|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 200 out of 203 for Pnkp

<< First    < Previous  |  Next >    Last >>
0.045s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein Coding Gene
MGI:1919353 | Aplf
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Gene
500247 | Aplf
Type: gene
Organism: rat
•
•
•
•
•
Gene
481405 | APLF
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
459293 | APLF
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
507989 | APLF
Type: gene
Organism: cattle
•
•
•
•
•
Gene
421264 | APLF
Type: gene
Organism: chicken
•
•
•
•
•
Gene
705875 | APLF
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Gene
101884102 | aplf
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
100127823 | aplf
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Publication
25590633 | J:248592
First Author: Gao R
Year: 2015
Journal: PLoS Genet
Title: Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3.
Volume: 11
Issue: 1
Pages: e1004834
•
•
•
•
•
Publication
21211721 | J:168260
First Author: Rulten SL
Year: 2011
Journal: Mol Cell
Title: PARP-3 and APLF function together to accelerate nonhomologous end-joining.
Volume: 41
Issue: 1
Pages: 33-45
•
•
•
•
•
Gene
108716577 | aplf.L
Type: gene
Organism: frog, African clawed
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6293928
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3284227
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6358701
Age: postnatal day 2
Note: Authors state the ordered six-layer lamination is maintained, but there were reduced numbers of neurons, particularly in upper cortical layers.
Specimen Label: 1E PNKP nes-cre Satb2
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6293928
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3284227
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6358701
Age: postnatal day 0
Specimen Label: 3B Pnkp Nes-Cre Satb2
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6358695
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3284227
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6358703
Age: postnatal day 2
Note: Authors state the ordered six-layer lamination is maintained, but there were reduced numbers of neurons, particularly in upper cortical layers.
Specimen Label: 1E PNKP nes-cre Brn2
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5447971
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3284227
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6358704
Age: postnatal day 2
Note: Authors state the ordered six-layer lamination is maintained.
Specimen Label: 1E PNKP nes-cre Ctip2
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5447971
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3284227
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6358705
Age: postnatal day 0
Specimen Label: 3B PNKP Nes-Cre Ctip2
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5762883
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284227
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6358706
Age: postnatal day 2
Note: Authors state that the ordered six-layer lamination is maintained in the mutant.
Specimen Label: 1E PNKP nes-cre Tbr1
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5447973
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284227
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6358707
Age: postnatal day 2
Note: Authors state that the ordered six-layer lamination is maintained in the mutant.
Specimen Label: 1E PNKP nes-cre Cux1
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1335311
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1778727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6358711
Age: postnatal day 0
Specimen Label: 3C Pnkp Nes-Cre
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6358696
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-09
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754721
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6358709
Age: embryonic day 13.5
Specimen Label: 6C Pnkp Neo/Neo gH2AX
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6358696
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-09
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6358709
Age: embryonic day 15.5
Note: Small nuclear puncta indicating DNA damage and also large diffuse apoptotic foci.
Specimen Label: 2B Pnkp Nes-Cre gH2AX
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1314837
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6358710
Age: embryonic day 15.5
Specimen Label: 2B Pnkp Nes-Cre PCNA
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1314837
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6358710
Age: embryonic day 13.5
Specimen Label: 6C Pnkp Neo/Neo PCNA
Detected: true
Specimen Num: 5
•
•
•
•
•
Allele
Aplf<+> | MGI:3809856
 
