | Mediator_Med13_N

Type:

Domain

Description:

This entry represents the N-terminal domain of Med13.Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species [, ]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med13 is part of the ancillary kinase module, together with Med12, CDK8 and CycC, which in yeast is implicated in transcriptional repression, though most of this activity is likely attributable to the CDK8 kinase. The large Med12 and Med13 proteins are required for specific developmental processes in Drosophila [], zebrafish, and Caenorhabditis elegans but their biochemical functions are not understood [].

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Publication

38742628 | J:358890

First Author:	Bolívar S
Year:	2024
Journal:	Elife
Title:	Neuron-specific RNA-sequencing reveals different responses in peripheral neurons after nerve injury.
Volume:	12

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Publication

25255084 | J:228776

First Author:	Muto A
Year:	2014
Journal:	PLoS Genet
Title:	Nipbl and mediator cooperatively regulate gene expression to control limb development.
Volume:	10
Issue:	9
Pages:	e1004671

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Protein

Q6JPI3

Organism:	Mus musculus/domesticus
Length:	2207
Fragment?:	false

•

Protein

A0A0J9YUA8

Organism:	Mus musculus/domesticus
Length:	2216
Fragment?:	false

•

Protein

E9QLJ3

Organism:	Mus musculus/domesticus
Length:	2207
Fragment?:	false

•

Publication

12738880 | -

First Author:	Samuelsen CO
Year:	2003
Journal:	Proc Natl Acad Sci U S A
Title:	TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.
Volume:	100
Issue:	11
Pages:	6422-7

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Publication

15175151 | J:90894

First Author:	Bourbon HM
Year:	2004
Journal:	Mol Cell
Title:	A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.
Volume:	14
Issue:	5
Pages:	553-7

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Publication

- | J:100256

First Author:	The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year:	2005
Journal:	Database Download
Title:	MGI download of GENSAT transgene data

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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