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Search results 101 to 166 out of 166 for Nek8

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:5475297
Assay Type: Immunohistochemistry
Annotation Date: 2013-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2778228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5475530
Age: postnatal day 7
Note: Expressed in the luminal cilia. Expressed in 26% medullary dubules, 26% in cortical tubules. Decreased expression, compared with heterozygous control.
Specimen Label: jck/jck cystic
Detected: true
Specimen Num: 3
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Publication
- | J:73571
   
First Author: Liu S
Year: 2001
Journal: GenBank Submission
Title: Mus musculus NIMA-related kinase 8 (Nek8) mRNA, complete cds
Pages: AF407579
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Publication
20921623 | J:166941
First Author: Viau A
Year: 2010
Journal: J Clin Invest
Title: Lipocalin 2 is essential for chronic kidney disease progression in mice and humans.
Volume: 120
Issue: 11
Pages: 4065-76
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Publication
24166835 | J:309681
First Author: Liu S
Year: 2014
Journal: J Bone Miner Res
Title: Role of TGF-β in a mouse model of high turnover renal osteodystrophy.
Volume: 29
Issue: 5
Pages: 1141-57
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Publication
38039285 | J:359682
First Author: Djaziri N
Year: 2023
Journal: PLoS One
Title: Cleavage of periostin by MMP9 protects mice from kidney cystic disease.
Volume: 18
Issue: 12
Pages: e0294922
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Publication
27053712 | J:236705
First Author: Husson H
Year: 2016
Journal: Hum Mol Genet
Title: Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.
Volume: 25
Issue: 11
Pages: 2245-2255
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Publication
31915367 | J:297134
First Author: Zhang JQJ
Year: 2020
Journal: Lab Invest
Title: Role of cyclin-dependent kinase 2 in the progression of mouse juvenile cystic kidney disease.
Volume: 100
Issue: 5
Pages: 696-711
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Publication
25934702 | J:225446
First Author: Lee EJ
Year: 2015
Journal: FASEB J
Title: Soluble receptor for advanced glycation end products inhibits disease progression in autosomal dominant polycystic kidney disease by down-regulating cell proliferation.
Volume: 29
Issue: 8
Pages: 3506-14
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Publication
20937855 | J:165518
First Author: Hellman NE
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch.
Volume: 107
Issue: 43
Pages: 18499-504
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Publication
36523654 | J:337557
 
First Author: Swenson-Fields KI
Year: 2022
Journal: Front Mol Biosci
Title: Caspase-1 and the inflammasome promote polycystic kidney disease progression.
Volume: 9
Pages: 971219
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Publication
28826940 | J:256270
First Author: Monirujjaman M
Year: 2017
Journal: Biochim Biophys Acta
Title: Distinct oxylipin alterations in diverse models of cystic kidney diseases.
Volume: 1862
Issue: 12
Pages: 1562-1574
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Publication
20562878 | J:162080
First Author: Natoli TA
Year: 2010
Journal: Nat Med
Title: Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models.
Volume: 16
Issue: 7
Pages: 788-92
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Publication
20554900 | J:162084
First Author: Ahmadie R
Year: 2010
Journal: J Nutr
Title: A high-lipid diet potentiates left ventricular dysfunction in nitric oxide synthase 3-deficient mice after chronic pressure overload.
Volume: 140
Issue: 8
Pages: 1438-44
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Publication
24700869 | J:213263
First Author: Tran PV
Year: 2014
Journal: J Am Soc Nephrol
Title: Downregulating hedgehog signaling reduces renal cystogenic potential of mouse models.
Volume: 25
Issue: 10
Pages: 2201-12
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Publication
14600027 | J:87130
First Author: Guay-Woodford LM
Year: 2003
Journal: Am J Physiol Renal Physiol
Title: Murine models of polycystic kidney disease: molecular and therapeutic insights.
Volume: 285
Issue: 6
Pages: F1034-49
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Publication
21565611 | J:173396
First Author: Sang L
Year: 2011
Journal: Cell
Title: Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Volume: 145
Issue: 4
Pages: 513-28
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Publication
25807483 | J:222159
First Author: Li Y
Year: 2015
Journal: Nature
Title: Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Volume: 521
Issue: 7553
Pages: 520-4
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Publication
- | J:175213
     
First Author: Lo C
Year: 2011
Journal: MGI Direct Data Submission (B2B/CvDC)
Title: Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC)
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: Serine/threonine-protein kinase Nek8
Type: chain
End: 698
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Protein
Q91ZR4
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
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Protein
E9Q258
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
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GXD Expression
GXD Expression
 
Probe: MGI:3526694
Assay Type: Immunohistochemistry
Annotation Date: 2013-04-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2840726
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:5475489
Age: embryonic day 18.5
Note: Expressed in the developing and maturing collecting ducts expressing Nek8 in their cilia.
Specimen Label: 2b
Detected: true
Specimen Num: 1
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DO Term
DOID:0111120 | nephronophthisis 9
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Protein Domain
IPR044120 | STKc_Nek8
Type: Domain
Description: Nek8 contains an N-terminal kinase catalytic domain and a C-terminal RCC1 (regulator of chromosome condensation) domain. Nek8 human mutations have been shown to cause major organ developmental defects due to altered ciliogenesis and cell differentiation/proliferation through deregulation of the Hippo pathway []. Nek8 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control [].This entry represents the catalytic domain of Nek8.
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Allele
l11Jus74 | MGI:4999624
 
Name: lethal, Chr 11, Justice 74
Allele Type: Chemically induced (ENU)
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Allele
Nek8<m1Btlr> | MGI:6268750
Name: NIMA (never in mitosis gene a)-related expressed kinase 8; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6268751 | C57BL/6J-Nek8<m1Btlr>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Genotype
Genotype
Symbol: l11Jus74/l11Jus74
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nek8/Nek8
Background: C57BL/6J-Nek8
Zygosity: hm
Has Mutant Allele: true
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Publication
16280549 | -
First Author: Quarmby LM
Year: 2005
Journal: J Cell Sci
Title: Caught Nek-ing: cilia and centrioles.
Volume: 118
Issue: Pt 22
Pages: 5161-9
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Publication
29401581 | J:273819
First Author: Nikonova AS
Year: 2018
Journal: FASEB J
Title: Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD).
Volume: 32
Issue: 5
Pages: 2735-2746
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Publication
21917142 | J:176116
First Author: Fairfield H
Year: 2011
Journal: Genome Biol
Title: Mutation discovery in mice by whole exome sequencing.
Volume: 12
Issue: 9
Pages: R86
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Publication
12955145 | J:85113
First Author: Kile BT
Year: 2003
Journal: Nature
Title: Functional genetic analysis of mouse chromosome 11.
Volume: 425
Issue: 6953
Pages: 81-6
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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