Name: aprataxin and PNKP like factor; wild type
Allele Type: Not Specified
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0028615 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0030995 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0030961 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0030892 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0030974 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0030736 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_1919353 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0031431 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0030083 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0030658 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0030814 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0030767 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0030891 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0030800 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0031458 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0029798 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0030164 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0022352 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0029626 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
Publication
27875275 | J:247123
First Author: Syed KM
Year: 2016
Journal: J Cell Sci
Title: Histone chaperone APLF regulates induction of pluripotency in murine fibroblasts.
Volume: 129
Issue: 24
Pages: 4576-4591
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6885835
Assay Type: RT-PCR
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:6885859
Age: embryonic day 2.0
Specimen Label: 4-cell
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6885835
Assay Type: RT-PCR
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318653
Stage: TS03
Assay Id: MGI:6885859
Age: embryonic day 2.5
Specimen Label: 8-cell
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6885835
Assay Type: RT-PCR
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Stage: TS04
Assay Id: MGI:6885859
Age: embryonic day 3.0
Specimen Label: morula
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6885835
Assay Type: RT-PCR
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360354
Stage: TS04
Assay Id: MGI:6885859
Age: embryonic day 3.5
Specimen Label: blastocyst
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:6885855
Age: embryonic day 2.0
Note: Expressed within the nucleus, as well as in the cytosol.
Specimen Label: 1A
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:6885855
Age: embryonic day 2.0
Note: Expressed within the nucleus, as well as in the cytosol.
Specimen Label: S1A
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1605911
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:6885855
Age: embryonic day 7.5
Specimen Label: 2F/H/I
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187711
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:6885855
Age: embryonic day 7.5
Specimen Label: 2F/H/I
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360354
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:6885855
Age: embryonic day 3.5
Note: Significantly downregulated expression. A significant level of expression was enhanced within the trophectoderm.
Specimen Label: 1C
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360354
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:6885855
Age: embryonic day 3.5
Specimen Label: S1C
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360354
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:6885855
Age: embryonic day 3.5
Note: Significantly downregulated expression. A significant level of expression was enhanced within the trophectoderm.
Specimen Label: S1D
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360354
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:6885855
Age: embryonic day 3.5
Note: Significantly downregulated expression. A significant level of expression was enhanced within the trophectoderm.
Specimen Label: 1E
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:6885855
Age: embryonic day 3.0
Note: Enhanced expression.
Specimen Label: 1B upper
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:6885855
Age: embryonic day 3.0
Note: Enhanced expression.
Specimen Label: 1B lower
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:6885855
Age: embryonic day 3.0
Note: Enhanced expression.
Specimen Label: S1B
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610711
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:6885855
Age: embryonic day 7.5
Specimen Label: 2F/H/I
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160464
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:6885855
Age: embryonic day 3.5
Specimen Label: 1C
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160464
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:6885855
Age: embryonic day 3.5
Specimen Label: S1D
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160464
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:6885855
Age: embryonic day 3.5
Specimen Label: 1E
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6885839
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604611
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:6885855
Age: embryonic day 7.5
Specimen Label: 2F/H/I
Detected: true
Specimen Num: 6
•
•
•
•
•
Publication
22308407 | -
First Author: Smith P
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The adenylyltransferase domain of bacterial Pnkp defines a unique RNA ligase family.
Volume: 109
Issue: 7
Pages: 2296-301
•
•
•
•
•
Allele
Aplf<Gt(RRF189)Byg> | MGI:4128102
Name: aprataxin and PNKP like factor; gene trap RRF189, BayGenomics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
•
•
•
•
•
Allele
Aplf<tm1Okad> | MGI:7524704
Name: aprataxin and PNKP like factor; targeted mutation 1, Hitoshi Okada
Allele Type: Targeted
Attribute String: Null/knockout
•
•
•
•
•
Allele
Aplf<Gt(CG0791)Wtsi> | MGI:3870573
 
