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Search results 101 to 191 out of 191 for Nnmt

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Hits by Pathway

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Hits by Strain

Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1775122
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274122
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287422
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3266022
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1624622
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Note: Expression was not detected in the digestive system.
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721422
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1646922
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1683322
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1700022
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1832122
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Note: Expression was not detected in the immune system.
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1741222
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754022
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1833322
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287022
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1821522
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702122
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756322
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757722
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5310047
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5423371
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: EH954; Specimen C2514
Detected: false
Specimen Num: 1
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Publication
9726248 | J:49397
First Author: Yan L
Year: 1998
Journal: DNA Cell Biol
Title: Mouse nicotinamide N-methyltransferase gene: molecular cloning, structural characterization, and chromosomal localization.
Volume: 17
Issue: 8
Pages: 659-67
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Publication
24717514 | J:208844
First Author: Kraus D
Year: 2014
Journal: Nature
Title: Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Volume: 508
Issue: 7495
Pages: 258-62
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Publication
10552930 | J:58612
First Author: Thompson MA
Year: 1999
Journal: Genomics
Title: Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization.
Volume: 61
Issue: 3
Pages: 285-97
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Publication
15820311 | J:97535
First Author: Yaguchi H
Year: 2005
Journal: Genomics
Title: Identification of candidate genes in the type 2 diabetes modifier locus using expression QTL.
Volume: 85
Issue: 5
Pages: 591-9
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Publication
17916774 | J:127711
First Author: Wang SS
Year: 2007
Journal: Arterioscler Thromb Vasc Biol
Title: Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice.
Volume: 27
Issue: 12
Pages: 2671-6
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Publication
26874185 | J:241101
First Author: Fame RM
Year: 2017
Journal: Cereb Cortex
Title: Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex.
Volume: 27
Issue: 3
Pages: 1817-1830
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Publication
22737085 | J:187177
First Author: Bochkis IM
Year: 2012
Journal: PLoS Genet
Title: Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2.
Volume: 8
Issue: 6
Pages: e1002770
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Publication
33732701 | J:314181
 
