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Search results 101 to 200 out of 412 for Pdc

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4416546
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827110
Age: embryonic day 14.5
Image: euxassay_009925_11
Specimen Label: euxassay_009925_11
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:4416546
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827110
Age: embryonic day 14.5
Image: euxassay_009925_12
Specimen Label: euxassay_009925_12
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:4416546
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827110
Age: embryonic day 14.5
Image: euxassay_009925_13
Specimen Label: euxassay_009925_13
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:4416546
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827110
Age: embryonic day 14.5
Image: euxassay_009925_14
Specimen Label: euxassay_009925_14
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:4416546
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827110
Age: embryonic day 14.5
Image: euxassay_009925_15
Specimen Label: euxassay_009925_15
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:4416546
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827110
Age: embryonic day 14.5
Image: euxassay_009925_16
Specimen Label: euxassay_009925_16
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:4416546
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827110
Age: embryonic day 14.5
Image: euxassay_009925_17
Specimen Label: euxassay_009925_17
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
 
Probe: MGI:4416546
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827110
Age: embryonic day 14.5
Image: euxassay_009925_18
Specimen Label: euxassay_009925_18
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
 
Probe: MGI:4416546
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827110
Age: embryonic day 14.5
Image: euxassay_009925_19
Specimen Label: euxassay_009925_19
Detected: true
Specimen Num: 19
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GXD Expression
GXD Expression
 
Probe: MGI:4416546
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827110
Age: embryonic day 14.5
Image: euxassay_009925_20
Specimen Label: euxassay_009925_20
Detected: true
Specimen Num: 20
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GXD Expression
GXD Expression
 
Probe: MGI:4416546
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827110
Age: embryonic day 14.5
Image: euxassay_009925_21
Specimen Label: euxassay_009925_21
Detected: true
Specimen Num: 21
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GXD Expression
GXD Expression
 
Probe: MGI:4416546
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827110
Age: embryonic day 14.5
Image: euxassay_009925_22
Specimen Label: euxassay_009925_22
Detected: true
Specimen Num: 22
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Publication
18547251 | J:137182
First Author: Pozdeyev N
Year: 2008
Journal: Eur J Neurosci
Title: Dopamine modulates diurnal and circadian rhythms of protein phosphorylation in photoreceptor cells of mouse retina.
Volume: 27
Issue: 10
Pages: 2691-700
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Publication
14973130 | J:89499
First Author: Sokolov M
Year: 2004
Journal: J Biol Chem
Title: Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse.
Volume: 279
Issue: 18
Pages: 19149-56
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Publication
20203183 | J:159023
First Author: Herrmann R
Year: 2010
Journal: J Neurosci
Title: Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse.
Volume: 30
Issue: 9
Pages: 3239-53
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Publication
1675982 | J:11278
First Author: Danciger M
Year: 1991
Journal: Cytogenet Cell Genet
Title: The gene for retinal rod 33-kDa protein is on mouse chromosome 1, near Lamb2.
Volume: 56
Issue: 3-4
Pages: 202-5
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Publication
18367617 | J:133487
First Author: Lobanova ES
Year: 2008
Journal: J Neurosci
Title: Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability.
Volume: 28
Issue: 13
Pages: 3510-20
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Publication
2071146 | J:11329
First Author: Craft CM
Year: 1991
Journal: Genomics
Title: Rat pineal gland phosducin: cDNA isolation, nucleotide sequence, and chromosomal assignment in the mouse.
Volume: 10
Issue: 2
Pages: 400-9
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Publication
14648843 | J:86801
First Author: Hirano M
Year: 2003
Journal: Dev Dyn
Title: Generation of structures formed by lens and retinal cells differentiating from embryonic stem cells.
Volume: 228
Issue: 4
Pages: 664-71
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Publication
7882992 | J:23912
First Author: Sugiyama S
Year: 1995
Journal: Eur J Biochem
Title: Cloning and expression of the mouse laminin gamma 2 (B2t) chain, a subunit of epithelial cell laminin.
Volume: 228
Issue: 1
Pages: 120-8
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Publication
29665410 | J:264207
 
