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Search results 101 to 200 out of 3238 for Psen1

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Type Details Score
Publication
34758364 | J:321426
 
First Author: Si Y
Year: 2022
Journal: Behav Brain Res
Title: Noncognitive species-typical and home-cage behavioral alterations in conditional presenilin 1/presenilin 2 double knockout mice.
Volume: 418
Pages: 113652
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Publication
34292306 | J:321625
 
First Author: Wouters R
Year: 2021
Journal: J Cell Biol
Title: Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.
Volume: 220
Issue: 9
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Publication
17596450 | J:122975
First Author: Lazarov O
Year: 2007
Journal: J Neurosci
Title: Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1.
Volume: 27
Issue: 26
Pages: 7011-20
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Publication
9160754 | J:40365
First Author: Shen J
Year: 1997
Journal: Cell
Title: Skeletal and CNS defects in Presenilin-1-deficient mice.
Volume: 89
Issue: 4
Pages: 629-39
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Publication
15519767 | J:94236
First Author: Wen PH
Year: 2004
Journal: Neurosci Lett
Title: Neural progenitor cells do not differentiate prematurely in presenilin-1 null mutant mice.
Volume: 371
Issue: 2-3
Pages: 249-54
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Publication
30059908 | J:264269
 
First Author: Azimi M
Year: 2018
Journal: Differentiation
Title: Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens.
Volume: 102
Pages: 40-52
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Publication
38226162 | J:351216
First Author: Saito J
Year: 2024
Journal: iScience
Title: Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy.
Volume: 27
Issue: 1
Pages: 108636
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Publication
37143894 | J:337547
 
First Author: Tiberi A
Year: 2023
Journal: Front Cell Dev Biol
Title: Reduced levels of NGF shift astrocytes toward a neurotoxic phenotype.
Volume: 11
Pages: 1165125
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Publication
27069115 | J:233316
First Author: Yuede CM
Year: 2016
Journal: J Exp Med
Title: Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer's mouse model.
Volume: 213
Issue: 5
Pages: 677-85
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Publication
18304749 | J:135640
First Author: Pistell PJ
Year: 2008
Journal: Neuroscience
Title: Acquisition of conditioned taste aversion is impaired in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease.
Volume: 152
Issue: 3
Pages: 594-600
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Publication
37298502 | J:348455
 
First Author: Choi Y
Year: 2023
Journal: Int J Mol Sci
Title: Capacitive Electrode-Based Electric Field Treatments on Redox-Toxic Iron Deposits in Transgenic AD Mouse Models: The Electroceutical Targeting of Alzheimer's Disease Feasibility Study.
Volume: 24
Issue: 11
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Publication
21239495 | J:170632
First Author: Greenough MA
Year: 2011
Journal: J Biol Chem
Title: Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity.
Volume: 286
Issue: 11
Pages: 9776-86
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Publication
23259730 | J:309717
 
First Author: De Gasperi R
Year: 2012
Journal: BMC Biochem
Title: Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cells.
Volume: 13
Pages: 28
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Publication
19936202 | J:155410
First Author: Willuweit A
Year: 2009
Journal: PLoS One
Title: Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.
Volume: 4
Issue: 11
Pages: e7931
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16303255 | J:105507
First Author: Spencer JP
Year: 2006
Journal: Neuroscience
Title: Transgenic mice over-expressing human beta-amyloid have functional nicotinic alpha 7 receptors.
Volume: 137
Issue: 3
Pages: 795-805
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Publication
15261108 | J:91273
First Author: Howlett DR
Year: 2004
Journal: Brain Res
Title: Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.
Volume: 1017
Issue: 1-2
Pages: 130-6
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Publication
17088253 | J:118134
First Author: Priller C
Year: 2007
Journal: J Biol Chem
Title: Mutant presenilin 1 alters synaptic transmission in cultured hippocampal neurons.
Volume: 282
Issue: 2
Pages: 1119-27
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Publication
30089166 | J:269173
First Author: Cummings M
Year: 2018
Journal: PLoS One
Title: Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis.
Volume: 13
Issue: 8
Pages: e0200752
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Publication
31142678 | J:275647
 
First Author: Habets RA
Year: 2019
Journal: Sci Transl Med
Title: Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.
Volume: 11
Issue: 494
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Publication
17233641 | J:116798
First Author: Reiserer RS
Year: 2007
Journal: Genes Brain Behav
Title: Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.
Volume: 6
Issue: 1
Pages: 54-65
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Publication
33450722 | J:305544
 
