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Search results 101 to 190 out of 190 for Palb2

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798830
Specimen Label: JAX_1798830
Detected: true
Specimen Num: 42
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798807
Specimen Label: JAX_1798807
Detected: true
Specimen Num: 19
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798811
Specimen Label: JAX_1798811
Detected: true
Specimen Num: 23
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Publication
29426838 | J:262752
First Author: Chiang HC
Year: 2018
Journal: Sci Rep
Title: Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development.
Volume: 8
Issue: 1
Pages: 2731
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Publication
31242413 | J:294372
First Author: Brandsma I
Year: 2019
Journal: Cell Rep
Title: HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
Volume: 27
Issue: 13
Pages: 3790-3798.e7
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
24870022 | J:215229
First Author: Pauty J
Year: 2014
Journal: Biochem J
Title: Exploring the roles of PALB2 at the crossroads of DNA repair and cancer.
Volume: 460
Issue: 3
Pages: 331-42
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Publication
34548335 | J:316877
First Author: Pulver EM
Year: 2021
Journal: Cancer Res
Title: A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair.
Volume: 81
Issue: 24
Pages: 6171-6182
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Interaction Experiment
Bowman-Colin C (2013)
Description: Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.
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DO Term
DOID:0111094 | Fanconi anemia complementation group N
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Publication
20332121 | -
First Author: Hayakawa T
Year: 2010
Journal: J Cell Sci
Title: MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.
Volume: 123
Issue: Pt 7
Pages: 1124-30
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Protein
D3Z7I5
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Publication
19413330 | J:192795
First Author: Gauci S
Year: 2009
Journal: Anal Chem
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Volume: 81
Issue: 11
Pages: 4493-501
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Publication
9396801 | -
First Author: Kovalenko OV
Year: 1997
Journal: Nucleic Acids Res
Title: A novel nucleic acid-binding protein that interacts with human rad51 recombinase.
Volume: 25
Issue: 24
Pages: 4946-53
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Protein Domain
IPR026632 | RAD51-assoc_prot_1
Type: Family
Description: RAD51-associated protein 1 may participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair []. It functionally cooperates with PALB2 in promoting of D-loop formation by RAD51 [, ]. It binds to single and double stranded DNA, and is capable of aggregating DNA []. It also binds RNA []. It is phosphorylated upon DNA damage, probably by ATM or ATR [, , ].
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Protein
Q8C551
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Protein
A0A0R4J1H1
Organism: Mus musculus/domesticus
Length: 336  
Fragment?: false
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Protein
A0A0R4J1G4
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Publication
16990250 | -
First Author: Kovalenko OV
Year: 2006
Journal: Nucleic Acids Res
Title: RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51.
Volume: 34
Issue: 18
Pages: 5081-92
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Publication
31653568 | J:286257
First Author: Callen E
Year: 2020
Journal: Mol Cell
Title: 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.
Volume: 77
Issue: 1
Pages: 26-38.e7
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Publication
30257212 | J:271205
First Author: Nacson J
Year: 2018
Journal: Cell Rep
Title: BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
Volume: 24
Issue: 13
Pages: 3513-3527.e7
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Publication
25483966 | J:310371
First Author: Cicchini M
Year: 2014
Journal: Autophagy
Title: Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity.
Volume: 10
Issue: 11
Pages: 2036-52
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Publication
21557222 | J:173250
First Author: Tischkowitz M
Year: 2011
Journal: J Pathol
Title: Using mouse models to investigate the biological and physiological consequences of defects in the Fanconi anaemia/breast cancer DNA repair signalling pathway.
Volume: 224
Issue: 3
Pages: 301-5
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Publication
22863773 | J:188614
First Author: Godon C
Year: 2012
Journal: EMBO J
Title: Generation of DNA single-strand displacement by compromised nucleotide excision repair.
Volume: 31
Issue: 17
Pages: 3550-63
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Publication
7951246 | -
First Author: Nouspikel T
Year: 1994
Journal: Hum Mol Genet
Title: Mutations that disable the DNA repair gene XPG in a xeroderma pigmentosum group G patient.
Volume: 3
Issue: 6
Pages: 963-7
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Publication
8855246 | -
First Author: Habraken Y
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Transcription factor TFIIH and DNA endonuclease Rad2 constitute yeast nucleotide excision repair factor 3: implications for nucleotide excision repair and Cockayne syndrome.
Volume: 93
Issue: 20
Pages: 10718-22
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Publication
12110180 | -
First Author: Lee SK
Year: 2002
Journal: Cell
Title: Requirement of yeast RAD2, a homolog of human XPG gene, for efficient RNA polymerase II transcription. implications for Cockayne syndrome.
Volume: 109
Issue: 7
Pages: 823-34
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Publication
32522879 | -
First Author: Tsutakawa SE
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.
Volume: 117
Issue: 25
Pages: 14127-14138
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Publication
26833090 | J:233035
First Author: Trego KS
Year: 2016
Journal: Mol Cell
Title: Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability.
