Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_09 |
|
Specimen Label: |
euxassay_001138_09 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_10 |
|
Specimen Label: |
euxassay_001138_10 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_11 |
|
Specimen Label: |
euxassay_001138_11 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_12 |
|
Specimen Label: |
euxassay_001138_12 |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_13 |
|
Specimen Label: |
euxassay_001138_13 |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_14 |
|
Specimen Label: |
euxassay_001138_14 |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_15 |
|
Specimen Label: |
euxassay_001138_15 |
Detected: |
true |
Specimen Num: |
15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_17 |
|
Specimen Label: |
euxassay_001138_17 |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_18 |
|
Specimen Label: |
euxassay_001138_18 |
Detected: |
true |
Specimen Num: |
18 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_19 |
|
Specimen Label: |
euxassay_001138_19 |
Detected: |
true |
Specimen Num: |
19 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_20 |
|
Specimen Label: |
euxassay_001138_20 |
Detected: |
true |
Specimen Num: |
20 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_21 |
|
Specimen Label: |
euxassay_001138_21 |
Detected: |
true |
Specimen Num: |
21 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_22 |
|
Specimen Label: |
euxassay_001138_22 |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1830623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_23 |
|
Specimen Label: |
euxassay_001138_23 |
Detected: |
true |
Specimen Num: |
23 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1683323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_13 |
|
Specimen Label: |
euxassay_001138_13 |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1683323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_14 |
|
Specimen Label: |
euxassay_001138_14 |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1683323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_15 |
|
Specimen Label: |
euxassay_001138_15 |
Detected: |
true |
Specimen Num: |
15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1627779 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1683323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826971 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_001138_16 |
|
Specimen Label: |
euxassay_001138_16 |
Detected: |
true |
Specimen Num: |
16 |
|
•
•
•
•
•
|
Publication |
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Wai T |
Year: |
2015 |
Journal: |
Science |
Title: |
Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice. |
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350 |
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6265 |
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•
•
•
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Publication |
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Kondadi AK |
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2014 |
Journal: |
EMBO J |
Title: |
Loss of the m-AAA protease subunit AFG₃L₂ causes mitochondrial transport defects and tau hyperphosphorylation. |
Volume: |
33 |
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Pages: |
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•
•
•
•
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Publication |
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2022 |
Journal: |
Cell Rep |
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110370 |
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•
•
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•
•
•
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•
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Publication |
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J Biol Chem |
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Proc Natl Acad Sci U S A |
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Publication |
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Wellcome Trust Sanger Institute |
Year: |
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MGI Direct Data Submission |
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Publication |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
|
UniProt Feature |
Begin: |
141 |
Description: |
Cleavage; by OMA1 |
Type: |
site |
End: |
142 |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Allele |
Name: |
OMA1 zinc metallopeptidase; wild type |
|
|
|
•
•
•
•
•
|
Allele |
Name: |
OMA1 zinc metallopeptidase; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
OMA1 zinc metallopeptidase; targeted mutation 2a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
OMA1 zinc metallopeptidase; targeted mutation 2e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
OMA1 zinc metallopeptidase; targeted mutation 1e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
OMA1 zinc metallopeptidase; targeted mutation 3e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
OMA1 zinc metallopeptidase; targeted mutation 1, Carlos Lopez-Otin |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
OMA1 zinc metallopeptidase; targeted mutation 1, Thomas Langer |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready |
|
•
•
•
•
•
|
Allele |
Name: |
OMA1 zinc metallopeptidase; targeted mutation 1.1, Thomas Langer |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
OMA1 zinc metallopeptidase; endonuclease-mediated mutation 1, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
OMA1 zinc metallopeptidase; endonuclease-mediated mutation 1, Cyagen Biosciences |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Anderson CJ |
Year: |
2020 |
Journal: |
Cell Death Differ |
Title: |
Prohibitin levels regulate OMA1 activity and turnover in neurons. |
Volume: |
27 |
Issue: |
6 |
Pages: |
1896-1906 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Oma1/Oma1 |
Background: |
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Oma1/Oma1 |
Background: |
C57BL/6N-Oma1/Ieg |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Chchd10/Chchd10 Oma1/Oma1 |
Background: |
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion LU178, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Oma1/Oma1 Yme1l1/Yme1l1 Tg(Myh6-cre)2182Mds/? |
Background: |
involves: C57BL/6 * C57BL/6NCrl * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Oma1/Oma1 Yme1l1/Yme1l1 Tg(Ckmm-cre)5Khn/? |
Background: |
involves: C57BL/6 * C57BL/6NCrl * FVB |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Chchd10/Chchd10 Oma1/Oma1<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Frezza C |
Year: |
2006 |
Journal: |
Cell |
Title: |
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. |
Volume: |
126 |
Issue: |
1 |
Pages: |
177-89 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Opa1 is a dynamin-like guanosine triphosphatase required for mitochondrial fusion and regulation of apoptosis. Its activity is controlled by proteolytic cleavage. Stress conditions that cause loss of mitochondrial membrane potential can induce the cleavage of Opa1 at S1 position by OMA1 (an ATP-independent peptidase), and this triggers mitochondrial fragmentation []. It is also involved in mitochondrial cristae remodeling during apoptosis []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang R |
Year: |
2021 |
Journal: |
Mol Biol Cell |
Title: |
Identification of new OPA1 cleavage site reveals that short isoforms regulate mitochondrial fusion. |
Volume: |
32 |
Issue: |
2 |
Pages: |
157-168 |
|
•
•
•
•
•
|
Publication |
First Author: |
Consolato F |
Year: |
2018 |
Journal: |
J Cell Sci |
Title: |
m-AAA and i-AAA complexes coordinate to regulate OMA1, the stress-activated supervisor of mitochondrial dynamics. |
Volume: |
131 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou Z |
Year: |
2018 |
Journal: |
J Biol Chem |
Title: |
Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. |
Volume: |
293 |
Issue: |
13 |
Pages: |
4735-4751 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sood A |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver. |
Volume: |
111 |
Issue: |
45 |
Pages: |
16017-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin HP |
Year: |
2024 |
Journal: |
EMBO J |
Title: |
DELE1 maintains muscle proteostasis to promote growth and survival in mitochondrial myopathy. |
Volume: |
43 |
Issue: |
22 |
Pages: |
5548-5585 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
296
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
960
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
953
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
692
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
978
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
567
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|