First Author: Cheng Z
Year: 2021
Journal: Neurobiol Aging
Title: Presenilin 1 mutation likely contributes to U1 small nuclear RNA dysregulation and Alzheimer's disease-like symptoms.
Volume: 100
Pages: 1-10
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Publication
33314529 | J:331908
First Author: Audrain M
Year: 2021
Journal: Alzheimers Dement
Title: Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice.
Volume: 17
Issue: 2
Pages: 149-163
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Publication
32522344 | J:293057
 
First Author: Kuroda E
Year: 2020
Journal: Neuroscience
Title: Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ.
Volume: 438
Pages: 217-228
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Publication
37213691 | J:338490
 
First Author: Demuth H
Year: 2023
Journal: Front Mol Neurosci
Title: Deletion of p75(NTR) rescues the synaptic but not the inflammatory status in the brain of a mouse model for Alzheimer's disease.
Volume: 16
Pages: 1163087
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Publication
30120949 | J:270232
 
First Author: Wang M
Year: 2018
Journal: Neurosci Lett
Title: Beta-secretase/BACE1 promotes APP endocytosis and processing in the endosomes and on cell membrane.
Volume: 685
Pages: 63-67
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Publication
23747948 | J:199082
First Author: Frost JL
Year: 2013
Journal: Am J Pathol
Title: Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.
Volume: 183
Issue: 2
Pages: 369-81
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Publication
23833557 | J:202532
First Author: Lee JE
Year: 2013
Journal: Exp Neurobiol
Title: An update of animal models of Alzheimer disease with a reevaluation of plaque depositions.
Volume: 22
Issue: 2
Pages: 84-95
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Publication
15009636 | J:107993
First Author: Yang Y
Year: 2004
Journal: J Neurochem
Title: Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake.
Volume: 88
Issue: 6
Pages: 1361-72
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Publication
27425031 | J:255474
First Author: Kamphuis W
Year: 2016
Journal: Biochim Biophys Acta
Title: Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease.
Volume: 1862
Issue: 10
Pages: 1847-60
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Publication
28855626 | J:255802
First Author: Baglietto-Vargas D
Year: 2017
Journal: Sci Rep
Title: Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease.
Volume: 7
Issue: 1
Pages: 10085
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Publication
25741723 | J:219929
First Author: Xia D
Year: 2015
Journal: Neuron
Title: Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.
Volume: 85
Issue: 5
Pages: 967-81
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Publication
9883847 | J:51950
First Author: Guo Q
Year: 1999
Journal: Nat Med
Title: Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.
Volume: 5
Issue: 1
Pages: 101-6
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Publication
10764737 | J:62820
First Author: Chan SL
Year: 2000
Journal: J Biol Chem
Title: Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons.
Volume: 275
Issue: 24
Pages: 18195-200
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Publication
12390529 | J:79892
First Author: Milhavet O
Year: 2002
Journal: J Neurochem
Title: Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations.
Volume: 83
Issue: 3
Pages: 673-81
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Publication
18068871 | J:152964
First Author: Wang Y
Year: 2009
Journal: Neurobiol Aging
Title: Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices.
Volume: 30
Issue: 7
Pages: 1061-8
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Publication
26455952 | J:232370
First Author: Kim S
Year: 2015
Journal: Neurobiol Aging
Title: Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant.
Volume: 36
Issue: 12
Pages: 3239-3246
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Publication
10526115 | J:57847
First Author: Zhu H
Year: 1999
Journal: Brain Res
Title: Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation.
Volume: 842
Issue: 1
Pages: 224-9
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Publication
14724250 | J:87452
First Author: Stutzmann GE
Year: 2004
Journal: J Neurosci
Title: Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.
Volume: 24
Issue: 2
Pages: 508-13
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Publication
12064358 | J:106192
First Author: LaFontaine MA
Year: 2002
Journal: Neurochem Res
Title: Oxidative stress in synaptosomal proteins from mutant presenilin-1 knock-in mice: implications for familial Alzheimer's disease.
Volume: 27
Issue: 5
Pages: 417-21
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Publication
18205190 | J:156283
First Author: Wang G
Year: 2008
Journal: Glia
Title: Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes.
Volume: 56
Issue: 4
Pages: 449-56
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Publication
23726841 | J:199100
First Author: Chu TH
Year: 2013
Journal: Cancer Lett
Title: miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII.
Volume: 337
Issue: 1
Pages: 115-24
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Publication
10811821 | J:62231
First Author: Leissring MA
Year: 2000
Journal: J Cell Biol
Title: Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice.
Volume: 149
Issue: 4
Pages: 793-8
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Publication
10662826 | J:60290
First Author: Mattson MP
Year: 2000
Journal: J Neurosci
Title: Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.
Volume: 20
Issue: 4
Pages: 1358-64
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Publication
10097174 | J:54086
First Author: Guo Q
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation.
Volume: 96
Issue: 7
Pages: 4125-30
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Publication
11578614 | J:72044
First Author: Xie J
Year: 2001
Journal: Brain Res
Title: Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice.
Volume: 915
Issue: 1
Pages: 1-10
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Publication
10037473 | J:53132
First Author: Guo Q
Year: 1999
Journal: J Neurochem
Title: Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.
Volume: 72
Issue: 3
Pages: 1019-29
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Publication
18466334 | J:139367
First Author: Malik B
Year: 2008
Journal: J Neurochem
Title: Cell cycle-driven neuronal apoptosis specifically linked to amyloid peptide Abeta1-42 exposure is not exacerbated in a mouse model of presenilin-1 familial Alzheimer's disease.
Volume: 106
Issue: 2
Pages: 912-6
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Publication
8986743 | J:83861
First Author: Citron M
Year: 1997
Journal: Nat Med
Title: Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Volume: 3
Issue: 1
Pages: 67-72
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Publication
10880403 | J:63138
First Author: Takeuchi A
Year: 2000
Journal: Am J Pathol
Title: Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.
Volume: 157
Issue: 1
Pages: 331-9
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Publication
16307858 | J:128243
First Author: Wirths O
Year: 2006
Journal: Exp Gerontol
Title: Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease.
Volume: 41
Issue: 2
Pages: 220-4
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Publication
38684238 | J:357877
First Author: Erkert L
Year: 2024
Journal: Gut
Title: Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis.
Volume: 73
Issue: 10
Pages: 1618-1631
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Publication
18834536 | J:187802
 
First Author: Mirnics K
Year: 2008
Journal: Mol Neurodegener
Title: Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice.
Volume: 3
Pages: 14
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Publication
30201812 | J:266223
First Author: Tanaka Y
Year: 2018
Journal: J Immunol
Title: Presenilin 1 Regulates NF-κB Activation via Association with Breakpoint Cluster Region and Casein Kinase II.
Volume: 201
Issue: 8
Pages: 2256-2263
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Publication
22496554 | J:184454
First Author: Watanabe H
Year: 2012
Journal: J Neurosci
Title: Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice.
Volume: 32
Issue: 15
Pages: 5085-96
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Publication
34329683 | J:312987
First Author: Sato K
Year: 2021
Journal: J Biol Chem
Title: A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide.
Volume: 297
Issue: 3
Pages: 101004
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Publication
10821758 | J:62163
First Author: Handler M
Year: 2000
Journal: Development
Title: Presenilin-1 regulates neuronal differentiation during neurogenesis.
Volume: 127
Issue: 12
Pages: 2593-606
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Publication
31577226 | J:290203
   
First Author: Javier-Torrent M
Year: 2019
Journal: Elife
Title: Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA.
Volume: 8
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Publication
20399254 | J:165240
First Author: Odero GL
Year: 2010
Journal: Neuroscience
Title: Evidence for the involvement of calbindin D28k in the presenilin 1 model of Alzheimer's disease.
Volume: 169
Issue: 1
Pages: 532-43
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Publication
17196556 | J:118185
First Author: Payette DJ
Year: 2007
Journal: Brain Res
Title: Reduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in mice.
Volume: 1135
Issue: 1
Pages: 12-21
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19005074 | J:142399
First Author: Tamboli IY
Year: 2008
Journal: J Neurosci
Title: Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.
Volume: 28
Issue: 46
Pages: 12097-106
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Publication
22311977 | J:316671
First Author: Shilling D
Year: 2012
Journal: J Biol Chem
Title: Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels.
Volume: 287
Issue: 14
Pages: 10933-44
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Publication
12460542 | J:125448
First Author: Chan SL
Year: 2002
Journal: Neurobiol Dis
Title: Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12.
Volume: 11
Issue: 1
Pages: 2-19
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Publication
11896164 | J:75588
First Author: Jantzen PT
Year: 2002
Journal: J Neurosci
Title: Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.
Volume: 22
Issue: 6
Pages: 2246-54
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Publication
11822882 | J:74751
First Author: Gordon MN
Year: 2002
Journal: Exp Neurol
Title: Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse.
Volume: 173
Issue: 2
Pages: 183-95
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11520121 | J:71666
First Author: Kurt MA
Year: 2001
Journal: Exp Neurol
Title: Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes.
Volume: 171
Issue: 1
Pages: 59-71
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9427614 | J:45724
First Author: Holcomb L
Year: 1998
Journal: Nat Med
Title: Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.
Volume: 4
Issue: 1
Pages: 97-100
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Publication
11476589 | J:71061
First Author: Jaffar S
Year: 2001
Journal: Exp Neurol
Title: Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway.
Volume: 170
Issue: 2
Pages: 227-43
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11493021 | J:71187
First Author: Poduslo JF
Year: 2001
Journal: Neurobiol Dis
Title: Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease.
Volume: 8
Issue: 4
Pages: 555-67
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22393443 | J:185288
First Author: Trushina E
Year: 2012
Journal: PLoS One
Title: Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease.
Volume: 7
Issue: 2
Pages: e32737
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33255764 | J:305084
 
First Author: Kartalou GI
Year: 2020
Journal: Int J Mol Sci
Title: Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model.
Volume: 21
Issue: 23
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Publication
20359773 | J:188249
First Author: Gengler S
Year: 2012
Journal: Neurobiol Aging
Title: Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice.
Volume: 33
Issue: 2
Pages: 265-76
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Publication
15207348 | J:91277
First Author: Wang R
Year: 2004
Journal: Neuroscience
Title: Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis.
Volume: 126
Issue: 2
Pages: 305-12
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Publication
24145027 | J:209333
First Author: Almenar-Queralt A
Year: 2013
Journal: J Biol Chem
Title: Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation.
Volume: 288
Issue: 49
Pages: 35222-36
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30519973 | J:352127
First Author: Zhang H
Year: 2019
Journal: Angiogenesis
Title: Mouse models of Alzheimer's disease cause rarefaction of pial collaterals and increased severity of ischemic stroke.
Volume: 22
Issue: 2
Pages: 263-279
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33302995 | J:351231
First Author: Kang J
Year: 2020
Journal: Mol Neurodegener
Title: Cell-autonomous role of Presenilin in age-dependent survival of cortical interneurons.
Volume: 15
Issue: 1
Pages: 72
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28739891 | J:244685
First Author: Keskin AD
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: BACE inhibition-dependent repair of Alzheimer's pathophysiology.
Volume: 114
Issue: 32
Pages: 8631-8636
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12805290 | J:83886
First Author: Pigino G
Year: 2003
Journal: J Neurosci
Title: Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
Volume: 23
Issue: 11
Pages: 4499-508
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Publication
10964951 | J:64209
First Author: Dewachter I
Year: 2000
Journal: J Neurosci
Title: Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1.
Volume: 20
Issue: 17
Pages: 6452-8
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Publication
17222948 | J:137684
First Author: Dewachter I
Year: 2008
Journal: Neurobiol Aging
Title: Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1.
Volume: 29
Issue: 5
Pages: 639-52
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Publication
16574645 | J:113453
First Author: Wang R
Year: 2006
Journal: J Biol Chem
Title: Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology.
Volume: 281
Issue: 22
Pages: 15330-6
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Publication
8878479 | J:80861
First Author: Duff K
Year: 1996
Journal: Nature
Title: Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.
Volume: 383
Issue: 6602
Pages: 710-3
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10037474 | J:53131
First Author: Begley JG
Year: 1999
Journal: J Neurochem
Title: Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.
Volume: 72
Issue: 3
Pages: 1030-9
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Publication
38462606 | J:347713
First Author: Zhong MZ
Year: 2024
Journal: Mol Neurodegener
Title: Updates on mouse models of Alzheimer's disease.
Volume: 19
Issue: 1
Pages: 23
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Publication
21725313 | J:175901
First Author: Saito T
Year: 2011
Journal: Nat Neurosci
Title: Potent amyloidogenicity and pathogenicity of Aβ43.
Volume: 14
Issue: 8
Pages: 1023-32
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