Type |
Details |
Score |
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
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Title: |
Nomenclature Committee Use |
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Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
116
 |
Fragment?: |
false |
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Allele |
Name: |
methionine sulfoxide reductase B2; endonuclease-mediated mutation 1, Robert Levine |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Strain |
Attribute String: |
mutant stock, targeted mutation, endonuclease-mediated mutation |
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Publication |
First Author: |
Kim HY |
Year: |
2004 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase. |
Volume: |
320 |
Issue: |
4 |
Pages: |
1277-83 |
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Publication |
First Author: |
Gladyshev VN |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Selenoprotein Gene Nomenclature. |
Volume: |
291 |
Issue: |
46 |
Pages: |
24036-24040 |
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•
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Publication |
First Author: |
Tarrago L |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Plant thioredoxin CDSP32 regenerates 1-cys methionine sulfoxide reductase B activity through the direct reduction of sulfenic acid. |
Volume: |
285 |
Issue: |
20 |
Pages: |
14964-72 |
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Publication |
First Author: |
Pérez-Ruiz JM |
Year: |
2006 |
Journal: |
Plant Cell |
Title: |
Rice NTRC is a high-efficiency redox system for chloroplast protection against oxidative damage. |
Volume: |
18 |
Issue: |
9 |
Pages: |
2356-68 |
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Protein Domain |
Type: |
Family |
Description: |
Thioredoxins (Trxs) are ubiquitous enzymes with a CXXC active site that catalyses the reduction of disulfide bonds. This entry represents a group of plant thioredoxin-like proteins, including AtCDSP32 from Arabidopsis and OsCDSP32 from rice. AtCDSP32 includes two Trx modules with one potential active site (219)CGPC(222) and three extra Cys, this region is responsible for the insulin reduction activity of the protein []. It forms a heterodimeric complex with MSRB1 (methionine sulfoxide reductases B 1) via reduction of the sulfenic acid formed on MSRB1 catalytic Cys after methionine sulfoxide reduction [].Thioredoxins [, , , ]are small disulphide-containing redox proteins that have been found in all the kingdoms of living organisms. Thioredoxin serves as a general protein disulphide oxidoreductase. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of two cysteine thiol groups to a disulphide, accompanied by the transfer of two electrons and two protons. The net result is the covalent interconversion of a disulphide and a dithiol. In the NADPH-dependent protein disulphide reduction, thioredoxin reductase (TR) catalyses the reduction of oxidised thioredoxin (trx) by NADPH using FAD and its redox-active disulphide; reduced thioredoxin then directly reduces the disulphide in the substrate protein [].Thioredoxin is present in prokaryotes and eukaryotes and the sequence around the redox-active disulphide bond is well conserved. All thioredoxins contain a cis-proline located in a loop preceding β-strand 4, which makes contact with the active site cysteines, and is important for stability and function []. Thioredoxin belongs to astructural family that includes glutaredoxin, glutathione peroxidase, bacterial protein disulphide isomerase DsbA, and the N-terminal domain of glutathione transferase []. Thioredoxins have a beta-alpha unit preceding the motif common to all these proteins.A number of eukaryotic proteins contain domains evolutionary related to thioredoxin, most of them are protein disulphide isomerases (PDI). PDI () [, , ]is an endoplasmic reticulum multi-functional enzyme that catalyses the formation and rearrangement of disulphide bonds during protein folding []. All PDI contains two or three (ERp72) copies of the thioredoxin domain, each of which contributes to disulphide isomerase activity, but which are functionally non-equivalent []. Moreover, PDI exhibits chaperone-like activity towards proteins that contain no disulphide bonds, i.e. behaving independently of its disulphide isomerase activity []. The various forms of PDI which are currently known are:PDI major isozyme; a multifunctional protein that also function as the beta subunit of prolyl 4-hydroxylase (), as a component of oligosaccharyl transferase (), as thyroxine deiodinase (), as glutathione-insulin transhydrogenase () and as a thyroid hormone-binding proteinERp60 (ER-60; 58 Kd microsomal protein). ERp60 was originally thought to be a phosphoinositide-specific phospholipase C isozyme and later to be a protease.ERp72.ERp5.Bacterial proteins that act as thiol:disulphide interchange proteins that allows disulphide bond formation in some periplasmic proteins also contain a thioredoxin domain. These proteins include:Escherichia coli DsbA (or PrfA) and its orthologs in Vibrio cholerae (TtcpG) and Haemophilus influenzae (Por).E. coli DsbC (or XpRA) and its orthologues in Erwinia chrysanthemi and H. influenzae.E. coli DsbD (or DipZ) and its H. influenzae orthologue.E. coli DsbE (or CcmG) and orthologues in H. influenzae.Rhodobacter capsulatus (Rhodopseudomonas capsulata) (HelX), Rhiziobiacae (CycY and TlpA). |
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Publication |
First Author: |
Holmgren A |
Year: |
1985 |
Journal: |
Annu Rev Biochem |
Title: |
Thioredoxin. |
Volume: |
54 |
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Pages: |
237-71 |
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•
•
•
•
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Publication |
First Author: |
Freedman RB |
Year: |
1988 |
Journal: |
Biochem Soc Trans |
Title: |
Protein disulphide-isomerase: a homologue of thioredoxin implicated in the biosynthesis of secretory proteins. |
Volume: |
16 |
Issue: |
2 |
Pages: |
96-9 |
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•
•
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•
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Publication |
First Author: |
Song JL |
Year: |
1995 |
Journal: |
Eur J Biochem |
Title: |
Chaperone-like activity of protein disulfide-isomerase in the refolding of rhodanese. |
Volume: |
231 |
Issue: |
2 |
Pages: |
312-6 |
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•
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•
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Publication |
First Author: |
Kivirikko KI |
Year: |
1989 |
Journal: |
FASEB J |
Title: |
Protein hydroxylation: prolyl 4-hydroxylase, an enzyme with four cosubstrates and a multifunctional subunit. |
Volume: |
3 |
Issue: |
5 |
Pages: |
1609-17 |
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•
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Publication |
First Author: |
Puig A |
Year: |
1994 |
Journal: |
J Biol Chem |
Title: |
The role of the thiol/disulfide centers and peptide binding site in the chaperone and anti-chaperone activities of protein disulfide isomerase. |
Volume: |
269 |
Issue: |
29 |
Pages: |
19128-35 |
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Publication |
First Author: |
Lyles MM |
Year: |
1994 |
Journal: |
J Biol Chem |
Title: |
Mutations in the thioredoxin sites of protein disulfide isomerase reveal functional nonequivalence of the N- and C-terminal domains. |
Volume: |
269 |
Issue: |
49 |
Pages: |
30946-52 |
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•
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Publication |
First Author: |
Saarinen M |
Year: |
1995 |
Journal: |
Structure |
Title: |
Crystal structure of thioredoxin-2 from Anabaena. |
Volume: |
3 |
Issue: |
10 |
Pages: |
1097-108 |
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•
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Publication |
First Author: |
Holmgren A |
Year: |
1995 |
Journal: |
Structure |
Title: |
Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide. |
Volume: |
3 |
Issue: |
3 |
Pages: |
239-43 |
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•
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Publication |
First Author: |
Martin JL |
Year: |
1995 |
Journal: |
Structure |
Title: |
Thioredoxin--a fold for all reasons. |
Volume: |
3 |
Issue: |
3 |
Pages: |
245-50 |
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•
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Publication |
First Author: |
Freedman RB |
Year: |
1994 |
Journal: |
Trends Biochem Sci |
Title: |
Protein disulphide isomerase: building bridges in protein folding. |
Volume: |
19 |
Issue: |
8 |
Pages: |
331-6 |
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•
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Publication |
First Author: |
Holmgren A |
Year: |
1989 |
Journal: |
J Biol Chem |
Title: |
Thioredoxin and glutaredoxin systems. |
Volume: |
264 |
Issue: |
24 |
Pages: |
13963-6 |
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