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Search results 101 to 167 out of 167 for Npff

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Type Details Score
Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q924H0
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
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Publication
16443306 | -
First Author: Yang HY
Year: 2006
Journal: Peptides
Title: Modulatory roles of the NPFF system in pain mechanisms at the spinal level.
Volume: 27
Issue: 5
Pages: 943-52
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Allele
Npff<em1Smoc> | MGI:7291367
Name: neuropeptide FF-amide peptide precursor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7718170 | C57BL/6JSmoc-Npff<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Npff<tm1.1(icre)Xen> | MGI:7464745
Name: neuropeptide FF-amide peptide precursor; targeted mutation 1.1, Taconic Biosciences
Allele Type: Targeted
Attribute String: Recombinase
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Genotype
Genotype
Symbol: Npff/Npff<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Publication
11481330 | J:72028
First Author: Liu Q
Year: 2001
Journal: J Biol Chem
Title: Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception.
Volume: 276
Issue: 40
Pages: 36961-9
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Genotype
Genotype
Symbol: Grpr/Grpr<+> Npff/Npff<+>
Background: involves: ICR
Zygosity: cx
Has Mutant Allele: true
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Publication
10536200 | -
First Author: Roumy M
Year: 1999
Journal: Brain Res
Title: Neuropeptide FF selectively attenuates the effects of nociceptin on acutely dissociated neurons of the rat dorsal raphe nucleus.
Volume: 845
Issue: 2
Pages: 208-14
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Publication
12932818 | -
First Author: Roumy M
Year: 2003
Journal: Neurosci Lett
Title: Neuropeptide FF receptors 1 and 2 exert an anti-opioid activity in acutely dissociated rat dorsal raphe and periventricular hypothalamic neurones.
Volume: 348
Issue: 3
Pages: 159-62
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Publication
16488058 | -
First Author: Kersanté F
Year: 2006
Journal: Peptides
Title: Anti-opioid activities of NPFF1 receptors in a SH-SY5Y model.
Volume: 27
Issue: 5
Pages: 980-9
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Publication
15608144 | -
First Author: Mollereau C
Year: 2005
Journal: Mol Pharmacol
Title: Neuropeptide FF (NPFF) analogs functionally antagonize opioid activities in NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells.
Volume: 67
Issue: 3
Pages: 965-75
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Publication
22375000 | -
First Author: Moulédous L
Year: 2012
Journal: J Biol Chem
Title: GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors.
Volume: 287
Issue: 16
Pages: 12736-49
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Protein Domain
IPR005397 | NPFF_rcpt_2
Type: Family
Description: Neuropeptide FF receptors []belong to a family of neuropeptides containing an RF-amide motif at their C terminus which have a high affinity for the pain modulatory peptide neuropeptide NPFF (NPFF) []. Neuropeptide FF (NPFF) receptors have two subtypes, neuropeptide FF receptor type 1 (NPFF1) and neuropeptide FF receptor type 2 (NPFF2), they are members of rhodopsin G protein-coupled receptor family. The neuropeptide FF is found at high concentrations in the posterior pituitary, spinal cord, hypothalamus and medulla and is believed to be involved in pain modulation, opioid tolerance, cardiovascular regulation, memory and neuroendocrine regulation [, , , ].Comparing the distribution of NPFF1 and NPFF2 receptors in different species reveals important species differences []. The NPFF1 receptor is broadly distributed in the central nervous system with the highest levels found in the limbic system and the hypothalamus, is thought to participate in neuroendocrine functions. Whereas as the NPFF2 receptor is present in high density, particularly in mammals in the superficial layers of the spinal cord []where it is involved in nociception and modulation of opioid functions [], consistent with a potential role of NPFF in the modulation of sensory inputs, like pain responses [, , ].This entry represents NPFF2, which is expressed at high levels in the thymus and placenta, with moderate levels in the pituitary, spleen, testis and brain. Low levels were detected in the spinal cord, pancreas, small intestine, uterus, stomach, lung, heart and skeletal muscle. No expression was detected in liver or kidney []. The NPFF2 receptor has been found to regulate adenylyl cyclase in some recombinant cell lines [, ]. In acutely dissociated neurons, the NPFF2 receptors specifically counteract N-type Ca2+ channel inhibition by opioids [, ]. In SH-SY5Y neuroblastoma cells stably expressing human NPFF receptors, NPFF agonists also reduce the inhibitory effect of mu-opioid and delta-opioid receptor activation on an N-type Ca2+ channel [, ]. These regulations could be due in part to receptor heteromerisation since NPFF2 receptors have been shown to physically interact with mu-opiod receptors []]and induce their trans-phosphorylations [].
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Npff/Npff<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
10837915 | J:62656
First Author: Parker RM
Year: 2000
Journal: Brain Res Mol Brain Res
Title: Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family.
Volume: 77
Issue: 2
Pages: 199-208
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Publication
8804117 | -
First Author: Panula P
Year: 1996
Journal: Prog Neurobiol
Title: Neuropeptide FF, a mammalian neuropeptide with multiple functions.
Volume: 48
Issue: 4-5
Pages: 461-87
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Publication
10851242 | -
First Author: Elshourbagy NA
Year: 2000
Journal: J Biol Chem
Title: Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.
Volume: 275
Issue: 34
Pages: 25965-71
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Publication
17224450 | -
First Author: Roumy M
Year: 2007
Journal: J Biol Chem
Title: Physical association between neuropeptide FF and micro-opioid receptors as a possible molecular basis for anti-opioid activity.