Name: aprataxin and PNKP like factor; gene trap CG0791, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
•
•
•
•
•
Strain
MGI:4840219 | B6;129P2-Aplf<Gt(RRF189)Byg>/Mmucd
Attribute String: gene trap, mutant stock
•
•
•
•
•
Allele
Aplf<tm1e(EUCOMM)Hmgu> | MGI:5009615
Name: aprataxin and PNKP like factor; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
•
•
•
•
•
Allele
Aplf<tm1a(EUCOMM)Hmgu> | MGI:5009616
Name: aprataxin and PNKP like factor; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
•
•
•
•
•
Allele
Aplf<em3Gpt> | MGI:7309938
Name: aprataxin and PNKP like factor; endonuclease-mediated mutation 3, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Allele
Aplf<em1Gpt> | MGI:7376214
Name: aprataxin and PNKP like factor; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Strain
MGI:6353227 | B6.129P2-Aplf<tm1Okad>/OkadRbrc
Attribute String: congenic, mutant strain, targeted mutation
•
•
•
•
•
Genotype
Genotype
Symbol: Aplf/Aplf
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Strain
MGI:7381226 | C57BL/6JGpt-Aplf<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
Protein Domain
IPR044493 | PNKP_C_HAD
Type: Domain
Description: This entry represents the C-terminal domain of the bifunctional enzyme T4 polynucleotide kinase/phosphatase, PNKP (also known as PseT). The PNKP phosphatase domain can catalyse the hydrolytic removal of the 3'-phosphoryl of DNA, RNA and deoxynucleoside 3'-monophosphates [].
•
•
•
•
•
Publication
33277378 | J:311886
 
First Author: Varghese PC
Year: 2021
Journal: J Cell Sci
Title: Histone chaperone APLF level dictates the implantation of mouse embryos.
Volume: 134
Issue: 1
•
•
•
•
•
DO Term
DOID:0080457 | microcephaly, seizures, and developmental delay
•
•
•
•
•
DO Term
DOID:0081383 | ataxia-oculomotor apraxia type 4
•
•
•
•
•
Publication
17277741 | J:118199
 
First Author: Danciger M
Year: 2007
Journal: Mol Vis
Title: Quantitative genetics of age-related retinal degeneration: a second F1 intercross between the A/J and C57BL/6 strains.
Volume: 13
Pages: 79-85
•
•
•
•
•
Publication
2444436 | -
First Author: Amitsur M
Year: 1987
Journal: EMBO J
Title: Bacteriophage T4 anticodon nuclease, polynucleotide kinase and RNA ligase reprocess the host lysine tRNA.
Volume: 6
Issue: 8
Pages: 2499-503
•
•
•
•
•
Protein Domain
IPR032380 | PNKP_ligase_dom
Type: Domain
Description: This entry represents the ligase domain found in the PNKP (polynucleotide kinase-phosphatase) protein, which is a classical ligase nucleotidyltransferase module of bacteria. PNKP is the end-healing and end-sealing component of an RNA-repair system present in diverse bacteria from ten different phyla. RNA breakage by site-specific 'ribotoxins' is an ancient mechanism by which microbes respond to cellular stress and distinguish self from non-self. Ribotoxins are trans-esterifying endonucleases that generate 5'-OH and 2',3' cyclic phosphate termini. Repair of this type of RNA damage is feasible via sequential enzymatic end-healing and end-sealing steps [].
•
•
•
•
•
Publication
17986465 | -
First Author: Keppetipola N
Year: 2007
Journal: Nucleic Acids Res
Title: Characterization of the 2',3' cyclic phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase and bacteriophage lambda phosphatase.
Volume: 35
Issue: 22
Pages: 7721-32
•
•
•
•
•
Protein Domain
IPR024028 | PNKP_bac
Type: Family
Description: Members of this family are the bacterial polynucleotide kinase-phosphatase (Pnkp) enzymes that prepare broken RNA termini for sealing by RNA ligase []. Their genes co-occur with genes for the 3' terminal RNA ribose 2'-O-methyltransferase Hen1, and the pair are thought to form a bacterial RNA repair cassette, where a combination of Pnkp (RNA repair) and Hen1 (RNA modification) serves to first repair RNA damage from ribotoxins and then perform a modification that prevents the damage from recurring [].
•
•
•
•
•
Publication
28002403 | J:241443
First Author: Hoch NC
Year: 2017
Journal: Nature
Title: XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.
Volume: 541
Issue: 7635
Pages: 87-91
•
•
•
•
•
Publication
23964092 | J:201067
First Author: Li M
Year: 2013
Journal: Genes Dev
Title: The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response.
Volume: 27
Issue: 16
Pages: 1752-68
•
•
•
•
•
Publication
32205441 | J:290131
First Author: Chakraborty A
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.
Volume: 117
Issue: 14
Pages: 8154-8165
•
•
•
•
•
Publication
25633985 | J:222893
First Author: Chatterjee A
Year: 2015
Journal: PLoS Genet
Title: The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.
Volume: 11
Issue: 1
Pages: e1004749
•
•
•
•
•
Publication
33468657 | J:301531
 
