Search our database by keyword

Examples

Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 105 out of 105 for Mob1a

<< First < Previous | Next > Last >>

0.016s

Type

Details

Score

Protein Domain

IPR028741 | LATS1

Type:

Family

Description:

There are two mammalian homologue of Drosophila tumor suppressor Lats (large tumor suppressor, also known as Warts): LATS1 and LATS2. Lats/Warts is a serine/threonine-protein kinase that negatively regulates YAP1 (Drosophila Yorkie (Yki) homologue) in the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis [, ]. This entry represents LATS1 from mammals. During cell division, LATS1 interacts with MOB1A and serves as a mitotic exit network kinase [].

•

Publication

18158288 | -

First Author:	Hao Y
Year:	2008
Journal:	J Biol Chem
Title:	Tumor suppressor LATS1 is a negative regulator of oncogene YAP.
Volume:	283
Issue:	9
Pages:	5496-509

•

Publication

16061636 | -

First Author:	Bothos J
Year:	2005
Journal:	Cancer Res
Title:	Human LATS1 is a mitotic exit network kinase.
Volume:	65
Issue:	15
Pages:	6568-75

•

Publication

16096061 | -

First Author:	Huang J
Year:	2005
Journal:	Cell
Title:	The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.
Volume:	122
Issue:	3
Pages:	421-34

•

Protein

Q8BYR2

Organism:	Mus musculus/domesticus
Length:	1129
Fragment?:	false

•

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/keywordSearchResults.do?searchOffset=100&searchTerm=Mob1a

MouseMine

Search our database by keyword

Examples

Search results 101 to 105 out of 105 for Mob1a

Categories

Hits by Pathway

Hits by Category

Hits by Strain