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Search results 101 to 200 out of 419 for Mus81

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Type Details Score
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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UniProt Feature
UniProt Feature
Begin: 1
Description: Crossover junction endonuclease MUS81
Type: chain
End: 551
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Allele
Mus81<em1Smoc> | MGI:7291191
Name: MUS81 structure-specific endonuclease subunit; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Gene
108713940 | mus81.L
Type: gene
Organism: frog, African clawed
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Protein
D6RCJ5
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
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Publication
29035360 | J:251677
First Author: Rondinelli B
Year: 2017
Journal: Nat Cell Biol
Title: EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.
Volume: 19
Issue: 11
Pages: 1371-1378
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Allele
Mus81<tm1Esse> | MGI:3785405
Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1, Jeroen Essers
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
18054789 | J:166501
First Author: Shimura T
Year: 2008
Journal: J Mol Biol
Title: Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.
Volume: 375
Issue: 4
Pages: 1152-64
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Strain
MGI:6475838 | C57BL/6JSmoc-Mus81<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Mus81/Mus81
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mus81/Mus81
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mus81/Mus81<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mus81/Mus81<+>
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Allele
Mus81<+> | MGI:3049049
   
Name: MUS81 structure-specific endonuclease subunit; wild type
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Interaction Experiment
Nair N (2014)
Description: Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein.
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Publication
14609959 | -
First Author: Abraham J
Year: 2003
Journal: EMBO J
Title: Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells.
Volume: 22
Issue: 22
Pages: 6137-47
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Allele
Mus81<tm1Raz> | MGI:3050210
Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1, Razqallah Hakem
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Mus81<tm1Lex> | MGI:3528875
Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1, Lexicon Genetics
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Mus81<tm1Chmg> | MGI:3588581
Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1, Clare H McGowan
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Mus81<Gt(OST45602)Lex> | MGI:4159718
 
Name: MUS81 structure-specific endonuclease subunit; gene trap OST45602, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mus81<Gt(OST172805)Lex> | MGI:4214698
 
Name: MUS81 structure-specific endonuclease subunit; gene trap OST172805, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mus81<Gt(OST257916)Lex> | MGI:4253960
 
Name: MUS81 structure-specific endonuclease subunit; gene trap OST257916, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mus81<Gt(OST258624)Lex> | MGI:4254286
 
Name: MUS81 structure-specific endonuclease subunit; gene trap OST258624, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mus81<Gt(OST285545)Lex> | MGI:4264726
 
Name: MUS81 structure-specific endonuclease subunit; gene trap OST285545, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mus81<Gt(OST290808)Lex> | MGI:4267174
 
Name: MUS81 structure-specific endonuclease subunit; gene trap OST290808, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mus81<Gt(OST419061)Lex> | MGI:4311101
 
Name: MUS81 structure-specific endonuclease subunit; gene trap OST419061, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mus81<Gt(OST445264)Lex> | MGI:4319775
 
Name: MUS81 structure-specific endonuclease subunit; gene trap OST445264, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mus81<tm1(KOMP)Vlcg> | MGI:5051301
Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Mus81<em1Gpt> | MGI:7302627
Name: MUS81 structure-specific endonuclease subunit; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Mus81<em25Gpt> | MGI:7302628
Name: MUS81 structure-specific endonuclease subunit; endonuclease-mediated mutation 25, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Mus81<em26Gpt> | MGI:7302629
Name: MUS81 structure-specific endonuclease subunit; endonuclease-mediated mutation 26, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Mus81<em1Cya> | MGI:7585185
Name: MUS81 structure-specific endonuclease subunit; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Mus81<em2Cya> | MGI:7585186
Name: MUS81 structure-specific endonuclease subunit; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6439238 | B6;129S5-Mus81<tm1Lex>/Tac
Attribute String: mutant stock, targeted mutation
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Allele
Mus81<tm1e(EUCOMM)Wtsi> | MGI:4431733
Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Mus81<tm1a(EUCOMM)Wtsi> | MGI:4432337
Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Mus81<Gt(466A11)Cmhd> | MGI:4959555
 
Name: MUS81 structure-specific endonuclease subunit; gene trap 466A11, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Mus81<Gt(IST13550B4)Tigm> | MGI:5176724
 
Name: MUS81 structure-specific endonuclease subunit; gene trap IST13550B4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Mus81<Gt(IST13991G4)Tigm> | MGI:5208464
 
Name: MUS81 structure-specific endonuclease subunit; gene trap IST13991G4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Strain
MGI:7592620 | C57BL/6J-Mus81<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7590149 | C57BL/6J-Mus81<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Mus81/Mus81
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mus81/Mus81
Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mus81/Mus81
Background: involves: 129S5/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mus81/Mus81
Background: involves: 129S5/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
25224045 | -
 