First Author: Morozko EL
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease.
Volume: 118
Issue: 4
•
•
•
•
•
Publication
12059787 | -
First Author: Iwanicki A
Year: 2002
Journal: Biochem J
Title: PrpE, a PPP protein phosphatase from Bacillus subtilis with unusual substrate specificity.
Volume: 366
Issue: Pt 3
Pages: 929-36
•
•
•
•
•
Publication
20007328 | -
First Author: Jain R
Year: 2010
Journal: RNA
Title: Bacterial Hen1 is a 3' terminal RNA ribose 2'-O-methyltransferase component of a bacterial RNA repair cassette.
Volume: 16
Issue: 2
Pages: 316-23
•
•
•
•
•
Publication
23595150 | -
First Author: Wang LK
Year: 2013
Journal: Nucleic Acids Res
Title: Structure and mechanism of the 2',3' phosphatase component of the bacterial Pnkp-Hen1 RNA repair system.
Volume: 41
Issue: 11
Pages: 5864-73
•
•
•
•
•
Protein Domain
IPR041780 | MPP_PrpE-like
Type: Domain
Description: This entry represents the metallophosphatase domain of Bacillus subtilis PrpE and related proteins. PrpE (protein phosphatase E) is a bacterial member of the PPP (phosphoprotein phosphatase) family of serine/threonine phosphatases and a key signal transduction pathway component controlling the expression of spore germination receptors GerA and GerK in Bacillus subtilis. PrpE is closely related to ApaH (also known symmetrical Ap(4)A hydrolase and bis(5'nucleosyl)-tetraphosphatase). PrpE has specificity for phosphotyrosine only, unlike the serine/threonine phosphatases to which it is related []. The Bacilli members of this family are single domain proteins while the other members have N- and C-terminal domains in addition to this phosphatase domain. Polynucleotide kinase/phosphatase (Pnkp) is the end-healing and end-sealing component of an RNA repair system present in bacteria []. It is composed of three catalytic modules: an N-terminal polynucleotide 5' kinase, a central 2',3' phosphatase, and a C-terminal ligase. Pnkp is a Mn(2+)-dependent phosphodiesterase-monoesterase that dephosphorylates 2',3'-cyclic phosphate RNA ends. An RNA binding site is suggested by a continuous tract of positive surface potential flanking the active site [].The PPP (phosphoprotein phosphatase) family, to which PrpE belongs, is one of two known protein phosphatase families specific for serine and threonine. The PPP family also includes: PP1, PP2A, PP2B (calcineurin), PP4, PP5, PP6, PP7, Bsu1, RdgC, PrpA/PrpB, and ApA4 hydrolase. The PPP catalytic domain is defined by three conserved motifs (-GDXHG-, -GDXVDRG- and -GNHE-). The PPP enzyme family is ancient with members found in all eukaryotes, and in most bacterial and archeal genomes. Dephosphorylation of phosphoserines and phosphothreonines on target proteins plays a central role in the regulation of many cellular processes [, ]. PPPs belong to the metallophosphatase (MPP) superfamily.
•
•
•
•
•
Publication
9192069 | J:40791
First Author: Jia Z
Year: 1997
Journal: Biochem Cell Biol
Title: Protein phosphatases: structures and implications.
Volume: 75
Issue: 1
Pages: 17-26
•
•
•
•
•
Publication
9646865 | -
 
First Author: Barford D
Year: 1998
Journal: Annu Rev Biophys Biomol Struct
Title: The structure and mechanism of protein phosphatases: insights into catalysis and regulation.
Volume: 27
Pages: 133-64
•
•
•
•
•
Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
•
•
•
•
•
Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom