Type |
Details |
Score |
Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
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•
•
•
•
•
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Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
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•
•
•
•
•
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Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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•
•
•
•
•
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Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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•
•
•
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•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
•
•
•
•
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Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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•
•
•
•
•
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Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
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•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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|
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•
•
•
•
•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
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•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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Publication |
First Author: |
Basova LV |
Year: |
2017 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Manipulation of Panx1 Activity Increases the Engraftment of Transplanted Lacrimal Gland Epithelial Progenitor Cells. |
Volume: |
58 |
Issue: |
13 |
Pages: |
5654-5665 |
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•
•
•
•
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Publication |
First Author: |
Whyte-Fagundes P |
Year: |
2018 |
Journal: |
Front Mol Neurosci |
Title: |
A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model. |
Volume: |
11 |
|
Pages: |
135 |
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•
•
•
•
•
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Publication |
First Author: |
Abitbol JM |
Year: |
2016 |
Journal: |
Biochem J |
Title: |
Differential effects of pannexins on noise-induced hearing loss. |
Volume: |
473 |
Issue: |
24 |
Pages: |
4665-4680 |
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•
•
•
•
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Publication |
First Author: |
Beckel JM |
Year: |
2014 |
Journal: |
Glia |
Title: |
Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain. |
Volume: |
62 |
Issue: |
9 |
Pages: |
1486-501 |
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•
•
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•
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Publication |
First Author: |
Penuela S |
Year: |
2014 |
Journal: |
Biochem J |
Title: |
Pannexin channels and their links to human disease. |
Volume: |
461 |
Issue: |
3 |
Pages: |
371-81 |
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•
•
•
•
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Publication |
First Author: |
Panchin Y |
Year: |
2000 |
Journal: |
Curr Biol |
Title: |
A ubiquitous family of putative gap junction molecules. |
Volume: |
10 |
Issue: |
13 |
Pages: |
R473-4 |
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•
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•
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Publication |
First Author: |
Phelan P |
Year: |
1998 |
Journal: |
Nature |
Title: |
Drosophila Shaking-B protein forms gap junctions in paired Xenopus oocytes. |
Volume: |
391 |
Issue: |
6663 |
Pages: |
181-4 |
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•
•
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•
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Publication |
First Author: |
Kroemer JA |
Year: |
2004 |
Journal: |
Annu Rev Entomol |
Title: |
Polydnavirus genes and genomes: emerging gene families and new insights into polydnavirus replication. |
Volume: |
49 |
|
Pages: |
431-56 |
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•
•
•
•
•
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Publication |
First Author: |
Turnbull M |
Year: |
2002 |
Journal: |
Adv Virus Res |
Title: |
Perspectives on polydnavirus origins and evolution. |
Volume: |
58 |
|
Pages: |
203-54 |
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•
•
•
•
•
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Publication |
First Author: |
Aloe L |
Year: |
1972 |
Journal: |
J Neurobiol |
Title: |
Interrelation and dynamic activity of visceral muscle and nerve cells from insect embryos in long-term cultures. |
Volume: |
3 |
Issue: |
1 |
Pages: |
3-23 |
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•
•
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•
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Publication |
First Author: |
Kelmanson IV |
Year: |
2002 |
Journal: |
Eur J Neurosci |
Title: |
Altering electrical connections in the nervous system of the pteropod mollusc Clione limacina by neuronal injections of gap junction mRNA. |
Volume: |
16 |
Issue: |
12 |
Pages: |
2475-6 |
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Protein Domain |
Type: |
Family |
Description: |
This entry includes pannexins from vertebrates and innexins from invertebrate []. Gap junctions are composed of membrane proteins,which form a channel permeable for ions and small molecules connectingcytoplasm of adjacent cells. Although gap junctions provide similar functionsin all multicellular organisms, until recently it was believed thatvertebrates and invertebrates use unrelated proteins for this purpose. Whilethe connexins family of gap junction proteins is well-characterised in vertebrates, no homologues have been found in invertebrates. Inturn, gap junction molecules with no sequence homology to connexins have beenidentified in insects and nematodes. It has been suggested that these proteinsare specific invertebrate gap junctions, and they were thus named innexins(invertebrate analog of connexins) []. As innexin homologues were recently identified in other taxonomic groups including vertebrates, indicating their ubiquitous distribution in the animal kingdom, they were called pannexins(from the Latin pan-all, throughout, and nexus-connection, bond) [, , ].Genomes of vertebrates carry probably a conserved set of 3 pannexin paralogs(PANX1, PANX2 and PANX3). Invertebrate genomes may contain more than a dozenpannexin (innexin) genes. Vinnexins, viral homologues of pannexins/innexins,were identified in Polydnaviruses that occur in obligate symbioticassociations with parasitoid wasps. It was suggested that virally encodedvinnexin proteins may function to alter gap junction proteins in infected hostcells, possibly modifying cell-cell communication during encapsulationresponses in parasitized insects [, ]. Structurally pannexins are simillar to connexins. Both types of proteinconsist of a cytoplasmic N-terminal domain, followed by four transmembranesegments that delimit two extracellular and one cytoplasmic loops; the C-terminal domain is cytoplasmic. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
426
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
392
 |
Fragment?: |
false |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
677
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
426
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
392
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Phelan P |
Year: |
1998 |
Journal: |
Trends Genet |
Title: |
Innexins: a family of invertebrate gap-junction proteins. |
Volume: |
14 |
Issue: |
9 |
Pages: |
348-9 |
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