Type |
Details |
Score |
Publication |
First Author: |
Spatazza J |
Year: |
2013 |
Journal: |
Cell Rep |
Title: |
Choroid-plexus-derived Otx2 homeoprotein constrains adult cortical plasticity. |
Volume: |
3 |
Issue: |
6 |
Pages: |
1815-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Broccoli V |
Year: |
1999 |
Journal: |
Nature |
Title: |
The caudal limit of Otx2 expression positions the isthmic organizer. |
Volume: |
401 |
Issue: |
6749 |
Pages: |
164-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Acampora D |
Year: |
2003 |
Journal: |
Gene Expr Patterns |
Title: |
OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm. |
Volume: |
3 |
Issue: |
4 |
Pages: |
497-501 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin O |
Year: |
2001 |
Journal: |
Int J Dev Biol |
Title: |
Otx2 and HNF3beta genetically interact in anterior patterning. |
Volume: |
45 |
Issue: |
1 |
Pages: |
357-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang J |
Year: |
2018 |
Journal: |
Nature |
Title: |
OTX2 restricts entry to the mouse germline. |
Volume: |
562 |
Issue: |
7728 |
Pages: |
595-599 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fossat N |
Year: |
2005 |
Journal: |
Dev Dyn |
Title: |
Alternative usage of Otx2 promoters during mouse development. |
Volume: |
233 |
Issue: |
1 |
Pages: |
154-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Johansson PA |
Year: |
2013 |
Journal: |
Development |
Title: |
The transcription factor Otx2 regulates choroid plexus development and function. |
Volume: |
140 |
Issue: |
5 |
Pages: |
1055-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Torero Ibad R |
Year: |
2020 |
Journal: |
eNeuro |
Title: |
OTX2 Non-Cell Autonomous Activity Regulates Inner Retinal Function. |
Volume: |
7 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kim HT |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons. |
Volume: |
13 |
Issue: |
5 |
Pages: |
990-1002 |
|
•
•
•
•
•
|
Publication |
First Author: |
Planques A |
Year: |
2019 |
Journal: |
eNeuro |
Title: |
OTX2 Signals from the Choroid Plexus to Regulate Adult Neurogenesis. |
Volume: |
6 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sherf O |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Otx2 Requires Lmx1b to Control the Development of Mesodiencephalic Dopaminergic Neurons. |
Volume: |
10 |
Issue: |
10 |
Pages: |
e0139697 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1309322 |
Assay Type: |
Western blot |
Annotation Date: |
2001-09-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:2150151 |
Age: |
embryonic day 7.5 |
Image: |
4 |
|
Specimen Label: |
Otx2 l/l |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1309322 |
Assay Type: |
Western blot |
Annotation Date: |
2001-09-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:2150151 |
Age: |
embryonic day 7.5 |
Image: |
4 |
|
Specimen Label: |
Otx2 +/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1309322 |
Assay Type: |
Western blot |
Annotation Date: |
2001-09-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:2150151 |
Age: |
embryonic day 7.5 |
Image: |
4 |
|
Specimen Label: |
Otx2 l/- |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2155340 |
Assay Type: |
Western blot |
Annotation Date: |
2002-01-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:2155396 |
Age: |
embryonic day 7.5 |
Image: |
8 |
|
Specimen Label: |
Otx2 +/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perea-Gomez A |
Year: |
2001 |
Journal: |
Development |
Title: |
Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo. |
Volume: |
128 |
Issue: |
5 |
Pages: |
753-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bernard C |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
Graded Otx2 activities demonstrate dose-sensitive eye and retina phenotypes. |
Volume: |
23 |
Issue: |
7 |
Pages: |
1742-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fant B |
Year: |
2015 |
Journal: |
Genesis |
Title: |
Comprehensive interactome of Otx2 in the adult mouse neural retina. |
Volume: |
53 |
Issue: |
11 |
Pages: |
685-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee HHC |
Year: |
2017 |
Journal: |
Mol Psychiatry |
Title: |
Genetic Otx2 mis-localization delays critical period plasticity across brain regions. |
Volume: |
22 |
Issue: |
5 |
Pages: |
680-688 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakai A |
Year: |
2017 |
Journal: |
Front Neurosci |
Title: |
Genome-Wide Target Analyses of Otx2 Homeoprotein in Postnatal Cortex. |
Volume: |
11 |
|
Pages: |
307 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