Volume: 282
Issue: 11
Pages: 8332-42
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Publication
17854890 | -
First Author: Yang HY
Year: 2008
Journal: Neuropeptides
Title: Modulatory role of neuropeptide FF system in nociception and opiate analgesia.
Volume: 42
Issue: 1
Pages: 1-18
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Publication
18804517 | -
First Author: Betourne A
Year: 2008
Journal: Neuroscience
Title: Decreased motivational properties of morphine in mouse models of cancerous- or inflammatory-chronic pain: implication of supraspinal neuropeptide FF(2) receptors.
Volume: 157
Issue: 1
Pages: 12-21
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Publication
18823989 | -
First Author: Cline MA
Year: 2008
Journal: Gen Comp Endocrinol
Title: Anoretic effects of neuropeptide FF are mediated via central mu and kappa subtypes of opioid receptors and receptor ligands.
Volume: 159
Issue: 2-3
Pages: 125-9
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Publication
9593588 | -
First Author: Roumy M
Year: 1998
Journal: Eur J Pharmacol
Title: Neuropeptide FF, pain and analgesia.
Volume: 345
Issue: 1
Pages: 1-11
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Publication
10612711 | -
First Author: Panula P
Year: 1999
Journal: Brain Res
Title: Neuropeptide FF and modulation of pain.
Volume: 848
Issue: 1-2
Pages: 191-6
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Publication
20803521 | -
First Author: Moulédous L
Year: 2010
Journal: Biofactors
Title: Opioid-modulating properties of the neuropeptide FF system.
Volume: 36
Issue: 6
Pages: 423-9
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Publication
14696013 | -
First Author: Gouardères C
Year: 2004
Journal: Synapse
Title: Detailed distribution of neuropeptide FF receptors (NPFF1 and NPFF2) in the rat, mouse, octodon, rabbit, guinea pig, and marmoset monkey brains: a comparative autoradiographic study.
Volume: 51
Issue: 4
Pages: 249-69
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Protein Domain
IPR005395 | NPFF_rcpt
Type: Family
Description: Neuropeptide FF receptors []belong to a family of neuropeptides containing an RF-amide motif at their C terminus which have a high affinity for the pain modulatory peptide neuropeptide NPFF (NPFF) []. Neuropeptide FF (NPFF) receptors have two subtypes, neuropeptide FF receptor type 1 (NPFF1) and neuropeptide FF receptor type 2 (NPFF2), they are members of rhodopsin G protein-coupled receptor family. The neuropeptide FF is found at high concentrations in the posterior pituitary, spinal cord, hypothalamus and medulla and is believed to be involved in pain modulation, opioid tolerance, cardiovascular regulation, memory and neuroendocrine regulation [, , , ].Comparing the distribution of NPFF1 and NPFF2 receptors in different species reveals important species differences []. The NPFF1 receptor is broadly distributed in the central nervous system with the highest levels found in the limbic system and the hypothalamus, is thought to participate in neuroendocrine functions. Whereas as the NPFF2 receptor is present in high density, particularly inmammals in the superficial layers of the spinal cord []where it is involved in nociception and modulation of opioid functions [], consistent with a potential role of NPFF in the modulation of sensory inputs, like pain responses [, , ].This entry represents the neuropeptide FF receptor family.
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Publication
11551509 | J:71586
First Author: Dong X
Year: 2001
Journal: Cell
Title: A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.
Volume: 106
Issue: 5
Pages: 619-32
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Publication
11025660 | J:65018
First Author: Hinuma S
Year: 2000
Journal: Nat Cell Biol
Title: New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
Volume: 2
Issue: 10
Pages: 703-8
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Protein Domain
IPR005396 | NPFF_rcpt_1
Type: Family
Description: Neuropeptide FF receptors []belong to a family of neuropeptides containing an RF-amide motif at their C terminus which have a high affinity for the pain modulatory peptide neuropeptide NPFF (NPFF) []. Neuropeptide FF (NPFF) receptors have two subtypes, neuropeptide FF receptor type 1 (NPFF1) and neuropeptide FF receptor type 2 (NPFF2), they are members of rhodopsin G protein-coupled receptor family. The neuropeptide FF is found at high concentrations in the posterior pituitary, spinal cord, hypothalamus andmedulla and is believed to be involved in pain modulation, opioid tolerance, cardiovascular regulation, memory and neuroendocrine regulation [, , , ].Comparing the distribution of NPFF1 and NPFF2 receptors in different species reveals important species differences []. The NPFF1 receptor is broadly distributed in the central nervous system with the highest levels found in the limbic system and the hypothalamus, is thought to participate in neuroendocrine functions. Whereas as the NPFF2 receptor is present in high density, particularly in mammals in the superficial layers of the spinal cord []where it is involved in nociception and modulation of opioid functions [], consistent with a potential role of NPFF in the modulation of sensory inputs, like pain responses [, , ].This entry represents NPFF1 receptor, which is expressed at highest levels in the hypothalamus, with moderate expression in the thalamus, midbrain, medulla oblongata, testis and eye []. NPFF1 receptor has been found to regulate adenylyl cyclase in some recombinant cell lines [, ]. It also couples with Gi protein to inhibit adenylyl cyclase (AC) [], and reduces the activities of cAMP-dependent protein kinase (PKA) and mitogen-activated protein kinase (MAPK) signaling cascade.
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Protein
Q924N0
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: false
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Publication
26641552 | J:231046
First Author: Dai Y
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Neuropeptide FF Promotes Recovery of Corneal Nerve Injury Associated With Hyperglycemia.
Volume: 56
Issue: 13
Pages: 7754-65
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Publication
31421202 | J:282857
 
