Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5660028 |
Assay Type: |
Western blot |
Annotation Date: |
2015-08-28 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5660254 |
Age: |
embryonic day 14.0 |
|
|
Specimen Label: |
IP antibody PCM1 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Viggars MR |
Year: |
2023 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
PCM1 labeling reveals myonuclear and nuclear dynamics in skeletal muscle across species. |
Volume: |
324 |
Issue: |
1 |
Pages: |
C85-C97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martello A |
Year: |
2020 |
Journal: |
EMBO Rep |
Title: |
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. |
Volume: |
21 |
Issue: |
7 |
Pages: |
e48192 |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 15.5 |
Stage: |
23 |
Structure . Name: |
heart |
Notes: |
nuclei purified from heart using PCM1 antibody |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 15.5 |
Stage: |
23 |
Structure . Name: |
heart |
Notes: |
nuclei purified from heart using PCM1 antibody |
Curation Status: |
Curated |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis. |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Hori A |
Year: |
2016 |
Journal: |
EMBO Rep |
Title: |
A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation. |
Volume: |
17 |
Issue: |
3 |
Pages: |
326-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang C |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. |
Volume: |
288 |
Issue: |
41 |
Pages: |
29518-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toomer KA |
Year: |
2019 |
Journal: |
Sci Transl Med |
Title: |
Primary cilia defects causing mitral valve prolapse. |
Volume: |
11 |
Issue: |
493 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lv M |
Year: |
2020 |
Journal: |
J Med Genet |
Title: |
Homozygous mutations in DZIP1 can induce asthenoteratospermia with severe MMAF. |
Volume: |
57 |
Issue: |
7 |
Pages: |
445-453 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
125
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Sekimizu K |
Year: |
2004 |
Journal: |
Development |
Title: |
The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. |
Volume: |
131 |
Issue: |
11 |
Pages: |
2521-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Glazer AM |
Year: |
2010 |
Journal: |
Dev Biol |
Title: |
The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. |
Volume: |
337 |
Issue: |
1 |
Pages: |
148-56 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the N-terminal region of the cilium assembly protein DZIP1, which acts as a molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body [, , , ]. It also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium []. DZIP1 is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum []and it is also indirectly involved in heart development through its function in ciliogenesis []. Zebrafish Dzip1 acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals []. It is required for establishment of left-right asymmetry during embryogenesis and has a role in primary cilium formation []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang Y |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability. |
Volume: |
14 |
Issue: |
1 |
Pages: |
5246 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao H |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Fibrogranular materials function as organizers to ensure the fidelity of multiciliary assembly. |
Volume: |
12 |
Issue: |
1 |
Pages: |
1273 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sedjaï F |
Year: |
2010 |
Journal: |
J Cell Sci |
Title: |
Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein. |
Volume: |
123 |
Issue: |
Pt 14 |
Pages: |
2391-401 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurtulmus B |
Year: |
2016 |
Journal: |
J Cell Sci |
Title: |
WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis. |
Volume: |
129 |
Issue: |
3 |
Pages: |
621-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dias AP |
Year: |
2024 |
Journal: |
Open Biol |
Title: |
Tail-anchored membrane protein SLMAP3 is essential for targeting centrosomal proteins to the nuclear envelope in skeletal myogenesis. |
Volume: |
14 |
Issue: |
10 |
Pages: |
240094 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stowe TR |
Year: |
2012 |
Journal: |
Mol Biol Cell |
Title: |
The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium. |
Volume: |
23 |
Issue: |
17 |
Pages: |
3322-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arbogast F |
Year: |
2019 |
Journal: |
Autophagy |
Title: |
ATG5 is required for B cell polarization and presentation of particulate antigens. |
Volume: |
15 |
Issue: |
2 |
Pages: |
280-294 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
774
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
852
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
773
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
852
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
774
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
385
 |
Fragment?: |
false |
|
•
•
•
•
•
|