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Search results 101 to 132 out of 132 for Mtbp

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Type Details Score
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
37760565 | J:341361
 
First Author: Ranjan A
Year: 2023
Journal: Cancers (Basel)
Title: Characterization of an Mtbp Hypomorphic Allele in a Diethylnitrosamine-Induced Liver Carcinogenesis Model.
Volume: 15
Issue: 18
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Protein Domain
IPR029420 | MTBP_central
Type: Domain
Description: This entry represents the central domain of the MDM2-binding protein (MTBP). MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53, leading to its degradation by the proteasome []. MTBP inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability, and this promotes MDM2-mediated ubiquitination of p53 and its subsequent degradation []. Mouse MTBP also inhibits cancer cell migration by interacting with alpha-actinin-4 (ACTN4) [].
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Protein Domain
IPR029421 | MTBP_N
Type: Domain
Description: This entry represents the N-terminal domain of the MDM2-binding protein (MTBP). MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53, leading to its degradation by the proteasome []. MTBP inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability, and this promotes MDM2-mediated ubiquitination of p53 and its subsequent degradation []. Mouse MTBP also inhibits cancer cell migration by interacting with alpha-actinin-4 (ACTN4) [].
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Protein Domain
IPR029418 | MTBP_C
Type: Domain
Description: This entry represents the C-terminal domain of the MDM2-binding protein (MTBP). MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53, leading to its degradation by the proteasome []. MTBP inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability, and this promotes MDM2-mediated ubiquitination of p53 and its subsequent degradation []. Mouse MTBP also inhibits cancer cell migration by interacting with alpha-actinin-4 (ACTN4) [].
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Publication
8769130 | J:34974
First Author: Ohbayashi T
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Promoter structure of the mouse TATA-binding protein (TBP) gene.
Volume: 225
Issue: 1
Pages: 275-80
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Publication
18541670 | J:137926
First Author: Bouska A
Year: 2008
Journal: Mol Cell Biol
Title: Mdm2 promotes genetic instability and transformation independent of p53.
Volume: 28
Issue: 15
Pages: 4862-74
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Publication
22733537 | -
First Author: Tang YA
Year: 2012
Journal: Clin Cancer Res
Title: MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer.
Volume: 18
Issue: 16
Pages: 4325-33
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Publication
8570197 | -
First Author: Dubs-Poterszman MC
Year: 1995
Journal: Oncogene
Title: MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest.
Volume: 11
Issue: 11
Pages: 2445-9
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Publication
20308078 | -
First Author: Xu H
Year: 2010
Journal: J Biol Chem
Title: MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change.
Volume: 285
Issue: 24
Pages: 18407-14
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Publication
19321440 | -
First Author: Fu W
Year: 2009
Journal: J Biol Chem
Title: MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.
Volume: 284
Issue: 21
Pages: 13987-4000
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Publication
19411066 | -
First Author: Gu L
Year: 2009
Journal: Cancer Cell
Title: Regulation of XIAP translation and induction by MDM2 following irradiation.
Volume: 15
Issue: 5
Pages: 363-75
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Publication
23885265 | -
First Author: Nag S
Year: 2013
Journal: J Biomed Res
Title: The MDM2-p53 pathway revisited.
Volume: 27
Issue: 4
Pages: 254-71
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Publication
16965791 | -
First Author: Kostic M
Year: 2006
Journal: J Mol Biol
Title: Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53.
Volume: 363
Issue: 2
Pages: 433-50
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Protein Domain
IPR028340 | Mdm2
Type: Family
Description: MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome []. p53 acts as an important defense mechanism against cancer, and is negatively regulated by interaction with the oncoprotein MDM2 []. MDM2 overexpression correlates with metastasis and advanced forms of several cancers and may be used as a cancer drug target []. In addition, MDM2 has important roles in the cell independent of p53. It interacts with several proteins such as Rb/E2F-1 complex [], the DNA methyltransferase DNMT3A [], p107 [], MTBP []and the cyclin kinase inhibitor p21 []. MDM2 also affects cell apoptosis [, ]. The core of MDM2 folds into an open bundle of four helices which is capped by two small 3-strandedβ-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 α-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain. In addition to its N-terminal p53 binding domain, MDM2 contains a central acidic domain, zinc finger domain and a C-terminal RING-finger domain.
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Protein Domain
IPR044080 | MDM2_mRING-HC-C2H2C4
Type: Domain
Description: MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome []. p53 acts as an important defense mechanism against cancer, and is negatively regulated by interaction with the oncoprotein MDM2 []. MDM2 overexpression correlates with metastasis and advanced forms of several cancers and may be used as a cancer drug target []. In addition, MDM2 has important roles in the cell independent of p53. It interacts with several proteins such as Rb/E2F-1 complex [], the DNA methyltransferase DNMT3A [], p107 [], MTBP []and the cyclin kinase inhibitor p21 []. MDM2 also affects cell apoptosis [, ].MDM2 contains an N-terminal p53-binding domain, and a C-terminal modified C2H2C4-type RING-HC finger conferring E3 ligase activity that is required for ubiquitination and nuclear export of p53. It is also responsible for the hetero-oligomerization of MDM2, which is crucial for the suppression of P53 activity during embryonic development, and the recruitment of E2 ubiquitin-conjugating enzymes []. MDM2 also harbours a RanBP2-type zinc finger (Znf-RanBP2) domain, as well as a nuclear localisation signal (NLS) and a nuclear export signal (NES), near the central acidic region. The Znf-RanBP2 domain plays an important role in mediating MDM2 binding to ribosomal proteins and thus is involved in MDM2-mediated p53 suppression.This entry represents the C-terminal modified C2H2C4-type RING-HC finger.
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Protein
P23804
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q3TVL4
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q569X0
Organism: Mus musculus/domesticus
Length: 487  
Fragment?: false
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