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Search results 101 to 200 out of 206 for Pkn1

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Type Details Score
Publication
34499618 | J:326961
 
First Author: Jin YJ
Year: 2021
Journal: J Clin Invest
Title: Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation.
Volume: 131
Issue: 21
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Publication
27569559 | J:318379
First Author: Chung LK
Year: 2016
Journal: Cell Host Microbe
Title: The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome.
Volume: 20
Issue: 3
Pages: 296-306
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Publication
9570957 | J:47553
First Author: Bartsch JW
Year: 1998
Journal: Genomics
Title: The protein kinase N (PKN) gene PRKCL1/Prkcl1 maps to human chromosome 19p12-p13.1 and mouse chromosome 8 with close linkage to the myodystrophy (myd) mutation.
Volume: 49
Issue: 1
Pages: 129-32
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Publication
26526197 | J:228507
First Author: Ajima R
Year: 2015
Journal: Dev Biol
Title: DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly.
Volume: 408
Issue: 1
Pages: 126-39
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Pkn1<tm1.1Hmuk> | MGI:6118985
Name: protein kinase N1; targeted mutation 1.1, Hideyuki Mukai
Allele Type: Targeted
Attribute String: Hypomorph
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Publication
17591691 | J:124217
First Author: Fischer A
Year: 2007
Journal: J Cell Sci
Title: Impaired tight junction sealing and precocious involution in mammary glands of PKN1 transgenic mice.
Volume: 120
Issue: Pt 13
Pages: 2272-83
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Publication
18519042 | -
First Author: Manser C
Year: 2008
Journal: FEBS Lett
Title: Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport.
Volume: 582
Issue: 15
Pages: 2303-2308
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Publication
21037231 | -
First Author: Kajimoto K
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Hypotonic swelling-induced activation of PKN1 mediates cell survival in cardiac myocytes.
Volume: 300
Issue: 1
Pages: H191-200
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Pathway
R-MMU-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
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Allele
Tg(Pbsn-PKN1)#Bmp | MGI:6159651
Name: transgene insertion, Bryce M Paschal
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Pkn1<tm1Ajmc> | MGI:5911979
Name: protein kinase N1; targeted mutation 1, Angus JM Cameron
Allele Type: Targeted
Attribute String: Null/knockout
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Protein
P70268
Organism: Mus musculus/domesticus
Length: 946  
Fragment?: false
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Strain
MGI:5912001 | B6.129P2-Pkn1<tm1Ajmc>
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Tg(Pbsn-PKN1*)#Bmp | MGI:6159652
Name: transgene insertion, Bryce M Paschal
Allele Type: Transgenic
Attribute String: Constitutively active, Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Pkn1/Pkn1
Background: B6.129P2-Pkn1
Zygosity: hm
Has Mutant Allele: true
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Publication
8571126 | J:40343
First Author: Watanabe G
Year: 1996
Journal: Science
Title: Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho.
Volume: 271
Issue: 5249
Pages: 645-8
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Publication
15993750 | -
First Author: Lim WG
Year: 2005
Journal: Cell Signal
Title: The last five amino acid residues at the C-terminus of PRK1/PKN is essential for full lipid responsiveness.
Volume: 17
Issue: 9
Pages: 1084-97
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Protein Domain
IPR037317 | PKN1_HR1_2
Type: Domain
Description: PKN1 is a serine/threonine protein kinase activated by the Rho family of small GTPases, and by fatty acids such as arachidonic and linoleic acids [, ]. It is expressed ubiquitously and is the most abundant PKN isoform in neurons []. PKN1 is implicated in a variety of functions including cytoskeletal reorganization, cardiac cell survival, cell adhesion, and glucose transport, among others [, ]. PKN1 contains three HR1 domains, a C2 domain, and a kinase domain.This entry represents the second HR1 domain of PKN1. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family; PKN1 binds the GTPases RhoA, RhoB, and RhoC, and can also interact weakly with Rac [].
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Genotype
Genotype
Symbol: Pkn1/Pkn1 Pkn3/Pkn3
Background: involves: 129P2/OlaHsd * C57BL/6NTac
Zygosity: cx
Has Mutant Allele: true
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Allele
Ptger1<tm1Matb> | MGI:3764892
 