289
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
297
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Apulei J |
Year: |
2019 |
Journal: |
Cereb Cortex |
Title: |
Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g. |
Volume: |
29 |
Issue: |
6 |
Pages: |
2384-2395 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hide T |
Year: |
2002 |
Journal: |
Development |
Title: |
Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice. |
Volume: |
129 |
Issue: |
18 |
Pages: |
4347-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vernay B |
Year: |
2005 |
Journal: |
J Neurosci |
Title: |
Otx2 regulates subtype specification and neurogenesis in the midbrain. |
Volume: |
25 |
Issue: |
19 |
Pages: |
4856-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tripathi PP |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice. |
Volume: |
28 |
Issue: |
37 |
Pages: |
9271-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kinder SJ |
Year: |
2001 |
Journal: |
Int J Dev Biol |
Title: |
Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. |
Volume: |
45 |
Issue: |
1 |
Pages: |
347-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rhinn M |
Year: |
1998 |
Journal: |
Development |
Title: |
Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. |
Volume: |
125 |
Issue: |
5 |
Pages: |
845-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pensieri P |
Year: |
2021 |
Journal: |
eNeuro |
Title: |
Photoreceptor cKO of OTX2 Enhances OTX2 Intercellular Transfer in the Retina and Causes Photophobia. |
Volume: |
8 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Roger JE |
Year: |
2014 |
Journal: |
J Clin Invest |
Title: |
OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness. |
Volume: |
124 |
Issue: |
2 |
Pages: |
631-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ang SL |
Year: |
1996 |
Journal: |
Development |
Title: |
A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. |
Volume: |
122 |
Issue: |
1 |
Pages: |
243-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morsli H |
Year: |
1999 |
Journal: |
Development |
Title: |
Otx1 and Otx2 activities are required for the normal development of the mouse inner ear. |
Volume: |
126 |
Issue: |
11 |
Pages: |
2335-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fossat N |
Year: |
2006 |
Journal: |
EMBO Rep |
Title: |
Temporal and spatial delineation of mouse Otx2 functions by conditional self-knockout. |
Volume: |
7 |
Issue: |
8 |
Pages: |
824-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suda Y |
Year: |
1999 |
Journal: |
Development |
Title: |
Functional equivalency between Otx2 and Otx1 in development of the rostral head. |
Volume: |
126 |
Issue: |
4 |
Pages: |
743-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimura-Yoshida C |
Year: |
2004 |
Journal: |
Development |
Title: |
Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification. |
Volume: |
131 |
Issue: |
1 |
Pages: |
57-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mortensen AH |
Year: |
2015 |
Journal: |
Hum Mol Genet |
Title: |
Deletion of OTX2 in neural ectoderm delays anterior pituitary development. |
Volume: |
24 |
Issue: |
4 |
Pages: |
939-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Omodei D |
Year: |
2008 |
Journal: |
Development |
Title: |
Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon. |
Volume: |
135 |
Issue: |
20 |
Pages: |
3459-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sugiyama S |
Year: |
2008 |
Journal: |
Cell |
Title: |
Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity. |
Volume: |
134 |
Issue: |
3 |
Pages: |
508-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ruiz-Reig N |
Year: |
2019 |
Journal: |
J Neurosci |
Title: |
Developmental Requirement of Homeoprotein Otx2 for Specific Habenulo-Interpeduncular Subcircuits. |
Volume: |
39 |
Issue: |
6 |
Pages: |
1005-1019 |
|
•
•
•
•
•
|
Publication |
First Author: |
Di Giovannantonio LG |
Year: |
2014 |
Journal: |
Development |
Title: |
Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity. |
Volume: |
141 |
Issue: |
2 |
Pages: |
377-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Di Salvio M |
Year: |
2010 |
Journal: |
Nat Neurosci |
Title: |
Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP. |
Volume: |
13 |
Issue: |
12 |
Pages: |
1481-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Acampora D |
Year: |
1998 |
Journal: |
Development |
Title: |
Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation. |
Volume: |
125 |
Issue: |
24 |
Pages: |
5091-104 |
|
•
•
•
•
•
|
Publication |
First Author: |