Volume: 61
Issue: 4
Pages: 535-546
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Publication
18669648 | -
First Author: Dephoure N
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A quantitative atlas of mitotic phosphorylation.
Volume: 105
Issue: 31
Pages: 10762-7
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Publication
12397079 | -
First Author: Pardo PS
Year: 2002
Journal: J Biol Chem
Title: MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation.
Volume: 277
Issue: 52
Pages: 50860-6
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Protein Domain
IPR038011 | MRG15
Type: Family
Description: Mortality factor 4-like protein 1 (MORF4L1 or MRG15) is a transcription factor and a chromodomain protein. It is a component of the NuA4 histone acetyltransferase complex [], the Sin3 complex which acts to repress transcription by deacetylation of nucleosomal histones [], and the nuclear protein complexes MAF1 and MAF2 []. MRG15 also interacts with the BRCA complex, especially with subunit PALB2 []. MRG15 has an MRG domain in its C-terminal region, which interacts with the nucleoprotein PAM14 during transcriptional regulation [].The NuA4 histone acetyltransferase complex (also known as the TRRAP/TIP60-containing histone acetyltransferase complex) acetylates nucleosomal histones H4 and H2A thereby activating selected genes for transcription and is a a key regulator of transcription, cellular response to DNA damage and cell cycle control []. In yeast, where the complex was first identified, NuA4 consists of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2 []. In humans, the complex is composed of the histone acetyltransferase KAT5 (also known as TIP60) plus the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, MAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 [].
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Protein Domain
IPR001044 | XPG/Rad2_eukaryotes
Type: Family
Description: This entry represents XPG (ERCC-5, alsoknown as Rad2 in budding yeast, AtRAD2 or UVH3 in Arabidopsis and Rad13 in fission yeast), a single-stranded structure-specific DNA endonuclease, which cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA []. It makes the 3' incision in DNA nucleotide excision repair (NER); it binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble [, ]. XPG is required for DNA replication fork maintenance and preservation of genomic stability [, ]. It is involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site []. During HRR, binds to the replication fork with high specificity and stabilizes it []and upstream of HRR, it promotes the release of BRCA1 from DNA [].In Saccharomyces cerevisiae, Rad2 forms the Nucleotide Excision Repair Factor 3 (NEF3) complex with a subset of subunits of the transcription factor TFIIH []. Besides DNA damage repair, it is also required for efficient transcription []. Defects in XPG are the cause of xeroderma pigmentosum complementation group G (XP-G), which is an autosomal recessive pigmentary skin disorder characterised by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities [].
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Publication
17525332 | -
First Author: Matsuoka S
Year: 2007
Journal: Science
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Volume: 316
Issue: 5828
Pages: 1160-6
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Publication
17008723 | -
First Author: Zhang P
Year: 2006
Journal: Protein Sci
Title: The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14.
Volume: 15
Issue: 10
Pages: 2423-34
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Protein
A0A087WQ34
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
Q5DTS9
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: true
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Protein
Q3U5J6
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: true
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Protein
P60762
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: false
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Protein
P35689
Organism: Mus musculus/domesticus
Length: 1170  
Fragment?: false
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Protein
Q6P9Q0
Organism: Mus musculus/domesticus
Length: 790  
Fragment?: true
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Protein
Q569V4
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
Q3TUN4
Organism: Mus musculus/domesticus
Length: 898  
Fragment?: true
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Protein
B2RUC3
Organism: Mus musculus/domesticus
Length: 1170  
Fragment?: false
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Protein
A0A087WQB0
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein
Q3UV64
Organism: Mus musculus/domesticus
Length: 1166  
Fragment?: true
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Protein
Q3TUT3
Organism: Mus musculus/domesticus
Length: 644  
Fragment?: true
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Protein
Q3UBK1
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
Q3UIS6
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
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Protein
Q3TPQ3
Organism: Mus musculus/domesticus
Length: 1043  
Fragment?: true
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Protein
Q8CAG2
Organism: Mus musculus/domesticus
Length: 274  
Fragment?: true
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Protein
E9QM61
Organism: Mus musculus/domesticus
Length: 1170  
Fragment?: false
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Publication
32821917 | -
First Author: González-Corrochano R
Year: 2020
Journal: Nucleic Acids Res
Title: The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair.
Volume: 48
Issue: 17
Pages: 9943-9958
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Publication
14966270 | J:320265
First Author: Doyon Y
Year: 2004
Journal: Mol Cell Biol
Title: Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.
Volume: 24
Issue: 5
Pages: 1884-96
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Publication
15045029 | -
First Author: Kobor MS
Year: 2004
Journal: PLoS Biol
Title: A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin.
Volume: 2
Issue: 5
Pages: E131
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Publication
15196461 | -
First Author: Doyon Y
Year: 2004
Journal: Curr Opin Genet Dev
Title: The highly conserved and multifunctional NuA4 HAT complex.
Volume: 14
Issue: 2
Pages: 147-54
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom