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Search results 101 to 200 out of 205 for Micu1

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Hits by Pathway

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Hits by Strain

Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:6267361
Assay Type: Western blot
Annotation Date: 2018-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:6267402
Age: postnatal day 0
Image: 1
Specimen Label: P0 lane 3
Detected: true
Specimen Num: 6
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•
GXD Expression
GXD Expression
   
Probe: MGI:6267361
Assay Type: Western blot
Annotation Date: 2018-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:6267402
Age: postnatal day 2
Image: 1
Specimen Label: P2 lane 1
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6267361
Assay Type: Western blot
Annotation Date: 2018-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:6267402
Age: postnatal day 2
Image: 1
Specimen Label: P2 lane 2
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6267361
Assay Type: Western blot
Annotation Date: 2018-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:6267402
Age: postnatal day 2
Image: 1
Specimen Label: P2 lane 3
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6267361
Assay Type: Western blot
Annotation Date: 2018-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6267402
Age: postnatal day 4
Image: 1
Specimen Label: P4 lane 1
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6267361
Assay Type: Western blot
Annotation Date: 2018-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6267402
Age: postnatal day 4
Image: 1
Specimen Label: P4 lane 2
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6267361
Assay Type: Western blot
Annotation Date: 2018-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6267402
Age: postnatal day 4
Image: 1
Specimen Label: P4 lane 3
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6267361
Assay Type: Western blot
Annotation Date: 2018-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:6267393
Age: embryonic day 13.5
Image: 1
Specimen Label: E13.5 lane 2
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692543
Age: postnatal adult
Image: MRC Harwell_1313757
Note: kidney
Specimen Label: MRC Harwell_1313757
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1666528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692543
Age: postnatal adult
Image: MRC Harwell_1313749
Specimen Label: MRC Harwell_1313749
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1619828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692543
Age: postnatal adult
Image: MRC Harwell_1313750
Specimen Label: MRC Harwell_1313750
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1898428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692543
Age: postnatal adult
Image: MRC Harwell_1313751
Specimen Label: MRC Harwell_1313751
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3667028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692543
Age: postnatal adult
Image: MRC Harwell_1313748
Specimen Label: MRC Harwell_1313748
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6267361
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-19
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1672824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6267384
Age: embryonic day 16.5
Image: 1g E16.5 Lungs
Specimen Label: 1g E16.5 Lungs
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6267361
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-19
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1672827
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6267384
Age: postnatal day 0
Image: 1g P0 Lungs
Specimen Label: 1g P0 Lungs
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6267361
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-19
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1672828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6267384
Age: postnatal day 7
Image: 1g P7 Lungs
Specimen Label: 1g P7 Lungs
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6267361
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-19
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1610524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6267384
Age: embryonic day 16.5
Image: 1g E16.5 Heart
Specimen Label: 1g E16.5 Heart
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6267361
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-19
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1610527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6267384
Age: postnatal day 0
Image: 1g P0 Heart
Specimen Label: 1g P0 Heart
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6267361
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-19
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1610528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6267384
Age: postnatal day 7
Image: 1g P7 Heart
Specimen Label: 1g P7 Heart
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1685328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692543
Age: postnatal adult
Image: MRC Harwell_1313753
Specimen Label: MRC Harwell_1313753
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6267361
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-19
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684624
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6267384
Age: embryonic day 16.5
Image: 1g E16.5 Liver
Specimen Label: 1g E16.5 Liver
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6267361
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-19
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6267384
Age: postnatal day 0
Image: 1g P0 Liver
Specimen Label: 1g P0 Liver
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6267361
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-19
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6267384
Age: postnatal day 7
Image: 1g P7 Liver
Specimen Label: 1g P7 Liver
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692543
Age: postnatal adult
Image: MRC Harwell_1313747
Specimen Label: MRC Harwell_1313747
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3273028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692543
Age: postnatal adult
Image: MRC Harwell_1313756
Specimen Label: MRC Harwell_1313756
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692543
Age: postnatal adult
Image: MRC Harwell_1313752
Specimen Label: MRC Harwell_1313752
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3281228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692543
Age: postnatal adult
Image: MRC Harwell_1313753
Specimen Label: MRC Harwell_1313753
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6267361
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-19
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6267384
Age: embryonic day 16.5
Image: 1g E16.5 Brain
Specimen Label: 1g E16.5 Brain
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6267361
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-19
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6267384
Age: postnatal day 0
Image: 1g P0 Brain
Specimen Label: 1g P0 Brain
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6267361
Assay Type: Immunohistochemistry
Annotation Date: 2018-12-19
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6267384
Age: postnatal day 7
Image: 1g P7 Brain
Specimen Label: 1g P7 Brain
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692543
Age: postnatal adult
Image: MRC Harwell_1313754
Specimen Label: MRC Harwell_1313754
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692543
Age: postnatal adult
Image: MRC Harwell_1313755
Specimen Label: MRC Harwell_1313755
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692543
Age: postnatal adult
Image: MRC Harwell_1313758
Specimen Label: MRC Harwell_1313758
Detected: true
Specimen Num: 10
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Publication
- | J:297104
       
First Author: National Laboratory Animal Center
Year: 2020
Title: National Laboratory Animal Center Website
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
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First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
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First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Micu1<em#Fink> | MGI:6158962
Name: mitochondrial calcium uptake 1; endonuclease-mediated mutation #, Toren Finkel
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
31801413 | J:299355
First Author: Banavath HN
Year: 2019
Journal: J Am Heart Assoc
Title: miR-181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart.
Volume: 8
Issue: 24
Pages: e012919
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Publication
26903221 | -
First Author: Matesanz-Isabel J
Year: 2016
Journal: Biochim Biophys Acta
Title: Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake.
Volume: 1858
Issue: 6
Pages: 1110-7
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Publication
35269658 | J:329149
 
First Author: Vecellio Reane D
Year: 2022
Journal: Int J Mol Sci
Title: The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation.
Volume: 23
Issue: 5
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Publication
23101630 | -
First Author: Mallilankaraman K
Year: 2012
Journal: Cell
Title: MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.
Volume: 151
Issue: 3
Pages: 630-44
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Allele
Micu1<em1Smoc> | MGI:7291071
Name: mitochondrial calcium uptake 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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DO Term
DOID:0111335 | myopathy with extrapyramidal signs
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Publication
24231807 | J:203524
First Author: Sancak Y
Year: 2013
Journal: Science
Title: EMRE is an essential component of the mitochondrial calcium uniporter complex.
Volume: 342
Issue: 6164
Pages: 1379-82
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Strain
MGI:7623433 | C57BL/6JSmoc-Micu1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein
V9GXX9
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: false
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Publication
29725115 | -
     
First Author: Patron M
Year: 2018
Journal: Cell Death Differ
Title: MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.
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Publication
28194521 | -
 
First Author: Mishra J
Year: 2017
Journal: Handb Exp Pharmacol
Title: The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology.
Volume: 240
Pages: 129-156
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Protein Domain
IPR039800 | MICU1/2/3
Type: Family
Description: This entry represents a group of calcium uptake proteins, including MICU1/2/3 from humans. They contain the conserved EF-hand Ca2+-binding domains. MICU1 and MICU2 are the main regulators of the mitochondrial Ca(2+)-uniporter (MCU) []. MICU2 forms a heterodimer with MICU1 to modulate MCU channel activity []. MICU3 a tissue-specific enhancer of mitochondrial calcium uptake [].
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Protein
Q9DB10
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: false
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Protein
A0A2R8VHK6
Organism: Mus musculus/domesticus
Length: 45  
Fragment?: false
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Protein
E0CZF0
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: false
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Protein Domain
IPR018782 | MCU_reg
Type: Family
Description: Essential MCU regulator (EMRE) is a component of the mitochondrial calcium uniporter complex in metazoa, a complex that mediates calcium uptake into mitochondria. It bridges the calcium-sensing components of the complex, MICU1 and MICU2, and the pore-forming subunit MCU, and it is essential for the complex uniporter activity [].
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Publication
16185709 | -
First Author: Hofmann S
Year: 2005
Journal: J Mol Biol
Title: Functional and mutational characterization of human MIA40 acting during import into the mitochondrial intermembrane space.
Volume: 353
Issue: 3
Pages: 517-28
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Publication
23676665 | -
First Author: Fischer M
Year: 2013
Journal: Mol Biol Cell
Title: Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells.
Volume: 24
Issue: 14
Pages: 2160-70
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Publication
21059946 | -
First Author: Banci L
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import.
Volume: 107
Issue: 47
Pages: 20190-5
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Publication
26387864 | -
First Author: Petrungaro C
Year: 2015
Journal: Cell Metab
Title: The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake.
Volume: 22
Issue: 4
Pages: 721-33
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Protein Domain
IPR039289 | CHCHD4
Type: Family
Description: Mitochondrial intermembrane space import and assembly protein 40 (CHCHD4) is a chaperone and catalyses the formation of disulfide bonds in proteins within the mitochondrial intermembrane space (IMS) such as COX17 [], COX19 [], MICU1 []and GFER []. A precursor of one of these proteins in a reduced state is imported into the mitochondrion where it associates with CHCHD4 forming a transient intermolecular disulfide bridge. This leads to oxidation of the precursor, formation of an intramolecular disulfide bond and the folding in the IMS [].This entry also includes the uncharacterized protein F42H10.2 from Caenorhabditis elegans.
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Publication
35977541 | J:329297
First Author: Xue K
Year: 2022
Journal: Cell Metab
Title: The mitochondrial calcium uniporter engages UCP1 to form a thermoporter that promotes thermogenesis.
Volume: 34
Issue: 9
Pages: 1325-1341.e6
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Protein
Q8CD10
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Publication
31377553 | J:326309
 
First Author: Niemann J
Year: 2019
Journal: Cell Calcium
Title: Cytosolic and mitochondrial Ca2+ concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation.
Volume: 82
Pages: 102055
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Protein
Q8VCX5
Organism: Mus musculus/domesticus
Length: 477  
Fragment?: false
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Protein
Q9CTY5
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
F6WMX7
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: true
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Protein
E9Q9E0
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: true
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Protein
B7ZND1
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: true
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Protein
A0JLX6
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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