Name: prostaglandin E receptor 1 (subtype EP1); targeted mutation 1, Matthew D Breyer
Allele Type: Targeted
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Protein Coding Gene
MGI:88064 | Ar
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P19091
Organism: Mus musculus/domesticus
Length: 899  
Fragment?: false
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Strain
MGI:3764937 | 129S6/SvEvTac-Ptger1<tm1Matb>
Attribute String: coisogenic, mutant strain, targeted mutation
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Publication
17710229 | J:127410
First Author: Guan Y
Year: 2007
Journal: J Clin Invest
Title: Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.
Volume: 117
Issue: 9
Pages: 2496-505
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Publication
30980293 | J:298434
First Author: Feigenson M
Year: 2020
Journal: Ann Biomed Eng
Title: Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair.
Volume: 48
Issue: 3
Pages: 927-939
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Publication
25446888 | J:219300
 
First Author: Zhang M
Year: 2015
Journal: Bone
Title: Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength.
Volume: 72
Pages: 92-100
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Publication
20939055 | J:184244
First Author: Zhang M
Year: 2011
Journal: J Bone Miner Res
Title: EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair.
Volume: 26
Issue: 4
Pages: 792-802
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Publication
22110249 | J:181788
First Author: Singh P
Year: 2012
Journal: Blood
Title: Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells.
Volume: 119
Issue: 7
Pages: 1671-82
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Genotype
Genotype
Symbol: Ptger1/Ptger1
Background: 129S6/SvEvTac-Ptger1
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:1276533 | Ncoa2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61026
Organism: Mus musculus/domesticus
Length: 1462  
Fragment?: false
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Publication
27270401 | J:259950
First Author: Park YH
Year: 2016
Journal: Nat Immunol
Title: Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
Volume: 17
Issue: 8
Pages: 914-21
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Publication
19389932 | J:148777
First Author: Keene CD
Year: 2009
Journal: Am J Pathol
Title: Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2.
Volume: 174
Issue: 6
Pages: 2300-9
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Protein Domain
IPR042095 | SUMF_sf
Type: Homologous_superfamily
Description: This superfamily represents a domain is found in sulfatase-modifying factors (SUMFs) []and Chlamydia serine/threonine-protein kinase pkn1 []. It is also found in iron(II)-dependent oxidoreductase from Mycobacterium [, ]. The structure of this domain is homologous to the complex alpha/beta topology found in sulfatase-modifying factors (SUMF1). SUMF1 is a paralogue of oxoalanine-generating enzyme, also called C(alpha)-formylglycine generating enzyme (FGE). SUMF1 converts newly synthesized inactive sulfatases to their active form by modifying an active site cysteine residue to oxoalanine. Sulfatases are essential for the degradation of sulfate esters, whose catalytic activity is dependent upon an oxoalanine residue []. Defects in SUMF1 or FGE cause multiple sulfatase deficiency (MSD), which leads to the impairment of all sulfatases and to the accumulation of glycoaminoglycans or sulfolipids, causing early infant death [, , ]Known substrates for SUMF1 are: N-acetylgalactosamine-6-sulfate sulfatase (GALNS), arylsulfatase A (ARSA), steroid sulfatase (STS) and arylsulfatase E (ARSE). SUMF1 occurs in the endoplasmic reticulum or its lumen.
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Protein Domain
IPR005532 | SUMF_dom
Type: Domain
Description: This domain is found in sulfatase-modifying factors (SUMFs) []and Chlamydia serine/threonine-protein kinase pkn1 []. It is also found in iron(II)-dependent oxidoreductase from Mycobacterium [, ]. The structure of this domain is homologous to the complex alpha/beta topology found in sulfatase-modifying factors (SUMF1). SUMF1 is a paralogue of oxoalanine-generating enzyme, also called C(alpha)-formylglycine generating enzyme (FGE). SUMF1 converts newly synthesized inactive sulfatases to their active form by modifying an active site cysteine residue to oxoalanine. Sulfatases are essential for the degradation of sulfate esters, whose catalytic activity is dependent upon an oxoalanine residue []. Defects in SUMF1 or FGE cause multiple sulfatase deficiency (MSD), which leads to the impairment of all sulfatases and to the accumulation of glycoaminoglycans or sulfolipids, causing early infant death [, , ]Known substrates for SUMF1 are: N-acetylgalactosamine-6-sulfate sulfatase (GALNS), arylsulfatase A (ARSA), steroid sulfatase (STS) and arylsulfatase E (ARSE). SUMF1 occurs in the endoplasmic reticulum or its lumen.
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Publication
16174644 | -
First Author: Sardiello M
Year: 2005
Journal: Hum Mol Genet
Title: Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship.
Volume: 14
Issue: 21
Pages: 3203-17
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Publication
14563551 | -
 
