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Search results 101 to 200 out of 269 for Osm

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Hits by Strain

Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:2451085
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2451120
Age: postnatal day 10
Specimen Label: 10-day, 35
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:2451085
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2451120
Age: postnatal day 10
Specimen Label: 10-day, 40
Detected: true
Specimen Num: 8
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•
GXD Expression
GXD Expression
     
Probe: MGI:2451085
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2451120
Age: postnatal adult
Specimen Label: Adult, 35
Detected: true
Specimen Num: 9
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•
GXD Expression
GXD Expression
     
Probe: MGI:2451085
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2451120
Age: postnatal adult
Specimen Label: Adult, 40
Detected: true
Specimen Num: 10
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•
GXD Expression
GXD Expression
     
Probe: MGI:2662321
Assay Type: RT-PCR
Annotation Date: 2003-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:2662341
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
     
Probe: MGI:2662321
Assay Type: RT-PCR
Annotation Date: 2003-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:2662341
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
     
Probe: MGI:2662321
Assay Type: RT-PCR
Annotation Date: 2003-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:2662341
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
     
Probe: MGI:2662321
Assay Type: RT-PCR
Annotation Date: 2003-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2662341
Age: postnatal day 0
Specimen Label: Neonatal
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
     
Probe: MGI:2662321
Assay Type: RT-PCR
Annotation Date: 2003-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2662341
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 5
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•
GXD Expression
GXD Expression
     
Probe: MGI:5292489
Assay Type: RT-PCR
Annotation Date: 2011-10-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:5292504
Age: embryonic day 14.5
Specimen Label: e14.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5292489
Assay Type: RT-PCR
Annotation Date: 2011-10-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:5292504
Age: embryonic day 14.5
Specimen Label: e14.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5292489
Assay Type: RT-PCR
Annotation Date: 2011-10-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:5292504
Age: embryonic day 16.5
Specimen Label: e16.5
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
     
Probe: MGI:5292489
Assay Type: RT-PCR
Annotation Date: 2011-10-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:5292504
Age: embryonic day 16.5
Specimen Label: e16.5
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
     
Probe: MGI:5292489
Assay Type: RT-PCR
Annotation Date: 2011-10-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:5292504
Age: embryonic day 18.5
Specimen Label: e18.5
Detected: true
Specimen Num: 5
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•
GXD Expression
GXD Expression
     
Probe: MGI:5292489
Assay Type: RT-PCR
Annotation Date: 2011-10-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:5292504
Age: embryonic day 18.5
Specimen Label: e18.5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:2451085
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3820119
Stage: TS19
Assay Id: MGI:2451096
Age: embryonic day 11.5
Specimen Label: 11.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7641537
Assay Type: RT-PCR
Annotation Date: 2024-05-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3787919
Stage: TS19
Assay Id: MGI:7641786
Age: embryonic day 11.5
Image: 6
Specimen Label: Niche
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7641537
Assay Type: RT-PCR
Annotation Date: 2024-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:7641786
Age: embryonic day 11.5
Image: 6
Specimen Label: Bulk
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7641537
Assay Type: RT-PCR
Annotation Date: 2024-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604619
Stage: TS19
Assay Id: MGI:7641786
Age: embryonic day 11.5
Image: 6
Specimen Label: Bulk
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7751197
Assay Type: RT-PCR
Annotation Date: 2024-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:7751326
Age: embryonic day 12.5
Specimen Label: CTR
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7751197
Assay Type: RT-PCR
Annotation Date: 2024-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:7751326
Age: embryonic day 12.5
Specimen Label: TKO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691015
Age: postnatal adult
Image: JAX_1799121
Note: kidney
Specimen Label: JAX_1799121
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691015
Age: postnatal adult
Image: JAX_1799124
Specimen Label: JAX_1799124
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:1196881
Assay Type: RNA in situ
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:2451090
Age: embryonic day 11.5
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1196881
Assay Type: RNA in situ
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1738319
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:2451090
Age: embryonic day 11.5
Note: Expression at the periphery of the genital ridge.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691015
Age: postnatal adult
Image: JAX_1799120
Specimen Label: JAX_1799120
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691015
Age: postnatal adult
Image: JAX_1799119
Specimen Label: JAX_1799119
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Absent
Sex: Female
Emaps: EMAPS:1881228
Stage: TS28
Assay Id: MGI:6691015
Age: postnatal adult
Image: JAX_1799122
Specimen Label: JAX_1799122
Detected: false
Specimen Num: 4
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691015
Age: postnatal adult
Image: JAX_1799125
Specimen Label: JAX_1799125
Detected: true
Specimen Num: 6
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Publication
10205167 | J:54660
First Author: Kamiya A
Year: 1999
Journal: EMBO J
Title: Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer.
Volume: 18
Issue: 8
Pages: 2127-36
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Publication
8605875 | J:31887
First Author: Yoshimura A
Year: 1996
Journal: EMBO J
Title: Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway.
Volume: 15
Issue: 5
Pages: 1055-63
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Publication
32600062 | J:303638
First Author: Li Y
Year: 2020
Journal: Circulation
Title: gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration.
Volume: 142
Issue: 10
Pages: 967-982
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Publication
12121663 | J:77523
First Author: Broxmeyer HE
Year: 2002
Journal: Immunity
Title: Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M.
Volume: 16
Issue: 6
Pages: 815-25
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Publication
8187629 | J:15716
First Author: Conover JC
Year: 1993
Journal: Development
Title: Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells.
Volume: 119
Issue: 3
Pages: 559-65
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Publication
7508917 | J:16744
First Author: Yin T
Year: 1994
Journal: J Biol Chem
Title: Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells.
Volume: 269
Issue: 5
Pages: 3731-8
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Publication
7780034 | J:27800
First Author: Fantuzzi G
Year: 1995
Journal: Cytokine
Title: Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice.
Volume: 7
Issue: 2
Pages: 150-6
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Publication
24129709 | J:206059
 
