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Search results 101 to 200 out of 202 for Pak4

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1775122
Pattern: Scattered
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3274122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3287422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3266022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1624622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Note: Expression was weak in the digestive system.
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721422
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1646922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1683322
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1700022
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1832122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Note: Expression was not detected in the immune system.
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1741222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1833322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3287022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1821522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1738322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Note: Expression was weak in whisker follicle.
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
Publication
14517284 | J:85956
First Author: Li X
Year: 2003
Journal: Mol Cell Biol
Title: Targeted disruption of the gene for the PAK5 kinase in mice.
Volume: 23
Issue: 20
Pages: 7134-42
•
•
•
•
•
Publication
23509247 | J:194236
First Author: Dolan BM
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.
Volume: 110
Issue: 14
Pages: 5671-6
•
•
•
•
•
Publication
38079473 | J:357470
First Author: Hu B
Year: 2024
Journal: Brain
Title: PAK2 is necessary for myelination in the peripheral nervous system.
Volume: 147
Issue: 5
Pages: 1809-1821
•
•
•
•
•
Publication
16300676 | J:104456
 
First Author: Michaud EJ
Year: 2005
Journal: BMC Genomics
Title: Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice.
Volume: 6
Pages: 164
•
•
•
•
•
Publication
26002917 | J:239366
First Author: Chintala H
Year: 2015
Journal: Development
Title: The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling.
Volume: 142
Issue: 13
Pages: 2364-74
•
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•
•
•
Publication
24472646 | J:229358
 
First Author: Teo ZL
Year: 2014
Journal: Exp Eye Res
Title: Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.
Volume: 121
Pages: 130-42
•
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•
•
•
Publication
26273529 | J:227247
 
First Author: Brommage R
Year: 2014
Journal: Bone Res
Title: High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.
Volume: 2
Pages: 14034
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•
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Publication
- | J:165963
     
First Author: Centre for Modeling Human Disease
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
•
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•
•
•
Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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•
•
•
•
Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
•
•
•
•
•
Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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•
•
•
•
Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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•
•
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
•
•
•
•
•
Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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•
•
•
•
Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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•
•
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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•
•
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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•
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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•
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
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•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
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•
•
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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•
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
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•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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•
•
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
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•
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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•
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE200913 | Effect of Pak4 deficiency on transcriptome in liver of mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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UniProt Feature
UniProt Feature
Begin: 143
Description: Phosphoserine; by PAK4
Type: modified residue
End: 143
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UniProt Feature
UniProt Feature
Begin: 895
Description: Phosphoserine; by PAK4
Type: modified residue
End: 895
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HT Experiment
GSE214769 | Effect of Pak4 deficiency on transcriptomic profile in eWAT of mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
36301793 | J:330575
First Author: Yamada S
Year: 2022
Journal: PLoS Genet
Title: Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development.
Volume: 18
Issue: 10
Pages: e1010438
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Publication
30685413 | J:271221
 
First Author: Liu X
Year: 2019
Journal: Cancer Lett
Title: miR-193a-3p inhibition of the Slug activator PAK4 suppresses non-small cell lung cancer aggressiveness via the p53/Slug/L1CAM pathway.
Volume: 447
Pages: 56-65
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Publication
11413130 | -
First Author: Dan C
Year: 2001
Journal: J Biol Chem
Title: Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin.
Volume: 276
Issue: 34
Pages: 32115-21
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Publication
26607847 | -
 
First Author: Baskaran Y
Year: 2015
Journal: Nat Commun
Title: An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1.
Volume: 6
Pages: 8681
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Publication
21381077 | -
First Author: Nekrasova T
Year: 2011
Journal: J Cell Biochem
Title: PAK4 is required for regulation of the cell-cycle regulatory protein p21, and for control of cell-cycle progression.
Volume: 112
Issue: 7
Pages: 1795-806
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Publication
30485810 | J:270789
First Author: Lee S
Year: 2018
Journal: Cell Rep
Title: Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity.
Volume: 25
Issue: 9
Pages: 2417-2430.e5
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Protein
Q3U261
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
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Protein
Q8CG12
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
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Publication
31225512 | -
First Author: Keller L
Year: 2019
Journal: Cell Stress
Title: Biology and clinical relevance of EpCAM.
Volume: 3
Issue: 6
Pages: 165-180
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Publication
22819673 | J:190580
First Author: Lei Z
Year: 2012
Journal: Dev Biol
Title: EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins.
Volume: 371
Issue: 2
Pages: 136-45
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Publication
20651236 | -
First Author: Nakatsukasa M
Year: 2010
Journal: Am J Pathol
Title: Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy.
Volume: 177
Issue: 3
Pages: 1344-55
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Publication
18281513 | -
First Author: Wang J
Year: 2008
Journal: Mol Cancer Ther
Title: Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers.
Volume: 7
Issue: 2
Pages: 280-5
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Publication
31177095 | -
First Author: Mori Y
Year: 2019
Journal: J Biol Chem
Title: Trophoblast cell surface antigen 2 (Trop-2) phosphorylation by protein kinase C α/δ (PKCα/δ) enhances cell motility.
Volume: 294
Issue: 30
Pages: 11513-11524
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Publication
30628064 | -
First Author: Yahyazadeh Mashhadi SM
Year: 2019
Journal: J Cell Physiol
Title: Shedding light on the EpCAM: An overview.
Volume: 234
Issue: 8
Pages: 12569-12580
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Publication
23536555 | -
First Author: Trerotola M
Year: 2013
Journal: Cancer Res
Title: Trop-2 promotes prostate cancer metastasis by modulating β(1) integrin functions.
Volume: 73
Issue: 10
Pages: 3155-67
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Protein Domain
IPR043406 | EPCAM/Trop-2
Type: Family
Description: This entry includes transmembrane glycoprotein EpCAM (epithelial cell adhesion molecule, also known as Trop-1) and Trop-2 (also known as tumor-associated calcium signal transducer 2, TACSTD2). They belong to the tumour-associated calcium signal transducer (TACSTD) family. They have been reported to directly interact with claudin-1 and claudin-7 [, , ]. EpCAM mediates homotypic cell contacts in epithelia tissues and regulates cell proliferation and cancer stemness. It has been used as a diagnostic marker for circulating tumour cells (CTCs) in the blood []. EpCAM has been shown to contribute to formation of intestinal barrier by recruiting claudins to cell-cell junctions []. Mutations in the EpCAM gene lead to congenital tufting enteropathy, severe intestinal epithelium homeostasis disorders, and Lynch syndrome []. Trop-2 is highly expressed in a variety of epithelial cancer cells. It has been identified as an oncogene leading to invasiveness and tumorigenesis []. It has been shown to regulate integrin-dependent signalling for cell-substrate adhesion and cell migration. It also modulates Rac1 GTPase activity and induces activation of PAK4 [].
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Publication
18675265 | J:141962
First Author: Nekrasova T
Year: 2008
Journal: Dev Biol
Title: Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion.
Volume: 322
Issue: 1
Pages: 95-108
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Publication
23593460 | J:200575
First Author: Furnari MA
Year: 2013
Journal: PLoS One
Title: Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice.
Volume: 8
Issue: 4
Pages: e61321
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Publication
36586159 | J:333156
 
First Author: Yamada S
Year: 2023
Journal: Biochem Biophys Res Commun
Title: Inka2 expression in smooth muscle cells and its involvement in cell migration.
Volume: 643
Pages: 55-60
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Publication
27486147 | J:240343
First Author: Barry DM
Year: 2016
Journal: Circ Res
Title: Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II.
Volume: 119
Issue: 7
Pages: 810-26
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Protein
Q99JW5
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
Q8BGV3
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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