First Author: Landgrebe J
Year: 2003
Journal: Gene
Title: The human SUMF1 gene, required for posttranslational sulfatase modification, defines a new gene family which is conserved from pro- to eukaryotes.
Volume: 316
Pages: 47-56
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Publication
17206939 | J:121678
First Author: Fraldi A
Year: 2007
Journal: Biochem J
Title: SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies.
Volume: 403
Issue: 2
Pages: 305-12
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Publication
16124866 | -
 
First Author: Diez-Roux G
Year: 2005
Journal: Annu Rev Genomics Hum Genet
Title: Sulfatases and human disease.
Volume: 6
Pages: 355-79
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Publication
15064399 | -
First Author: Seshadri R
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.
Volume: 101
Issue: 15
Pages: 5646-51
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Publication
18429822 | J:141705
First Author: Kato T Jr
Year: 2008
Journal: Genes Cells
Title: Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.
Volume: 13
Issue: 5
Pages: 509-20
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Publication
28102564 | J:274505
First Author: Danno S
Year: 2017
Journal: Genes Cells
Title: PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts.
Volume: 22
Issue: 2
Pages: 220-236
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Publication
28222172 | J:245704
First Author: Wang F
Year: 2017
Journal: PLoS One
Title: RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling.
Volume: 12
Issue: 2
Pages: e0172613
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Publication
14500499 | -
First Author: Verma A
Year: 2003
Journal: Infect Immun
Title: Identification of two eukaryote-like serine/threonine kinases encoded by Chlamydia trachomatis serovar L2 and characterization of interacting partners of Pkn1.
Volume: 71
Issue: 10
Pages: 5772-84
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Publication
19419302 | J:160218
First Author: Tsutsumi R
Year: 2009
Journal: J Bone Miner Res
Title: PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis.
Volume: 24
Issue: 10
Pages: 1753-62
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Genotype
Genotype
Symbol: Pkn1/Pkn1 Pkn2/Pkn2<+> Pkn3/Pkn3
Background: involves: 129P2/OlaHsd * C57BL/6N * C57BL/6NTac
Zygosity: cx
Has Mutant Allele: true
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Publication
10619026 | -
First Author: Maesaki R
Year: 1999
Journal: Mol Cell
Title: The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.
Volume: 4
Issue: 5
Pages: 793-803
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Protein Domain
IPR023507 | Ser/Thr_kinase_PknD
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This entry contains the PknD family of serine/threonine protein kinases which are found in (for example) C. trachomatis. In conjunction with Pkn1 they may play a role in specific interactions with host proteins during intracellular growth [].
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Publication
23485965 | J:195129
First Author: Hoggatt J
Year: 2013
Journal: Nature
Title: Differential stem- and progenitor-cell trafficking by prostaglandin E2.
Volume: 495
Issue: 7441
Pages: 365-9
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Protein
Q8BPG6
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: false
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Protein
Q8R0F3
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: false
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Protein
Q0VDW5
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: false
•
•
•
•
•
Protein
E9Q265
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: false
•
•
•
•
•
Protein
F6QZU1
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: true
•
•
•
•
•
Protein
A0A0J9YUK9
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: true
•
•
•
•
•
Protein
Q3TM08
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
•
•
•
•
•
Protein
A0A0J9YUF6
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
•
•
•
•
•
Protein
E9Q0Z7
Organism: Mus musculus/domesticus
Length: 240  
Fragment?: false
•
•
•
•
•
Publication
16041070 | -
First Author: Roeser D
Year: 2005
Journal: Acta Crystallogr D Biol Crystallogr
Title: De novo calcium/sulfur SAD phasing of the human formylglycine-generating enzyme using in-house data.
Volume: 61
Issue: Pt 8
Pages: 1057-66
•
•
•
•
•
Protein
D6RH37
Organism: Mus musculus/domesticus
Length: 796  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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