First Author: Qin S
Year: 2013
Journal: Nat Commun
Title: Cross-talk between KLF4 and STAT3 regulates axon regeneration.
Volume: 4
Pages: 2633
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Publication
11203703 | J:67053
First Author: Chuma S
Year: 2001
Journal: Dev Biol
Title: Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling.
Volume: 229
Issue: 2
Pages: 468-79
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Publication
11599050 | J:72087
First Author: Takabayashi S
Year: 2001
Journal: Mol Reprod Dev
Title: Novel growth factor supporting survival of murine primordial germ cells: evidence from conditioned medium of ter fetal gonadal somatic cells.
Volume: 60
Issue: 3
Pages: 384-96
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Publication
16467531 | J:105646
First Author: Oberle S
Year: 2006
Journal: J Neurosci
Title: Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla.
Volume: 26
Issue: 6
Pages: 1823-32
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Publication
20980401 | J:166908
First Author: Sasaki T
Year: 2010
Journal: Development
Title: Regulation of hematopoietic cell clusters in the placental niche through SCF/Kit signaling in embryonic mouse.
Volume: 137
Issue: 23
Pages: 3941-52
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Publication
21514445 | J:171578
First Author: Chen W
Year: 2011
Journal: Am J Pathol
Title: Protein phosphatase 2A catalytic subunit α (PP2Acα) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway.
Volume: 178
Issue: 5
Pages: 2333-43
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Publication
18617288 | J:138863
First Author: Hayhurst GP
Year: 2008
Journal: J Hepatol
Title: Morphogenetic competence of HNF4 alpha-deficient mouse hepatic cells.
Volume: 49
Issue: 3
Pages: 384-95
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Publication
9175833 | J:40624
First Author: Beebe AM
Year: 1997
Journal: Immunity
Title: Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice.
Volume: 6
Issue: 5
Pages: 551-7
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Publication
25127137 | J:314320
First Author: Wang H
Year: 2014
Journal: Cell Rep
Title: Gli3 repressor controls cell fates and cell adhesion for proper establishment of neurogenic niche.
Volume: 8
Issue: 4
Pages: 1093-104
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Publication
29596938 | J:309497
First Author: Piao X
Year: 2019
Journal: J Allergy Clin Immunol
Title: Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation.
Volume: 143
Issue: 1
Pages: 213-228.e10
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Publication
26416771 | J:227211
 
