|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 173 out of 173 for Nlrp12

<< First    < Previous  |  Next >    Last >>
0.014s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Interaction Experiment
Chen ST (2019)
Description: NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25.
•
•
•
•
•
Publication
21978668 | -
First Author: Pinheiro AS
Year: 2011
Journal: J Mol Biol
Title: The NLRP12 pyrin domain: structure, dynamics, and functional insights.
Volume: 413
Issue: 4
Pages: 790-803
•
•
•
•
•
DO Term
DOID:0090063 | familial cold autoinflammatory syndrome 2
•
•
•
•
•
Allele
Nlrp12<em1Smoc> | MGI:7291324
Name: NLR family, pyrin domain containing 12; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Strain
MGI:6355056 | C57BL/6JSmoc-Nlrp12<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
Publication
18039395 | -
First Author: Stein C
Year: 2007
Journal: Genome Biol
Title: Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish.
Volume: 8
Issue: 11
Pages: R251
•
•
•
•
•
Publication
11786556 | -
First Author: Manji GA
Year: 2002
Journal: J Biol Chem
Title: PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B.
Volume: 277
Issue: 13
Pages: 11570-5
•
•
•
•
•
Protein Domain
IPR029495 | NACHT-assoc
Type: Domain
Description: This domain is frequently found associated with the NACHT domain () in fish and other vertebrates []. Proteins containing this domain include NACHT, LRR and PYD domains-containing protein 3/12 (NLRP3/12). In humans, NLRP3 (also known as PYPAF1) may function as an inducer of apoptosis []. NLRP12 is a non-inflammasome NLR (nucleotide-binding domain and leucine-rich repeat-containing receptors) that has been implicated in the regulation of Toll-like receptor-dependent nuclear factor-kappaB activation [].
•
•
•
•
•
Allele
Tg(Tyr-cre/ERT2)1Lru | MGI:3617509
Name: transgene insertion 1, Lionel Larue
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
•
•
•
•
•
Publication
37267949 | J:358036
First Author: Sundaram B
Year: 2023
Journal: Cell
Title: NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs.
Volume: 186
Issue: 13
Pages: 2783-2801.e20
•
•
•
•
•
Strain
MGI:6107859 | B6N.Cg-Tg(Tyr-cre/ERT2)1Lru/J
Attribute String: transgenic, mutant strain, congenic
•
•
•
•
•
Publication
35563010 | J:324552
 
First Author: Bernardazzi C
Year: 2022
Journal: Int J Mol Sci
Title: The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut Microbiota and the Inflammasome.
Volume: 23
Issue: 9
•
•
•
•
•
Publication
19234190 | J:146247
First Author: Lord CA
Year: 2009
Journal: J Immunol
Title: Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1.
Volume: 182
Issue: 5
Pages: 2948-58
•
•
•
•
•
Publication
22820643 | J:317304
First Author: Gembarska A
Year: 2012
Journal: Nat Med
Title: MDM4 is a key therapeutic target in cutaneous melanoma.
Volume: 18
Issue: 8
Pages: 1239-47
•
•
•
•
•
Publication
34417458 | J:308952
First Author: Diener J
Year: 2021
Journal: Nat Commun
Title: Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4.
Volume: 12
Issue: 1
Pages: 5056
•
•
•
•
•
Publication
16419042 | J:105276
First Author: Yajima I
Year: 2006
Journal: Genesis
Title: Spatiotemporal gene control by the Cre-ERT2 system in melanocytes.
Volume: 44
Issue: 1
Pages: 34-43
•
•
•
•
•
Publication
20516123 | J:161625
First Author: Milagre C
Year: 2010
Journal: Cancer Res
Title: A mouse model of melanoma driven by oncogenic KRAS.
Volume: 70
Issue: 13
Pages: 5549-57
•
•
•
•
•
Publication
23303902 | J:198244
First Author: Pedersen M
Year: 2013
Journal: Cancer Discov
Title: Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes.
Volume: 3
Issue: 4
Pages: 458-469
•
•
•
•
•
Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Braf/Braf<+> Kras/Kras<+> Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Nras/Nras Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Nras/Nras<+> Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
28658220 | J:249306
First Author: Olmeda D
Year: 2017
Journal: Nature
Title: Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.
Volume: 546
Issue: 7660
Pages: 676-680
•
•
•
•
•
Publication
20141835 | J:161180
First Author: Heidorn SJ
Year: 2010
Journal: Cell
Title: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.
Volume: 140
Issue: 2
Pages: 209-21
•
•
•
•
•
Publication
22796458 | J:188523
First Author: Hooijkaas AI
Year: 2012
Journal: Am J Pathol
Title: Targeting BRAFV600E in an inducible murine model of melanoma.
Volume: 181
Issue: 3
Pages: 785-94
•
•
•
•
•
Publication
19345328 | J:147434
First Author: Dhomen N
Year: 2009
Journal: Cancer Cell
Title: Oncogenic Braf induces melanocyte senescence and melanoma in mice.
Volume: 15
Issue: 4
Pages: 294-303
•
•
•
•
•
Publication
34878101 | J:321576
 
