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Search results 101 to 172 out of 172 for Myrf

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Type Details Score
Publication
26525805 | J:231103
First Author: Baroti T
Year: 2016
Journal: J Neurochem
Title: Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.
Volume: 136
Issue: 2
Pages: 316-28
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Publication
29500351 | J:260476
First Author: Weider M
Year: 2018
Journal: Nat Commun
Title: Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning.
Volume: 9
Issue: 1
Pages: 899
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Publication
28336932 | J:274105
First Author: Huang H
Year: 2017
Journal: Sci Rep
Title: Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo.
Volume: 7
Issue: 1
Pages: 337
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Publication
25680202 | J:224004
First Author: Weider M
Year: 2015
Journal: PLoS Genet
Title: Elevated in vivo levels of a single transcription factor directly convert satellite glia into oligodendrocyte-like cells.
Volume: 11
Issue: 2
Pages: e1005008
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Publication
29361054 | J:260791
First Author: Truch K
Year: 2018
Journal: Hum Mol Genet
Title: Analysis of the human SOX10 mutation Q377X in mice and its implications for genotype-phenotype correlation in SOX10-related human disease.
Volume: 27
Issue: 6
Pages: 1078-1092
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Publication
23332759 | J:193501
First Author: Yu Y
Year: 2013
Journal: Cell
Title: Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation.
Volume: 152
Issue: 1-2
Pages: 248-61
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Publication
22365546 | J:182704
First Author: Weng Q
Year: 2012
Journal: Neuron
Title: Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system.
Volume: 73
Issue: 4
Pages: 713-28
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Publication
26395480 | J:239772
First Author: Parada C
Year: 2015
Journal: Development
Title: Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence.
Volume: 142
Issue: 21
Pages: 3734-45
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Publication
37371026 | J:337458
 
First Author: Waldhauser V
Year: 2023
Journal: Cells
Title: PBAF Subunit Pbrm1 Selectively Influences the Transition from Progenitors to Pre-Myelinating Cells during Oligodendrocyte Development.
Volume: 12
Issue: 12
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Publication
25568100 | J:218900
First Author: Bischof M
Year: 2015
Journal: J Neurosci
Title: Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation.
Volume: 35
Issue: 1
Pages: 21-35
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Publication
23575864 | J:196667
First Author: Vogl MR
Year: 2013
Journal: J Neurosci
Title: Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia.
Volume: 33
Issue: 15
Pages: 6679-90
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Publication
24257626 | J:206315
First Author: Hoffmann SA
Year: 2014
Journal: Development
Title: Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes.
Volume: 141
Issue: 1
Pages: 39-50
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Publication
39671488 | J:359856
First Author: Xu X
Year: 2024
Journal: Sci Adv
Title: Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing HDAC1-mediated histone deacetylation.
Volume: 10
Issue: 50
Pages: eadf8405
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Publication
32266943 | J:288669
First Author: Wedel M
Year: 2020
Journal: Nucleic Acids Res
Title: Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation.
Volume: 48
Issue: 9
Pages: 4839-4857
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Publication
27149841 | J:235473
     
First Author: Moyon S
Year: 2016
Journal: Cell Rep
Title: Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage.
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Publication
26928066 | J:234565
First Author: He D
Year: 2016
Journal: Nat Neurosci
Title: Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination.
Volume: 19
Issue: 5
Pages: 678-89
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Publication
- | J:165963
     
First Author: Centre for Modeling Human Disease
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto
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Publication
32290105 | J:282558
 
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
32997974 | J:300525
First Author: Milan M
Year: 2020
Journal: Dev Cell
Title: Pancreatic Cancer Cells Require the Transcription Factor MYRF to Maintain ER Homeostasis.
Volume: 55
Issue: 4
Pages: 398-412.e7
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Publication
31964908 | -
First Author: An H
Year: 2020
Journal: Sci Rep
Title: Functional mechanism and pathogenic potential of MYRF ICA domain mutations implicated in birth defects.
Volume: 10
Issue: 1
Pages: 814
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Interaction Experiment
Nakayama S (2018)
Description: Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.
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Publication
25946230 | J:273519
First Author: Fu W
Year: 2015
Journal: J Interferon Cytokine Res
Title: The Secreted Form of Transmembrane Protein 98 Promotes the Differentiation of T Helper 1 Cells.
Volume: 35
Issue: 9
Pages: 720-33
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Protein
Q91X86
Organism: Mus musculus/domesticus
Length: 226  
Fragment?: false
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Protein Domain
IPR029668 | TMEM98
Type: Family
Description: This entry represents a family of transmembrane proteins, which function as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation []. The secreted TMEM98 form promotes differentiation of T helper 1 cells (Th1) [].
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Protein Domain
IPR026932 | MYRF_ICA
Type: Domain
Description: Myelin regulatory factor (Myrf) is a transcription regulator required in vertebrates for expression of central nervous system (CNS) myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and CNS myelination []. It is also required for the maintenance of expression of myelin genes and the mature oligodendrocytes identity in the adult CNS [, ]. A Caenorhabditis elegans orthologue, pqn-47, may function as a regulator of molting [], while a Dictyostelium orthologue has been described to regulate prestalk differentiation [].This domain is found towards the C terminus of myelin regulatory factor (Myrf) and corresponds to the Intramolecular Chaperone Auto-processing (ICA) domain. It forms a homo-trimer and carries out the auto-cleavage of Myrf releasing the N-terminal homo-trimer from the ER membrane. This allows its entry to the nucleus to function as a homo-trimer transcription factor [].
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Publication
30554964 | J:307134
First Author: Osipovitch M
Year: 2019
Journal: Cell Stem Cell
Title: Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation.
Volume: 24
Issue: 1
Pages: 107-122.e7
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Publication
34678058 | J:312934
First Author: Qian Z
Year: 2021
Journal: Sci Adv
Title: Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brain.
Volume: 7
Issue: 43
Pages: eabi5811
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Publication
20118935 | -
First Author: Schulz EC
Year: 2010
Journal: Nat Struct Mol Biol
Title: Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding.
Volume: 17
Issue: 2
Pages: 210-5
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Publication
23966832 | -
First Author: Li Z
Year: 2013
Journal: PLoS Biol
Title: A Bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF.
Volume: 11
Issue: 8
Pages: e1001624
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Protein Domain
IPR030392 | S74_ICA
Type: Domain
Description: The Intramolecular Chaperone Auto-processing (ICA) []domain, also called Intramolecuar Chaperone Domain (ICD) []or C-terminal Intramolecular Chaperone Domain (CIMCD) [], is capable of catalysing trimerisation-dependent auto-proteolysis. The ICA domain contains two absolutely conserved serine and lysine residues. They form a catalytic dyad that mediates cleavage at the serine residue. The correct positioning of these catalytic residues, along with an arginine residue that stabilises the oxyanion during the peptide bond breakage, is thought to be achieved only upon folding and trimerisation, enabling the ICA domain to function as a folding sensor. The ICA domain belongs to peptidase family S74.The ICA domain displays an α1-β1-α2-β2-α3-β3-β4-α4 fold. The ICA domain homotrimer has a jellyfish-like outline with a central threefold symmetry axis and mainly consists of α-helices. It comprises a quite globular core and an extended loop region, reminiscent oftentacles, protruding from the centre. The central part of the core is a slightly twisted three helix bundle, forming the trimerisation interface [].Some proteins known to contain an ICA domain are listed below:Animal myelin regulatory factor (MYRF), a key transcriptional regulator for of oligodendrocyte differentiation and central nervous system (CNS) myelination. The MYRF protein undergoes an activating cleavage event to release the functional transcription factor from the transmembrane domain that otherwise anchors it to the endoplasmic reticulum [, ].Tailed bacteriophage (Caudovirus) endosialidases, the tailspike proteins essential for bacteriophages to infect bacteria encapsulated with polysaccharides [].
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Publication
25429144 | J:218185
First Author: Ishii A
Year: 2014
Journal: J Neurosci
Title: Role of ERK1/2 MAPK signaling in the maintenance of myelin and axonal integrity in the adult CNS.
Volume: 34
Issue: 48
Pages: 16031-45
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Protein
A0A087WRZ9
Organism: Mus musculus/domesticus
Length: 477  
Fragment?: true
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Publication
22811266 | -
First Author: Senoo H
Year: 2012
Journal: Int J Dev Biol
Title: An orthologue of the Myelin-gene Regulatory Transcription Factor regulates Dictyostelium prestalk differentiation.
Volume: 56
Issue: 5
Pages: 325-32
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Publication
21989027 | -
First Author: Russel S
Year: 2011
Journal: Dev Biol
Title: Regulation of the C. elegans molt by pqn-47.
Volume: 360
Issue: 2
Pages: 297-309
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Publication
24198424 | -
First Author: Zivanovic Y
Year: 2014
Journal: J Virol
Title: Insights into bacteriophage T5 structure from analysis of its morphogenesis genes and protein components.
Volume: 88
Issue: 2
Pages: 1162-74
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Publication
28193689 | J:239814
First Author: Furusho M
Year: 2017
Journal: J Neurosci
Title: Signaling by FGF Receptor 2, Not FGF Receptor 1, Regulates Myelin Thickness through Activation of ERK1/2-MAPK, Which Promotes mTORC1 Activity in an Akt-Independent Manner.
Volume: 37
Issue: 11
Pages: 2931-2946
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Protein
Q3UN70
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
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Protein
Q3UR85
Organism: Mus musculus/domesticus
Length: 1138  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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