First Author: Zhang Y
Year: 2015
Journal: Nat Commun
Title: Maternal bile acid transporter deficiency promotes neonatal demise.
Volume: 6
Pages: 8186
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Publication
28700664 | J:246066
First Author: Sundberg JP
Year: 2017
Journal: PLoS One
Title: Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Volume: 12
Issue: 7
Pages: e0180682
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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GO Term
GO:0038165 | oncostatin-M-mediated signaling pathway
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Publication
29038604 | J:255551
First Author: Ayaub EA
Year: 2017
Journal: Sci Rep
Title: Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis.
Volume: 7
Issue: 1
Pages: 13281
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Publication
19112126 | J:164636
First Author: Juan TS
Year: 2009
Journal: Vet Pathol
Title: Mice overexpressing murine oncostatin M (OSM) exhibit changes in hematopoietic and other organs that are distinct from those of mice overexpressing human OSM or bovine OSM.
Volume: 46
Issue: 1
Pages: 124-37
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Allele
Osm<em1Smoc> | MGI:7291477
Name: oncostatin M; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein
Q8K2Y9
Organism: Mus musculus/domesticus
Length: 453  
Fragment?: false
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Protein
Q8K2Y9-2
Organism: Mus musculus/domesticus
Length: 438  
Fragment?: false
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Strain
MGI:6429306 | C57BL/6JSmoc-Osm<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Protein Domain
IPR020956 | TF_Aft1_OSM
Type: Domain
Description: This region is found in the transcription factor Aft1 which is required for a wide range of stress responses. The OSM domain has been shown to be involved in the osmotic stress response [].
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Protein Domain
IPR001581 | Leukemia_IF/oncostatin
Type: Family
Description: On the basis of functional and structural similarities, the small cytokines leukemia inhibitory factor (LIF) and oncostatin (OSM) can be classified into a single family [, ].It has been said []that LIF and OSM can be included in the IL-6 family of cytokines, but while all these cytokines seem to be structurally related, the sequence similarity is not high enough to allow the use of a single consensus pattern.
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Publication
2026606 | -
First Author: Kallestad JC
Year: 1991
Journal: J Biol Chem
Title: Disulfide bond assignment and identification of regions required for functional activity of oncostatin M.
Volume: 266
Issue: 14
Pages: 8940-5
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Publication
18375981 | -
First Author: Gao J
Year: 2008
Journal: Nucleic Acids Res
Title: Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response.
Volume: 36
Issue: 9
Pages: 2838-51
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Publication
18775332 | -
First Author: Skiniotis G
Year: 2008
Journal: Mol Cell
Title: Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex.
Volume: 31
Issue: 5
Pages: 737-48
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Publication
22325776 | -
First Author: Dagil R
Year: 2012
Journal: Structure
Title: The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor.
Volume: 20
Issue: 2
Pages: 270-82
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Protein Domain
IPR019827 | Leukemia_IF/oncostatin_CS
Type: Conserved_site
Description: On the basis of functional and structural similarities, the small cytokines leukemia inhibitory factor (LIF) and oncostatin (OSM) can be classified into a single family [, ].It has been said []that LIF and OSM can be included in the IL-6 family of cytokines, but while all these cytokines seem to be structurally related, the sequence similarity is not high enough to allow the use of a single consensus pattern.The signature pattern for this entry is based on a conserved region in the C-terminal region. This region is centred on a conserved cysteine which has been shown, in OSM, to be involved in a disulphide bond [].
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Protein Domain
IPR040817 | LIFR_D2
Type: Domain
Description: This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif [, ]. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation [].
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Publication
1717982 | -
First Author: Rose TM
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6.
Volume: 88
Issue: 19
Pages: 8641-5
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Publication
1566332 | -
First Author: Hilton DJ
Year: 1992
Journal: Trends Biochem Sci
Title: LIF: lots of interesting functions.
Volume: 17
Issue: 2
Pages: 72-6
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Publication
17652170 | J:123404
First Author: Huyton T
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor.
Volume: 104
Issue: 31
Pages: 12737-42
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Publication
8404048 | J:14732
First Author: Giovannini M
Year: 1993
Journal: Cytogenet Cell Genet
Title: Tandem linkage of genes coding for leukemia inhibitory factor (LIF) and oncostatin M (OSM) on human chromosome 22.
Volume: 64
Issue: 3-4
Pages: 240-4
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Protein
P09056
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: false
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Protein
F8WH42
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: false
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