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Search results 101 to 178 out of 178 for Otop1

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:5439275
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729324
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5478602
Age: embryonic day 16.5
Note: Expression is near the apical surface in supporting cells in the extrastriolar regions of the sensory epithelium.
Specimen Label: 3,E,F
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6429877
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729324
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:6429885
Age: embryonic day 16.5
Note: Expression is in the gelatinous membrane/otoconia.
Specimen Label: 5D
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759721
Stage: TS21
Assay Id: MGI:5476788
Age: embryonic day 13.5
Specimen Label: 2A, B
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759722
Stage: TS22
Assay Id: MGI:5476788
Age: embryonic day 14.5
Specimen Label: 2C, D
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759724
Stage: TS24
Assay Id: MGI:5476788
Age: embryonic day 16.5
Specimen Label: 2E, F
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5439275
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759726
Stage: TS26
Assay Id: MGI:5478602
Age: embryonic day 18.5
Specimen Label: not shown
Detected: false
Specimen Num: 2
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3553527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:5476788
Age: postnatal day 0
Note: Expression is in the sensory epithelium and is absent in the striola region.
Specimen Label: 2G
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3553527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:5476788
Age: postnatal day 0
Note: Expression is in the sensory and transitionary epithelium.
Specimen Label: 2J
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3553528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5476788
Age: postnatal day 12
Note: Expression is in the sensory and transitionary epithelium, absent in striola region.
Specimen Label: 2K
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3553528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5476788
Age: postnatal month 6
Note: Expression is in the sensory and transitionary epithelium.
Specimen Label: 2L
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:5476763
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3553527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5476800
Age: postnatal day 0
Specimen Label: 4D,E
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
   
Probe: MGI:5476763
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3553527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5476800
Age: postnatal day 0
Specimen Label: 4F
Detected: true
Specimen Num: 5
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•
GXD Expression
GXD Expression
 
Probe: MGI:5476763
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3553528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5476800
Age: postnatal
Note: Expression is near the apical surface in supporting cells in the extrastriolar regions of the sensory epithelium.
Specimen Label: S1 A
Detected: true
Specimen Num: 6
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•
GXD Expression
GXD Expression
   
Probe: MGI:5476763
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3553528
Pattern: Punctate
Stage: TS28
Assay Id: MGI:5476800
Age: postnatal
Specimen Label: S1 B
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:5476763
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3553528
Pattern: Punctate
Stage: TS28
Assay Id: MGI:5476800
Age: postnatal
Specimen Label: S1 C
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:5439275
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3553528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5478602
Age: postnatal
Note: Signals are absent in the striola.
Specimen Label: S2,C,D
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
 
Probe: MGI:5439275
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3553528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5478602
Age: postnatal
Note: Signals are absent in the striola.
Specimen Label: S2 G,H
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5439275
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3279126
Stage: TS26
Assay Id: MGI:5478602
Age: embryonic day 18.5
Specimen Label: not shown
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6423791
Assay Type: RNA in situ
Annotation Date: 2020-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729524
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:6429884
Age: embryonic day 16.5
Note: Expression is in the sensory epithelium and is absent from nonsensory regions.
Specimen Label: 5B
Detected: true
Specimen Num: 1
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Publication
18355969 | J:136073
First Author: Zhao X
Year: 2008
Journal: Neuroscience
Title: Otoconin-90 deletion leads to imbalance but normal hearing: a comparison with other otoconia mutants.
Volume: 153
Issue: 1
Pages: 289-99
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Publication
18459000 | J:244092
First Author: Zhao X
Year: 2008
Journal: J Assoc Res Otolaryngol
Title: Osteopontin is not critical for otoconia formation or balance function.
Volume: 9
Issue: 2
Pages: 191-201
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Publication
- | J:30803
 
First Author: Lane PW
Year: 1986
Journal: Mouse News Lett
Title: Tilted (tlt)
Volume: 75
Pages: 28
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Publication
- | J:14115
 
First Author: Lane PW
Year: 1987
Journal: Mouse News Lett
Title: Tilted (tlt)
Volume: 77
Pages: 129
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Publication
10341082 | J:55078
First Author: Ying HC
Year: 1999
Journal: Mamm Genome
Title: High-resolution mapping of tlt, a mouse mutant lacking otoconia.
Volume: 10
Issue: 6
Pages: 544-8
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Publication
27792272 | J:237620
First Author: Xu Y
Year: 2016
Journal: Genesis
Title: Spatiotemporal differences in otoconial gene expression.
Volume: 54
Issue: 12
Pages: 613-625
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Publication
15109702 | J:89392
First Author: Jones SM
Year: 2004
Journal: Hear Res
Title: Gravity receptor function in mice with graded otoconial deficiencies.
Volume: 191
Issue: 1-2
Pages: 34-40
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Publication
16972005 | J:227974
First Author: Massironi SM
Year: 2006
Journal: Braz J Med Biol Res
Title: Inducing mutations in the mouse genome with the chemical mutagen ethylnitrosourea.
Volume: 39
Issue: 9
Pages: 1217-26
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Publication
20856818 | J:263439
First Author: Deans MR
Year: 2010
Journal: PLoS One
Title: Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.
Volume: 5
Issue: 9
Pages: e12765
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Publication
18719582 | J:138823
First Author: Seale P
Year: 2008
Journal: Nature
Title: PRDM16 controls a brown fat/skeletal muscle switch.
Volume: 454
Issue: 7207
Pages: 961-7
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Publication
23987512 | J:204551
First Author: Park JH
Year: 2013
Journal: Dev Cell
Title: A multifunctional protein, EWS, is essential for early brown fat lineage determination.
Volume: 26
Issue: 4
Pages: 393-404
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Publication
23536097 | J:196582
First Author: Romand R
Year: 2013
Journal: J Neurosci
Title: Retinoic acid deficiency impairs the vestibular function.
Volume: 33
Issue: 13
Pages: 5856-66
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Publication
11597144 | J:72229
First Author: Hurle B
Year: 2001
Journal: Genomics
Title: Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development.
Volume: 77
Issue: 3
Pages: 189-99
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: Proton channel OTOP1
Type: chain
End: 600
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Protein
Q80VM9
Organism: Mus musculus/domesticus
Length: 600  
Fragment?: false
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Protein
A0A5H1ZRK5
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
Q80VM9-2
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
Q80VM9-3
Organism: Mus musculus/domesticus
Length: 597  
Fragment?: false
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Publication
31160780 | -
First Author: Saotome K
Year: 2019
Journal: Nat Struct Mol Biol
Title: Structures of the otopetrin proton channels Otop1 and Otop3.
Volume: 26
Issue: 6
Pages: 518-525
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Publication
17606897 | -
First Author: Hughes I
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium.
Volume: 104
Issue: 29
Pages: 12023-8
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Allele
Tas1r3<em1(Otop1)Csz> | MGI:6728134
Name: taste receptor, type 1, member 3; endonuclease-mediated mutation 1, Charles S Zuker
Allele Type: Endonuclease-mediated
Attribute String: Inserted expressed sequence, Null/knockout
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Allele
Otop1<em1Csz> | MGI:6728127
Name: otopetrin 1; endonuclease-mediated mutation 1, Charles S Zuker
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Otop1<em2Csz> | MGI:6728128
Name: otopetrin 1; endonuclease-mediated mutation 2, Charles S Zuker
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein
Q80UF9
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: false
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Protein
Q80SX5
Organism: Mus musculus/domesticus
Length: 563  
Fragment?: false
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Protein
B7ZP39
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: false
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Protein
F8VQ32
Organism: Mus musculus/domesticus
Length: 596  
Fragment?: false
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Protein
Q9D7E9
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: false
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Publication
18254951 | -
 
First Author: Hughes I
Year: 2008
Journal: BMC Evol Biol
Title: Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members.
Volume: 8
Pages: 41
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Publication
30973323 | -
   
First Author: Chen Q
Year: 2019
Journal: Elife
Title: Structural and functional characterization of an otopetrin family proton channel.
Volume: 8
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Protein Domain
IPR004878 | Otopetrin
Type: Family
Description: The otopetrins are a group of proteins evolutionarily conserved among metazoan []. In most vertebrates there are three Otopetrin genes that encode three proteins, OTOP1, OTOP2, and OTOP3. All form proton-selective ion channels that allow influx of protons into cells []. The structure of otopetrin-1 () shows it to have 12 transmembrane domains, with three conserved sub-domains (OD-1 to OD-III) [, , ]. Otopetrins were initially thought to modulate calcium homeostasis and influx of calcium in response to extracellular ATP []but were subsequently shown to form proton-selective ion channels []. The otopetrins are required for normal formation of otoconia/otoliths in the inner ear. Otoconia are minute biomineral particles embedded in a gelatinous membrane that overlies the sensory epithelium in the inner ear. Gravity and acceleration cause the octoconia to deflect the stereocilia of sensory hair cells. Otoconia are required for normal processing of information regarding spatial orientation and acceleration []. OTOP1 also functions as a receptor for sour taste in mice [, ].
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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