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Search results 101 to 133 out of 133 for Pnpla3

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0.018s

Type

Details

Score

Protein Domain

IPR039185 | Pat_PNPLA3

Type:

Family

Description:

This family represents PNPLA3 (patatin-like phospholipase domain-containing protein 3) from mammals, also known as ADPN (adiponutrin) or iPLA2-epsilon (calcium-independent phospholipase A2). PNPLA3 is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes and is an indicator of the nutritional state. Human adiponutrins are bound to the cell membrane of adipocytes and show transacylase, TG hydrolase, and PLA2 activity [, , ]. In murine models, PNPLA3 was found to be involved in the hepatic metabolism of triglycerides and in the regulation of systemic glucose homeostasis [].

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UniProt Feature

Begin:	1
Description:	1-acylglycerol-3-phosphate O-acyltransferase Pnpla3
Type:	chain
End:	413

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Allele

Pnpla3<em1Smoc> | MGI:7291741

Name:	patatin-like phospholipase domain containing 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Not Specified

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Strain

MGI:6429382 | C57BL/6JSmoc-Pnpla3<em1Smoc>/Smoc

Attribute String:

coisogenic, mutant strain, endonuclease-mediated mutation

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Publication

19029121 | -

First Author:	Kienesberger PC
Year:	2009
Journal:	J Lipid Res
Title:	Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions.
Volume:	50 Suppl

Pages:	S63-8

•

Publication

16799181 | -

First Author:	Wilson PA
Year:	2006
Journal:	J Lipid Res
Title:	Characterization of the human patatin-like phospholipase family.
Volume:	47
Issue:	9
Pages:	1940-9

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Publication

36103835 | J:329333

First Author:	Kabbani M
Year:	2022
Journal:	Cell Rep
Title:	Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice.
Volume:	40
Issue:	11
Pages:	111321

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Publication

26083785 | -

First Author:	Xie M
Year:	2015
Journal:	PLoS Genet
Title:	The Causative Gene in Chanarian Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans.
Volume:	11
Issue:	6
Pages:	e1005284

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Publication

19052547 | -

First Author:	Narbonne P
Year:	2009
Journal:	Nature
Title:	Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival.
Volume:	457
Issue:	7226
Pages:	210-4

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Publication

20176933 | -

First Author:	Zhang SO
Year:	2010
Journal:	Proc Natl Acad Sci U S A
Title:	Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans.
Volume:	107
Issue:	10
Pages:	4640-5

•

Publication

24120942 | -

First Author:	Noble T
Year:	2013
Journal:	Cell Metab
Title:	An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat.
Volume:	18
Issue:	5
Pages:	672-84

•

Publication

25202121 | -

First Author:	Lee JH
Year:	2014
Journal:	Mol Cell Biol
Title:	Lipid droplet protein LID-1 mediates ATGL-1-dependent lipolysis during fasting in Caenorhabditis elegans.
Volume:	34
Issue:	22
Pages:	4165-76

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Publication

26098762 | -

First Author:	Xie M
Year:	2015
Journal:	PLoS One
Title:	AMP-Activated Kinase Regulates Lipid Droplet Localization and Stability of Adipose Triglyceride Lipase in C. elegans Dauer Larvae.
Volume:	10
Issue:	6
Pages:	e0130480

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Protein Domain

IPR033562 | PLPL

Type:

Family

Description:

This entry includes patatin-like phospholipase domain-containing proteins 1-5 (PNPLA1-5) from humans and Atgl-1 from Caenorhabditis elegans. They are a group of lipid hydrolases. Atgl-1 may play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion [, , , , , ]. In humans PNPLA1 has a role in the formation of the epidermal lipid barrier; mutations in this gene are associated with the skin disorder known as ichthyosis []. PNPLA1 acts as an omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation [, ]. It catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramid [].Human PNPLA2 catalyses the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets []. PNPLA3 has both triacylglycerol lipase and acylglycerol O-acyltransferase activities [].

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Publication

31813960 | J:285758

First Author:	Saeed A
Year:	2020
Journal:	Hum Mol Genet
Title:	Glycogen storage disease type 1a is associated with disturbed vitamin A metabolism and elevated serum retinol levels.
Volume:	29
Issue:	2
Pages:	264-273

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Publication

38294943 | J:358003

First Author:	Das A
Year:	2024
Journal:	Proc Natl Acad Sci U S A
Title:	The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3.
Volume:	121
Issue:	6
Pages:	e2312291121

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Publication

23977068 | J:206346

First Author:	Kosters A
Year:	2013
Journal:	PLoS One
Title:	Sexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRα) determines male-female differences in the expression of hepatic lipid processing genes in mice.
Volume:	8
Issue:	8
Pages:	e71538

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Publication

31529722 | J:296056

First Author:	Matsuzaka T
Year:	2020
Journal:	Hepatology
Title:	Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice.
Volume:	71
Issue:	5
Pages:	1609-1625

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Publication

15550674 | J:289460

First Author:	Zimmermann R
Year:	2004
Journal:	Science
Title:	Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
Volume:	306
Issue:	5700
Pages:	1383-6

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Publication

27751867 | J:240053

First Author:	Grond S
Year:	2017
Journal:	J Invest Dermatol
Title:	PNPLA1 Deficiency in Mice and Humans Leads to a Defect in the Synthesis of Omega-O-Acylceramides.
Volume:	137
Issue:	2
Pages:	394-402

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Publication

22246504 | -

First Author:	Grall A
Year:	2012
Journal:	Nat Genet
Title:	PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans.
Volume:	44
Issue:	2
Pages:	140-7

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Publication

28248318 | -

First Author:	Ohno Y
Year:	2017
Journal:	Nat Commun
Title:	PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide.
Volume:	8

Pages:	14610

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Protein

Q3V1D5

Organism:	Mus musculus/domesticus
Length:	599
Fragment?:	false

•

Protein

Q32LZ8

Organism:	Mus musculus/domesticus
Length:	432
Fragment?:	false

•

Protein

E9PZA4

Organism:	Mus musculus/domesticus
Length:	305
Fragment?:	true

•

Protein

E9Q323

Organism:	Mus musculus/domesticus
Length:	158
Fragment?:	true

•

Protein

B2KF06

Organism:	Mus musculus/domesticus
Length:	599
Fragment?:	false

•

Protein

H3BIT5

Organism:	Mus musculus/domesticus
Length:	70
Fragment?:	false

•

Publication

15364929 | -

First Author:	Jenkins CM
Year:	2004
Journal:	J Biol Chem
Title:	Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.
Volume:	279
Issue:	47
Pages:	48968-75

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Protein

Q8BJ56

Organism:	Mus musculus/domesticus
Length:	486
Fragment?:	false

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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