Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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DO Term |
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Publication |
First Author: |
Khan RT |
Year: |
2014 |
Journal: |
Front Immunol |
Title: |
Genetic dissection of the ity3 locus identifies a role for ncf2 co-expression modules and suggests selp as a candidate gene underlying the ity3.2 locus. |
Volume: |
5 |
|
Pages: |
375 |
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•
•
•
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•
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Publication |
First Author: |
Liu S |
Year: |
2024 |
Journal: |
J Exp Med |
Title: |
NADPH oxidase exerts a B cell-intrinsic contribution to lupus risk by modulating endosomal TLR signals. |
Volume: |
221 |
Issue: |
4 |
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•
•
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Publication |
First Author: |
Mitchison NA |
Year: |
2005 |
Journal: |
Immunol Lett |
Title: |
Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection. |
Volume: |
97 |
Issue: |
1 |
Pages: |
63-7 |
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•
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Protein Domain |
Type: |
Domain |
Description: |
NADPH oxidase is a multisubunit complex that assembles during phagocytosis to generate reactive oxygen species. NCF2 (p67-phox), NCF1 (p47-phox) are required for activation of the phagocyte NADPH oxidase. The activators p67-phox and p47-phox form a ternary complex together with adaptor protein p40-phox, which participates in activation of the phagocyte oxidase by regulating membrane recruitment of p67-phox and p47-phox [, ].A PB1 domain is present in p67-phox. p40-phox associates with p67-phox via binding of the p40-phox PC motif to the p67-phox PB1 domain [].PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions []. The p67-phox proteins contain a type II PB1 domain. |
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Publication |
First Author: |
Khan RT |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Fine-mapping and phenotypic analysis of the Ity3 Salmonella susceptibility locus identify a complex genetic structure. |
Volume: |
9 |
Issue: |
2 |
Pages: |
e88009 |
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•
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Publication |
First Author: |
Jacob CO |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. |
Volume: |
109 |
Issue: |
2 |
Pages: |
E59-67 |
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Publication |
First Author: |
Martner A |
Year: |
2019 |
Journal: |
J Pathol |
Title: |
NOX2 in autoimmunity, tumor growth and metastasis. |
Volume: |
247 |
Issue: |
2 |
Pages: |
151-154 |
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•
•
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•
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Publication |
First Author: |
Li L |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
NCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillance. |
Volume: |
15 |
Issue: |
1 |
Pages: |
5170 |
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•
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•
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Publication |
First Author: |
Greve HJ |
Year: |
2020 |
Journal: |
J Neuroinflammation |
Title: |
Diesel exhaust impairs TREM2 to dysregulate neuroinflammation. |
Volume: |
17 |
Issue: |
1 |
Pages: |
351 |
|
•
•
•
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•
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Publication |
First Author: |
Scoggin K |
Year: |
2022 |
Journal: |
PLoS Genet |
Title: |
Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross. |
Volume: |
18 |
Issue: |
4 |
Pages: |
e1010075 |
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•
•
•
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•
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Publication |
First Author: |
Yoshida L |
Year: |
2002 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Expression of a p67(phox) homolog in Caco-2 cells giving O(2)(-)-reconstituting ability to cytochrome b(558) together with recombinant p47(phox). |
Volume: |
296 |
Issue: |
5 |
Pages: |
1322-8 |
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•
•
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•
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Publication |
First Author: |
Kuribayashi F |
Year: |
2016 |
Journal: |
EMBO J |
Title: |
The adaptor protein p40phox as a positive regulator of the superoxide-producing phagocyte oxidase. |
Volume: |
35 |
Issue: |
3 |
Pages: |
369-70 |
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•
•
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Publication |
First Author: |
Sumimoto H |
Year: |
2007 |
Journal: |
Sci STKE |
Title: |
Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants. |
Volume: |
2007 |
Issue: |
401 |
Pages: |
re6 |
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•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
525
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
525
 |
Fragment?: |
false |
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•
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