Type |
Details |
Score |
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8-12 |
Stage: |
28 |
Structure . Name: |
bone marrow |
Notes: |
MPP1 (LSK CD34+ CD135- CD150+ CD48-) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8-12 |
Stage: |
28 |
Structure . Name: |
bone marrow |
Notes: |
MPP1 (LSK CD34+ CD135- CD150+ CD48-) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
Allele |
Name: |
membrane protein, palmitoylated; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
394
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
340
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1774
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1734
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1348
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1762
 |
Fragment?: |
false |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Li L |
Year: |
2022 |
Journal: |
Neuron |
Title: |
Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes. |
Volume: |
110 |
Issue: |
16 |
Pages: |
2646-2663.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Little JN |
Year: |
2019 |
Journal: |
Hum Mol Genet |
Title: |
p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects. |
Volume: |
28 |
Issue: |
3 |
Pages: |
434-447 |
|
•
•
•
•
•
|
Publication |
First Author: |
Du W |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Inflammation-mediated notch signaling skews fanconi anemia hematopoietic stem cell differentiation. |
Volume: |
191 |
Issue: |
5 |
Pages: |
2806-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamijo A |
Year: |
2016 |
Journal: |
Histochem Cell Biol |
Title: |
Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine. |
Volume: |
145 |
Issue: |
1 |
Pages: |
81-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Westendorf JM |
Year: |
1994 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope. |
Volume: |
91 |
Issue: |
2 |
Pages: |
714-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alla JA |
Year: |
2023 |
Journal: |
Biochem Pharmacol |
Title: |
Identification of membrane palmitoylated protein 1 (MPP1) as a heart-failure-promoting protein triggered by cardiovascular risk factors and aging. |
Volume: |
217 |
|
Pages: |
115789 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nunomura W |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
Regulation of protein 4.1R, p55, and glycophorin C ternary complex in human erythrocyte membrane. |
Volume: |
275 |
Issue: |
32 |
Pages: |
24540-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marfatia SM |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. Analysis of the binding interface by in vitro mutagenesis. |
Volume: |
272 |
Issue: |
39 |
Pages: |
24191-7 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SH3 domain of MPP1, which is a ubiquitously-expressed scaffolding protein that plays roles in regulating neutrophil polarity, cell shape, hair cell development, and neural development and patterning of the retina [, ]. It was originally identified as an erythrocyte protein that stabilizes the actin cytoskeleton to the plasma membrane by forming a complex with 4.1R protein and glycophorin C [, ]. MPP1 belongs to the membrane-associated guanylate kinase (MAGUK) p55 subfamily.The membrane-associated guanylate kinase (MAGUK) p55 subfamily (also known as MPP subfamily) members include the Drosophila Stardust protein and its vertebrate homologues, MPP1-7. They contain the core of three domains characteristic of MAGUK (membrane-associated guanylate kinase) proteins: PDZ, SH3, and guanylate kinase (GuK). In addition, they also contain the Hook (Protein 4.1 Binding) motif in between the SH3 and GuK domains []. MPP2-7 have two additional L27 domains at their N terminus. The GuK domain in MAGUK proteins is enzymatically inactive; instead, the domain mediates protein-protein interactions and associates intramolecularly with the SH3 domain []. |
|
•
•
•
•
•
|
Publication |
First Author: |
McNeely KC |
Year: |
2017 |
Journal: |
Neural Dev |
Title: |
Mutation of Kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis. |
Volume: |
12 |
Issue: |
1 |
Pages: |
5 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
156
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Stöhr H |
Year: |
2001 |
Journal: |
Genomics |
Title: |
Cloning and characterization of the human retina-specific gene MPP4, a novel member of the p55 subfamily of MAGUK proteins. |
Volume: |
74 |
Issue: |
3 |
Pages: |
377-84 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
205
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
te Velthuis AJ |
Year: |
2007 |
Journal: |
BMC Evol Biol |
Title: |
Molecular evolution of the MAGUK family in metazoan genomes. |
Volume: |
7 |
|
Pages: |
129 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
466
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
452
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
427
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
466
 |
Fragment?: |
false |
|
•
•
•
•
•
|