First Author: Colombo S
Year: 2022
Journal: Development
Title: Stabilization of β-catenin promotes melanocyte specification at the expense of the Schwann cell lineage.
Volume: 149
Issue: 2
•
•
•
•
•
Publication
32503808 | J:293703
First Author: Vandamme N
Year: 2020
Journal: Cancer Res
Title: The EMT Transcription Factor ZEB2 Promotes Proliferation of Primary and Metastatic Melanoma While Suppressing an Invasive, Mesenchymal-Like Phenotype.
Volume: 80
Issue: 14
Pages: 2983-2995
•
•
•
•
•
Publication
31972251 | J:297200
First Author: Braun AD
Year: 2020
Journal: J Invest Dermatol
Title: Activated Hgf-Met Signaling Cooperates with Oncogenic BRAF to Drive Primary Cutaneous Melanomas and Angiotropic Lung Metastases in Mice.
Volume: 140
Issue: 7
Pages: 1410-1417.e2
•
•
•
•
•
Publication
26511633 | J:230591
First Author: Hölzel M
Year: 2016
Journal: Cancer Res
Title: A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells.
Volume: 76
Issue: 2
Pages: 251-63
•
•
•
•
•
Strain
MGI:5447425 | B6.Cg-Braf<tm1Mmcm> Tg(Tyr-cre/ERT2)1Lru Pten<tm1Mro>
Attribute String: congenic, mutant strain, targeted mutation
•
•
•
•
•
Publication
27999416 | J:309460
 
First Author: Deken MA
Year: 2016
Journal: Int J Mol Sci
Title: Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in PtenLoxP/LoxP;BrafCA/+ Mice.
Volume: 17
Issue: 12
•
•
•
•
•
Publication
24667377 | J:259219
First Author: Sanchez-Laorden B
Year: 2014
Journal: Sci Signal
Title: BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling.
Volume: 7
Issue: 318
Pages: ra30
•
•
•
•
•
Publication
22113477 | J:183166
First Author: Rae J
Year: 2012
Journal: J Invest Dermatol
Title: (V600E)Braf::Tyr-CreERT2::K14-Kitl mice do not develop superficial spreading-like melanoma: keratinocyte Kit ligand is insufficient to "translocate" (V600E)Braf-driven melanoma to the epidermis.
Volume: 132
Issue: 2
Pages: 488-91
•
•
•
•
•
Publication
28647344 | J:252204
First Author: van Tuyn J
Year: 2017
Journal: J Invest Dermatol
Title: Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function.
Volume: 137
Issue: 10
Pages: 2197-2207
•
•
•
•
•
Publication
31806640 | J:285658
First Author: Boussouar A
Year: 2020
Journal: Cancer Res
Title: Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression.
Volume: 80
Issue: 4
Pages: 747-756
•
•
•
•
•
Publication
32051401 | J:287086
First Author: Galvani E
Year: 2020
Journal: Nat Commun
Title: Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma.
Volume: 11
Issue: 1
Pages: 853
•
•
•
•
•
Publication
30510256 | J:314412
First Author: Trucco LD
Year: 2019
Journal: Nat Med
Title: Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma.
Volume: 25
Issue: 2
Pages: 221-224
•
•
•
•
•
Publication
32450073 | J:314307
First Author: Trucco LD
Year: 2021
Journal: J Invest Dermatol
Title: Map3k1 Loss Cooperates with BrafV600E to Drive Melanomagenesis.
Volume: 141
Issue: 1
Pages: 221-225.e6
•
•
•
•
•
Publication
31679174 | J:282623
     