First Author: Holzman MA
Year: 2021
Journal: Front Cell Dev Biol
Title: HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation.
Volume: 9
Pages: 632303
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Publication
23499423 | J:198125
First Author: Rajakumari S
Year: 2013
Journal: Cell Metab
Title: EBF2 determines and maintains brown adipocyte identity.
Volume: 17
Issue: 4
Pages: 562-74
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Publication
24703692 | J:213153
First Author: Harms MJ
Year: 2014
Journal: Cell Metab
Title: Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.
Volume: 19
Issue: 4
Pages: 593-604
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Nnmt<em1Smoc> | MGI:7291342
Name: nicotinamide N-methyltransferase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
8182091 | J:18157
First Author: Aksoy S
Year: 1994
Journal: J Biol Chem
Title: Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization.
Volume: 269
Issue: 20
Pages: 14835-40
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Protein Domain
IPR025820 | NNMT/PNMT/TEMT_CS
Type: Conserved_site
Description: Several cytoplasmic vertebrate methyltransferases are evolutionary related [], includingnicotinamide N-methyltransferase () (NNMT); phenylethanolamine N-methyltransferase () (PNMT); and thioether S-methyltransferase () (TEMT). NNMT catalyses the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for the biotransformation of many drugs and xenobiotic compounds. PNMT catalyses the last step in catecholamine biosynthesis, the conversion of noradrenalin to adrenalin; and TEMT catalyses themethylation of dimethyl sulphide into trimethylsulphonium. These three enzymes use S-adenosyl-L-methionine as the methyl donor. They are proteins of 30 to 32kDa.This entry represents the most conserved region, a stretch of 16 residues which are located in the N-terminal section of these enzymes.
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Publication
38212381 | J:352038
First Author: Zhang Q
Year: 2024
Journal: EMBO J
Title: Control of NAD(+) homeostasis by autophagic flux modulates mitochondrial and cardiac function.
Volume: 43
Issue: 3
Pages: 362-390
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Publication
9703363 | J:48943
First Author: Okamura A
Year: 1998
Journal: Jpn J Cancer Res
Title: Increased hepatic nicotinamide N-methyltransferase activity as a marker of cancer cachexia in mice bearing colon 26 adenocarcinoma.
Volume: 89
Issue: 6
Pages: 649-56
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Publication
26571212 | J:230743
First Author: Sperber H
Year: 2015
Journal: Nat Cell Biol
Title: The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.
Volume: 17
Issue: 12
Pages: 1523-35
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Publication
29483571 | J:263087
First Author: Kannt A
Year: 2018
Journal: Sci Rep
Title: A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.
Volume: 8
Issue: 1
Pages: 3660
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Publication
36104373 | J:333493
First Author: Ruf S
Year: 2022
Journal: Sci Rep
Title: Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.
Volume: 12
Issue: 1
Pages: 15440
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Protein Domain
IPR000940 | NNMT_TEMT_trans
Type: Family
Description: Methyl transfer from the ubiquitous S-adenosyl-L-methionine (AdoMet) to either nitrogen, oxygen or carbon atoms is frequently employed in diverse organisms ranging from bacteria to plants and mammals. The reaction is catalysed by methyltransferases (Mtases) and modifies DNA, RNA, proteins and small molecules, such as catechol for regulatory purposes. The various aspects of the role of DNA methylation in prokaryotic restriction-modification systems and in a number of cellular processes in eukaryotes including gene regulation and differentiation is well documented.Three classes of DNA Mtases transfer the methyl group from AdoMet to the target base to form either N-6-methyladenine, or N-4-methylcytosine, or C-5- methylcytosine. In C-5-cytosine Mtases, ten conserved motifs are arranged in the same order []. Motif I (a glycine-rich or closely related consensus sequence; FAGxGG in M.HhaI []), shared by other AdoMet-Mtases [], is part of the cofactor binding site and motif IV (PCQ) is part of the catalytic site. In contrast, sequence comparison among N-6-adenine and N-4-cytosine Mtases indicated two of the conserved segments [], although more conserved segments may be present. One of them corresponds to motif I in C-5-cytosine Mtases, and the other is named (D/N/S)PP(Y/F). Crystal structures are known for a number of Mtases [, , , ]. The cofactor binding sites are almost identical and the essential catalytic amino acids coincide. The comparable protein folding and the existence of equivalent amino acids in similar secondary and tertiary positions indicate that many (if not all) AdoMet-Mtases have a common catalytic domain structure. This permits tertiary structure prediction of other DNA, RNA, protein, and small-molecule AdoMet-Mtases from their amino acid sequences [].Several cytoplasmic vertebrate methyltransferases are evolutionary related [], includingnicotinamide N-methyltransferase () (NNMT); phenylethanolamine N-methyltransferase () (PNMT); and thioether S-methyltransferase () (TEMT). NNMT catalyses the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for the biotransformation of many drugs and xenobiotic compounds. PNMT catalyses the last step in catecholamine biosynthesis, the conversion of noradrenalin to adrenalin; and TEMT catalyses themethylation of dimethyl sulphide into trimethylsulphonium. These three enzymes use S-adenosyl-L-methionine as the methyl donor. They are proteins of 30 to 32kDa.
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Protein
P40935
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
P40936
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein
O55239
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein
Q0VB50
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
D3YX59
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: false
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Protein
Q9D9X3
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: false
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Publication
8343957 | -
First Author: Cheng X
Year: 1993
Journal: Cell
Title: Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine.
Volume: 74
Issue: 2
Pages: 299-307
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Publication
2690010 | -
First Author: Klimasauskas S
Year: 1989
Journal: Nucleic Acids Res
Title: Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases.
Volume: 17
Issue: 23
Pages: 9823-32
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Publication
2684970 | -
First Author: Ingrosso D
Year: 1989
Journal: J Biol Chem
Title: Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases.
Volume: 264
Issue: 33
Pages: 20131-9
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Publication
7607476 | -
First Author: Schluckebier G
Year: 1995
Journal: Gene
Title: A model for DNA binding and enzyme action derived from crystallographic studies of the TaqI N6-adenine-methyltransferase.
Volume: 157
Issue: 1-2
Pages: 131-4
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Publication
8127644 | -
First Author: Kumar S
Year: 1994
Journal: Nucleic Acids Res
Title: The DNA (cytosine-5) methyltransferases.
Volume: 22
Issue: 1
Pages: 1-10
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Publication
7971991 | -
First Author: Labahn J
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Three-dimensional structure of the adenine-specific DNA methyltransferase M.Taq I in complex with the cofactor S-adenosylmethionine.
Volume: 91
Issue: 23
Pages: 10957-61
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Publication
7897657 | -
First Author: Schluckebier G
Year: 1995
Journal: J Mol Biol
Title: Universal catalytic domain structure of AdoMet-dependent methyltransferases.
Volume: 247
Issue: 1
Pages: 16-20
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