Simeone A |
Year: |
1998 |
Journal: |
EMBO J |
Title: |
Otx1 and Otx2 in the development and evolution of the mammalian brain. |
Volume: |
17 |
Issue: |
23 |
Pages: |
6790-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Samuel A |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Otx2 ChIP-seq reveals unique and redundant functions in the mature mouse retina. |
Volume: |
9 |
Issue: |
2 |
Pages: |
e89110 |
|
•
•
•
•
•
|
Publication |
First Author: |
Acampora D |
Year: |
2001 |
Journal: |
Development |
Title: |
OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation. |
Volume: |
128 |
Issue: |
23 |
Pages: |
4801-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rhinn M |
Year: |
1999 |
Journal: |
Development |
Title: |
Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain. |
Volume: |
126 |
Issue: |
19 |
Pages: |
4295-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Larder R |
Year: |
2013 |
Journal: |
Mol Cell Endocrinol |
Title: |
Gene dosage of Otx2 is important for fertility in male mice. |
Volume: |
377 |
Issue: |
1-2 |
Pages: |
16-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Simeone A |
Year: |
1993 |
Journal: |
EMBO J |
Title: |
A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. |
Volume: |
12 |
Issue: |
7 |
Pages: |
2735-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koike C |
Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
Functional roles of Otx2 transcription factor in postnatal mouse retinal development. |
Volume: |
27 |
Issue: |
23 |
Pages: |
8318-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heimbucher T |
Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors. |
Volume: |
27 |
Issue: |
1 |
Pages: |
340-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suda Y |
Year: |
1996 |
Journal: |
Genes Cells |
Title: |
Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain. |
Volume: |
1 |
Issue: |
11 |
Pages: |
1031-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishida A |
Year: |
2003 |
Journal: |
Nat Neurosci |
Title: |
Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. |
Volume: |
6 |
Issue: |
12 |
Pages: |
1255-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ip CK |
Year: |
2014 |
Journal: |
Development |
Title: |
Head formation: OTX2 regulates Dkk1 and Lhx1 activity in the anterior mesendoderm. |
Volume: |
141 |
Issue: |
20 |
Pages: |
3859-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurokawa D |
Year: |
2004 |
Journal: |
Development |
Title: |
Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. |
Volume: |
131 |
Issue: |
14 |
Pages: |
3319-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Millet S |
Year: |
1999 |
Journal: |
Nature |
Title: |
A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer. |
Volume: |
401 |
Issue: |
6749 |
Pages: |
161-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurokawa D |
Year: |
2004 |
Journal: |
Development |
Title: |
Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm. |
Volume: |
131 |
Issue: |
14 |
Pages: |
3307-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suda Y |
Year: |
1997 |
Journal: |
Mech Dev |
Title: |
Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain. |
Volume: |
69 |
Issue: |
1-2 |
Pages: |
125-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Borgkvist A |
Year: |
2006 |
Journal: |
Mol Cell Neurosci |
Title: |
Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice. |
Volume: |
31 |
Issue: |
2 |
Pages: |
293-302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ang SL |
Year: |
1994 |
Journal: |
Development |
Title: |
Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. |
Volume: |
120 |
Issue: |
10 |
Pages: |
2979-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Binato R |
Year: |
2007 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Otx2 is a putative candidate to activate mice Msx1 gene from distal enhancer. |
Volume: |
358 |
Issue: |
2 |
Pages: |
655-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Housset M |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
Loss of Otx2 in the adult retina disrupts retinal pigment epithelium function, causing photoreceptor degeneration. |
Volume: |
33 |
Issue: |
24 |
Pages: |
9890-904 |
|
•
•
•
•
•
|
Publication |
First Author: |
Béby F |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration. |
Volume: |
5 |
Issue: |
7 |
Pages: |
e11673 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beurdeley M |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex. |
Volume: |
32 |
Issue: |
27 |
Pages: |
9429-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bhansali P |
