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Search results 101 to 174 out of 174 for Pacsin2

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Hits by Strain

Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:7526219
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2760527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7526221
Age: postnatal newborn
Note: Strong apical labeling.
Specimen Label: 2a2/3
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:7526219
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2760527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7526221
Age: postnatal newborn
Note: Strong apical labeling.
Specimen Label: 2a4/5
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:7526219
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1897627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7526305
Age: postnatal newborn
Note: Expressed on the primary cilia.
Specimen Label: 3b
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7526219
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2823927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7526221
Age: postnatal newborn
Specimen Label: 2b1/2
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:7526219
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2823928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7526221
Age: postnatal month 3
Note: There was a remarkable upregulation.
Specimen Label: 2b3/4
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691454
Age: postnatal adult
Image: JAX_1803892
Specimen Label: JAX_1803892
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3273028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691454
Age: postnatal adult
Image: JAX_1803899
Specimen Label: JAX_1803899
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691454
Age: postnatal adult
Image: JAX_1803890
Specimen Label: JAX_1803890
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691454
Age: postnatal adult
Image: JAX_1803894
Specimen Label: JAX_1803894
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691454
Age: postnatal adult
Image: JAX_1803897
Specimen Label: JAX_1803897
Detected: true
Specimen Num: 12
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Publication
10431838 | J:56265
First Author: Ritter B
Year: 1999
Journal: FEBS Lett
Title: PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins.
Volume: 454
Issue: 3
Pages: 356-62
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Publication
23235565 | J:315020
First Author: Yao G
Year: 2013
Journal: Kidney Int
Title: The cytoplasmic protein Pacsin 2 in kidney development and injury repair.
Volume: 83
Issue: 3
Pages: 426-37
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Publication
11082044 | J:66805
 
First Author: Modregger J
Year: 2000
Journal: J Cell Sci
Title: All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.
Volume: 113 Pt 24
Pages: 4511-21
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Publication
24385601 | J:209160
First Author: Yao G
Year: 2014
Journal: Hum Mol Genet
Title: Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex.
Volume: 23
Issue: 10
Pages: 2769-79
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Publication
15930129 | J:101755
First Author: Braun A
Year: 2005
Journal: Mol Biol Cell
Title: EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling.
Volume: 16
Issue: 8
Pages: 3642-58
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Publication
24013648 | J:201740
First Author: Ludwig A
Year: 2013
Journal: PLoS Biol
Title: Molecular composition and ultrastructure of the caveolar coat complex.
Volume: 11
Issue: 8
Pages: e1001640
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Publication
32888949 | J:319821
 
First Author: Li K
Year: 2021
Journal: Metabolism
Title: Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice.
Volume: 114
Pages: 154349
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Publication
29107716 | J:276621
 
First Author: Semmler J
Year: 2018
Journal: Pharmacol Res
Title: Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.
Volume: 128
Pages: 200-210
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Publication
26884322 | J:259558
 
First Author: Bhattacharyya S
Year: 2016
Journal: Sci Rep
Title: Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.
Volume: 6
Pages: 20727
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Publication
23793062 | J:205441
First Author: Liang Y
Year: 2013
Journal: Nat Immunol
Title: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Volume: 14
Issue: 8
Pages: 858-66
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Publication
23604909 | J:198500
First Author: Nakahara M
Year: 2013
Journal: Mamm Genome
Title: Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice.
Volume: 24
Issue: 5-6
Pages: 228-39
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Publication
16537572 | J:108241
First Author: Desai J
Year: 2006
Journal: Hum Mol Genet
Title: Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Volume: 15
Issue: 8
Pages: 1329-41
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
25838348 | J:224105
First Author: Begonja AJ
Year: 2015
Journal: Blood
Title: FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.
Volume: 126
Issue: 1
Pages: 80-8
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Publication
26092940 | -
First Author: Senju Y
Year: 2015
Journal: J Cell Sci
Title: Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane.
Volume: 128
Issue: 15
Pages: 2766-80
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Protein Domain
IPR035743 | PACSIN1/PACSIN2_SH3
Type: Domain
Description: PACSIN1 and PACSIN2 belong to the PACSIN family that contains a N-terminal F-BAR (FCH-BAR) domain and a C-terminal SH3 domain []. They are cytoplasmic phosphoproteins that play a role in vesicle formation and transport [].PACSIN1 (also known as Syndapin-1) is upregulated upon differentiation into neuronal cells []. The SH3 domain of PACSIN1 mediates activation of neural WASP (N-WASP), which is required to regulate actin polymerisation and is essential for proper neuromorphogenesis and cellular motility []. Two phosphorylation sites within the F-BAR domain of PACSIN1 are used for membrane tubulation regulation []. PACSIN2 interacts with several proteins such as Rac1, dynamin, Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP), and synaptojanin via its C-terminal SH3 domain []. PACSIN2 negatively regulates the EGF (epidermal growth factor) receptor activation and signaling [, ]. It plays an important role in caveolae membrane sculpting []. This entry represents the SH3 domain of PACSINs 1 and 2.
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Protein Domain
IPR037453 | PACSIN2_F-BAR
Type: Domain
Description: PACSIN2 (protein kinase C and casein kinase substrate in neurons protein 2, also known as Syndapin-2) belongs to the PACSIN family that contains a N-terminal F-BAR (FCH-BAR) domain and a C-terminal SH3 domain []. They are cytoplasmic phosphoproteins that play a role in vesicle formation and transport []. PACSIN2 interacts with several proteins such as Rac1, dynamin, Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP), and synaptojanin via its C-terminal Src homology 3 (SH3) domain []. PACSIN2 negatively regulates the EGF (epidermal growth factor) receptor activation and signaling [, ]. It plays an important role in caveolae membrane sculpting []. This entry represents the F-BAR domain of PACSIN2. F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization [].
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Publication
17761170 | J:201255
First Author: Thornhill PB
Year: 2007
Journal: FEBS Lett
Title: A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells.
Volume: 581
Issue: 23
Pages: 4455-62
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Publication
9746365 | J:55204
First Author: Plomann M
Year: 1998
Journal: Eur J Biochem
Title: PACSIN, a brain protein that is upregulated upon differentiation into neuronal cells.
Volume: 256
Issue: 1
Pages: 201-11
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Publication
19846719 | -
First Author: Dharmalingam E
Year: 2009
Journal: J Neurosci
Title: F-BAR proteins of the syndapin family shape the plasma membrane and are crucial for neuromorphogenesis.
Volume: 29
Issue: 42
Pages: 13315-27
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Publication
22355135 | J:182137
First Author: Quan A
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation.
Volume: 109
Issue: 10
Pages: 3760-5
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Publication
22323287 | J:197000
First Author: Morén B
Year: 2012
Journal: Mol Biol Cell
Title: EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization.
Volume: 23
Issue: 7
Pages: 1316-29
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Publication
19549836 | -
First Author: Wang Q
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin.
Volume: 106
Issue: 31
Pages: 12700-5
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Protein
Q61644
Organism: Mus musculus/domesticus
Length: 441  
Fragment?: false
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Protein
Q543Y7
Organism: Mus musculus/domesticus
Length: 441  
Fragment?: false
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Protein
Q3TYF2
Organism: Mus musculus/domesticus
Length: 441  
Fragment?: false
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