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Search results 101 to 200 out of 336 for Prmt5

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Hits by Pathway

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Hits by Strain

Type Details Score
Protein Coding Gene
MGP_BALBcJ_G0021275 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021055 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1351645 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021714 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020574 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021022 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021143 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021125 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0021217 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021149 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021740 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0020320 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020627 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030277 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020148 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
25687507 | J:220166
First Author: Berrens RV
Year: 2015
Journal: EMBO J
Title: Prmt5: a guardian of the germline protects future generations.
Volume: 34
Issue: 6
Pages: 689-90
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GXD Expression
GXD Expression
   
Probe: MGI:5689336
Assay Type: Western blot
Annotation Date: 2015-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691017
Stage: TS17
Assay Id: MGI:5689370
Age: embryonic day 10.5
Image: 5
Specimen Label: Input
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6164183
Assay Type: Western blot
Annotation Date: 2018-07-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116915
Stage: TS15
Assay Id: MGI:6164184
Age: embryonic day 9.5
Image: 2
Specimen Label: Rostral
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6164183
Assay Type: Western blot
Annotation Date: 2018-07-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116915
Stage: TS15
Assay Id: MGI:6164184
Age: embryonic day 9.5
Image: 2
Specimen Label: Medial
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6164183
Assay Type: Western blot
Annotation Date: 2018-07-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116915
Stage: TS15
Assay Id: MGI:6164184
Age: embryonic day 9.5
Image: 2
Specimen Label: Caudal
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6402950
Assay Type: Immunohistochemistry
Annotation Date: 2020-04-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:6402951
Age: embryonic day 2.0
Image: 4D
Specimen Label: 4D
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6415673
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Pattern: Not Specified
Stage: TS01
Assay Id: MGI:6415679
Age: embryonic day 0.5
Image: 1A Zygote
Note: Protein is in the cytoplasm.
Specimen Label: 1A Zygote
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6415673
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160414
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:6415679
Age: embryonic day 3.5
Image: 1A E3.5
Note: Protein is nuclear.
Specimen Label: 1A E3.5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:3585057
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585511
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:6415673
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318653
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:6415679
Age: embryonic day 2.5
Image: 1A 8-cell
Specimen Label: 1A 8-cell
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5689336
Assay Type: Immunohistochemistry
Annotation Date: 2015-10-07
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5689342
Age: embryonic day 13.5
Image: 7D
Specimen Label: 7D
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5689336
Assay Type: Immunohistochemistry
Annotation Date: 2015-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5689342
Age: embryonic day 10.5
Image: 5C
Note: Expression is present in neuroepithelial cells.
Specimen Label: 5C
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3585057
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585511
Age: postnatal day 6
Note: Expression was widespread.
Specimen Label: CNS
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:3585057
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585511
Age: embryonic day 16.0
Note: Expression was widespread.
Specimen Label: Embryo
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
Probe: MGI:6415673
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160399
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6415679
Age: embryonic day 6.5
Image: 1A E6.5
Note: Protein is predominantly cytoplasmic and is upregulated in the epiblast.
Specimen Label: 1A E6.5
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:3585057
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3585511
Age: embryonic day 18.0
Image: E18
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E18
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3585057
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:3585511
Age: postnatal day 0-1
Image: P0/1
Note: Expression was detected in the vitreal outer neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:3585057
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585511
Age: postnatal day 2-3
Image: P2/3
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:3585057
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585511
Age: postnatal day 4-5
Image: P4/5
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P4/5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:3585057
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585511
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:3585057
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:3585511
Age: embryonic day 16.0
Image: E16
Note: Expression was detected in the outer neuroblastic layer but was higher in a subset of cells.
Specimen Label: E16
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6415673
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160403
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:6415679
Age: embryonic day 3.0
Image: 1A Morula
Specimen Label: 1A Morula
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:6415673
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160464
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:6415679
Age: embryonic day 3.5
Image: 1A E3.5
Note: Protein is nuclear.
Specimen Label: 1A E3.5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:6415673
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160466
Pattern: Not Specified
Stage: TS06
Assay Id: MGI:6415679
Age: embryonic day 4.5
Image: 1A E4.5
Note: Protein is nuclear.
Specimen Label: 1A E4.5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:6415673
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-11
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:160506
Pattern: Not Specified
Stage: TS06
Assay Id: MGI:6415679
Age: embryonic day 4.5
Image: 1A E4.5
Specimen Label: 1A E4.5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:6415673
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-11
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6415679
Age: postnatal adult
Image: 1A Oocyte
Note: Protein is in the cytoplasm.
Specimen Label: 1A Oocyte
Detected: true
Specimen Num: 1
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Publication
25810472 | J:277545
First Author: Wang Y
Year: 2015
Journal: Biol Reprod
Title: Protein arginine methyltransferase 5 (Prmt5) is required for germ cell survival during mouse embryonic development.
Volume: 92
Issue: 4
Pages: 104
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Publication
25284789 | J:320270
First Author: Takai H
Year: 2014
Journal: Cell Rep
Title: 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
Volume: 9
Issue: 1
Pages: 48-60
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Publication
25970242 | J:226373
First Author: Koh CM
Year: 2015
Journal: Nature
Title: MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis.
Volume: 523
Issue: 7558
Pages: 96-100
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Publication
11756452 | J:320168
First Author: Friesen WJ
Year: 2002
Journal: J Biol Chem
Title: A novel WD repeat protein component of the methylosome binds Sm proteins.
Volume: 277
Issue: 10
Pages: 8243-7
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Publication
35705491 | J:341703
 
First Author: Lee J
Year: 2022
Journal: Life Sci Alliance
Title: PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system.
Volume: 5
Issue: 10
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Publication
30846735 | J:276643
First Author: Oqani RK
Year: 2019
Journal: Sci Rep
Title: Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation.
Volume: 9
Issue: 1
Pages: 3831
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Publication
19858291 | J:156247
First Author: van Dijk TB
Year: 2010
Journal: Mol Cell Biol
Title: Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases.
Volume: 30
Issue: 1
Pages: 260-72
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Publication
29908641 | J:264087
 
First Author: Sato A
Year: 2018
Journal: Placenta
Title: Gestational changes in PRMT1 expression of murine placentas.
Volume: 65
Pages: 47-54
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Publication
18495660 | J:138740
First Author: Fronz K
Year: 2008
Journal: J Biol Chem
Title: Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior.
Volume: 283
Issue: 29
Pages: 20408-20
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Publication
19584108 | J:151086
First Author: Vagin VV
Year: 2009
Journal: Genes Dev
Title: Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.
Volume: 23
Issue: 15
Pages: 1749-62
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Publication
16690984 | J:126896
First Author: Yildirim AO
Year: 2006
Journal: Am J Respir Cell Mol Biol
Title: Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases.
Volume: 35
Issue: 4
Pages: 436-43
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Publication
19525957 | J:149352
First Author: Pettitt SJ
Year: 2009
Journal: Nat Methods
Title: Agouti C57BL/6N embryonic stem cells for mouse genetic resources.
Volume: 6
Issue: 7
Pages: 493-5
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Publication
25329411 | J:217429
First Author: Cho OH
Year: 2015
Journal: Dev Dyn
Title: Contrasting roles for MyoD in organizing myogenic promoter structures during embryonic skeletal muscle development.
Volume: 244
Issue: 1
Pages: 43-55
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Publication
16787967 | J:112036
First Author: Costa Y
Year: 2006
Journal: Hum Mol Genet
Title: Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?
Volume: 15
Issue: 15
Pages: 2324-34
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Protein Domain
IPR007857 | Arg_MeTrfase_PRMT5
Type: Family
Description: This entry represents a group of arginine N-methyltransferases, including Skb1 from S. pombe [], Hsl7 from S. cerevisiae []and their homologues PRMT5 from animals [, , ]and plants []. Skb1 is a mediator of hyperosmotic stress response in Schizosaccharomyces pombe []. Plant PMRT15 is involved in the post-transcriptional regulation of the circadian clock []. Human PRMT5 is a component of multiple protein complexes and contributes to essential cellular processes, such as RNA transport and splicing, cell cycle regulation, tumour growth, and chromatin remodelling, leading to either gene silencing or activation [].
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Publication
18404153 | -
First Author: Lacroix M
Year: 2008
Journal: EMBO Rep
Title: The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5.
Volume: 9
Issue: 5
Pages: 452-8
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Protein Domain
IPR029289 | COPR5
Type: Family
Description: Coordinator of PRMT5 and differentiation stimulator (also known as COPRS or COPR5) is a histone-binding protein required for histone H4 methyltransferase activity of PRMT5, which targets nuclear and cytoplasmic proteins. COPR5 is specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of nuclear PRMT5-containing complexes, atleast towards histones. Recombinant COPR5 binds to the N-terminal of histone H4 and is required to recruit PRMT5 to reconstituted nucleosomes in vitro [].
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Gene
290925 | Coprs
Type: gene
Organism: rat
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Gene
480617 | COPRS
Type: gene
Organism: dog, domestic
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Gene
748417 | COPRS
Type: gene
Organism: chimpanzee
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Gene
506999 | COPRS
Type: gene
Organism: cattle
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Gene
100363551 | Coprs-ps1
Type: gene
Organism: rat
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