Year: |
2020 |
Journal: |
Dev Dyn |
Title: |
A distal enhancer that directs Otx2 expression in the retinal pigment epithelium and neuroretina. |
Volume: |
249 |
Issue: |
2 |
Pages: |
209-221 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimura C |
Year: |
2001 |
Journal: |
Dev Biol |
Title: |
Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast. |
Volume: |
235 |
Issue: |
1 |
Pages: |
12-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Emerson MM |
Year: |
2013 |
Journal: |
Dev Cell |
Title: |
Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors. |
Volume: |
26 |
Issue: |
1 |
Pages: |
59-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baas D |
Year: |
2000 |
Journal: |
Brain Res Mol Brain Res |
Title: |
The subcellular localization of Otx2 is cell-type specific and developmentally regulated in the mouse retina. |
Volume: |
78 |
Issue: |
1-2 |
Pages: |
26-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurokawa D |
Year: |
2014 |
Journal: |
Dev Biol |
Title: |
Otx2 expression in anterior neuroectoderm and forebrain/midbrain is directed by more than six enhancers. |
Volume: |
387 |
Issue: |
2 |
Pages: |
203-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Puelles E |
Year: |
2006 |
Journal: |
J Neurosci |
Title: |
Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation. |
Volume: |
26 |
Issue: |
22 |
Pages: |
5955-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Frantz GD |
Year: |
1994 |
Journal: |
J Neurosci |
Title: |
Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum. |
Volume: |
14 |
Issue: |
10 |
Pages: |
5725-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto H |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development. |
Volume: |
30 |
Issue: |
3 |
Pages: |
658-671.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Di Giovannantonio LG |
Year: |
2013 |
Journal: |
Dev Biol |
Title: |
Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability. |
Volume: |
373 |
Issue: |
1 |
Pages: |
176-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inoue F |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with class III POU factors. |
Volume: |
32 |
Issue: |
13 |
Pages: |
2618-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Spieler D |
Year: |
2004 |
Journal: |
Dev Biol |
Title: |
Involvement of Pax6 and Otx2 in the forebrain-specific regulation of the vertebrate homeobox gene ANF/Hesx1. |
Volume: |
269 |
Issue: |
2 |
Pages: |
567-79 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5439552 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-04-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6402609 |
Age: |
postnatal month 1 |
|
|
Specimen Label: |
2A Otx2 Crx+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5439552 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-04-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6402609 |
Age: |
postnatal month 1 |
|
|
Specimen Label: |
2A Otx2 Crx-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2150046 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-09-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160589 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:2150147 |
Age: |
embryonic day 6.5 |
|
Note: |
Expression in the mutant is similar to that seen in wild type. |
Specimen Label: |
Not shown Otx2 l/l |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2150046 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-09-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1605811 |
Pattern: |
Not Specified |
Stage: |
TS11 |
Assay Id: |
MGI:2150147 |
Age: |
embryonic day 7.5 |
|
Note: |
Expression in the mutant is similar to that seen in wild type. |
Specimen Label: |
Not shown Otx2 l/l |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2150046 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-09-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607311 |
Pattern: |
Regionally restricted |
Stage: |
TS11 |
Assay Id: |
MGI:2150147 |
Age: |
embryonic day 7.5 |
|
Note: |
Expression is anterior. Expression in the mutant is similar to that seen in wild type. |
Specimen Label: |
Not shown Otx2 l/l |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2150046 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-09-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3276211 |
Pattern: |
Regionally restricted |
Stage: |
TS11 |
Assay Id: |
MGI:2150147 |
Age: |
embryonic day 7.5 |
|
Note: |
Expression is present in the axial mesendoderm. Expression in the mutant is similar to that seen in wild type. |
Specimen Label: |
Not shown Otx2 l/l |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mallamaci A |
Year: |
1996 |
Journal: |
Mech Dev |
Title: |
OTX2 homeoprotein in the developing central nervous system and migratory cells of the olfactory area. |
Volume: |
58 |
Issue: |
1-2 |
Pages: |
165-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boyl PP |
Year: |
2001 |
Journal: |
Development |
Title: |
Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR. |
Volume: |
128 |
Issue: |
15 |
Pages: |
2989-3000 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fossat N |
Year: |
2007 |
Journal: |
BMC Dev Biol |
Title: |
A new GFP-tagged line reveals unexpected Otx2 protein localization in retinal photoreceptors. |
Volume: |
7 |
|
Pages: |
122 |
|
•
•
•
•
•
|
Publication |
First Author: |
Panman L |
Year: |
2014 |
Journal: |
Cell Rep |
Title: |
Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons. |
Volume: |
8 |
Issue: |
4 |
Pages: |
1018-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tian E |
Year: |
2002 |
Journal: |
Dev Biol |
Title: |
Otx2 is required to respond to signals from anterior neural ridge for forebrain specification. |
Volume: |
242 |
Issue: |
2 |
Pages: |
204-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimura C |
Year: |
1997 |
Journal: |
Development |
Title: |
Cis-acting elements conserved between mouse and pufferfish Otx2 genes govern the expression in mesencephalic neural crest cells. |
Volume: |
124 |
Issue: |
20 |
Pages: |
3929-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakurai Y |
Year: |
2010 |
Journal: |
Dev Biol |
Title: |
Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization. |
Volume: |
347 |
Issue: |
2 |
Pages: |
392-403 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li JY |
Year: |
2001 |
Journal: |
Development |
Title: |
Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression. |
Volume: |
128 |
Issue: |
24 |
Pages: |
4979-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Puelles E |
Year: |
2004 |
Journal: |
Development |
Title: |
Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain. |
Volume: |
131 |
Issue: |
9 |
Pages: |
2037-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muranishi Y |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
An essential role for RAX homeoprotein and NOTCH-HES signaling in Otx2 expression in embryonic retinal photoreceptor cell fate determination. |
Volume: |
31 |
Issue: |
46 |
Pages: |
16792-807 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao J |
Year: |
2013 |
Journal: |
Biomed Res Int |
Title: |
Changes in Otx2 and parvalbumin immunoreactivity in the superior colliculus in the platelet-derived growth factor receptor-β knockout mice. |
Volume: |
2013 |
|
Pages: |
848265 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoch RV |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum. |
Volume: |
12 |
Issue: |
3 |
Pages: |
482-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen Ba-Charvet KT |
Year: |
1998 |
Journal: |
Development |
Title: |
A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain. |
Volume: |
125 |
Issue: |
21 |
Pages: |
4273-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Westenskow P |
Year: |
2009 |
Journal: |
Development |
Title: |
Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression. |
Volume: |
136 |
Issue: |
15 |
Pages: |
2505-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vendrell V |
Year: |
2015 |
Journal: |
Development |
Title: |
Otx2 is a target of N-myc and acts as a suppressor of sensory development in the mammalian cochlea. |
Volume: |
142 |
Issue: |
16 |
Pages: |
2792-800 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimura J |
Year: |
2005 |
Journal: |
J Neurosci |
Title: |
Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium. |
Volume: |
25 |
Issue: |
21 |
Pages: |
5097-108 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1346400 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-10-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1647015 |
Pattern: |
Regionally restricted |
Stage: |
TS15 |
Assay Id: |
MGI:1346420 |
Age: |
embryonic day 9.5 |
Image: |
3M |
Note: |
Otx2 is expressed in anterior neurectoderm. |
Specimen Label: |
3M |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
207
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
289
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Martinez-Barbera JP |
Year: |
2001 |
Journal: |
Development |
Title: |
Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2. |
Volume: |
128 |
Issue: |
23 |
Pages: |
4789-800 |
|
•
•
•
•
•
|