First Author: Rodgers HM
Year: 2018
Journal: Mech Dev
Title: The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification.
Volume: 151
Pages: 18-29
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Publication
33500475 | J:301112
First Author: Maddala R
Year: 2021
Journal: Sci Rep
Title: Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract.
Volume: 11
Issue: 1
Pages: 2203
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Publication
32071204 | J:285747
First Author: Liu S
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Foxn4 is a temporal identity factor conferring mid/late-early retinal competence and involved in retinal synaptogenesis.
Volume: 117
Issue: 9
Pages: 5016-5027
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Publication
29922981 | J:274446
First Author: Wei W
Year: 2019
Journal: Mol Neurobiol
Title: Requirement of the Mowat-Wilson Syndrome Gene Zeb2 in the Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.
Volume: 56
Issue: 3
Pages: 1719-1736
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Publication
25228773 | J:216471
First Author: Sapkota D
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development.
Volume: 111
Issue: 39
Pages: E4086-95
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:15839
       
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
38011375 | J:344149
   
First Author: Zhang Y
Year: 2023
Journal: Elife
Title: Regulation of pDC fate determination by histone deacetylase 3.
Volume: 12
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Publication
17823983 | J:125262
First Author: Toma-Hirano M
Year: 2007
Journal: Eur J Immunol
Title: Type I interferon regulates pDC maturation and Ly49Q expression.
Volume: 37
Issue: 10
Pages: 2707-14
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Publication
31346085 | J:279164
First Author: Sever L
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: SLAMF9 regulates pDC homeostasis and function in health and disease.
Volume: 116
Issue: 33
Pages: 16489-16496
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Publication
27827374 | J:337981
First Author: Swiecki M
Year: 2017
Journal: Mucosal Immunol
Title: Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state.
Volume: 10
Issue: 4
Pages: 936-945
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Publication
33773101 | J:303714
First Author: Heinemann-Yerushalmi L
Year: 2021
Journal: Dev Cell
Title: BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development.
Volume: 56
Issue: 8
Pages: 1182-1194.e6
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Publication
30001316 | J:263813
First Author: Mastio J
Year: 2018
Journal: PLoS Genet
Title: Ikaros cooperates with Notch activation and antagonizes TGFβ signaling to promote pDC development.
Volume: 14
Issue: 7
Pages: e1007485
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Publication
23028315 | J:194867
First Author: Blasius AL
Year: 2012
Journal: PLoS Pathog
Title: Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection.
Volume: 8
Issue: 9
Pages: e1002915
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Publication
23741395 | J:200827
First Author: Wu X
Year: 2013
Journal: PLoS One
Title: Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo.
Volume: 8
Issue: 5
Pages: e64800
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Publication
30534943 | J:276890
First Author: Wang J
Year: 2019
Journal: Int Immunol
Title: Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus.
Volume: 31
Issue: 3
Pages: 127-139
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Publication
24751730 | J:214771
First Author: Aspord C
Year: 2014
Journal: J Invest Dermatol
Title: Imiquimod inhibits melanoma development by promoting pDC cytotoxic functions and impeding tumor vascularization.
Volume: 134
Issue: 10
Pages: 2551-2561
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Allele
Pdc<em1Smoc> | MGI:7291567
Name: phosducin; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6355091 | C57BL/6JSmoc-Pdc<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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MP Term
MP:0004242 | abnormal plasmacytoid dendritic cell morphology
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CL Term
CL:0000784 | plasmacytoid dendritic cell
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MP Term
MP:0008524 | increased plasmacytoid dendritic cell number
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MP Term
MP:0008123 | abnormal plasmacytoid dendritic cell number
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Protein Domain
IPR035807 | PDC_E1_N
Type: Domain
Description: Pyruvate dehydrogenase multienzyme complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using thiamine pyrophosphate (TPP) and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme [].
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HT Experiment
GSE189780 | Plasmacytoid dendritic cell precursors give rise to conventional dendritic cells via a Siglec-H+ Zbtb46+ Ly6D+ intermediary stage
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE158595 | E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure protein translation fidelity during neuronal development
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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MP Term
MP:0008124 | decreased plasmacytoid dendritic cell number
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Publication
11955070 | -
First Author: Arjunan P
Year: 2002
Journal: Biochemistry
Title: Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution.
Volume: 41
Issue: 16
Pages: 5213-21
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Publication
2007123 | -
First Author: Lawson JE
Year: 1991
Journal: Biochemistry
Title: Disruption and mutagenesis of the Saccharomyces cerevisiae PDX1 gene encoding the protein X component of the pyruvate dehydrogenase complex.
Volume: 30
Issue: 11
Pages: 2834-9
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Publication
7030741 | -
First Author: Kresze GB
Year: 1981
Journal: Eur J Biochem
Title: Pyruvate dehydrogenase complex from baker's yeast. 2. Molecular structure, dissociation, and implications for the origin of mitochondria.
Volume: 119
Issue: 3
Pages: 581-7
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Publication
9399911 | -
First Author: Aral B
Year: 1997
Journal: Am J Hum Genet
Title: Mutations in PDX1, the human lipoyl-containing component X of the pyruvate dehydrogenase-complex gene on chromosome 11p1, in congenital lactic acidosis.
Volume: 61
Issue: 6
Pages: 1318-26
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Publication
16049940 | -
First Author: Head RA
Year: 2005
Journal: Ann Neurol
Title: Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency.
Volume: 58
Issue: 2
Pages: 234-41
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Publication
9655933 | -
First Author: de Kok A
Year: 1998
Journal: Biochim Biophys Acta
Title: The pyruvate dehydrogenase multi-enzyme complex from Gram-negative bacteria.
Volume: 1385
Issue: 2
Pages: 353-66
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Protein Domain
IPR045257 | E2/Pdx1
Type: Family
Description: In prokaryotes and eukaryotes, pyruvate dehydrogenase complex (PDC) contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) []. PDC catalyses the overall conversion of pyruvate to acetyl-CoA and CO2. In eukaryotes, PDC is located in the mitochondrial matrix [, ]. This entry represents agroup of E3-binding proteins, including dihydrolipoamide acetyltransferase (E2) and pyruvate dehydrogenase protein X component (known as Pdx1). Pdx1, found only in eukaryotes, plays a structural role in the complex by binding and positioning dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide acetyltransferase (E2) core []. Mutations in the Pdx1 gene has been linked to human disease [, ]. Mutations in the E2 gene cause pyruvate dehydrogenase deficiency [].
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HT Experiment
E-GEOD-57324 | Gene expression analysis in the spleen of wild type, Sle1.3 (lupus mice) and Sle1.3 mice haplodeficient for E2-2 (exhibiting non functional pDCs)
Series Id: GSE57324
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
1825611 | -
First Author: Russell GC
Year: 1991
Journal: Biochim Biophys Acta
Title: Sequence similarities within the family of dihydrolipoamide acyltransferases and discovery of a previously unidentified fungal enzyme.
Volume: 1076
Issue: 2
Pages: 225-32
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Publication
17272685 | J:310655
First Author: Lee HK
Year: 2007
Journal: Science
Title: Autophagy-dependent viral recognition by plasmacytoid dendritic cells.
Volume: 315
Issue: 5817
Pages: 1398-401
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Publication
17339429 | J:144296
First Author: Wang JP
Year: 2007
Journal: J Immunol
Title: Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA.
Volume: 178
Issue: 6
Pages: 3363-7
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Protein
Q99LL2
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
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Publication
26231120 | J:233103
First Author: Bunin A
Year: 2015
Journal: Immunity
Title: Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.
Volume: 43
Issue: 2
Pages: 277-88
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Publication
12538667 | J:110873
First Author: Tsujimura H
Year: 2003
Journal: J Immunol
Title: Cutting edge: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells.
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Title: PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon.
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Title: The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin.
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