First Author: Gutierrez-Mecinas M
Year: 2019
Journal: Neuroscience
Title: Expression of Neuropeptide FF Defines a Population of Excitatory Interneurons in the Superficial Dorsal Horn of the Mouse Spinal Cord that Respond to Noxious and Pruritic Stimuli.
Volume: 416
Pages: 281-293
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Publication
33564881 | J:307375
 
First Author: Constantin S
Year: 2021
Journal: Endocrinology
Title: An Inhibitory Circuit From Brainstem to GnRH Neurons in Male Mice: A New Role for the RFRP Receptor.
Volume: 162
Issue: 5
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Publication
33202667 | J:324859
 
First Author: Lin YT
Year: 2020
Journal: Cells
Title: Ablation of NPFFR2 in Mice Reduces Response to Single Prolonged Stress Model.
Volume: 9
Issue: 11
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Publication
11024015 | J:66241
First Author: Bonini JA
Year: 2000
Journal: J Biol Chem
Title: Identification and characterization of two G protein-coupled receptors for neuropeptide FF.
Volume: 275
Issue: 50
Pages: 39324-31
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Publication
7842499 | J:20981
First Author: Desprat C
Year: 1994
Journal: Brain Res Dev Brain Res
Title: Ontogeny of neuropeptide FF pharmacology and receptors in mouse brain.
Volume: 82
Issue: 1-2
Pages: 118-26
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Publication
15121216 | J:101867
First Author: Gouardères C
Year: 2004
Journal: J Chem Neuroanat
Title: Opposite alterations of NPFF1 and NPFF2 neuropeptide FF receptor density in the triple MOR/DOR/KOR-opioid receptor knockout mouse brains.
Volume: 27
Issue: 2
Pages: 119-28
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Publication
27243477 | J:266703
 
First Author: Lin YT
Year: 2016
Journal: Psychoneuroendocrinology
Title: Chronic activation of NPFFR2 stimulates the stress-related depressive behaviors through HPA axis modulation.
Volume: 71
Pages: 73-85
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Protein
E9Q468
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
Q80T60
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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