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Search results 101 to 159 out of 159 for Mlh3

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Type Details Score
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
33751106 | J:304790
First Author: Roy JCL
Year: 2021
Journal: Nucleic Acids Res
Title: Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection.
Volume: 49
Issue: 7
Pages: 3907-3918
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DO Term
DOID:0070276 | hereditary nonpolyposis colorectal cancer type 7
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Publication
11717305 | -
First Author: Hall MC
Year: 2002
Journal: J Biol Chem
Title: Differential ATP binding and intrinsic ATP hydrolysis by amino-terminal domains of the yeast Mlh1 and Pms1 proteins.
Volume: 277
Issue: 5
Pages: 3673-9
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Protein Domain
IPR038973 | MutL/Mlh/Pms
Type: Family
Description: Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex []. This entry represents a family of evolutionarily related DNA mismatch repair proteins, including MutL, Mlh1, Mlh2 and Mlh3, and Pms 1 and 2. Bacterial MutL proteins are homodimers, while their eukaryotic homologues form heterodimers consisting of the MutL homologue Mlh1 and either Pms1, Pms2 or Mlh3 [, ]. MutL homologues share a conserved ATP binding site [].
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Protein
D3YX04
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
Q9CTA7
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
F6R1G0
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
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Protein
D3Z611
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
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Publication
16024043 | -
First Author: Kosinski J
Year: 2005
Journal: J Mol Biol
Title: Analysis of the quaternary structure of the MutL C-terminal domain.
Volume: 351
Issue: 4
Pages: 895-909
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Publication
10946232 | -
First Author: Yang W
Year: 2000
Journal: Mutat Res
Title: Structure and function of mismatch repair proteins.
Volume: 460
Issue: 3-4
Pages: 245-56
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Publication
12052432 | -
First Author: Bernstein C
Year: 2002
Journal: Mutat Res
Title: DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis.
Volume: 511
Issue: 2
Pages: 145-78
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Protein Domain
IPR002099 | DNA_mismatch_repair_N
Type: Domain
Description: This entry represents the N-terminal domain of DNA mismatch repair proteins, such asMutL. Bacterial MutL proteins are homodimers, while their eukaryotic homologues form heterodimers consisting of the MutL homologue Mlh1 and either Pms1, Pms2 or Mlh3 [, ]. MutL proteins and their homologues share sequence homology at their N termini over the first 300-400 residues; the C termini are less well conserved, they constitute the main dimerization domain and are required for interaction between MutL and UvrD helicase []. The activity of the protein is modulated by the ATP-dependent dimerization of the N-terminal domain [].The dimeric MutL protein has a key function in communicating mismatch recognition by MutS to downstream repair processes. Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex [].
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Protein Domain
IPR020667 | DNA_mismatch_repair_MutL
Type: Family
Description: Mismatch repair is one of five major DNA repair pathways, the others being homologous recombination repair, non-homologous end joining, nucleotide excision repair, and base excision repair. The mismatch repair system recognises and repairs mispaired or unpaired nucleotides that result from errors in DNA replication. Many proteins involved in the different repair processes also play a role in apoptosis when DNA damage is excessive, thereby helping to prevent carcinogenesis []. The mismatch repair protein, Mlh1 (mutL homologue 1), has a dual role in DNA repair and apoptosis. Mlh1 acts as a heterodimer in conjunction with Pms2, Pms1 (post-meiotic segregation 1 and 2) or Mlh3 (MutL homologue 3), which function as adaptor proteins that link Msh (MutS homologue) heterodimers to the DNA repair machinery, resulting in excision and repair of the mispaired base [].This entry represents the mismatch repair protein MutL.
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Publication
26436461 | -
 
First Author: Kunkel TA
Year: 2015
Journal: Annu Rev Genet
Title: Eukaryotic Mismatch Repair in Relation to DNA Replication.
Volume: 49
Pages: 291-313
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Publication
15937223 | J:98718
First Author: de Vries FA
Year: 2005
Journal: Genes Dev
Title: Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation.
Volume: 19
Issue: 11
Pages: 1376-89
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Publication
29437857 | J:258735
 
First Author: Testa E
Year: 2018
Journal: J Cell Sci
Title: H2AFX and MDC1 promote maintenance of genomic integrity in male germ cells.
Volume: 131
Issue: 6
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Publication
14527292 | -
 
First Author: Schofield MJ
Year: 2003
Journal: Annu Rev Microbiol
Title: DNA mismatch repair: molecular mechanisms and biological function.
Volume: 57
Pages: 579-608
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Publication
38377115 | J:346200
First Author: Horan TS
Year: 2024
Journal: PLoS Genet
Title: The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice.
Volume: 20
Issue: 2
Pages: e1011175
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Protein
F6X8D5
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: true
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Protein
D3Z0R7
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: true
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Publication
12222686 | -
First Author: Drotschmann K
Year: 2002
Journal: Biol Chem
Title: DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers.
Volume: 383
Issue: 6
Pages: 969-75
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Protein
Q9JK91
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Protein
E9QLM4
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
Q8CAP8
Organism: Mus musculus/domesticus
Length: 653  
Fragment?: false
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Protein
Q8VDI4
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Protein
A0A0G2JDY9
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
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Protein
A4QPD7
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Protein
F6TK25
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
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Protein
P54279
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: false
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Protein
Q3UJP0
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: false
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Protein
B9EJ22
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: false
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Protein
Q8K119
Organism: Mus musculus/domesticus
Length: 917  
Fragment?: false
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Protein
Q3US89
Organism: Mus musculus/domesticus
Length: 669  
Fragment?: true
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Protein
E9Q8A5
Organism: Mus musculus/domesticus
Length: 669  
Fragment?: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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