First Author: Nair N
Year: 2014
Journal: DNA Repair (Amst)
Title: Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein.
Volume: 24
Pages: 131-137
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Genotype
Genotype
Symbol: Mus81/Mus81<+>
Background: involves: 129P2/OlaHsd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fan1/Fan1 Mus81/Mus81
Background: involves: 129S5/SvEvBrd * C57BL/6N * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mus81/Mus81 Slx1b/Slx1b
Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
27010503 | J:235782
First Author: Braun J
Year: 2016
Journal: PLoS One
Title: The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.
Volume: 11
Issue: 3
Pages: e0152278
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Protein Domain
IPR006166 | ERCC4_domain
Type: Domain
Description: This entry represents a structural domain found in several DNA repair nucleases, such as Rad1, XPF and crossover junction endonucleases EME1 and Mus81 [, ]. The XPF/Rad1/Mus81-dependent nuclease family specifically cleaves branched structures generated during DNA repair, replication, and recombination, and is essential for maintaining genome stability. The nuclease domain architecture exhibits remarkable similarity to those of restriction endonucleases.
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Publication
12679022 | -
First Author: Nishino T
Year: 2003
Journal: Structure
Title: X-ray and biochemical anatomy of an archaeal XPF/Rad1/Mus81 family nuclease: similarity between its endonuclease domain and restriction enzymes.
Volume: 11
Issue: 4
Pages: 445-57
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Publication
14527419 | -
First Author: Gaillard PH
Year: 2003
Journal: Mol Cell
Title: The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism.
Volume: 12
Issue: 3
Pages: 747-59
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Protein
Q8BJW7
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein Domain
IPR042530 | EME1/EME2_C
Type: Homologous_superfamily
Description: This superfamily includes the C-terminal domain found in Eme1 from fission yeasts, and EME1/EME2 from animals. They interact with Mus81 to from a complex, which acts as a structure-specific endonuclease that targets branched DNA structures with a 5'-end at the branch nick [, ]. The typical substrates of this complex include 3'-flap structures, replication forks and nicked Holliday junctions [, ].Similar to MUS81-EME1, human MUS81-EME2 cleaves 3'-flaps, replication forks and nicked Holliday junctions, and exhibits limited endonuclease activity with intact Holliday junctions. However, MUS81-EME2 can also cleave a variety of DNA structures including D-loop recombination intermediates and nicked duplex [, ].Both Mus81 and Eme1 consist of a central nuclease domain, two repeats of the helix-hairpin-helix (HhH) motif at their C-terminal region, and a linker helix [].
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Protein Domain
IPR043087 | Eme1_nucdom_sub2
Type: Homologous_superfamily
Description: The Mus81-Eme1 complex is a structure-specific endonuclease that plays an important role in rescuing stalled replication forks and resolving the meiotic recombination intermediates in eukaryotes. Mus81 and Eme1 consist of a central nuclease domain, two repeats of the helix-hairpin-helix (HhH) motif at their C-terminal region, and a linker helix.The nuclease domain is found in several DNA repair nucleases, including Rad1, XPF and crossover junction endonucleases EME1 (an essential component of a Holliday junction resolvase) and Mus81 [, ]. The XPF/Rad1/Mus81-dependent nuclease family specifically cleaves branched structures generated during DNA repair, replication, and recombination, and is essential for maintaining genome stability. The nuclease domain architecture exhibits remarkable similarity to those of restriction endonucleases.This superfamily consists of the second subdomain of the nuclease domain found in EME1.
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Protein Domain
IPR043086 | EME1_nucdom_sub1
Type: Homologous_superfamily
Description: The Mus81-Eme1 complex is a structure-specific endonuclease that plays an important role in rescuing stalled replication forks and resolving the meiotic recombination intermediates in eukaryotes. Mus81 and Eme1 consist of a central nuclease domain, two repeats of the helix-hairpin-helix (HhH) motif at their C-terminal region, and a linker helix.The nuclease domain is found in several DNA repair nucleases, including Rad1, XPF and crossover junction endonucleases EME1 (an essential component of a Holliday junction resolvase) and Mus81 [, ]. The XPF/Rad1/Mus81-dependent nuclease family specifically cleaves branched structures generated during DNA repair, replication, and recombination, and is essential for maintaining genome stability. The nuclease domain architecture exhibits remarkable similarity to those of restriction endonucleases.This superfamily consists of the first part of the nuclease domain found in EME1.
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Protein
Q56A04
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
D3Z6X0
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: false
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Protein
D6RIK4
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: false
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Protein Domain
IPR033310 | Mms4/EME1/EME2
Type: Family
Description: This entry includes Mms4 from budding yeast, Eme1 from fission yeasts, and EME1/EME2 from animals. They interact with Mus81 to from a complex, which acts as a structure-specific endonuclease that targets branched DNA structures with a 5'-end at the branch nick [, ]. The typical substrates of this complex include 3'-flap structures, replication forks and nicked Holliday junctions [, ].Similar to MUS81-EME1, human MUS81-EME2 cleaves 3'-flaps, replication forks and nicked Holliday junctions, and exhibits limited endonuclease activity with intact Holliday junctions. However, MUS81-EME2 can also cleave a variety of DNA structures including D-loop recombination intermediates and nicked duplex [, ].
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Protein Coding Gene
MGI:1891209 | Efemp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0022553 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024710 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024676 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024649 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024676 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024444 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1891209 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025123 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023916 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024416 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024543 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024510 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024629 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025171 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023662 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023978 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014050 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023467 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10380882 | J:65051
First Author: Gallagher WM
Year: 1999
Journal: Oncogene
Title: MBP1: a novel mutant p53-specific protein partner with oncogenic properties.
Volume: 18
Issue: 24
Pages: 3608-16
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Publication
16478991 | J:106902
First Author: McLaughlin PJ
Year: 2006
Journal: Mol Cell Biol
Title: Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice.
Volume: 26
Issue: 5
Pages: 1700-9
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Publication
26178373 | J:223792
First Author: Igoucheva O
Year: 2015
Journal: J Biol Chem
Title: Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities.
Volume: 290
Issue: 35
Pages: 21443-59
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Publication
26486174 | J:259726
First Author: Yamashiro Y
Year: 2015
Journal: Sci Signal
Title: Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice.
Volume: 8
Issue: 399
Pages: ra105
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Publication
26690653 | J:232351
 
First Author: Sasaki T
Year: 2016
Journal: Matrix Biol
Title: Loss of fibulin-4 results in abnormal collagen fibril assembly in bone, caused by impaired lysyl oxidase processing and collagen cross-linking.
Volume: 50
Pages: 53-66
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Publication
28508064 | J:258180
First Author: Halabi CM
Year: 2017
Journal: Sci Adv
Title: Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries.
Volume: 3
Issue: 5
Pages: e1602532
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Publication
10982184 | J:60560
First Author: Katsanis N
Year: 2000
Journal: Hum Genet
Title: Isolation of a paralog of the Doyne honeycomb retinal dystrophy gene from the multiple retinopathy critical region on 11q13.
Volume: 106
Issue: 1
Pages: 66-72
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Publication
36565192 | J:341869
First Author: Nguyen TAV
Year: 2023
Journal: J Am Heart Assoc
Title: Protective Role of Endothelial Fibulin-4 in Valvulo-Arterial Integrity.
Volume: 12
Issue: 1
Pages: e026942
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Publication
25934097 | J:224626
First Author: Kim J
Year: 2015
Journal: Am J Physiol Heart Circ Physiol
Title: Differences in genetic signaling, and not mechanical properties of the wall, are linked to ascending aortic aneurysms in fibulin-4 knockout mice.
Volume: 309
Issue: 1
Pages: H103-13
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Publication
11231014 | J:67262
First Author: Gallagher WM
Year: 2001
Journal: FEBS Lett
Title: Human fibulin-4: analysis of its biosynthetic processing and mRNA expression in normal and tumour tissues.
Volume: 489
Issue: 1
Pages: 59-66
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GXD Expression
GXD Expression
   
Probe: MGI:2661685
Assay Type: Northern blot
Annotation Date: 2003-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2661686
Age: embryonic day 7.0
Image: 1
Specimen Label: 7
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2661685
Assay Type: Northern blot
Annotation Date: 2003-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2661686
Age: embryonic day 11.0
Image: 1
Specimen Label: 11
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2661685
Assay Type: Northern blot
Annotation Date: 2003-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2661686
Age: embryonic day 15.0
Image: 1
Specimen Label: 15
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:2661685
Assay Type: Northern blot
Annotation Date: 2003-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2661686
Age: embryonic day 17.0
Image: 1
Specimen Label: 17
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:2661685
Assay Type: Northern blot
Annotation Date: 2003-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2661687
Age: postnatal adult
Image: 1
Specimen Label: HEART
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:2661685
Assay Type: Northern blot
Annotation Date: 2003-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2661687
Age: postnatal adult
Image: 1
Specimen Label: BRAIN
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:2661685
Assay Type: Northern blot
Annotation Date: 2003-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2661687
Age: postnatal adult
Image: 1
Specimen Label: SPLEEN
Detected: true
Specimen Num: 3
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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