First Author: Aktary Z
Year: 2019
Journal: Pigment Cell Melanoma Res
Title: Sequencing two Tyr::CreERT2 transgenic mouse lines.
•
•
•
•
•
Genotype
Genotype
Symbol: Braf/Braf Cdkn2a/Cdkn2a Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Braf/Braf Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Braf/Braf<+> Tg(GFP/KRAS2/ALPP)1Brn/? Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: C57BL/6 * DBA/2 * FVB/N
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Braf/Braf<+> Pten/Pten Tg(Tyr-cre/ERT2)1Lru/?
Background: B6.Cg-Braf Tg(Tyr-cre/ERT2)1Lru Pten
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Protein
Q5SXI6
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
•
•
•
•
•
Publication
30581152 | J:270032
First Author: Karras P
Year: 2019
Journal: Cancer Cell
Title: p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
Volume: 35
Issue: 1
Pages: 46-63.e10
•
•
•
•
•
Publication
21924960 | J:178787
First Author: Li A
Year: 2011
Journal: Dev Cell
Title: Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.
Volume: 21
Issue: 4
Pages: 722-34
•
•
•
•
•
Publication
22718121 | J:335347
First Author: Li A
Year: 2012
Journal: J Invest Dermatol
Title: Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism.
Volume: 132
Issue: 11
Pages: 2610-21
•
•
•
•
•
Publication
28497782 | J:335349
 
First Author: Dorard C
Year: 2017
Journal: Nat Commun
Title: RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma.
Volume: 8
Pages: 15262
•
•
•
•
•
Publication
23382837 | J:195917
First Author: Yajima I
Year: 2013
Journal: PLoS One
Title: A subpopulation of smooth muscle cells, derived from melanocyte-competent precursors, prevents patent ductus arteriosus.
Volume: 8
Issue: 1
Pages: e53183
•
•
•
•
•
Publication
33091424 | J:314330
First Author: Le Coz M
Year: 2021
Journal: J Invest Dermatol
Title: Targeted Knockout of β-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects.
Volume: 141
Issue: 5
Pages: 1363-1366.e9
•
•
•
•
•
Publication
25256614 | J:217894
First Author: Smith MP
Year: 2014
Journal: Cancer Discov
Title: The immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNFα.
Volume: 4
Issue: 10
Pages: 1214-1229
•
•
•
•
•
Publication
34140478 | J:307915
First Author: Hamm M
Year: 2021
Journal: Nat Commun
Title: BRN2 is a non-canonical melanoma tumor-suppressor.
Volume: 12
Issue: 1
Pages: 3707
•
•
•
•
•
Publication
26765561 | J:229442
 
First Author: Kümper S
Year: 2016
Journal: Elife
Title: Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
Volume: 5
Pages: e12994
•
•
•
•
•
Publication
36107619 | J:331385
 
First Author: Yao W
Year: 2022
Journal: JCI Insight
Title: Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment.
Volume: 7
Issue: 21
•
•
•
•
•
Protein
Q3TZ22
Organism: Mus musculus/domesticus
Length: 684  
Fragment?: false
•
•
•
•
•
Protein
Q6UQE6
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: true
•
•
•
•
•
Protein
Q8R4B8
Organism: Mus musculus/domesticus
Length: 1033  
Fragment?: false
•
•
•
•
•
Protein
E9Q5R7
Organism: Mus musculus/domesticus
Length: 1054  
Fragment?: false
•
•
•
•
•
Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom