Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3506300 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2874723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539319 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5620 |
|
Specimen Label: |
GUDMAP:5620 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506300 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3507823 |
Age: |
embryonic day 13.5 |
Image: |
1 |
|
Specimen Label: |
1 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506300 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757727 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3507823 |
Age: |
postnatal newborn |
Image: |
2 |
|
Specimen Label: |
2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506300 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2850023 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5539319 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5620 |
|
Specimen Label: |
GUDMAP:5620 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506300 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796223 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539319 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5620 |
|
Specimen Label: |
GUDMAP:5620 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clark JM |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells. |
Volume: |
6 |
Issue: |
9 |
Pages: |
e24504 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie T |
Year: |
2019 |
Journal: |
Int J Mol Med |
Title: |
Proteasome activator REGγ promotes inflammation in Leydig cells via IkBε signaling. |
Volume: |
43 |
Issue: |
5 |
Pages: |
1961-1968 |
|
•
•
•
•
•
|
Publication |
First Author: |
Samson SI |
Year: |
2004 |
Journal: |
Blood |
Title: |
Combined deficiency in IkappaBalpha and IkappaBepsilon reveals a critical window of NF-kappaB activity in natural killer cell differentiation. |
Volume: |
103 |
Issue: |
12 |
Pages: |
4573-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goudeau B |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival. |
Volume: |
100 |
Issue: |
26 |
Pages: |
15800-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu J |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis. |
Volume: |
7 |
|
Pages: |
10761 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adelaja A |
Year: |
2021 |
Journal: |
Immunity |
Title: |
Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses. |
Volume: |
54 |
Issue: |
5 |
Pages: |
916-930.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marruecos L |
Year: |
2020 |
Journal: |
EMBO Rep |
Title: |
IκBα deficiency imposes a fetal phenotype to intestinal stem cells. |
Volume: |
21 |
Issue: |
6 |
Pages: |
e49708 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoffmann A |
Year: |
2002 |
Journal: |
Science |
Title: |
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. |
Volume: |
298 |
Issue: |
5596 |
Pages: |
1241-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alves BN |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner. |
Volume: |
192 |
Issue: |
7 |
Pages: |
3121-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Molotski N |
Year: |
2008 |
Journal: |
Toxicol Appl Pharmacol |
Title: |
Teratogen-induced distortions in the classical NF-kappaB activation pathway: correlation with the ability of embryos to survive teratogenic stress. |
Volume: |
229 |
Issue: |
2 |
Pages: |
197-205 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ghosh S |
Year: |
1998 |
Journal: |
Annu Rev Immunol |
Title: |
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. |
Volume: |
16 |
|
Pages: |
225-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng QJ |
Year: |
2021 |
Journal: |
Science |
Title: |
NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages. |
Volume: |
372 |
Issue: |
6548 |
Pages: |
1349-1353 |
|
•
•
•
•
•
|
Publication |
First Author: |
Malty RH |
Year: |
2017 |
Journal: |
Cell Syst |
Title: |
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. |
Volume: |
5 |
Issue: |
6 |
Pages: |
564-577.e12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shih VF |
Year: |
2012 |
Journal: |
Nat Immunol |
Title: |
Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways. |
Volume: |
13 |
Issue: |
12 |
Pages: |
1162-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu Y |
Year: |
1999 |
Journal: |
Science |
Title: |
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. |
Volume: |
284 |
Issue: |
5412 |
Pages: |
316-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reed JC |
Year: |
2003 |
Journal: |
Genome Res |
Title: |
Comparative analysis of apoptosis and inflammation genes of mice and humans. |
Volume: |
13 |
Issue: |
6B |
Pages: |
1376-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wiese CB |
Year: |
2012 |
Journal: |
Front Neurosci |
Title: |
A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. |
Volume: |
6 |
|
Pages: |
130 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama S |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
Volume: |
17 |
Issue: |
6 |
Pages: |
836-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
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|
|
•
•
•
•
•
|
Allele |
Name: |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Allele |
Name: |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
170
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
263
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
56
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
228
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
510
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
253
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
249
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
252
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
154
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
146
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes budding yeast Sit4-associated proteins, such as Sap155, Sap185, and Sap190. Sit4 is a phosphatase involved in a variety of processes including transcription, translation, bud formation, glycogen metabolism, monovalent ion homeostasis, H+ transport, and telomere function []. This entry also includes mammalian PP6 (Sit4 homologue)-associated proteins, such as PP6R1, PP6R2, and PP6R3 []. They are regulatory subunits of PP6 involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Mansouri L |
Year: |
2016 |
Journal: |
Semin Cancer Biol |
Title: |
NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions. |
Volume: |
39 |
|
Pages: |
40-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
923
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
844
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
856
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
923
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
950
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
856
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
873
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
814
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
282
 |
Fragment?: |
false |
|
•
•
•
•
•
|