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Search results 101 to 130 out of 130 for Pir

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0.021s

Type

Details

Score

Publication

10359805 | J:55620

First Author:	Chen CC
Year:	1999
Journal:	Proc Natl Acad Sci U S A
Title:	Paternal monoallelic expression of the paired immunoglobulin-like receptors PIR-A and PIR-B.
Volume:	96
Issue:	12
Pages:	6868-72

•

Protein Domain

IPR035037 | Grb10_SH2

Type:

Domain

Description:

This entry represents the SH2 domain of Grb10.The Grb7 (growth factor receptor-bound 7) family includes Grb7, Grb10, and Grb14. These are adapter proteins mediating signal transduction from multiple cell surface receptors to diverse downstream pathways. They are composed of an N-terminal proline-rich domain, a Ras Associating-like (RA) domain, a Pleckstrin Homology (PH) domain, a PIR (phosphorylated insulin receptor interacting region) domain (also known as the family-specific BPS region), and a C-terminal SH2 domain []. Grb10 inhibits insulin receptor kinase activity and mediates insulin-stimulated degradation of the insulin receptor []. It binds to the regulatory kinase loop of the insulin receptor (IR) via its SH2 and BPS domains []. Grb10 is directly phosphorylated by mTORC1 and may participate in a feedback inhibition of the phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways [].

•

Protein Domain

IPR035036 | Grb10

Type:

Family

Description:

The Grb7 (growth factor receptor-bound 7) family includes Grb7, Grb10, and Grb14. These are adapter proteins mediating signal transduction from multiple cell surface receptors to diverse downstream pathways. They are composed of an N-terminal proline-rich domain, a Ras Associating-like (RA) domain, a Pleckstrin Homology (PH) domain, a PIR (phosphorylated insulin receptor interacting region) domain (also known as the family-specific BPS region), and a C-terminal SH2 domain []. Grb10 inhibits insulin receptor kinase activity and mediates insulin-stimulated degradation of the insulin receptor []. It binds to the regulatory kinase loop of the insulin receptor (IR) via its SH2 and BPS domains []. Grb10 is directly phosphorylated by mTORC1 and may participate in a feedback inhibition of the phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways [].

•

Publication

16434550 | -

First Author:	Ramos FJ
Year:	2006
Journal:	Am J Physiol Endocrinol Metab
Title:	Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation.
Volume:	290
Issue:	6
Pages:	E1262-6

•

Publication

14766376 | -

First Author:	Lim MA
Year:	2004
Journal:	Front Biosci
Title:	Grb10: more than a simple adaptor protein.
Volume:	9

Pages:	387-403

•

Publication

21659605 | -

First Author:	Yu Y
Year:	2011
Journal:	Science
Title:	Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
Volume:	332
Issue:	6035
Pages:	1322-6

•

Publication

19648926 | -

First Author:	Depetris RS
Year:	2009
Journal:	Nat Struct Mol Biol
Title:	Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.
Volume:	16
Issue:	8
Pages:	833-9

•

Publication

10611342 | J:119839

First Author:	Ho LH
Year:	1999
Journal:	Proc Natl Acad Sci U S A
Title:	Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B.
Volume:	96
Issue:	26
Pages:	15086-90

•

Publication

22042976 | J:178641

First Author:	Hickman HD
Year:	2011
Journal:	J Exp Med
Title:	Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.
Volume:	208
Issue:	12
Pages:	2511-24

•

Publication

19684158 | J:153772

First Author:	Imada M
Year:	2009
Journal:	Int Immunol
Title:	Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses.
Volume:	21
Issue:	10
Pages:	1151-61

•

Publication

15143182 | J:91093

First Author:	O'Connor S
Year:	2004
Journal:	Mol Cell Biol
Title:	Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells.
Volume:	24
Issue:	11
Pages:	4895-908

•

Publication

21486933 | J:174705

First Author:	Novitskaya T
Year:	2011
Journal:	Endocrinology
Title:	Organ-specific defects in insulin-like growth factor and insulin receptor signaling in late gestational asymmetric intrauterine growth restriction in Cited1 mutant mice.
Volume:	152
Issue:	6
Pages:	2503-16

•

Publication

22739121 | J:202658

First Author:	Sankova B
Year:	2012
Journal:	Cardiovasc Res
Title:	The effect of connexin40 deficiency on ventricular conduction system function during development.
Volume:	95
Issue:	4
Pages:	469-79

•

Publication

32497340 | J:297573

First Author:	Zhang N
Year:	2020
Journal:	Glia
Title:	GLAST-CreER^T2 mediated deletion of GDNF increases brain damage and exacerbates long-term stroke outcomes after focal ischemic stroke in mouse model.
Volume:	68
Issue:	11
Pages:	2395-2414

•

Publication

27638512 | J:279641

First Author:	Kono J
Year:	2017
Journal:	Brain Struct Funct
Title:	Distribution of corticotropin-releasing factor neurons in the mouse brain: a study using corticotropin-releasing factor-modified yellow fluorescent protein knock-in mouse.
Volume:	222
Issue:	4
Pages:	1705-1732

•

Publication

7499312 | J:29836

First Author:	Resing KA
Year:	1995
Journal:	J Biol Chem
Title:	Characterization of profilaggrin endoproteinase 1. A regulated cytoplasmic endoproteinase of epidermis.
Volume:	270
Issue:	47
Pages:	28193-8

•

Publication

16011512 | J:99753

First Author:	Takai T
Year:	2005
Journal:	Immunology
Title:	Paired immunoglobulin-like receptors and their MHC class I recognition.
Volume:	115
Issue:	4
Pages:	433-40

•

Publication

24040397 | J:207548

First Author:	Scroggins SM
Year:	2013
Journal:	PLoS One
Title:	Characterization of regulatory dendritic cells that mitigate acute graft-versus-host disease in older mice following allogeneic bone marrow transplantation.
Volume:	8
Issue:	9
Pages:	e75158

•

Publication

7558306 | J:30199

First Author:	Okamura H
Year:	1995
Journal:	Infect Immun
Title:	A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock.
Volume:	63
Issue:	10
Pages:	3966-72

•

Protein

A2ASX3

Organism:	Mus musculus/domesticus
Length:	93
Fragment?:	true

•

Protein

B1ATS7

Organism:	Mus musculus/domesticus
Length:	116
Fragment?:	true

•

Protein

B1ATS8

Organism:	Mus musculus/domesticus
Length:	84
Fragment?:	true

•

Protein

Q5SUW0

Organism:	Mus musculus/domesticus
Length:	171
Fragment?:	true

•

Protein

A2ASX4

Organism:	Mus musculus/domesticus
Length:	109
Fragment?:	true

•

Protein

Q9JLM9

Organism:	Mus musculus/domesticus
Length:	538
Fragment?:	false

•

Protein

A2ASX2

Organism:	Mus musculus/domesticus
Length:	538
Fragment?:	false

•

Protein

Q5SUW3

Organism:	Mus musculus/domesticus
Length:	550
Fragment?:	false

•

Protein

A2ASX1

Organism:	Mus musculus/domesticus
Length:	221
Fragment?:	true

•

Protein

Q60760

Organism:	Mus musculus/domesticus
Length:	621
Fragment?:	false

•

Protein

Q3TFU9

Organism:	Mus musculus/domesticus
Length:	299
Fragment?:	true

•

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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Search results 101 to 130 out of 130 for Pir

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